Publish in OALib Journal

ISSN: 2333-9721

APC: Only $99


Any time

2019 ( 144 )

2018 ( 194 )

2017 ( 219 )

2016 ( 332 )

Custom range...

Search Results: 1 - 10 of 200611 matches for " P. Chockley "
All listed articles are free for downloading (OA Articles)
Page 1 /200611
Display every page Item
Hydrogen Peroxide in Inflammation: Messenger, Guide, and Assassin
C. Wittmann,P. Chockley,S. K. Singh,L. Pase,G. J. Lieschke,C. Grabher
Advances in Hematology , 2012, DOI: 10.1155/2012/541471
Abstract: Starting as a model for developmental genetics, embryology, and organogenesis, the zebrafish has become increasingly popular as a model organism for numerous areas of biology and biomedicine over the last decades. Within haematology, this includes studies on blood cell development and function and the intricate regulatory mechanisms within vertebrate immunity. Here, we review recent studies on the immediate mechanisms mounting an inflammatory response by in vivo analyses using the zebrafish. These recently revealed novel roles of the reactive oxygen species hydrogen peroxide that have changed our view on the initiation of a granulocytic inflammatory response. 1. Introduction The innate immune system comprises the cells and mechanisms that defend the host from infection by other organisms or damage to tissue integrity, in a nonspecific manner. This means that the cells of the innate system recognise and respond to pathogens and trauma in a generic way, but unlike the adaptive immune system, it does not confer long-lasting or protective immunity to the host. The innate immune system provides an immediate defence. A typical vertebrate immune response depends on the orchestrated motility and activity of various haematopoietic compartments and their interactions that ultimately control the magnitude of the response [1–3]. Inflammation is one of the first responses of the immune system to infection or irritation. Stimulated by factors released from injured cells, it serves to establish a physical barrier against the spread of infection. This further promotes healing of any damaged tissue following the clearance of pathogens or cell debris. Molecules produced during inflammation sensitise pain receptors, cause localised vasodilatation of blood vessels, and attract phagocytes, especially neutrophils and macrophages, which then trigger other parts of the immune system. Failure to initiate a response allows uncontrolled proliferation of invading microorganisms and severe tissue damage that may become fatal. Failure to resolve an immune response can also cause severe tissue damage, due to persistent degranulation, and may lead to chronic inflammation, which ceases to be beneficial to the host. Overall, inflammation is now recognised as a central feature of prevalent pathologies, such as atherosclerosis, cancer, asthma, thyroiditis, inflammatory bowel disease, autoimmune disease, as well as Alzheimer’s and Parkinson’s disease [4–6]. Hence, the regulation of an inflammatory response is an active field of research. New players or novel functions of old players
Hybrid Fuzzy Controller Based Frequency Regulation in Restructured Power System  [PDF]
P. Anitha, P. Subburaj
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.76065
Abstract: This paper discusses the implementation of Load Frequency Control (LFC) in restructured power system using Hybrid Fuzzy controller. The formulation of LFC in open energy market is much more challenging; hence it needs an intelligent controller to adapt the changes imposed by the dynamics of restructured bilateral contracts. Fuzzy Logic Control deals well with uncertainty and indistinctness while Particle Swarm Optimization (PSO) is a well-known optimization tool. Abovementioned techniques are combined and called as Hybrid Fuzzy to improve the dynamic performance of the system. Frequency control of restructured system has been achieved by automatic Membership Function (MF) tuned fuzzy logic controller. The parameters defining membership function has been tuned and updated from time to time using Particle Swarm Optimization (PSO). The robustness of the proposed hybrid fuzzy controller has been compared with conventional fuzzy logic controller using performance measures like overshoot and settling time following a step load perturbation. The motivation for using membership function tuning using PSO is to show the behavior of the controller for a wide range of system parameters and load changes. Error based analysis with parametric uncertainties and load changes is tested on a two-area restructured power system.
Integral Performance Criteria Based Analysis of Load Frequency Control in Bilateral Based Market  [PDF]
P. Anitha, P. Subburaj
Circuits and Systems (CS) , 2016, DOI: 10.4236/cs.2016.76086
Abstract: Performance index based analysis is made to examine and highlight the effective application of Particle Swarm Optimization (PSO) to optimize the Proportional Integral gains for Load Frequency Control (LFC) in a restructured power system that operates under Bilateral based policy scheme. Various Integral Performance Criteria measures are taken as fitness function in PSO and are compared using overshoot, settling time and frequency and tie-line power deviation following a step load perturbation (SLP). The motivation for using different fitness technique in PSO is to show the behavior of the controller for a wide range of system parameters and load changes. Error based analysis with parametric uncertainties and load changes are tested on a two-area restructured power system. The results of the proposed PSO based controller show the better performance compared to the classical Ziegler-Nichols (Z-N) tuned PI andFuzzy Rule based PI controller.
Projection of the Semi-Axes of the Ellipse of Intersection  [PDF]
P. P. Klein
Applied Mathematics (AM) , 2017, DOI: 10.4236/am.2017.89097
It is well known that the line of intersection of an ellipsoid and a plane is an ellipse (see for instance [1]). In this note the semi-axes of the ellipse of intersection will be projected from 3d space onto a 2d plane. It is shown that the projected semi-axes agree with results of a method used by Bektas [2] and also with results obtained by Schrantz [3].
黄金科学技术 , 1991,
Land Use and Land Cover Changes in a Tropical River Basin: A Case from Bharathapuzha River Basin, Southern India  [PDF]
P. P. Nikhil Raj, P. A. Azeez
Journal of Geographic Information System (JGIS) , 2010, DOI: 10.4236/jgis.2010.24026
Abstract: A study of the spatial and temporal changes in land use and land cover (LULC) was conducted using Remote Sensing and GIS. We analyzed the LULC of Bharathapuzha river basin, south India using multispectral LANDSAT imageries of 1973-2005 time periods. 31% depletion in the natural vegetation cover and 8.7% depletion in wetland agriculture area were seen in the basin during the period. On the other hand the urban spread in the basin increased by 32%. The study highlights the need for a scientific management plan for the sustainability of the river basin, keeping in view the recent climatic anomalies and hydrological conditions of the basin.
Morphometric Analysis of a Tropical Medium River System: A Case from Bharathapuzha River Southern India  [PDF]
P. P. Nikhil Raj, P. A. Azeez
Open Journal of Modern Hydrology (OJMH) , 2012, DOI: 10.4236/ojmh.2012.24011
Abstract: Baseline morphometric information at a sub basin level is essential to develop appropriate strategy for sustainable, socially acceptable, ecologically benign and economically viable development of a river basin. The present study was carried out in one of the less studied Bharathapuzha river basin (BRB), the second longest river in the state of Kerala, India. The annual discharge of the river is 3.94 km3. Nevertheless the basin, which receives about 1828 mm of annual rainfall, in recent years has been facing dearth of water. We used GIS and RS tools to study the morphometric characteristics of the basin. The seventh order main river is formed by several lower order streams forming a dentritic flow pattern. Basin geology, slope and rainfall pattern in the basin determine the morphometric characteristics of the basin. The linear aspects of the basin including stream length ratio and bifurcation ratio indicate the role of relief in the basin while the areal ratios indicate the elongate nature of the basin.
Dielectric Property Studies of Biologically Compatible Brushite Single Crystals Used as Bone Graft Substitute  [PDF]
M. P. Binitha, P. P. Pradyumnan
Journal of Biomaterials and Nanobiotechnology (JBNB) , 2013, DOI: 10.4236/jbnb.2013.42016

The electrical characterization of bone is essential for the better understanding of the role of electrical stimulation in bone remodeling. Calcium Hydrogen Phosphate Dihydrate or brushite (CaHPO4 2H2O) has been used in bone substitution owing to their fast resorption under physiological condition. Brushite is a suitable matrix for osteoconductive bone grafts. In this work, Calcium Hydrogen Phosphate single crystals have been grown by single diffusion gel growth technique. The powder XRD studies revealed the monoclinic structure of the grown crystals. The vibrational analysis of the crystals is done with FTIR spectroscopy and the major functional groups and their assigned vibrations are discussed. The frequency dependence of dielectric constant and ac conductivity at different temperatures have been studied in detail. This study shows decrease in the dielectric constant with the increase in frequency and temperature. The variation of ac conductivity is found to be increasing with frequency and decreasing with temperature.

How to Introduce the Basis of Algorithmics? Thanks to the Enumeration and Composition of All Riffle Shuffles from a N Card Deck Used in MathMagic  [PDF]
P. Schott
Creative Education (CE) , 2012, DOI: 10.4236/ce.2012.34082
Abstract: Why use magic for teaching combinatory, algorithms and finally informatics basis as tables, control structure, loops and recursive function? Magicians know that once the surprise has worn off, the audience will seek to understand how the trick works. The aim of every teacher is to interest their students, and a magic trick will lead them to ask ‘how?’ and ‘why?’ and ‘how can I create one myself?’ In this article we consider a project I presented in 2009, the subject of which was ‘How many riffle shuffles does exist from a N card deck? Find the composition of each possible riffle shuffle’. The aim of the paper is not only to describe the project scope, the students’ theoretical studies, their approach to this problem and their computer realizations, but also to give ideas for a course or project using pedagogy. That is why only remarkable students’ realizations are shown. In order to complete the given project, the students must answer three steps: the first one is to answer to the following question: “how can I find all possible riffle shuffles with few cards? (for exe*ample 3, 4 or 5 cards) the second one (to go further ) is to answer to the following question “how can I generalize this solution through an algorithm?” the last one (to obtain the results!) is to program the algorithm with a recursive and a non-recursive solution). Each step of the Matlab? solution code is associated with an informatics basis. Whatever the student's professional ambitions, they will be able to see the impact that originality and creativity have when combined with an interest in one’s work. That’s why, two ameliorations of the ‘basic’ algorithm are proposed and a study of the gain thanks to these ameliorations is done. The students know how to “perform” a magic trick for their family and friends thanks to the use of riffle shuffle in Gilbreath’s principles, a trick that they will be able to explain and so enjoy a certain amount of success with. Sharing a mathematical/informatics demonstration is not easy and the fact that they do so means that they will have worked on and understood and are capable of explaining this knowledge. Isn’t this the aim of all teaching?
Teaching Transferable Skills to Doctoral Level Engineers—The Challenge and the Solutions  [PDF]
P. Kapranos
Open Journal of Social Sciences (JSS) , 2014, DOI: 10.4236/jss.2014.25014
Abstract: At Sheffield University, we designed a “Skills Diploma” that supports and certifies our graduates in the areas of Transferable Skills. The Diploma in Personal and Professional Skills for Centers of Doctoral Training (CDT’s) has been built into the 4-year PhD scheme in the following format: Part of the Diploma in Year one provides training in essential personal effectiveness skills to enable students to carry out their PhD research projects; training covers skills such as networking, communication & presentation, motivation, assertiveness, project and time management and creative thinking and later in Year three, students build on the personal skills training delivered in year one and focus on professional skills required in business and industry. Students record their reflections and development in their Personal Development Planning (PDP) log supported by in-class and on line tutorials. A “blended learning” teaching approach is adopted with interactive sessions, including work in small groups, short presentations, individual reflection, plenary discussions and structured tasks. Students are encouraged to take a reflective approach to their learning and to identify their own additional training needs. A very important part of their learning experience is
the SME Project where groups of students have to solve “real” problems and present their solutions within two working weeks. The teaching strategies and methods, learning objectives, assessment and feedback have all been constructively aligned within a flexible curriculum and we believe that the approach outlined above represents a paradigm shift in training tomorrow’s leaders for UK industry.


Page 1 /200611
Display every page Item

Copyright © 2008-2017 Open Access Library. All rights reserved.