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Search Results: 1 - 10 of 464426 matches for " Orlando A; "
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La investigación con células troncales humanas embrionarias y adultas: El nacimiento de la medicina regenerativa Perspectivas científicas, implicaciones epistemológicas y dilemas bioéticos
Mejía Rivera,Orlando;
Acta Medica Colombiana , 2007,
Abstract: research with stem cells is the most promising medical discovery for understanding and management of pathologies incurable so far. but besides that, it also announces the birth of regenerative medicine. this article analyses the state of the art with human embryonic and adult stem cells research, from the perspective of its revolutionary biological implications (questioning the classical embryology dogma of modern cardiology as well as the modern neurology dogma, epistemology (insufficient explanation of the mechanistic model of molecular biology) and its bioethical dilemma (moral statute of the embryo, creation of human - non - human and clinical research protocols).
La genética y la medicina predictiva: Implicaciones epistemológicas y consideraciones bioéticas
Mejía,Orlando;
Acta Medica Colombiana , 2005,
Abstract: el desarrollo de las pruebas diagnósticas genéticas, tanto de las enfermedades monogenéticas de aparición temprana como de las enfermedades de aparición tardía, y de las pruebas de predisposición, están generando una transformación epistemológica en la medicina contemporánea. pues se comienza a pasar de los modelos clásicos del diagnóstico clínico basado en lo anatomopatológico, lo fisiopatológico y lo etiopatogénico, a un nuevo paradigma diagnóstico que se puede denominar como el modelo genómico. en este trabajo se analizan los dilemas bioéticos y sociales de los distintos tipos de pruebas predictivas del diagnóstico genético.
Las posibilidades de la terapia génica y sus dilemas bioéticos
Mejía,Orlando;
Acta Medica Colombiana , 2005,
Abstract: according to anderson, gene therapy has four levels of application; somatic cells, germinal cells, perfective therapy and eugenic manipulation. an analysis of the bio-ethical dilemma in each therapy level is made and the so called evolution concept is stated to question the wish of some scientists to start gene therapy from germ cells. likewise, there is a warning about the hazards of starting perfective therapy and eugenic manipulation due to the social and political implications of positive eugenics programs reactivation.
El nuevo paradigma genético y la naturaleza humana: Una perspectiva desde la bioética reflexiva y secular
Orlando,Mejía;
Acta Medica Colombiana , 2005,
Abstract: genetics has become the scientific area with the greatest bio-ethical and social implications, due its transformation power upon what has been considered, so far, as human nature. this work's objective is to analyze the relationship between the genetic paradigm, the historical notion of human essence and the contemporary anthropocentric and evolution models of human nature; using conceptual elements that correspond to reflexive, secular and critical bio-ethics to try to better understand the ideological basis of genomic medicine technologies.
El diagnóstico de preimplantación genética. Perspectivas científicas y dilemas bioéticos
Mejía,Orlando;
Acta Medica Colombiana , 2005,
Abstract: the diagnosis of genetic pre-implantation (pgd) is the most recent test amongst the genetic diagnostic techniques. this works analyses its development, medical indications and bio-ethical dilemma that may occur with indiscriminate use. it has been proposed as well that some questions guiding the physicians in the decision making process to implant or not an embryo with some genetic defect. and last, some philosophical issues are also analyzed in pro or against pgd.
El diagnóstico de preimplantación genética, el caso Nash y las indicaciones no médicas: De la transgresión del imperativo kantiano a las advertencias de Habermas
Mejía,Orlando;
Acta Medica Colombiana , 2005,
Abstract: the diagnosis of genetic pre-implantation (gpd) has extended its use and indications beyond the limits of genetic abnormalities detection. with the nash case, the first step to the so called, embryos' constructions has been taken, and for the first time, an embryo has been manipulated to benefit a third party alive. this work analyses the scientific and bio ethical aspects of this case. interpretation of the implications of kant's mandate transgression, that says that every rational being must be an end by itself and not a means to serve others. likewise, the warnings made by the philosopher jurgen habermas are exposed; the use of gpd as a positive eugenics technique. and last, other non medical indications of gpd and the bio-ethical dilemma are shown.
Potencial medicinal del género Sapindus L. (Sapindaceae) y de la especie Sapindus saponaria L.
Abreu Guirado,Orlando A;
Revista Cubana de Plantas Medicinales , 2005,
Abstract: the etnomedical information and the tested biological activities of the genus sapindus (sapindaceae) and of the species that grows in cuba, s. saponaria l. , published in the available literature and included in the napralert, native american ethnobotany and phytochemical & ethnobotanical database, are exposed. 55 traditional uses and 29 different biological effects of the genus have been reported, whereas of s. saponaria , commonly known as “jaboncillo”, 32 and 14 have been found, respectively. this species is acknowledged the greatest amount of traditional applications and as s. trifoliatu , it presents the higest number of biological tests. several of the uses referred in cuba for the species of the genus sapindus coincide with those in other latitudes. it is stressed the use of different parts of the trees or bushes of these species in other cultures, mainly for health problems in the gynecoobstetric field, such as an abortive, delivery inducer and in the treatment of uterine pain. it is also used as an emetic, in the treatment of hysteria., antifebrile, piscicide and molluscacide , among others. in one way or another, various traditional uses have been confirmed by laboratory tests, which demonstrate the validity of the traditional knowledge of the peoples as a criterion for studying the medicinal plants.
La investigación con células troncales humanas embrionarias y adultas: El nacimiento de la medicina regenerativa Perspectivas científicas, implicaciones epistemológicas y dilemas bioéticos Research with embryo and adult stem cells: Birth of regenerative medicine Scientific perspectives, epistemiological perspectives and bioethical dilemma
Orlando Mejía Rivera
Acta Medica Colombiana , 2007,
Abstract: La investigación con células troncales es el descubrimiento médico más prometedor para la comprensión y manejo de patologías que en la actualidad son incurables. Pero, además, anuncia el nacimiento de la medicina regenerativa. En este artículo se analiza el estado del arte de las investigaciones con las células troncales embrionarias humanas y con las células troncales adultas humanas, desde la perspectiva de sus revolucionarias implicaciones biológicas (cuestionamiento del dogma de la embriología clásica, del dogma de la cardiología moderna y del dogma de la neurología moderna), epistemológicas (insuficiencia explicativa del modelo mecanicista de la biología molecular) y sus dilemas bioéticos (estatuto moral del embrión, creación de quimeras humanas-no humanas y protocolos clínicos de investigación). Research with stem cells is the most promising medical discovery for understanding and management of pathologies incurable so far. But besides that, it also announces the birth of regenerative medicine. This article analyses the state of the art with human embryonic and adult stem cells research, from the perspective of its revolutionary biological implications (questioning the classical embryology dogma of modern cardiology as well as the modern neurology dogma, epistemology (insufficient explanation of the mechanistic model of molecular biology) and its bioethical dilemma (moral statute of the embryo, creation of human - non - human and clinical research protocols).
Las posibilidades de la terapia génica y sus dilemas bioéticos The possibilities of gene therapy and its bio-ethical dilemmas
Orlando Mejía
Acta Medica Colombiana , 2005,
Abstract: La terapia génica tiene, de acuerdo con Anderson, cuatro niveles de aplicación: las células somáticas, las células germinales, la terapia perfectiva y la manipulación eugenésica. Se hace un análisis de los dilemas bioéticos en cada nivel de terapia y se plantea el denominado Argumento Evolutivo para cuestionar los deseos de algunos científicos de iniciar terapia génica de células germinales. De igual manera, se advierte de los peligros de iniciar terapia perfectiva y la manipulación eugénica por las implicaciones sociales y políticas de una reactivación de programas de eugenesia positiva. According to Anderson, gene therapy has four levels of application; somatic cells, germinal cells, perfective therapy and eugenic manipulation. An analysis of the bio-ethical dilemma in each therapy level is made and the so called Evolution Concept is stated to question the wish of some scientists to start gene therapy from germ cells. Likewise, there is a warning about the hazards of starting perfective therapy and eugenic manipulation due to the social and political implications of positive eugenics programs reactivation.
El nuevo paradigma genético y la naturaleza humana: Una perspectiva desde la bioética reflexiva y secular The new genetic paradigm and human nature: A perspective from reflexive and secular bio-ethics
Mejía Orlando
Acta Medica Colombiana , 2005,
Abstract: La genética se ha convertido en el área científica con mayores implicaciones bioéticas y sociales, debido al poder de transformación que tiene sobre lo que se ha considerado, hasta ahora, como la naturaleza humana. En este trabajo se propone analizar la relación entre el nuevo paradigma genético, la noción histórica de la esencia humana y los contemporáneos modelos antropocéntrico y evolutivo de la naturaleza humana. Utilizando elementos conceptuales que correspondan a una bioética reflexiva, secular y crítica, para intentar comprender mejor los fundamentos ideológicos de las tecnologías de la medicina genómica. Genetics has become the scientific area with the greatest bio-ethical and social implications, due its transformation power upon what has been considered, so far, as human nature. This work's objective is to analyze the relationship between the genetic paradigm, the historical notion of human essence and the contemporary anthropocentric and evolution models of human nature; using conceptual elements that correspond to reflexive, secular and critical bio-ethics to try to better understand the ideological basis of genomic medicine technologies.
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