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Search Results: 1 - 10 of 200622 matches for " P. Gentileschi "
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Laparoscopic Sleeve Gastrectomy as a Primary Operation for Morbid Obesity: Experience with 200 Patients
Paolo Gentileschi
Gastroenterology Research and Practice , 2012, DOI: 10.1155/2012/801325
Abstract: Introduction. Laparoscopic sleeve gastrectomy (LSG) represents a valid option for morbid obesity, either as a primary or as a staged procedure. The aim of this paper is to report the experience of a single surgeon with LSG as a standalone operation for morbid obesity. Methods. From April 2006 to April 2011, 200 patients underwent LSG for morbid obesity. Each patient record was registered and prospectively collected. In July 2011, a retrospective analysis was conducted. Results. Patients were 128 females and 72 males with a median age of 40.0 years. Median pre-operative BMI was 49.4?kg/m2. Median follow-up was 27.2 months. Median post-operative BMI was 30.4?kg/m2. Median %excess weight loss (%EWL) was 63.6%. Median post-operative hospital stay was 4.0 days in the first 84 cases and 3.0 days in the last 116 cases. Six major post-operative complications occurred (3%): two gastric stump leaks (1%), three major bleedings (1.5%) and 1 (0.5%) bowel obstruction. One case of mortality was registered (0.5%). To date only 4 patients are still in the range of morbid obesity (BMI > 35?kg/m2). Conclusions. Laparoscopic sleeve gastrectomy is a formidable operation in the short-term period. Median %EWL in this series was 63.6% at 27.2 months follow-up. 1. Introduction Obesity is a major worldwide problem in public health, reaching epidemic proportions in western countries. Bariatric surgery has been shown to be more effective in the management of morbid obesity, compared to medical treatments in terms of weight loss and amelioration of comorbidities [1]. Laparoscopic sleeve gastrectomy (LSG) represents a valid option for morbidly obese patients, either as a primary or as a staged bariatric procedure. Initially, LSG was conceived as a restrictive component of the biliopancreatic diversion and duodenal switch. Later on, LSG has been proposed as a step procedure in high-risk patients, followed by a second step Roux-en-Y gastric bypass or biliopancreatic diversion and duodenal switch [2]. Recently, LSG has been proposed as a standalone bariatric procedure. Excess weight loss and remission of comorbidities have been reported to take place in a frequency comparable with other well-established procedures [3]. The experience at our institution with LSG as a primary operation for morbid obesity started in 2006. The aim of this work is to report the five-year experience of a single surgeon single center with LSG as a sole operation for morbid obesity. 2. Methods At our Institution, the bariatric surgery program started in 1996, with a laparoscopic gastric banding. After a
Bariatric Surgery in Moderately Obese Patients: A Prospective Study
M. Cerci,M. I. Bellini,F. Russo,D. Benavoli,M. Capperucci,A. L. Gaspari,P. Gentileschi
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/276183
Abstract: Introduction. Moderate obesity (BMI 30–35?kg/m2) affects 25% of the western population. The role of bariatric surgery in this context is currently debated, reserved for patients with comorbidity, as an alternative to conservative medical treatment. We describe our experience in moderately obese patients treated with bariatric surgery. Materials and Methods. Between September 2011 and September 2012, 25 patients with grade I obesity and comorbidities underwent bariatric surgery: preoperative mean BMI 33.2?kg/m2, 10 males, mean age 42 years. In presence of type 2 diabetes mellitus (T2DM) (56%), gastric bypass was performed; in cases with hypertension (64%) and obstructive sleep apnea (OSA) (12%), sleeve gastrectomy was performed. All operations were performed laparoscopically. Results. Mean follow-up was 12.4 months. A postoperative complication occurred: bleeding from the trocar site was resolved with surgery in local anesthesia. Reduction in average BMI was 6 points, with a value of 27.2?kg/m2. Of the 14 patients with T2DM, 12 (86%) discontinued medical therapy because of a normalization of glycemia. Of the 16 patients with arterial hypertension, 14 (87%) showed remission and 2 (13%) improvement. Complete remission was observed in patients with OSAS. Conclusions. The results of our study support the validity of bariatric surgery in patients with BMI 30–35?kg/m2. Our opinion is that, in the future, bariatric surgery could be successful in selected cases of moderately obese patients. 1. Introduction Obesity is a world epidemic with remarkable sanitary, social, and economic consequences. Clinically, severe or morbid obesity is defined as values of BMI in the Class III (BMI ≥ 40?kg/m2) and Class II (35 ≤ BMI ≥ 39.9?kg/m2 in the presence of comorbidities). Obesity is associated with an increased hazard ratio for all-cause mortality [1], as well as significant comorbidity [2]. According to different studies, 25% of the western population is affected by some degree of obesity that can be defined as moderate or Class I obesity (BMI between 30–35?kg/m2). According to the literature, also patients with Class I obesity have a definite risk of significant comorbidity, such as diabetes mellitus, hypertension, dyslipidemia, obstructive sleep apnea syndrome, and mortality [3]. Other studies suggest that the clinical picture of patients affected by Class I obesity can be improved as well as in patients with severe obesity by bariatric surgery, with weight loss and resolution of comorbidities. The present prospective study aimed to investigate the improvements or
Defective Expression of Scavenger Receptors in Celiac Disease Mucosa
Maria Laura Cupi, Massimiliano Sarra, Daniela De Nitto, Eleonora Franzè, Irene Marafini, Ivan Monteleone, Giovanna Del Vecchio Blanco, Omero Alessandro Paoluzi, Davide Di Fusco, Paolo Gentileschi, Angela Ortenzi, Alfredo Colantoni, Francesco Pallone, Giovanni Monteleone
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0100980
Abstract: Celiac disease (CD) is a gluten sensitive enteropathy characterized by a marked infiltration of the mucosa with immune cells, over-production of inflammatory cytokines and epithelial cell damage. The factors/mechanisms that sustain and amplify the ongoing mucosal inflammation in CD are not however fully understood. Here, we have examined whether in CD there is a defective clearance of apoptotic cells/bodies, a phenomenon that helps promote tolerogenic signals thus liming pathogenic responses. Accumulation of apoptotic cells and bodies was more pronounced in the epithelial and lamina propria compartments of active CD patients as compared to inactive CD patients and normal controls. Expression of scavenger receptors, which are involved in the clearance of apoptotic cells/bodies, namely thrombospondin (TSP)-1, CD36 and CD61, was significantly reduced in active CD as compared to inactive CD and normal mucosal samples. Consistently, lamina propria mononuclear cells (LPMC) of active CD patients had diminished ability to phagocyte apoptotic cells. Interleukin (IL)-15, IL-21 and interferon-γ, cytokines over-produced in active CD, inhibited the expression of TSP-1, CD36, and CD61 in normal intestinal LPMC. These results indicate that CD-related inflammation is marked by diminished clearance of apoptotic cells/bodies, thus suggesting a role for such a defect in the ongoing mucosal inflammation in this disorder.
Hybrid Fuzzy Controller Based Frequency Regulation in Restructured Power System  [PDF]
P. Anitha, P. Subburaj
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.76065
Abstract: This paper discusses the implementation of Load Frequency Control (LFC) in restructured power system using Hybrid Fuzzy controller. The formulation of LFC in open energy market is much more challenging; hence it needs an intelligent controller to adapt the changes imposed by the dynamics of restructured bilateral contracts. Fuzzy Logic Control deals well with uncertainty and indistinctness while Particle Swarm Optimization (PSO) is a well-known optimization tool. Abovementioned techniques are combined and called as Hybrid Fuzzy to improve the dynamic performance of the system. Frequency control of restructured system has been achieved by automatic Membership Function (MF) tuned fuzzy logic controller. The parameters defining membership function has been tuned and updated from time to time using Particle Swarm Optimization (PSO). The robustness of the proposed hybrid fuzzy controller has been compared with conventional fuzzy logic controller using performance measures like overshoot and settling time following a step load perturbation. The motivation for using membership function tuning using PSO is to show the behavior of the controller for a wide range of system parameters and load changes. Error based analysis with parametric uncertainties and load changes is tested on a two-area restructured power system.
Integral Performance Criteria Based Analysis of Load Frequency Control in Bilateral Based Market  [PDF]
P. Anitha, P. Subburaj
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.76086
Abstract: Performance index based analysis is made to examine and highlight the effective application of Particle Swarm Optimization (PSO) to optimize the Proportional Integral gains for Load Frequency Control (LFC) in a restructured power system that operates under Bilateral based policy scheme. Various Integral Performance Criteria measures are taken as fitness function in PSO and are compared using overshoot, settling time and frequency and tie-line power deviation following a step load perturbation (SLP). The motivation for using different fitness technique in PSO is to show the behavior of the controller for a wide range of system parameters and load changes. Error based analysis with parametric uncertainties and load changes are tested on a two-area restructured power system. The results of the proposed PSO based controller show the better performance compared to the classical Ziegler-Nichols (Z-N) tuned PI andFuzzy Rule based PI controller.
Projection of the Semi-Axes of the Ellipse of Intersection  [PDF]
P. P. Klein
Applied Mathematics (AM) , 2017, DOI: 10.4236/am.2017.89097
It is well known that the line of intersection of an ellipsoid and a plane is an ellipse (see for instance [1]). In this note the semi-axes of the ellipse of intersection will be projected from 3d space onto a 2d plane. It is shown that the projected semi-axes agree with results of a method used by Bektas [2] and also with results obtained by Schrantz [3].
黄金科学技术 , 1991,
Land Use and Land Cover Changes in a Tropical River Basin: A Case from Bharathapuzha River Basin, Southern India  [PDF]
P. P. Nikhil Raj, P. A. Azeez
Journal of Geographic Information System (JGIS) , 2010, DOI: 10.4236/jgis.2010.24026
Abstract: A study of the spatial and temporal changes in land use and land cover (LULC) was conducted using Remote Sensing and GIS. We analyzed the LULC of Bharathapuzha river basin, south India using multispectral LANDSAT imageries of 1973-2005 time periods. 31% depletion in the natural vegetation cover and 8.7% depletion in wetland agriculture area were seen in the basin during the period. On the other hand the urban spread in the basin increased by 32%. The study highlights the need for a scientific management plan for the sustainability of the river basin, keeping in view the recent climatic anomalies and hydrological conditions of the basin.
Morphometric Analysis of a Tropical Medium River System: A Case from Bharathapuzha River Southern India  [PDF]
P. P. Nikhil Raj, P. A. Azeez
Open Journal of Modern Hydrology (OJMH) , 2012, DOI: 10.4236/ojmh.2012.24011
Abstract: Baseline morphometric information at a sub basin level is essential to develop appropriate strategy for sustainable, socially acceptable, ecologically benign and economically viable development of a river basin. The present study was carried out in one of the less studied Bharathapuzha river basin (BRB), the second longest river in the state of Kerala, India. The annual discharge of the river is 3.94 km3. Nevertheless the basin, which receives about 1828 mm of annual rainfall, in recent years has been facing dearth of water. We used GIS and RS tools to study the morphometric characteristics of the basin. The seventh order main river is formed by several lower order streams forming a dentritic flow pattern. Basin geology, slope and rainfall pattern in the basin determine the morphometric characteristics of the basin. The linear aspects of the basin including stream length ratio and bifurcation ratio indicate the role of relief in the basin while the areal ratios indicate the elongate nature of the basin.
Dielectric Property Studies of Biologically Compatible Brushite Single Crystals Used as Bone Graft Substitute  [PDF]
M. P. Binitha, P. P. Pradyumnan
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.42016

The electrical characterization of bone is essential for the better understanding of the role of electrical stimulation in bone remodeling. Calcium Hydrogen Phosphate Dihydrate or brushite (CaHPO4 2H2O) has been used in bone substitution owing to their fast resorption under physiological condition. Brushite is a suitable matrix for osteoconductive bone grafts. In this work, Calcium Hydrogen Phosphate single crystals have been grown by single diffusion gel growth technique. The powder XRD studies revealed the monoclinic structure of the grown crystals. The vibrational analysis of the crystals is done with FTIR spectroscopy and the major functional groups and their assigned vibrations are discussed. The frequency dependence of dielectric constant and ac conductivity at different temperatures have been studied in detail. This study shows decrease in the dielectric constant with the increase in frequency and temperature. The variation of ac conductivity is found to be increasing with frequency and decreasing with temperature.

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