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Search Results: 1 - 10 of 2000 matches for " Osvaldo Mirante "
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Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala
Osvaldo Mirante,Johannes Bohacek,Isabelle M. Mansuy
Frontiers in Molecular Neuroscience , 2014, DOI: 10.3389/fnmol.2014.00062
Abstract: N-methyl-D-aspartate receptor (NMDAR)-dependent long-term depression (LTD) in the lateral nucleus of the amygdala (LA) is a form of synaptic plasticity thought to be a cellular substrate for the extinction of fear memory. The LA receives converging inputs from the sensory thalamus and neocortex that are weakened following fear extinction. Combining field and patch-clamp electrophysiological recordings in mice, we show that a paired-pulse low-frequency stimulation can induce a robust LTD at thalamic and cortical inputs to LA, and we identify different underlying molecular components at these pathways. We show that while LTD depends on NMDARs and activation of the protein phosphatases PP2B and PP1 at both pathways, it requires NR2B-containing NMDARs at the thalamic pathway, but NR2C/D-containing NMDARs at the cortical pathway. LTD appears to be induced postsynaptically at the thalamic input but presynaptically at the cortical input, since postsynaptic calcium chelation and NMDAR blockade prevent thalamic but not cortical LTD. These results highlight distinct molecular features of LTD in LA that may be relevant for traumatic memory and its erasure, and for pathologies such as post-traumatic stress disorder (PTSD).
Endogenous Protease Nexin-1 Protects against Cerebral Ischemia
Osvaldo Mirante,Melanie Price,Wilfredo Puentes,Ximena Castillo,Corinne Benakis,Jonathan Thevenet,Denis Monard,Lorenz Hirt
International Journal of Molecular Sciences , 2013, DOI: 10.3390/ijms140816719
Abstract: The serine protease thrombin plays a role in signalling ischemic neuronal death in the brain. Paradoxically, endogenous neuroprotective mechanisms can be triggered by preconditioning with thrombin (thrombin preconditioning, TPC), leading to tolerance to cerebral ischemia. Here we studied the role of thrombin’s endogenous potent inhibitor, protease nexin-1 (PN-1), in ischemia and in tolerance to cerebral ischemia induced by TPC. Cerebral ischemia was modelled in vitro in organotypic hippocampal slice cultures from rats or genetically engineered mice lacking PN-1 or with the reporter gene lacZ knocked into the PN-1 locus PN-1HAPN-1-lacZ/HAPN-1-lacZ (PN-1 KI) exposed to oxygen and glucose deprivation (OGD). We observed increased thrombin enzyme activity in culture homogenates 24 h after OGD. Lack of PN-1 increased neuronal death in the CA1, suggesting that endogenous PN-1 inhibits thrombin-induced neuronal damage after ischemia. OGD enhanced β-galactosidase activity, reflecting PN-1 expression, at one and 24 h, most strikingly in the stratum radiatum, a glial cell layer adjacent to the CA1 layer of ischemia sensitive neurons. TPC, 24 h before OGD, additionally increased PN-1 expression 1 h after OGD, compared to OGD alone. TPC failed to induce tolerance in cultures from PN-1 ?/? mice confirming PN-1 as an important TPC target. PN-1 upregulation after TPC was blocked by the c-Jun N-terminal kinase (JNK) inhibitor, L-JNKI1, known to block TPC. This work suggests that PN-1 is an endogenous neuroprotectant in cerebral ischemia and a potential target for neuroprotection.
The Precise Determination of Mass through the Oscillations of a Very High-Q Electromechanical System  [PDF]
Osvaldo F. Schilling
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2013, DOI: 10.4236/jemaa.2013.53015

The present paper is based upon the fact that if an object is part of a highly stable oscillating system, it is possible to obtain an extremely precise measure for its mass in terms of the energy trapped in the system, rather than through a ratio between force and acceleration, provided such trapped energy can be properly measured. The subject is timely since there is great interest in Metrology on the establishment of a new electronic standard for the kilogram. Our contribution to such effort includes both the proposal of an alternative definition for mass, as well as the description of a realistic experimental system in which this new definition might actually be applied. The setup consists of an oscillating type-II superconducting loop subjected to the gravity and magnetic fields. The system is shown to be able to reach a dynamic equilibrium by trapping energy up to the point it levitates against the surrounding magnetic and gravitational fields, behaving as an extremely high-Q spring-load system. The proposed energy-mass equation applied to the electromechanical oscillating system eventually produces a new experimental relation between mass and the Planck constant.

A Phenomenological Model for the Electromagnetic Origin of Mass in Particles, and Its Quantitative Application to the Electron, the Muon, the Proton, and the Neutron  [PDF]
Osvaldo F. Schilling
Journal of Modern Physics (JMP) , 2013, DOI: 10.4236/jmp.2013.49161

A simple phenomenological model is developed, which indicates the existence of a direct link between the concept of rest mass of a particle and magnetodynamic energies associated to the formation of the particle. The model is based upon the principles of quantization and conservation of flux, well known for their application in superconductivity. The charge of particles is considered as forming vortices of superconducting currents, which we postulate are created by electromagnetic fluctuations from vacuum (or related processes). A new quantization rule gathers the size, the magnetic moment, and the rest mass of the particle and associates these quantities to the integer number of flux quanta that should be stored in the vortices corresponding to each particle. The model is applied to the electron, the muon, the proton, and the neutron. Quantitative consistency with available experimental data for these subatomic particles is obtained.

Genital schistosomiasis mansoni: tubal tumor and parietal peritoneum involvement diagnosed during laparoscopy
Lambertucci, José Roberto;Villamil, Quésia Tamara Mirante Ferreira;Savi, Daniela;Dias, Ilveu Cosme;
Revista da Sociedade Brasileira de Medicina Tropical , 2009, DOI: 10.1590/S0037-86822009000500019
Abstract: female genital schistosomiasis is not uncommon in endemic areas for schistosomiasis, but there are few reports in the brazilian medical literature. here, we describe the case of a 31-year-old woman with lower abdominal pain who was diagnosed as presenting a fallopian tube tumor caused by manson's schistosomiasis. the diagnosis was delayed because her symptoms were considered nonspecific. involvement of the parietal peritoneum of the ovarian fossa was observed during laparoscopy and confirmed by histological analysis. the left tube and the tumor were excised and schistosomiasis was treated with praziquantel. she presented a full recovery and options for future reproduction are under evaluation.
Approximation Method for the Relaxed Covariant Form of the Gravitational Field Equations for Particles  [PDF]
Emanuel Gallo, Osvaldo M. Moreschi
Journal of Modern Physics (JMP) , 2012, DOI: 10.4236/jmp.2012.329161
Abstract: We present a study of the so called relaxed field equations of general relativity in terms of a decomposition of the metric; which is designed to deal with the notion of particles. Several known results are generalized to a coordinate free covariant discussion. We apply our techniques to the study of a particle up to second order.
Utopía social y utopía tecnológica en el pensamiento de las izquierdas argentinas para la transformación del capitalismo agrario, 1890-1945
Mundo agrario , 2010,
Abstract: the objectives of this work are to rebuild the communist and socialist thinking and the political proposals used, between 1890 and 1945, to set a new model of economics and society within the agrarian sector in the pampas region, and which, on its basis, include elements of social and technological utopias. along the first half of the twentieth century, the left wings developed several projects aimed to transform the agrarian economics and society in argentina and thus, tried to influence the modifications of social and economics rural relations dominant in the country, and in particular in the pampas region. those proposals started to throw the imaginary of a rural world different to the current upon the speech and the political thinking of the left wings. in many of them shaped as a social utopia and in others shaped as a technological utopia, for its realization.
Perspectivas eticas para a educa?ao: uma reflex?o seus pressupostos humanisticos
Educere , 2007,
Abstract: este es resultado de una investigación bibliográfica, cuyos temas esenciales son la ética y la educación. se enfatiza que el sujeto humano aprehende la realidad, más específicamente, asimila de forma biológica y racional. a través de este procedimiento elabora el lenguaje que le permite expresarse. en la educación se produce una introyección del lenguaje. sus valores son clasificados por weil (1993) como lenguaje común, metafísica, moral, lógica, estética y psicología. simultáneamente se produce la socialización del hombre. la concepción de hombre anunciada por la iglesia den puebla de los ángeles, en 1979, se distingue por sus categorías: visión determinista, visión psicologista, visión economicista, visión individualista, visión colectivista, visión estatista y visión cientificista. a partir de estas inferencias se puede concluir que el hombre en el proceso de ense?anza-aprendizaje es conducido a despertar el sentido de ser y no el de tener, se valorizan las experiencias de los estudiantes, se incluye la interacción y reflexión en todos los aspectos sensibilizándolo para el espíritu ético. por lo tanto, es posible la humanización del hombre en el proceso de ense?anza aprendizaje
Propuesta metodológica para el análisis descriptivo de vidrios "retocados" del noroeste de la provincia de Mendoza
La zaranda de ideas , 2010,
Abstract: we present a methodological proposal for the descriptive analysis of glass materials that present retouched and / or reuse features. this proposal arises due to the few regional precedents of the topic and the need to systematize the criteria for the analytical description of the glassy record of the northwest of mendoza. the goal of this paper is the development of criteria to the knowledge of the reuse patterns, production and use of cutting-scraping instruments by human groups of northwestern mendoza.
Identifica??o colorimétrica em citrus
Bacchi, Osvaldo;
Bragantia , 1943, DOI: 10.1590/S0006-87051943000700003
Abstract: in order to study the susceptibility of the various stocks with regard to the new disease "tristeza" ("sadness"), a quick and acurate identification of the stock is required. in orchards this cannot be done in most cases as stocks do not always exhibit sprouts and on account of erroneus information frequently given by owners. we have tested the colorimetric identification, already employed in other countries. this identification is based on the differences of color obtained in the watery extract cf the bark taken from the trunk or from the root, when treated by special reagents. the results obtained are somewhat different from those described by the authors of the method. this is perhaps due to variation in environmental conditions. only the almen and ferric chloride tests gave satisfactory results, making it possible to arrange the species and varieties examined into four groups : (1) c. aurantium l. ; (2) c. sinensis osbeck; (3) c. limonia osbeck ("gigante" variety) and (4) all the others. although deficient in certain respects the test is valuable, permiting us to identify the stocks of orange trees, azeda as well as caipira the most employed in the citrus orchards of the state of s. paulo.
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