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Search Results: 1 - 10 of 50528 matches for " Ookura Y "
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Medial blepharosynechioplasty: a new surgical concept for severe dry eye
Sasaki T, Ota T, Ookura Y, Sugiyama K
Clinical Ophthalmology , 2012, DOI: http://dx.doi.org/10.2147/OPTH.S31001
Abstract: ial blepharosynechioplasty: a new surgical concept for severe dry eye Original Research (1976) Total Article Views Authors: Sasaki T, Ota T, Ookura Y, Sugiyama K Published Date June 2012 Volume 2012:6 Pages 963 - 965 DOI: http://dx.doi.org/10.2147/OPTH.S31001 Received: 18 February 2012 Accepted: 02 April 2012 Published: 22 June 2012 Tsugihisa Sasaki,1,2 Taeko Ota,3 Youko Ookura,4 Kazuhisa Sugiyama1 1Department of Ophthalmology, Kanazawa University School of Medicine, Kanazawa, Ishikawa; 2Department of Ophthalmology, Fukui Prefectural Hospital, Fukui; 3Department of Ophthalmology, Tonami General Hospital, Tonami-city, Toyama; 4Department of Ophthamology, Saiseikai Kanazawa Hospital, Kanazawa, Ishikawa, Japan Background: The purpose of this work was to report on the performance of medial blepharosynechioplasty (MBSP), a newly devised technique for treating severe dry eye. Methods: In this retrospective, nonrandomized clinical trial, three cases with severe dry eye (Sj gren’s syndrome) associated with repeated punctal plug loss were treated using MBSP to create a synechia between the upper and lower lid medial borders of the puncta to suppress the lacrimal pump. Results: Postoperative follow-up showed improvement in the corneal condition in all three cases that persisted for 12–35 months. None of the patients had visual impairment. Conclusion: MBSP is a promising treatment for severe dry eye and merits further study.
Medial blepharosynechioplasty: a new surgical concept for severe dry eye
Sasaki T,Ota T,Ookura Y,Sugiyama K
Clinical Ophthalmology , 2012,
Abstract: Tsugihisa Sasaki,1,2 Taeko Ota,3 Youko Ookura,4 Kazuhisa Sugiyama11Department of Ophthalmology, Kanazawa University School of Medicine, Kanazawa, Ishikawa; 2Department of Ophthalmology, Fukui Prefectural Hospital, Fukui; 3Department of Ophthalmology, Tonami General Hospital, Tonami-city, Toyama; 4Department of Ophthamology, Saiseikai Kanazawa Hospital, Kanazawa, Ishikawa, JapanBackground: The purpose of this work was to report on the performance of medial blepharosynechioplasty (MBSP), a newly devised technique for treating severe dry eye.Methods: In this retrospective, nonrandomized clinical trial, three cases with severe dry eye (Sj gren’s syndrome) associated with repeated punctal plug loss were treated using MBSP to create a synechia between the upper and lower lid medial borders of the puncta to suppress the lacrimal pump.Results: Postoperative follow-up showed improvement in the corneal condition in all three cases that persisted for 12–35 months. None of the patients had visual impairment.Conclusion: MBSP is a promising treatment for severe dry eye and merits further study.Keywords: dry eye, lacrimal pump suppression, medial blepharosynechioplasty
Nutrients Modulate T1r2 Transcript Levels in MIN 6 and Primary Cultured Taste Buds Cells under High Glucose Condition  [PDF]
Shin-ichi Nakmura, Tetsuya Ookura
Food and Nutrition Sciences (FNS) , 2016, DOI: 10.4236/fns.2016.74033
Abstract: The sweet taste receptors comprised of T1r2 and T1r3, sense glucose concentrations in the gastrointestine. While hyperglycemia was reported to decrease the T1R2 and T1R3 tanscript levels in healthy subjects, no change was observed in type 2 diabetes patients. We investigated which glucose level and nutrients affect those transcript levels in MIN 6 and primary cultured taste buds cells using quantitative Reverse Trancription Polymerase Chain Reaction. High glucose diminished T1r2 transcript levels in MIN 6 and primary cultured taste buds cells. Resveratrol and its analogue augmented transcript levels of T1r1 and T1r2 above normal levels in MIN 6 cells in the medium with 25 mM glucose. Adenine, but not guanine, augmented T1r2 transcript levels of MIN 6 cells in the medium with 25 mM glucose. These results imply that nutrients in meals could affect sweet taste sensitivity by modulating T1r2 transcript levels in response to blood glucose levels.
Phylogenetic Analysis and Taste Cell Expression of Calpain 9 in Catfish (Ictalurus punctatus)  [PDF]
Tetsuya Ookura, Eiki Koyama, Anne Hansen, John H. Teeter, Yukio Kawamura, Joseph G. Brand
Natural Science (NS) , 2015, DOI: 10.4236/ns.2015.73016
Abstract: The calpains, calcium-activated neutral proteases, play important roles in calcium-regulated intra-cellular signal transduction cascades. Here we report the isolation and initial characterization of a cDNA encoding a calpain 9, digestive tract specific calpain, from catfish taste epithelium. This calpain 9 (Ip-CAPN9a) shares 61% identity with human calpain 9. Phylogenetic analysis provides evidence that catfish calpain 9 and the related enzymes from Oncorhynchus mykiss, Danio rerio, Xenopus laevis, Mus musculus, Rattus norvegicus and Homo sapiens make up a distinct clade within the tissue-specific calpain family. Northern blot analysis reveals that Ip-CAPN9a is predominantly expressed in barbell and digestive tract, but not expressed in brain. An antibody against the N-terminal segment of Ip-CAPN9a recognizes cells within the taste buds in catfish barbells.
Investigation of β-Cryptoxanthin Fatty Acid Ester Compositions in Citrus Fruits Cultivated in Japan  [PDF]
Yusuke Wada, Atsuki Matsubara, Takato Uchikata, Yugo Iwasaki, Satoshi Morimoto, Katsuta Kan, Tetsuya Ookura, Eiichiro Fukusaki, Takeshi Bamba
Food and Nutrition Sciences (FNS) , 2013, DOI: 10.4236/fns.2013.49A1016
Abstract:


In this study, a catalog of β-cryptoxanthin (βCX) and its fatty acid esters (βCXFAs) in citrus fruits were constructed. The peel and pulp of citrus fruits from nine Japanese cultivars and one foreign cultivar were surveyed by supercritical fluid chromatography/triple quadrupole mass spectrometry (SFC/QqQMS). In each citrus sample, the major components were βCX and its laurate ester, myristate ester, palmitate ester, and oleate ester. However, the composition ratio of βCXFA varied with the citrus breed and between the pulp and the peel of the fruit in most cultivars. The SFC/QqQMS system could be used to obtain new information about βCXs and carry out further discussion on the feature and tendency of each citrus variety.


A New Paradigm for Metallic Alloys in Materials Science  [PDF]
Y. Ustinovshikov
Advances in Materials Physics and Chemistry (AMPC) , 2015, DOI: 10.4236/ampc.2015.57025
Abstract: In the article, taking into account the phase transition “ordering-phase separation” discovered in alloys, new concepts about the diffusion phase transformations in alloys are formulated: chemical interaction between dissimilar atoms exists always in all alloys and at any temperature of heating; alloys offer a surprising and not previously known property of changing the sign of the chemical interaction between dissimilar atoms at a change of the temperature or composition of alloys; diffusion processes occurring in alloys at different temperatures depend on the sign and the absolute magnitude of the energy of the chemical interaction between dissimilar atoms. All these three concepts are analyzed in detail, by the example of Ni-based and Co-based binary alloys using experimental results obtained by transmission electron microscopy. It is shown, on these ideas, how to carry out heat treatment of alloys more rationally, what principles should underpinned in the base of the construction of phase diagrams, how the microstructures of ordering and phase separation affect some properties of alloys.
Quasi-Square Wave Mode Phase-Shifted PWM LCC Resonant Converter for Regulated Power Supply  [PDF]
S. PADMANABHAN, Y. SUKHI, Y. JEYASHREE
Engineering (ENG) , 2009, DOI: 10.4236/eng.2009.13024
Abstract: This paper presents an improved self sustained oscillating controller circuit using LCC components for improving the overall efficiency of the system. It has a micro controller based active controller, which controls the performance from no-load up to full-load. The steady state characteristics are developed and a design example is given in detail. The proposed controller allows zero current switching at any loading condition which results in a reasonable reduction of power loss during switching with a promising efficiency. Analytical and experimental results verify the achievement the design specifications.
After the Treatment Phase of Colorectal Cancer Care: Survivorship and Follow-Up  [PDF]
Maria Y. Ho, Winson Y. Cheung
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.326125
Abstract: The number of long-term colorectal cancer (CRC) survivors has increased substantially over the past three decades due to both ongoing advances in early detection and improvements in cancer therapies. Adult survivors of CRC experience chronic health conditions due to normal issues associated with aging, which is further compounded by the long-term adverse effects of having had cancer and anti-cancer therapies. In addition, they are at a higher risk for CRC recurrences, new primary cancers, and other co-morbidities. This article will provide an overview of the clinical care of adult survivors of CRC. Epidemiologic data will be presented followed by a discussion of the approach to the care of long-term adult survivors of CRC, including surveillance of recurrences and new primary cancers, interventions to manage both physical and psychological consequences of cancer and its treatments, and strategies to address concerns related to unemployment and disability. Finally, we will explore the challenges of healthcare delivery, especially with respect to the coordination of follow-up between cancer specialists and primary care physicians, so as to ensure that all of the survivor’s health needs are met promptly and appropriately.
Electronic states and pairing symmetry in the two-dimensional 16 band d-p model for iron-based superconductor
Y. Yanagi,Y. Yamakawa,Y. ōno
Physics , 2008, DOI: 10.1143/JPSJS.77SC.149
Abstract: The electronic states of the FeAs plane in iron-based superconductors are investigated on the basis of the two-dimensional 16-band d-p model, where the tight-binding parameters are determined so as to fit the band structure obtained by the density functional calculation for LaFeAsO. The model includes the Coulomb interaction on a Fe site: the intra- and inter-orbital direct terms U and U', the exchange coupling J and the pair-transfer J'. Within the random phase approximation (RPA), we discuss the pairing symmetry of possible superconducting states including s-wave and d-wave pairing on the U'-J plane.
Detecting the light of the night sky in Mars  [PDF]
Nebil Y. Misconi
Natural Science (NS) , 2011, DOI: 10.4236/ns.2011.34036
Abstract: In this paper a new methodology is outlined to detect the dust content in the Martian atmosphere during nighttime. In the previous Lander missions to Mars, scientists were able to determine the dust load in the Martian atmosphere during daylight using spectral lines of the Sun. Since the dynamics of Martian dust storms had been determined to be very rapid changing over times of hours and not days, it is imperative to determine the dust load during nighttime, so future astronauts to Mars can take protective measures for their equipment. They can also factor this effect for their planned activities during daytime. The new methodology greatly improves on the classical method for determining the extinction in the Earth’s atmosphere. The classical method uses observations of bright stars from which the optical depth, ?total, can then be deduced from the classical brightness equation. The classical method succeeds reasonably well at high elevation angles from the horizon but fails dramatically at low elevation angles. It also determines ?total from the slope of a plot of observed brightness of a bright star vs. air mass at all elevations. The plot shows a straight line at high elevations angles, which then curves and becomes uncertain at low elevation angles. The new methodology bypasses this severe difficulty by simply eliminating this plot, and by acquiring the brightness of a bright star above the atmosphere (no extinction) and compares it to the observed bright- ness of the same star below the atmosphere at all elevations.
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