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Search Results: 1 - 10 of 39 matches for " Oufae Lahlou "
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Fathiah Zakham,Oufae Lahlou,Mohammed Akrim,Nada Bouklata
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: Background: Worldwide, tuberculosis (TB) is a major public health problem and the rapid diagnosis and appropriate chemotherapy become the first priority and a serious challenge to improve TB treatment. In the objective of early TB diagnosis and rapid detection of Mycobacterium tuberculosis (MTB) in the clinical specimens, the utility of the Polymerase Chain Reaction (PCR) using the Insertion Sequence 6110 (IS6110) as target was compared to conventional methods. Methods: Out of 305 patients with different clinical manifestations: suspected, new, drug relapse, drug failure and chronic cases were enrolled in this study and tested by mycobacteriological and PCR techniques for the investigation about the tubercle bacilli. Results: The results of the in house IS6110 PCR showed a good sensitivity (92, 42%) and high specificity (98%), the positive and negative predictive values were 96.4 % and 95.3 % respectively. Conclusion: This study showed clearly that the PCR testing using the IS6110 in the routine analysis is a potential tool for the rapid TB diagnosis, especially for critical cases and would be of great interest to help the clinician in the misdiagnosed critical cases by the traditional radiology.
The Success of Natural Products in Drug Discovery  [PDF]
Mouhssen Lahlou
Pharmacology & Pharmacy (PP) , 2013, DOI: 10.4236/pp.2013.43A003

Drug discovery leading to robust and viable lead candidates’ remains a challenging scientific task, which is the transition from a screening hit to a drug candidate, requires expertise and experience. Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and of structural diversity. However, in addition to their chemical structure diversity and their biodiversity, the development of new technologies has revolutionized the screening of natural products in discovering new drugs. Applying these technologies compensates for the inherent limitations of natural products and offers a unique opportunity to re-establish natural products as a major source for drug discovery. The present article attempts to describe the utilization of compounds derived from natural resources as drug candidates, with a focus on the success of these resources in the process of finding and discovering new and effective drug compounds, an approach commonly referred to as “natural product drug discovery”.

Effect of Salinity on in vitro Trichoderma harzianum Antagonism Against Verticillium dahliae
Amina Regragui,Houria Lahlou
Pakistan Journal of Biological Sciences , 2005,
Abstract: This in vitro study led to test the sodium chloride tolerance of Trichoderma harzianum and to evaluate the impact of salinity on its antagonistic capacities, in order to use it as a biological agent controlling Verticillium wilt of tomato in Moroccan saline soils. Trichoderma harzianum tolerates the salinity for its mycelial growth but its sporulation is significantly reduced. The efficiency of the antagonistic modes of action of Trichoderma against Verticillium depends on the saline concentration used. Thus, the antagonism by competition is slightly affected by moderated salt concentrations (6 g L-1). The antagonism by antibiosis decreases with the increase of salt. The antagonistic compounds produced by Trichoderma in presence of 8 g L-1 NaCl concentration still reduce the pathogen growth but have no action on the abundance of microsclerotia. The in vitro antagonistic properties of T. harzianum obtained at low salt concentrations may be applied for the biological control of Verticillium wilt of tomato in Moroccan saline soils where levels of salinity are equivalent to salt concentrations favorable to Trichoderma antagonism.
On Dedekind's criterion and monogenicity over Dedekind rings
M. E. Charkani,O. Lahlou
International Journal of Mathematics and Mathematical Sciences , 2003, DOI: 10.1155/s0161171203211534
Abstract: We give a practical criterion characterizing the monogenicity of the integral closure of a Dedekind ring R, based on results on the resultant Res (p,pi) of the minimal polynomial p of a primitive integral element and of its irreducible factors pi modulo prime ideals of R. We obtain a generalization and an improvement of the Dedekind criterion (Cohen, 1996), and we give some applications in the case where R is a discrete valuation ring or the ring of integers of a number field, generalizing some well-known classical results.
β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer
Hicham Lahlou, William J Muller
Breast Cancer Research , 2011, DOI: 10.1186/bcr2905
Abstract: Breast cancer continues to be the most common cancer diagnosed and the leading cause of cancer-related death in women worldwide. In North America it has been estimated that one woman out of nine will be diagnosed with breast cancer in her lifetime and that one in four among them will die from the disease [1]. As with other cancers, the combination of genetic and epigenetic alterations is fundamental in the genesis of breast cancer [2]. As the result of multiple alterations, mammary cancer progresses through multiple stages in a multistep process that drives normal breast cells into highly malignant cells. The resulting tumor cells can then invade through surrounding tissues and metastasize to distal organs, particularly to bones, brain, liver, and lungs [3].The majority of breast cancers are carcinomas of ductal origin since they arise from epithelial cells lining the mammary ducts. The pathogenesis involves an initial benign intraductal hyperplasia, which progresses through cellular atypia (atypical hyperplasia) and occlusion of the duct (ductal carcinoma in situ). This later step can be followed by locally invasive carcinoma and subsequent metastasis to secondary sites [4]. The acquired invasive properties include enhanced migratory behavior and the capacity of the tumor cells to breach the mammary basement membrane (BM), the dense matrix surrounding tumors and the blood vessel walls [5]. All of these processes involve dynamic adhesion of the tumor cell to extracellular matrices (ECMs) through integrins, a major family of α/β heterodimeric cell surface receptors [6].The integrin family contains, in mammals, 18 α-subunits and eight β-subunits that form 24 distinct receptors with specific tissue distribution and that appear to have specific and nonredundant functions as shown by their specificity for ECM ligands and knockout mouse phenotypes [7]. The primary function of the integrin family is to mediate cell-cell and cell-matrix adhesion. Furthermore, the binding of
Role of laboratory in the virological diagnosis of pandemic Influenza A(H1N1)v
I. Lahlou Amine,S. Zouhair
Technologies de Laboratoire , 2009,
Abstract: The new pandemic influenza, occurred in april 2009 in Mexico is also called swine Influenza. It is caused by a new Influenza virus A(H1N1)v, completely new, never before found in any species and results from complex genetic reassortment. The role of the laboratory is essential for the virological diagnosis of this emerging flu. It can provide the definitive diagnosis in patients whose clinical and epidemiological context is suggestive of infection with virus A(H1N1)v. The virological confirmation of an infection case caused by this virus is provided by the positivity of the laboratory following tests: RT-PCR and/or viral culture and/or four-fold rise in the rate of specific neutralizing antibodies directed against A(H1N1)v virus on a pair of sera collected two weeks apart. The real time RT-PCR is currently the tool of choice because of its rapidity, sensitivity and specificity. Immunological rapid diagnostic tests (RDTs) can detect the presence of the nucleoprotein antigens of seasonal influenza viruses type A and B. The evaluation of these tests showed, in the current pandemic context, a low sensitivity which not confer them a negative predictive value compatible with widespread use. Their results must be interpreted with caution and despite their good positive predictive value, they allow a presumptive diagnosis, confirmation by real time RT-PCR will be conducted whenever necessary.
Transient Signal Spaces and Decompositions
Tarek A. Lahlou,Anuran Makur
Mathematics , 2015,
Abstract: In this paper, we study the problem of transient signal analysis. A signal-dependent algorithm is proposed which sequentially identifies the countable sets of decay rates and expansion coefficients present in a given signal. We qualitatively compare our method to existing techniques such as orthogonal exponential transforms generated from orthogonal polynomial classes. The presented algorithm has immediate utility to signal processing applications wherein the decay rates and expansion coefficients associated with a transient signal convey information. We also provide a functional interpretation of our parameter extraction method via signal approximation using monomials over the unit interval from the perspective of biorthogonal constraint satisfaction.
Positive sub-definite matrices over a proper cone completeness of rank one matrix
T. S. Khan,A. Lahlou,A. Hassouni
Applied Mathematical Sciences , 2012,
Oblique Surface Waves on a Pair of Planar Periodic Slotted Waveguides
C. Tannous,R. Lahlou,M. Amram
Physics , 2001,
Abstract: The dispersion relation and mode amplitudes of oblique surface waves propagating on an acoustic double comb filter are obtained with a method based on the calculus of residues. We obtain a better agreement (below 480 Hz) between theoretical predictions and measurements reported previously when the filter was being supposed to be made of a single comb structure.
Conservative Signal Processing Architectures For Asynchronous, Distributed Optimization Part I: General Framework
Thomas A. Baran,Tarek A. Lahlou
Mathematics , 2014, DOI: 10.1109/GlobalSIP.2014.7032073
Abstract: This paper presents a framework for designing a class of distributed, asynchronous optimization algorithms, realized as signal processing architectures utilizing various conservation principles. The architectures are specifically based on stationarity conditions pertaining to primal and dual variables in a class of generally nonconvex optimization problems. The stationarity conditions, which are closely related to the principles of stationary content and co-content that can be derived using Tellegen's theorem in electrical networks, are in particular transformed via a linear change of coordinates to obtain a set of linear and nonlinear maps that form the basis for implementation. The resulting algorithms specifically operate by processing a linear superposition of primal and dual decision variables using the associated maps, coupled using synchronous or asynchronous delay elements to form a distributed system. A table is provided containing specific example elements that can be assembled to form various optimization algorithms directly from the corresponding problem statements.
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