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Search Results: 1 - 10 of 200695 matches for " P. Genova "
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An Experimental Evaluation of the Best-of-Many Christofides' Algorithm for the Traveling Salesman Problem
Kyle Genova,David P. Williamson
Mathematics , 2015,
Abstract: Recent papers on approximation algorithms for the traveling salesman problem (TSP) have given a new variant on the well-known Christofides' algorithm for the TSP, called the Best-of-Many Christofides' algorithm. The algorithm involves sampling a spanning tree from the solution the standard LP relaxation of the TSP, subject to the condition that each edge is sampled with probability at most its value in the LP relaxation. One then runs Christofides' algorithm on the tree by computing a minimum-cost matching on the odd-degree vertices in the tree, and shortcutting the resulting Eulerian graph to a tour. In this paper we perform an experimental evaluation of the Best-of-Many Christofides' algorithm to see if there are empirical reasons to believe its performance is better than that of Christofides' algorithm. Furthermore, several different sampling schemes have been proposed; we implement several different schemes to determine which ones might be the most promising for obtaining improved performance guarantees over that of Christofides' algorithm. In our experiments, all of the implemented methods perform significantly better than the Christofides' algorithm; an algorithm that samples from a maximum entropy distribution over spanning trees seems to be particularly good, though there are others that perform almost as well.
Genetic variability in ultrasound records of breast muscle in a broiler breeding program  [PDF]
Leila de Genova Gaya
Natural Science (NS) , 2013, DOI: 10.4236/ns.2013.58A2001
Abstract:

Breast weight is one of the most economically important traits in the poultry industry, but direct selection for weight is expensive. The use of ultrasonography enables in vivo measurements of the broiler’s breast muscle size, which may be much more feasible for broiler selection. Previous studies of broilers concluded that ultrasound of the breast muscle is feasible and favorable for meat production. According to previously obtained genetic parameters, breast weight could be efficiently improved by ultrasound of the breast muscle. The use of ultrasonography for the indirect selection of breast weight does not affect the body composition or meat quality of broilers, despite the meat’s paleness and shear force; therefore, the use of ultrasound as a selection criterion might be a useful monitoring tool. Studies on the utilization of ultrasound in broiler breeding programs allow a better understanding of the relationship between traits of economic interest and the establishment of the selection schemes.

Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors
I. Kostova,S. Raleva,P. Genova,R. Argirova
Bioinorganic Chemistry and Applications , 2006, DOI: 10.1155/bca/2006/68274
Abstract: HIV/AIDS pandemics is a serious threat to health and development of mankind, and searching for effective anti-HIV agents remains actual. Considerable progress has been made in recent years in the field of drug development against HIV. A lot of structurally different coumarins were found to display potent anti-HIV activity. The current review demonstrates the variety of synthetic coumarins having unique mechanism of action referring to the different stages of HIV replication. Recent studies based on the account of various synthetic coumarins seem to indicate that some of them serve as potent non-nucleoside RT-inhibitors, another as inhibitors of HIV-integrase or HIV-protease. The merits of selecting potential anti-HIV agents to be used in rational combination drugs design and structure-activity relationships are discussed.The scientific community is looking actively for new drugs and combinations for treatment of HIV infection effective for first-line treatment, as well as against resistant mutants. The investigation on chemical anti-HIV agents gives hope and optimism about it. This review article describes recent progress in the discovery, structure modification, and structure-activity relationship studies of potent anti-HIV coumarin derivatives.
Structure-Activity Relationships of Synthetic Coumarins as HIV-1 Inhibitors
I. Kostova,S. Raleva,P. Genova,R. Argirova
Bioinorganic Chemistry and Applications , 2006,
Abstract: HIV/AIDS pandemics is a serious threat to health and development of mankind, and searching for effective anti-HIV agents remains actual. Considerable progress has been made in recent years in the field of drug development against HIV. A lot of structurally different coumarins were found to display potent anti-HIV activity. The current review demonstrates the variety of synthetic coumarins having unique mechanism of action referring to the different stages of HIV replication. Recent studies based on the account of various synthetic coumarins seem to indicate that some of them serve as potent non-nucleoside RT-inhibitors, another as inhibitors of HIV-integrase or HIV-protease. The merits of selecting potential anti-HIV agents to be used in rational combination drugs design and structure-activity relationships are discussed.The scientific community is looking actively for new drugs and combinations for treatment of HIV infection effective for first-line treatment, as well as against resistant mutants. The investigation on chemical anti-HIV agents gives hope and optimism about it. This review article describes recent progress in the discovery, structure modification, and structure-activity relationship studies of potent anti-HIV coumarin derivatives.
Platinum(II) and Palladium(II) Complexes of Pyridine-2-Carbaldehyde Thiosemicarbazone as Alternative Antiherpes Simplex Virus Agents
D. Kovala-Demertzi,T. Varadinova,P. Genova,P. Souza,M. A. Demertzis
Bioinorganic Chemistry and Applications , 2007, DOI: 10.1155/2007/56165
Abstract: The cytotoxicity and the antivirus activity of Pd(II) and Pt(II) complexes with pyridine-2-carbaldehyde thiosemicarbazone (HFoTsc) against HSV replication were evaluated on four HSV strains—two wt strains Victoria (HSV-1) and BJA (HSV-2) and two ACVR mutants with different tk gene mutations R-100 (TKA, HSV-1) and PU (TKN, HSV-2). The experiments were performed on continuous MDBK cells and four HSV 1 and HSV 2 strains were used, two sensitive to acyclovir and two resistant mutants. The five complexes of HFoTsc, [Pt(FoTsc)Cl], [Pt(FoTsc)(H2FoTsc)]Cl2, [Pt(FoTsc)2], [Pd(FoTsc)(H2FoTsc)]Cl2, and [Pd(FoTsc)2], were found to be effective inhibitors of HSV replication. The most promising, active, and selective anti-HSV agent was found to be complex [Pt(FoTsc)(H2FoTsc)]Cl2. This complex could be useful in the treatment of HSV infections, since it is resistant to ACV mutants. PCR study of immediate early 300 bp ReIV Us1 region reveals that the complex [Pt(FoTsc)(H2FoTsc)]Cl2 specifically suppressed wt HSV-1 genome 2 hours after the infection, not inducing apoptosis/necrosis on the 8 hours after virus infection. The target was found to be most probably the viral, instead of the host cell DNA.
The Queer Politics of Migration: Reflections on “Illegality” and Incorrigibility
Nicholas De Genova
Studies in Social Justice , 2010,
Abstract: The most resounding expression of the truly unprecedented mobilizations of migrants throughout the United States in 2006 was a mass proclamation of collective defiance: Aquí Estamos, y No Nos Vamos! [Here we are, and we're not leaving!]. This same slogan was commonly accompanied by a still more forcefully incorrigible rejoinder: Y Si Nos Sacan, Nos Regresamos! [... and if they throw us out, we'll come right back!]. It is quite striking and, as this essay contends, not merely provocative but genuinely productive to note the affinity between the crucial articulation of this radically open-ended politics of migrant presence with the similarly abject and profoundly destabilizing politics of queer presence. In a manner remarkably analogous to the slogan, "We're here, we're queer, get used to it!", the dynamic enunciation of these phrases in the context of the mass mobilizations of migrants asserted an irreducible spirit of irreverence and disaffection for state power. Both gestures unreservedly and unapologetically assert not only their irreversible presence, furthermore, but also uphold the intractable challenge of their own intrinsic incorrigibility.
Inclusion Through Exclusion: Explosion or Implosion?
Nicholas De Genova
Amsterdam Law Forum , 2008,
Abstract: This essay seeks to destabilise some of the nationalist and racial premises of conventional discourses and debates surrounding "inclusion" and "exclusion," with particular reference to their currency for the politics of (im)migration (and race) in contemporary Europe. This interrogation of those presuppositions unfolds through a critique of the complacencies and complicities of J rgen Habermas's remarks on "multiculturalism," not so much in order to contribute to any presumably exhaustive dissection of Habermas's philosophical corpus, as such, but rather because his discourse around these preoccupations seems highly symptomatic and thus revelatory of the larger malaise with which this thematic issue is concerned.
Interoperability tools for the Virtual Observatory
Daniel Egret,Francoise Genova
Physics , 2001, DOI: 10.1117/12.447176
Abstract: Interoperability is one of the key issues in the current efforts to build the Virtual Observatory. We present here some of the tools which already contribute to the efficient exchange of information between archives, databases, and journals.
The SPECFIND V2.0 catalogue of radio cross-identifications and spectra. SPECFIND meets the Virtual Observatory
B. Vollmer,B. Gassmann,S. Derriere,T. Boch,M. Louys,F. Bonnarel,P. Dubois,F. Genova,F. Ochsenbein
Physics , 2009, DOI: 10.1051/0004-6361/200913460
Abstract: The new release of the SPECFIND radio cross-identification catalogue, SPECFIND V2.0, is presented. It contains 107488 cross-identified objects with at least three radio sources observed at three independent frequencies. Compared to the previous release the number of entry radio catalogues is increased from 20 to 97 containing 115 tables. This large increase was only made possible by the development of four tools at CDS which use the standards and infrastructure of the Virtual Observatory (VO). This was done in the framework of the VO-TECH European Design Study of the Sixth Framework Program. We give an overview of the different classes of radio sources that a user can encounter. Due to the increase of frequency coverage of the input radio catalogues, this release demonstrates that the SPECFIND algorithm is able to detect spectral breaks around a frequency of ~1 GHz.
The spatial distribution of galaxies within the CMB cold spot in the Corona Borealis supercluster
C. P. Padilla-Torres,C. M. Gutierrez,R. Rebolo,R. Genova-Santos,J. A. Rubino-Martin
Physics , 2009, DOI: 10.1111/j.1365-2966.2009.14785.x
Abstract: We study the spatial distribution and colours of galaxies within the region covered by the cold spot in the cosmic microwave background (CMB) recently detected by the Very Small Array (VSA; Genova-Santos et al. 2005, 2008) towards the Corona Borealis supercluster (CrB-SC). The spot is in the northern part of a region with a radius ~1 degree (~5 Mpc at the redshift of CrB-SC) enclosing the clusters Abell 2056, 2065, 2059 and 2073, and where the density of galaxies, excluding the contribution from those clusters, is ~2 times higher than the mean value in typical intercluster regions of the CrB-SC. Two of such clusters (Abell 2056 and 2065) are members of the CrB-SC, while the other two are in the background. This high density intercluster region is quite inhomogeneous, being the most remarkable feature a large concentration of galaxies in a narrow filament running from Abell 2065 with a length of ~35 arcmin (~3 Mpc at the redshift of CrB-SC) in the SW-NE direction. This intercluster population of galaxies probably results from the interaction of clusters Abell 2065 and 2056. The area subtended by the VSA cold spot shows an excess of faint (21
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