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Search Results: 1 - 10 of 27062 matches for " Omar Abdul Hakim Al-Maghrabi "
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Some Morphological Structural Studies of Cucurbitaceous Tendrils under Arid Conditions
Omar Abdul Hakim Al-Maghrabi
Pakistan Journal of Biological Sciences , 2009,
Abstract: This study was carried out at Khulis, Khulis Governorate, Makkah region, on the first of April during the growing season of 2007, to study the morphology and anatomy of tendrils in different eight of cucurbit genera. The results showed a great variation among the most tested cucurbit genera concerning the twisting, branching, number of tendrils per node and presence of tendril trunk. Also, shape of transverse sections were ovate, sinuate-rhombic, sinuate-emarginate oblong, emarginate-ovate, spherical, notched-ovate and reniform. Furthermore, presence of collenchymatous, sclerenchymatous tissues, number of vascular bundles in Transverse Section (TV) and arrangement of vascular bundles varied according to the studied species. It could be conclude from this research that there are a numerous of qualitative traits of tendrils which plays an important role in identification of cucrbitaceous plants for examples; the twisting, branching, transverse section shape, collenchymatous tissue, scleranchymatous tissue, tylosis and arrangement of vascular bundles.
Large cell calcifying sertoli cell tumor of the testis.
Al-Maghrabi Jaudah
Annals of Saudi Medicine , 2005,
Histiocytic necrotising lymphadenitis (Kikuchi-Fujimoto disease) in Saudi Arabia : Clinicopathology and immunohistochemistry.
Al-Maghrabi Jaudah,Kanaan Hassan
Annals of Saudi Medicine , 2005,
Abstract: BACKGROUND: Kikuchi-Fujimoto disease (KFD) is a rare entity of uncertain cause that commonly presents as a benign self-limiting disease of unknown origin. The objective of this study was to document the clinical features, mode of presentation, histopathological and immunohistochemical (IHC) features of KFD at our institutions since little is known about this disease in our region. METHODS: We reviewed the histopathological reports of all lymph nodes resected at or referred to King Abdulaziz University Hospital between 1990 and 2003 and King Faisal Specialist Hospital & Research Center, Jeddah, Kingdom of Saudi Arabia between 2000 and 2003. All cases diagnosed as KFD were identified and the histological slides and clinical data were reviewed. IHC was performed for the proliferative marker Ki- 67 and the apoptosis-related markers Bcl-2 and p53. RESULTS: In 2500 lymph node biopsies, 15 cases were diagnosed as KFD. The female to male ratio was 2.7:1. One patient presented with axillary lymphadenopathy and the others presented with cervical lymphadenopathy. Ages averaged 29 years and ranged from 13 to 46 years. There was no recurrence of the lymphadenopathy over 1 to 10 years of follow up. Bcl-2 and p53 were negative and Ki-67 was positive in 11 of 15 cases. CONCLUSION: The results support earlier findings that KFD is a selflimiting disorder that requires no specific management. We suggest a clinical follow-up for several years. The female predominance was striking. Apoptosis-regulating proteins are not helpful in the diagnosis. KFD usually expressed the proliferation-associated nuclear antigen Ki-67. Increased awareness of KFD will minimize the risk of confusing this entity with malignant lymphoma or other serious conditions.
Driving online shopping: Spending and behavioral differences among women in Saudi Arabia
Al-maghrabi, T.,Dennis, C.
International Journal of Business Science and Applied Management , 2010,
Abstract: This study proposes a revised technology acceptance model that integrates expectation confirmation theory to measure gender differences with regard to continuance online shopping intentions in Saudi Arabia. The sample consists of 650 female respondents. A structural equation model confirms model fit. Perceived enjoyment, usefulness, and subjective norms are determinants of online shopping continuance in Saudi Arabia. High and low online spenders among women in Saudi Arabia are equivalent. The structural weights are also largely equivalent, but the regression paths from perceived site quality to perceived usefulness is not invariant between high and low e-shoppers in Saudi Arabia. This research moves beyond online shopping intentions and includes factors affecting online shopping continuance. The research model explains 60% of the female respondentsa€ intention to continue shopping online. Online strategies cannot ignore either the direct and indirect spending differences on continuance intentions, and the model can be generalized across Saudi Arabia.
Loss of Villin Immunoexpression in Colorectal Carcinoma Is Associated with Poor Differentiation and Survival
Jaudah Al-Maghrabi,Wafaey Gomaa,Abdelbaset Buhmeida,Mohmmad Al-Qahtani,Mahmoud Al-Ahwal
ISRN Gastroenterology , 2013, DOI: 10.1155/2013/679724
Abstract: Background and Aims. Villin is a highly specialised protein and is expressed in intestinal and renal proximal tubular epithelium. It was detected in colorectal carcinomas (CRC) and other nongastrointestinal tumours. The aim of the current study is to investigate the immunohistochemical expression of villin in a subset of primary CRC and determine its relation to tumour differentiation, invasion, nodal metastasis, recurrence, and disease-free survival. Patients and Methods. Paraffin blocks of 93 cases of CRC were retrieved constituting 93 primary CRC and 58 adjacent normal mucosa. Immunohistochemistry was performed using antivillin antibody. The extent (%) of villin immunoexpression was categorised for statistical analysis. Statistical tests were used to determine the association of villin with clinicopathological characteristics: age, sex, tumour location, tumour size, depth of invasion, tumour grade, nodal metastasis, lymphovascular invasion, margin status, recurrence, and survival. Results. Villin immunostaining results showed that villin is downregulated in CRC. Villin has no association with age, sex, tumour location, depth of invasion, nodal metastasis, lymphovascular invasion, margin status, and recurrence. However, villin is expressed in higher rate in CRC less than 5?cm, well- and moderately differentiated CRC. Poor survival was associated with tumour with low villin immunoexpression. Conclusion. Villin was downregulated in CRC. Villin immunoexpression in CRC is associated with better survival, well-differentiated tumours, and small-sized tumours. Villin has no significant association with disease recurrence or nodal metastasis. More in vivo and in vitro studies are required for further elucidation of how villin may be involved in CRC. 1. Introduction Although 70% of colorectal carcinoma (CRC) cases undergo a curative surgery, 50% of surgically cured patients will have at a time an advanced local recurrence or metastases [1]. CRC is a common type of cancer with a considerably poor prognosis and mortality all over the world. The extent of local invasion and tumour metastasis are important factors to determine disease outcome. Distant metastases aggravate treatment failure, and patients will be subjected to palliative treatment. Molecular markers of metastasis are essential to improve treatment protocols [1, 2]. Understanding the molecular pathology underlying CRC needs continuous efforts to discover more prognostic molecules to predict disease outcome and improve therapeutic interventions. The Saudi Arabian National Cancer Registry in 2005 showed
IgA nephropathy: A clinicopathologic study from two centers in Saudi Arabia
Khawajah Azhar,Al-Maghrabi Jaudah,Kanaan Hassan,Al-Ghamdi Saeed
Saudi Journal of Kidney Diseases and Transplantation , 2010,
Abstract: A total of 42 patients, who were diagnosed to have primary Immunoglobulin A neph-ropathy (IgAN) at the King Abdul Aziz University Hospital and King Faisal Hospital, Jeddah over the last seven years, were studied. The objective was to analyze their clinical and pathological fea-tures and to classify them according to Hass Classification by using light, immunofluorescence and electron microscopy. Majority of the study cases were males in the second, third and fourth decades of life. Hematuria was the most common clinical complaint followed by proteinuria. There were varying degrees of mesangial proliferation. Majority of the cases presented with class-2 followed by class-3. Immunofluorescence demonstrated diffuse granular deposition of IgA in the glomerular mesangium in majority of the cases. Ultrastructural analysis showed electron dense deposits within the matrix of the mesangium and paramesangium in majority of the cases. Sub-endothelial deposits and mesangial interposition were demonstrated in few cases. Extensive effacement with fusion of the visceral epithelial foot processes was detected in only few patients while focal effacement was demonstrated in many cases. Irregularities of the glomerular basement membrane were seen in some cases. We conclude that IgA nephropathy is an immune-complex glomerular disease, which occurs at all ages and with higher frequency in males and presents mostly with hematuria and proteinuria. Public health awareness is seriously needed to perform the investigations at an early stage.
Expression of Estrogen Alpha and Beta Receptors in Prostate Cancer and Hyperplasia: Immunohistochemical Analysis
JA Al-Maghrabi, TM Hassan, TA Abdel-Meguid, HA Mosli
African Journal of Urology , 2010,
Abstract: Objectives: Estrogen receptors are believed to play a significant role in the pathogenesis of prostate carcinoma (PCa). The aim of this study is to evaluate the expression of ER-α and ER-β in human benign and malignant prostatic tissue. Patients and Methods: The archival materials of 100 prostatic specimens (65 PCa, 35 BPH) were collected from the Department of Pathology, King Abdul-Aziz University Hospital, Jeddah, Saudi Arabia. Seven PCa cases contained foci of high-grade prostate intraepithelial neoplasia (HGPIN). Immunohistochemistry was used to test the protein expression of ER-α and ER-β utilizing monoclonal mouse antihuman antibodies. Results: Among the 65 cases of PCa, ER-α was expressed in 3 cases (4.6%) in epithelial cells and 4 cases (6.1%) in stromal cells. ER-α was not expressed in any of the HGPIN foci. Additionally, ER-α was not expressed in either luminal or basal cells in any of the 35 BPH cases. However it was expressed in 4 cases (11.4%) in stromal cells of BPH. In PCa, ER-β was expressed in 61 cases (93.8%) and 35 cases (53.8%) in the epithelial and stromal cells respectively. ER-β was expressed only in 2 cases (28.5%) out of 7 HGPIN foci. It was expressed in 33 cases (94.3%) of epithelial and stromal cells of BPH. Conclusion: The majority of PCa and BPH exhibited nuclear immunoreactivity for ER-β in both tumor and stromal cells and they are usually negative for ER-α. There is probably partial loss of ER-β in HGPIN. ER-β may have a role in the process of prostatic hyperplasia and malignancy. Key Words: ER-α, ER-β, prostate, hyperplasia, premalignant, cancer, immunohistochemistry
Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma
Jaudah Al-Maghrabi,Abdelbaset Buhmeida,Eman Emam,Kari Syrj?nen
World Journal of Gastroenterology , 2012, DOI: 10.3748/wjg.v18.i15.1793
Abstract: AIM: To correlate cyclooxygenase-2 (COX-2) expression profile with clinical and pathological variables to assess their prognostic/predictive value in colorectal carcinoma (CRC). METHODS: Archival tumor samples were analyzed using immunohistochemistry for COX-2 expression in 94 patients with CRC. Patients were diagnosed and treated at the Departments of Surgery and Oncology, King Abdulaziz University Hospital, Saudi Arabia. RESULTS: Fifty-six percent of the tumors showed positive cytoplasmic COX-2 expression, whereas 44% of cases were completely COX-2-negative. There were no significant correlations between COX-2 expression and sex, age, grade or tumor location. However, COX-2 expression revealed a significant correlation with tumor stage (P = 0.01) and distant metastasis (P = 0.02), and a borderline association with lymph node involvement (P = 0.07). Tumors with high COX-2 expression showed a higher recurrence rate than tumors with no expression (P < 0.009). In univariate Kaplan-Meier survival analysis, there was a significant (P = 0.026) difference in disease-free survival between COX-2-positive and negative tumors in favor of the latter. COX-2 expression did not significantly predict disease-specific survival, which was much shorter for COX-2-positive tumors. In multivariate (COX) models, COX-2 did not appear among the independent predictors of disease-free survival or disease-specific survival. CONCLUSION: COX-2 expression seems to provide useful prognostic information in CRC, while predicting the patients at high risk for recurrent disease.
Determinants of Customer Continuance Intention of Online Shopping
Al-maghrabi, T.,Dennis, C.,Vaux Halliday, S.,BinAli, A.
International Journal of Business Science and Applied Management , 2011,
Abstract: The purpose of this study is to clarify theory and identify factors that could explain the level of continuance intention of e-shopping. A revised technology acceptance model integrates expectation confirmation theory and investigates effects of age differences. An online survey of internet shoppers in Saudi Arabia. Structural equation modelling and invariance analysis confirm model fit. The findings confirm that perceived usefulness, enjoyment and social pressure are determinants of e-shopping continuance. The structural weights are mostly equivalent between young and old but the regression path from perceived usefulness to social pressure is stronger for younger respondents. This research moves beyond e-shopping intentions to factors affecting e-shopping continuance, explaining 55% of intention to continue shopping online. Online strategies cannot ignore direct and indirect effects on continuance intentions. The findings contribute to literature on internet shopping and continuance intentions in the context of Saudi Arabia.
Burnout syndrome among multinational nurses working in Saudi Arabia
HA Al-Turki, RA Al-Turki, HA Al-Dardas, MR Al-Gazal, GH Al-Maghrabi, NH Al-Enizi, BA Ghareeb
Annals of African Medicine , 2010,
Abstract: Background: Nursing Staff is reported to be under extreme state of stress, leading to burnout syndrome (BS). Most of the studies have been conducted among the nurses working in their home countries. This study was conducted to assess the prevalence of BS among a multinational nursing workforce in Saudi Arabia. Materials and Methods: King Fahd University Hospital, AlKhobar, Saudi Arabia, is a tertiary care hospital employing 510 nurses of multinational workforce. Two hundred and fifty Maslach Burnout Inventory (MBI) individual-based questionnaires were distributed after modification to include the age, sex, marital status, nationality, unit working and number of years on the job. The data were entered in the database and analyzed using Statistical Package for the Social Sciences (SPSS), version 14.0. A P value of <0.05 was considered statistically significant . Results: One hundred and ninety-eight nurses (77.2%) completed the questionnaire. Their average age was 34.46 } 5.36 years. Forty-five percent (89) had high emotional exhaustion (EE) and 28.9% (57) had moderate suffering with EE. Staffs who were on the job for longer duration had a lesser frequency of EE (P . 0.001). The frequency of depersonalization (DP) was 83 (42%) and was graded as high and 61 (30.8%) were moderately affected. Personal accomplishment (PA) was moderate to low in the majority of the nurses (71.5%). Married nurses were prone to EE (28.17 } 12.1 versus 22.3 } 9.6) than unmarried nurses (P = 0.003, CI 95% and OR 2.4). The nurses in the patientsf wards and clinics were more emotionally exhausted with higher DP compared to nurses in the high stress and high activity areas (P < 0.001, OR .11.1; and P < 0.001, CI 95% and OR 9.65). Non-Saudi nurses were significantly more prone to EE (27.3 } 12.1 versus 21.6 } 2.9) than Saudi nurses (P = 0.004; 95% CI: <9.64). Conclusion: We found that majority of the nursing staff at our hospital were in a state of burnout with high frequency of EE and DP. Only a quarter of the surveyed staff felt that they had some level of PA. Age and working away from their home countries were the important predictors in the development of BS in nurses. We believe that working conditions have to be improved to develop strategies to cope and alleviate stressful situations.
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