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Search Results: 1 - 10 of 329581 matches for " Ovington Karen S "
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The enigmatic eosinophil: investigation of the biological role of eosinophils in parasitic helmint infection
Ovington, Karen S;Behm, Carolyn A;
Memórias do Instituto Oswaldo Cruz , 1997, DOI: 10.1590/S0074-02761997000800013
Abstract: in many helminth infected hosts the number of eosinophils increases dramatically, often without any concurrent increases in the number of other leukocytes, so that eosinophils become the dominant cell type. many experimental investigations have shown that the eosinophilia is induced by interleukin-5 (il-5) but its functional significance remains unclear. mice genetically deficient in il-5 (il-5-/-) have been used to evaluate the functional consequences of the il-5 dependent eosinophilia in helminth infected hosts. host pathology and level of infection were determined in il-5-/- and wild type mice infected with a range of species representative of each major group of helminths. the effects of il-5 deficiency were very heterogeneous. of the six species of helminth examined, il-5 dependent immune responses had no detectable effect in infections with three species, namely the cestodes mesocestoides corti and hymenolepis diminuta and the trematode fasciola hepatica. in contrast, il-5 dependent immune responses were functionally important in mice infected with three species, notably all nematodes. damage to the lungs caused by migrating larvae of toxocara canis was reduced in il-5-/- mice. infections of the intestine by adult stages of either strongyloides ratti or heligmosomoides polygyrus were more severe in il-5-/- mice. adult intestinal nematodes were clearly deleteriously affected by il-5 dependent processes since in its presence there were fewer worms which had reduced fecundity and longevity. the implications of these results for the viability of using inhibitors of il-5 as a therapy for asthma are considered.
The enigmatic eosinophil: investigation of the biological role of eosinophils in parasitic helmint infection
Ovington Karen S,Behm Carolyn A
Memórias do Instituto Oswaldo Cruz , 1997,
Abstract: In many helminth infected hosts the number of eosinophils increases dramatically, often without any concurrent increases in the number of other leukocytes, so that eosinophils become the dominant cell type. Many experimental investigations have shown that the eosinophilia is induced by interleukin-5 (IL-5) but its functional significance remains unclear. Mice genetically deficient in IL-5 (IL-5-/-) have been used to evaluate the functional consequences of the IL-5 dependent eosinophilia in helminth infected hosts. Host pathology and level of infection were determined in IL-5-/- and wild type mice infected with a range of species representative of each major group of helminths. The effects of IL-5 deficiency were very heterogeneous. Of the six species of helminth examined, IL-5 dependent immune responses had no detectable effect in infections with three species, namely the cestodes Mesocestoides corti and Hymenolepis diminuta and the trematode Fasciola hepatica. In contrast, IL-5 dependent immune responses were functionally important in mice infected with three species, notably all nematodes. Damage to the lungs caused by migrating larvae of Toxocara canis was reduced in IL-5-/- mice. Infections of the intestine by adult stages of either Strongyloides ratti or Heligmosomoides polygyrus were more severe in IL-5-/- mice. Adult intestinal nematodes were clearly deleteriously affected by IL-5 dependent processes since in its presence there were fewer worms which had reduced fecundity and longevity. The implications of these results for the viability of using inhibitors of IL-5 as a therapy for asthma are considered.
Consumer demand for low-alcohol wine in an Australian sample
Saliba AJ,Ovington LA,Moran CC
International Journal of Wine Research , 2013,
Abstract: Anthony J Saliba, Linda A Ovington, Carmen C MoranCharles Sturt University, Wagga Wagga, NSW, AustraliaBackground: The aim of this paper is to inform wine producers and marketers of those in the population who are interested in low-alcohol wine by describing the results of an Australian survey.Method: In the present study, 851 adult wine consumers completed an online questionnaire on their purchasing and consumption of wine, demographics, knowledge, and reasons for consuming wine. Reasons for consumption were defined using Brunner and Siegrist’s validated model. Self-reported interest in low-alcohol wine was used to determine the likely maximum possible market size.Results: The majority of respondents considered “low-alcohol wine” to contain around 3%–8% alcohol. Results indicated that those most likely to purchase low-alcohol wine were female and those who drink wine with food. Those who drank wine more frequently showed interest in wine sold in known-dose quantities, such as one standard drink. Reasons for preferring a low-alcohol wine included driving after drinking, to lessen the adverse effects of alcohol, and to consume more without the effects of a higher-alcohol wine. Finally, results pointed to the importance of taste as a driver of consumption.Conclusion: This is the first study to define the opportunity market for low-alcohol wine in Australia agnostic to intervening variables, thus defines the likely upper limit. Further, we showed what consumers currently define as low alcohol. Both of these findings allow wine companies to make a decision on the profitability of the low-alcohol market in Australia.Keywords: consumer demand, low alcohol, wine, consumer preference
Web-based Courses for All Disciplines: How?
Karen S. Y. Lee
Journal of Educational Media & Library Sciences , 2004,
Abstract: World Wide Web functions offer flexible and powerful tools to online course instructorsm across disciplines. WebCT being one of the leading providers of integrated elearning systems, provides features that are conducive to learning and instruction.This article will discuss how to: 1. design and conduct WebCT courses across disciplines, 2. use the constructivist pedagogy of learning and teaching in WebCT courses, and 3. enhance the problem-based and self-regulated features of Web-based learning.The focal points of this article emphasize pedagogical reengineering for designing and conducting online courses that differ in delivery, reception, and learner participation from courses being offered via traditional instructional mode. Qualitative and innovative online instruction demands more complicated work, time, and patience than traditional mode of instructional delivery. Examples from two uniquely different disciplines are elaborated. Suggestions for creating and delivering online courses are also provided.
Labor and place in Barbados, Jamaica, and Trinidad : a search for a comparative unified field theory revisited
Karen S. Dhanda
New West Indian Guide , 2001,
Abstract: Comparative study of 3 Anglophone Caribbean islands looks at the dynamics of economic change and development from 1750 to 1900. Author underlines the interplay between human agency and large- and small-scale forces in these sugar colonies. She focuses on labor, path dependence, and place to investigate economic change. She concludes that differing sets of attitudes, ideas, and practices as well as the availability of land and land use determined economic results.
Gastric Bezoar after Vertical Banded Gastroplasty: A Case Report and Review of the Literature  [PDF]
Abdul S. Bangura, Stelin Johnson, Karen E. Gibbs
Surgical Science (SS) , 2011, DOI: 10.4236/ss.2011.25053
Abstract: Gastric bezoars are uncommon in the bariatric surgery population. Though popular in earlier decades, the Vertical Banded Gastroplasty (VBG) is no longer a staple procedure in the United States. It has been supplanted by the Roux-en-Y gastric bypass (RYGBP) and the laparoscopic adjustable gastric band (LAGB) as the most commonly performed bariatric procedures. However, there are many patients who have previously undergone VBGs, and may present with associated complications. We present a case of a gastric obstruction caused by a bezoar in a patient who had a VBG fifteen years prior to presentation.
Beware of the Dog: Traumatic Extrusion of an Artificial Urinary Sphincter Following Blunt Trauma to the Scrotum by a Domestic Animal  [PDF]
Michael S. Floyd jr., Karen Chan, Andrew D. Baird
Open Journal of Urology (OJU) , 2011, DOI: 10.4236/oju.2011.14020
Abstract: Artificial urinary sphincters are commonly used in males with intrinsic sphincter deficiency to improve continence and quality of life. Complications include erosion, mechanical failure and infection. Frequently, a staged approach involving removal of the device, followed by a period of healing and subsequent reinsertion of a new sphincter is required to restore continence. We describe the first case ever reported of traumatic sphincter extrusion following blunt scrotal trauma by a dog and review its clinical features and management.
Vulvar basal cell carcinoma: A retrospective study of 29 cases from Queensland  [PDF]
Ian S. C. Jones, Alex Crandon, Karen Sanday
Open Journal of Obstetrics and Gynecology (OJOG) , 2012, DOI: 10.4236/ojog.2012.22026
Abstract: Objective: Review the clinical features, diagnosis, management and outcomes for 29 cases of Basal Cell Carcinoma (BCC) of the Vulva referred to Queensland Centre for Gynaecological Cancer (QCGC) between 1986 and 2010. Methods: Vulvar BCC cases from QCGC were reviewed and analysed using the computer software Statistical Package for the Social Sciences (SPSS) 11.0. Results: BCC of the vulva is uncommon with an incidence from the QCGC vulvar cancer registry of 3.2%. Of the 29 patients one died of their BCC and seven died of unrelated causes. The mean age at diagnosis was 69.5 years (range 40 to 91). All cases were Caucasian. Time from onset of symptoms to diagnosis averaged 22.6 months (range 0 - 120 months). Not until a biopsy was performed was the diagnosis made. The most common presenting complaints were pruritis and a lump. Initial treatment was surgical. Conclusions: The prognosis for vulvar BCC is excellent. Histological diagnosis and long term follow-up are important management issues. The status of disease at the margins of surgical specimens does not reliably equate to patient long term outcomes. Follow up should be supervised via a gynecological oncology register to reduce the risk of patient loss to follow up.
Melanoma of the vulva: A retrospective study of 46 cases from Queensland  [PDF]
Ian S. C. Jones, Alex Crandon, Karen Sanday
Open Journal of Obstetrics and Gynecology (OJOG) , 2012, DOI: 10.4236/ojog.2012.22023
Abstract: Objective: To review the records of cases of vulvar melanoma referred to the Queensland Centre for Gynaecological Cancer (QCGC) between 1986 and 2009 recognising the high incidence of cutaneous melanoma in Queensland. Methods: Vulvar melanoma case data from QCGC were reviewed and analysed using the computer software Statistical Package for the Social Sciences (SPSS) 11.0. Results: Of the 46 cases 22 died of their disease, nine died of other diseases, ten are still alive and five lost to follow up. The mean age at diagnosis was 65.5 years for nodular melanoma and 69 years for superficial spreading melanoma. All cases were Caucasian. Time from on-set of symptoms to diagnosis averaged 3.2 months. In all 46 cases diagnosis was confirmed histologically. Presenting symptoms included lumps, itch, stinging, bleeding and pain. The most common presenting complaint was a lump. The initial treatment was surgical without a trend to a less radical approach to management. Conclusions: Vulvar melanoma prognosis remains guarded. Increased tumor size, depth of invasion, mitotic rate, groin lymph node positivity and status of disease at the margins of surgical specimens reliably equate to long term outcome. The incidence of vulvar melanoma was not increased in Queensland.
Bartholin’s Gland Carcinomas: A 20 plus-year experience from Queensland  [PDF]
Ian S. C. Jones, Alex Crandon, Karen Sanday
Open Journal of Obstetrics and Gynecology (OJOG) , 2012, DOI: 10.4236/ojog.2012.24079
Abstract: Objective: To review the records of cases of Bartholin’s Gland Carcinoma referred to the Queensland Centre for Gynaecological Cancer (QCGC) between mid 1993 and mid 2012. Methods: Bartholin’s Gland Carcinoma case data from QCGC were reviewed and analysed using the computer software Statistical Package for the Social Sciences 11.0. Results: Of the 12 cases four died of their disease, seven are still alive and disease free and one is alive with recurrent disease. The mean age at diagnosis was 52.8 years. Time from onset of symptoms to diagnosis averaged 5.8 months. All diagnoses were confirmed histologically. Presenting symptoms included a lump and pain. The most common presenting complaint was a lump. Treatment included surgical excision, occasional biopsy followed by radiotherapy with or without chemotherapy. In some cases radiation and chemotherapy was followed by vulvectomy of various extent. Conclusions: Bartholin’s Gland Carcinoma is a rare condition with outcome dependent on duration of symptoms, including delay in diagnosis, cell-type, cellular differentiation and the International Federation of Gynecology and Obstetrics (FIGO) classification. A Bartholin’s gland mass in a woman aged 40 years or more should be considered malignant until a biopsy proves otherwise.The incidence of Bartholin’s Gland Carcinoma in Queensland is less than that reported elsewhere but a higher proportion of squamous cell carcinomas was found in this small series.
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