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Search Results: 1 - 10 of 200649 matches for " P. Giaccone "
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P. Catellani,L. Alberghini,V. Giaccone
Italian Journal of Food Safety , 2012, DOI: 10.4081/ijfs.2012.3.77
Abstract: Animal colostrum contains many substances with antibacterial activity such as lysozyme and lactoferrin which should inhibit the microbial growth. The aim of this research is to understand if colostrum can be considered a safe product, considering that Regulation (EC) N° 1662/2006, which has modified the Regulation (EC) N° 853/2004, introducing colostrum as human food. Microbiological tests, made on water buffalo colostrum, aiming to obtain the total microbial count (maximum concentration: 3,6 104 ufc/ml), the quantitative evaluation of total (maximum the highest concentration found: 2,3 103 ufc/ml) and fecal coliforms (maximum concentration: 4,9 102 ufc/ml) and the qualitative search of Salmonella spp. and Listeria monocytogenes, showed that there is not a microbial growth in colostrum, that it can be considered a safe food, from the microbial point of view
Factors associated with milk urea concentrations in Girgentana goats
P. Giaccone,M. Todaro,M.L. Scatassa
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2007.1s.622
Abstract: A total of 1,481 milk samples of 166 Girgentana goats, taken along the entire lactation, were utilised to evaluate the effect of non nutritional factors on milk urea (MU). Parity, stage of lactation and month of sampling significantly influenced MU, while no effect was found for born kids number. The first kidding goats produced lower MU than multiparous goats. Trend of MU was similar to milk production course with a peak found at 60 DIM. The different MU levels between several months of production are often linked to pasture chemical variations.
The influence of somatic cell count on sheep milk composition and cheese-making properties
P. Giaccone,M.L. Scatassa,M. Todaro
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2005.2s.345
Abstract: Somatic cell count (SCC) is an important tool for monitoring intramammary infections in dairy cows. However, systematic generalization of this decision rule is not easy in small ruminants. Determination of SCC in sheep milk is important for the processors of milk (indicator of quality), for breeders (mastitis indicator) and could be useful for selection as well. SCC value can be affected by some non-infective factors such as breed, stage of lactation, parity, type of lambing, type of milking, etc. (Bergonier et al., 1994), as well the health status of the udder (Fruganti et al., 1985; Ranucci et al., 1988). In addition, EC Directive 92/46, which regulates the production and commercialisation of milk and dairy products, imposes strict limits on SCC from dairy cattle but it does not dispel the uncertainty over recommended SCC levels in small ruminants.With the aim of knowing more about somatic cells count and their effects on milk quality and cheese-making properties an experimental trial was carried out.
L. Alberghini,P. Catellani,M.A. Norbiato,V. Giaccone
Italian Journal of Food Safety , 2012, DOI: 10.4081/ijfs.2012.3.7
Abstract: For its chemical and nutritional composition donkey milk is an excellent substitute for human breast milk. In fact, woman’s milk and donkey one are quite similar for their composition and for certain intrinsic properties. Based on these considerations, we performed a study on the microbiological characteristics of 86 jannet’s milk in 10 farms. Special attention was given to the aspects of health quality of the milk samples examined, referring to the analysis of total microbial count and pH, the possible presence of potentially pathogenic micro-organisms, especially by seeking the bacteria Escherichia coli O157, Salmonella spp., Listeria monocytogenes and Campylobacter spp. The samples of milk were picked up from January to March 2010. Our research showed a situation quite positive in terms of sanitation, finding levels of total microbial count (on average 1,8·104 cfu/ml) and pH (mean 7,02) entirely in line with data found in previous investigations of other Authors and with values reassuring in terms of healthiness of the product. Regarding the detection of potentially pathogenic microorganisms, only a milk sample of 86 tested was positive for E. coli O157; in an other sample low charges of Campylobacter spp. have been measured. Salmonella spp. and Listeria monocytogenes were not found in all samples. Total microbial count confirm the good quality of the donkey milk. However, occasional isolation of E. coli O157 and Campylobacter spp. suggests careful attention is to be done to the correct procedures of milking hygiene.
Grand Challenges in Oncology
Giuseppe Giaccone
Frontiers in Oncology , 2011, DOI: 10.3389/fonc.2011.00026
Palatability and In vivo Digestibility of Mulberry Leaves (Morus latifolia CV. Kokusou 21) in Sheep Feeding
M. Todaro,A. Sinacori,G. Marinaro,M.L. Alicata,P. Giaccone
Journal of Animal and Veterinary Advances , 2012,
Abstract: Mulberry (Morus latifolia L.) leaves and green tops were utilised to study the palatability and the digestibility in two sheep feeding trials. In trial 1 mulberry palatability was determined by cafeteria test, that studies the animal preferences in a short period of time without the interference of post-ingestive factors. Mulberry leaves were tested in respect to vetch hay and oat concentrate; results showed that mulberry leaves were significantly preferred to other feeds. In trial 2 an in vivo digestibility was carried out on 4 rams equipped with the bags for the faeces collection, housed in individual box and fed ad libitum. Results showed that mulberry leaves and green tops were more digestible (OM: 78.19%; CP: 79.19%: NDF: 77.77%; Cellulose: 88.32%) and with high nutrient value (NEL: 1.61 Mcal kg 1 DM, INRA method; NEL3m: 1.73 Mcal kg 1 DM, NRC method).
Stochastic Optimization of Service Provision with Selfish Users
F. Altarelli,A. Braunstein,C. F. Chiasserini,L. Dall'Asta,P. Giaccone,E. Leonardi,R. Zecchina
Computer Science , 2013,
Abstract: We develop a computationally efficient technique to solve a fairly general distributed service provision problem with selfish users and imperfect information. In particular, in a context in which the service capacity of the existing infrastructure can be partially adapted to the user load by activating just some of the service units, we aim at finding the configuration of active service units that achieves the best trade-off between maintenance (e.g.\ energetic) costs for the provider and user satisfaction. The core of our technique resides in the implementation of a belief-propagation (BP) algorithm to evaluate the cost configurations. Numerical results confirm the effectiveness of our approach.
Severe reversible cardiac failure after bortezomib treatment combined with chemotherapy in a non-small cell lung cancer patient: a case report
Jens Voortman, Giuseppe Giaccone
BMC Cancer , 2006, DOI: 10.1186/1471-2407-6-129
Abstract: We present here a case of severe, but reversible, congestive cardiac failure in a lung cancer patient who had no prior cardiac history, after receiving an experimental treatment of bortezomib combined with chemotherapy. Elevated levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP), as retrospectively measured in archived serum samples, were suggestive of pre-existent (sub-clinical) left ventricular dysfunction.Based on literature, we hypothesize that baseline presence of sub clinical cardiomyopathy, characterized by a dysregulation of the ubiquitin-proteasome system, could have predisposed this patient for a cardiac side effect induced by systemic proteasome inhibition.Patients with heart disease or risk factors for it should be closely monitored when being submitted to treatment with proteasome inhibition therapy such as bortezomib. Caution is therefore warranted in lung cancer patients who often present with cardiac comorbidities.The proteasome is a large protein complex with ATP-dependent proteolytic activity. In the evolutionarily highly conserved ubiquitin-proteasome pathway (UPP), a protein is "tagged" for degradation by the proteasome, when it is labeled with a chain of multiple ubiquitin molecules [1]. Bortezomib is a reversible inhibitor of the proteasome. Inhibition results in the accumulation of poly-ubiquitinated proteins involved in a plethora of signaling pathways. Among other effects, this can trigger apoptosis, with a relative selectivity in cytotoxicity for malignant as opposed to normal cells [2].Bortezomib, currently registered for multiple myeloma, showed some clinical activity as monotherapy in unselected non-small cell lung cancer (NSCLC) patients [3,4]. However, there is a strong preclinical rationale to investigate combination treatments of bortezomib and chemotherapy in solid tumors, including NSCLC. The patient we report here was included in a dose-finding study of bortezomib combined with cisplatin-gemcitabine chemotherapy in fi
Challenges in Cancer Molecular Targets and Therapeutics
Yisong Wang,Giuseppe Giaccone
Frontiers in Oncology , 2011, DOI: 10.3389/fonc.2011.00004
Errata and comments for "Numerical and analytical modeling of busbar systems"
Luca Giaccone,Aldo Canova
Mathematics , 2014,
Abstract: This note covers two parts. The first one provides an errata to the paper "Numerical and analytical modeling of busbar systems". We mainly give the correction for three equations affected by a typographical mistake. Despite the corrections that we are providing with this note, we think that the implementation of these equations can be quite onerous. Hence, in the second part of this document we provide the download link to our implementation of the equations (developed in MATLAB environment). Moreover, to help in using these functions, we explain their behavior by means of some examples.
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