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Search Results: 1 - 10 of 35497 matches for " Onur Ero?lu "
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The Evaluation of the Effects of Temozolomide on MGMT Gene Expression in MCF-7 and SKBR3 Human Breast Cancer Cell Lines  [PDF]
Onur Erolu, Bü?ra Sevim
Journal of Cancer Therapy (JCT) , 2019, DOI: 10.4236/jct.2019.103018
Abstract: Background and Aim: In this study, it was aimed to examine the cytotoxic effect of temozolomide (TMZ) treatment, on MCF-7 and SKBR3 cell lines, to study the methylation levels of MGMT gene expression and gene promoter region. Methods: The MTT test was performed to determine the effective dose of TMZ. The time-dependent cell survival test was performed after the IC50 value was found. Western blotting was performed to determine MGMT gene expression levels. High Resolution Melting (HRM) technique was used to determine the methylation levels of MGMT gene promoter region. Results: TMZ has been shown to have a high cytotoxic effect on SKBR3 cell line and low cytotoxicity on MCF-7. When MGMT expression levels before and after TMZ treatment were observed by western blotting, the gene expression levels of TMZ treatment were shown to decrease in both cell lines. It was observed that MGMT gene promoter region was hypermethylated in two cell lines, and that the application of TMZ further increased the methylation levels in the promoter region. Conclusions: It was seen that TMZ could be used as
?zge Onur,?zlem Güneysel,Serkan Erolu,Arzu Denizba??
Marmara Medical Journal , 2006,
Abstract: 30 years old male patient presented to our emergency clinic with complaint of left upper quadrant pain. We learned there has been a fight, he was assaulted with fists and iron bricks to his abdomen and right arm. Clinical examination revealed echymotic areas in his thorax, back and right arm; tenderness at left upper quadrant of abdomen. In laboratuary tests creatinin phosphokinase (CPK), creatinin(Cr) and potassium(K) levels were high. The patient admitted to emergency service with diagnosis of rhabdomyolysis. We started izotonic saline infusion, sodium bicarbonate and furosemide treatment. His serum levels returned to normal values in the fourth day of his admission. In a trauma patient independent from extent of muscle damage if enzymes are high; a probability of acute tubuler necrosis risk is also high. In patients presented to emergency clinic due to trauma, without looking at the extent of muscle injury ; CPK, Cr, K levels must be seen, and if they are high , to prevent complications treatment must be started immediately.
New and important guide in acute coronary syndrome: optical coherence tomography
Onur Ta?ar,?zcan Ba?aran,Elif Erolu,Cevat K?rma
Anadolu Kardiyoloji Dergisi , 2013,
Selcuk Universitesi Sosyal Bilimler Enstitusu Dergisi , 2008,
Abstract: Although identified among the elements constituting the wider public opinion of nationaland international scale, the local public opinion of the people living in a particular region has it’sown local scope and attributes. Within this regional frame that produces the local public opinion,local newspapers are appearing as determining organs in the local public opinion formationprocess. To evaluate this role of the local press on local opinion, a survey on the sample ofTrabzon has been conducted in the city center on 300 subjects by simple causal sampling. As aresult, it has been found that the great majority of the subjects (%92) was regarding the localpress as an information source and that another important part (%58) was appraising the localnewspapers as “influential” on the formation of a shared opinion.
The cytogenetic effects of black tea and green tea on cultured human lymphocytes
Erolu, Halil Erhan;
Brazilian Archives of Biology and Technology , 2011, DOI: 10.1590/S1516-89132011000600011
Abstract: in this study, the cytogenetic effects of black tea and green tea were determined in cultured peripheral blood lymphocytes. results showed that black tea and green tea induced the mitotic and replication indexes and decreased micronuclei. but these data were not statistically significant for green tea. the effects of black tea on the micronucleus formation and mitotic index were statistically significant. the decrease in micronucleus counts indicated that black tea and green tea had considerable anticlastogenic and antigenotoxic effects as observed in vitro in human lymphocytes. thus, it could be concluded that tea polyphenols protected the normal cells from genotoxic or carcinogenic agents, which indicated the therapeutic and antioxidative role of catechins, flavonoids or other tea compounds.
Values: Great challenge for construction of social structure with social institutions
Susran Erkan Erolu
International Journal of Human Sciences , 2012,
Abstract: Values and social institutions are inseparable in the construction of the social structure. There are 5 main social institutions; namely, family, education, religion, economy and politics. These institutions have their own structures and these structures were shaped by values. The scope of this study is to observe value system in general. Thus, it is possible to understand the motivations behind attitudes and behaviors related to values and to observe social interaction processes, institutional structure of key entities in the society and to understand cultural trends in the society general
Süleyman EROLU
Turkish Studies , 2009,
Abstract: saf is a poet statesman who lived in the sixteenth century. He started his career in the state as a scribe during the reign of Sultan Murad the third, and later continued as a combatant soldier, and eventually he advanced in the rank of grand seignior. Beside his successful service in the state, he was especially known with his ecaat-name masnavi. The theme of ecaat-name, which is one of the important examples of gazavatname, is the Ottoman’s travel to the Orient between the years 1578-1585. ecaat-name, which has a considerable place among the works containing Islamic features in the Turkish war literature, is a remarkable masterpiece since it has many historical documentary and literary significance. In this study, ecaat-name masnavi is examined from literary perspective, and information is given on saf ’s life and his literary characteristics are evaluated through his works. saf , XVI. yüzy lda ya am air bir devlet adam d r. Sultan III. Murad’ n saltanat y llar nda katiplik ile ba lad devlet g revini muharip bir asker olarak sürdürmü , sonras nda beylerbeyli e kadar yükselmi tir. Ba ar l devlet hizmetlerinin yan nda zellikle ecaat-name mesnevisi ile air olarak da tan nmaktad r. XVI. yüzy l n nemli gazavatname rneklerinden biri olan ecaat-name, 1578-1585 y llar aras Osmanl ark seferlerini konu etmektedir. Türk sava edebiyat n n slami nitelikli ürünleri i erisinde nemli bir yere sahip olan ecaat-name, tarih pek ok bilgiyi ihtiva etmekle birlikte edeb k ymeti y nüyle de kayda de er bir eserdir. Bu al mada ecaat-name mesnevisi edeb a dan incelenmi , saf ’nin hayat hakk nda bilgi verilerek eserlerinden hareketle edeb ki ili i de erlendirilmi tir.
Sald rganl k Davran n n Boyutlar ve li kili Oldu u Fakt rler: Lise ve üniversite rencileri üzerine Kar la t rmal Bir al ma
Susran Erkan EROLU
Selcuk Universitesi Sosyal Bilimler Enstitusu Dergisi , 2009,
Abstract: Nowadays one of the most debated subjects by the social scientists is anger and its further dimension aggression; because theintensity of the aggression emotion changes from person to person. There might be lots of reasons that determine individuals’aggressive behaviors and aggression behaviors can be projected in different ways depending on age. When developmental periodsare considered the behaviors that cause aggression in childhood, adolescence, adulthood or old age periods differentiate. Theenvironment in which individuals survive affects their emotional and behavioral development especially socio economicenvironment might cause aggression tendencies. This research in which aggression behaviors of high school students anduniversity students were observed according to several variables was carried on by survey method. The scope of the research wasconstituted of 2242 students who were students in Konya high schools and students in Sel uk University in 2008-2009educational semester (1294 high school (57,7%), 948 university (42,3%)). In order to gain research data “AggressionQuestionnaire” and “Personal Information Form” were used. Research’s data determined that the aggression behaviors of highschool students and university students differentiated according to aggression behavior sub dimensions. On the other handaggression behavior differentiated according to their gender. Recommendations were discussed according to findings of theresearch. Aggression concept is a multi dimensional concept like concepts used in behavioral sciences. For that reason thisconcept has different meanings in psychiatry, neurology, social psychology and psychology’s different sub branches. Aggressionand violence can be used for each other. There are several approaches which try to explain the reasons of aggression and itssources. These approaches observe the reasons of aggression as personal factors and factors independent from persons.Theoretical analyses depending on personal reasons try to explain the reasons with biological, instinctive and psycho-social causes.Individual is aggressive because s/he was genetically coded like that or structural abnormalities (hormonal disorders or braindamage) cause aggression. Theories focused on factors independent from persons developed a discourse which depends on social and cultural variables. In this research it was aimed to observe the aggression behavior of university and high school studentsaccording to their educational level, gender and socio economic status comparatively. It is seemingly important that educationallevel, gender an
rgütlerde leti im Kalitesini Etkileyen Fakt rlerin De erlendirilmesi
Selcuk Universitesi Sosyal Bilimler Enstitusu Dergisi , 2011,
Abstract: The basic task of a manager, in all types of organizations and at all levels, is defined as "the achievement of harmony ofindividual effort toward the accomplishment of group goals" Most managers have a variety of experiences of communicating withcolleagues, superiors and teams during the first half of their careers: some may have given presentations to internal or externalclients; others may even have addressed large audiences at meetings or conferences. Communication is vital for coordination andcollaboration within a firm, and for establishing relationships with clients. It is an essential skill for a manager. Today's businessworld places greater expectations on those who seek to lead. When recruiting new employees, increasingly companies say theylook for people with razor-sharp communication skills more than analytical ability. Boundaries have fallen at the national level,and this has been mirrored by an equivalent effect at the personal level. It is not enough to say what you want people to do - theywant to know why. "Knowing why" is as important as "knowing how".Beyond the extensive research done in job performance the past few decades, researchers have done some work on theorganization communication--job satisfaction construct. The prevailing evidence indicates these factors relate positively. Onlythree studies, though, have documented correlations specifically between. Jain's (1973) early study used a questionnaire interviewformat to examine the relationship between communication effectiveness of hospital supervisors and their job performance asperceived by their subordinates. Effectiveness criteria were supervisor communication behavior, supervisor-subordinatecommunication frequency and amount, employee knowledge of policies and procedures, employee communication satisfaction,and non- supervisory formal communication channels use. Results showed positive correlations between communicationeffectiveness and job performance, communication frequency and amount and job performance, and employee communicationsatisfaction and supervisor job performance. the positive relationship between organizational communication and job satisfactionappears to be well documented, while there is less reason to say this about the relationship between organizational communicationand job performance. Nor do we know much about the factors that compose organizational communication satisfaction andtheir interrelationships. Strong, continuing interest in the construct has appeared in books, conference proceedings, and doctoraldissertations. In summary, investigation of the o
Secondary Market Products in the Mortgage System and Global Practices
Erhan Erolu
??letme Ara?t?rmalar? Dergisi , 2010,
Abstract: In general terms, the mortgage market has two faces, the primary and the secondary markets. The primary market covers housing mortgage loans. On the other side of the mechanism, these loans are securitized and issued in financial markets with different form of securities in secondary markets. The common name of these instruments is “mortgage backed securities - MBS”. A mortgage backed security is a financial instrument issued in capital markets for investors, derived from either backed by the cash flow of the housing loan repayments (which is called pay-through) or backed by directly selling the mortgage pools to the MBS issuers (which is called passthrough). The most trading secondary mortgage market instruments and world practices are explained in this article.
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