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Search Results: 1 - 10 of 144443 matches for " Olusegun B. Olubanwo "
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Chiral Camphor-Based 1,3- and 1,4-Amino Alcohols and Aminodiols as Ligands for Diethylzinc Addition to Aldehydes  [PDF]
Olusegun B. Olubanwo, James A. Golen, Arnold L. Rheingold, Vesa Nevalainen
International Journal of Organic Chemistry (IJOC) , 2018, DOI: 10.4236/ijoc.2018.82018
Abstract: Syntheses of (1R,2S,3R,4S)-1,7,7-trimethyl-2-pyridin-2-ylmethylbicyclo[2.2.1]-heptane-2,3-diol (7), (1R,2S,3R,4S)-1,7,7-trimethyl-2-[(6-methyl)-pyridin-2-ylmethyl-bicyclo-[2.2.1]heptane-2,3-diol (13), and (1R,2S,2’R,4R)-1,7,7-trimethyl-2-piperidin-2-ylmethyl-bicyclo[2.2.1]heptan-2-ol (19b) from commercially available (d)-camphor (1) are described. Key steps of the syntheses involved substrate-controlled diastereoselective alkylation and platinum oxide-catalyzed hydrogenation reactions. These compounds, and other intermediate amino alcohols in their syntheses, were successfully utilized as ligands in enantioselective diethyl zinc (Et2Zn) addition to benzaldehyde with moderate enantioselectivity.
Trends of Temperature and Signature of Solar Activity in Selected Stations in Nigeria  [PDF]
Christiana F. Olusegun, Akeem B. Rabiu, Jared O. H. Ndeda, Emmanuel C. Okogbue
Atmospheric and Climate Sciences (ACS) , 2014, DOI: 10.4236/acs.2014.42020

This study investigates the variability and periodicity of minimum temperature, maximum temperature and sunspot number—a solar activity index in selected synoptic stations across Nigeria from 1946 to 2010. Annual and semiannual effect of solar activity on minimum temperature was observed in all the six stations. This was indicated in the occurrence of modal periodicities of 6-month and 12-month observed across the six synoptic stations. The synoptic stations are Sokoto (13.01°N, 5.15°E), Ilorin (8.29°N, 4.35°E), Ikeja (6.35°N, 3.20°E), Enugu (6.28°N, 7.33°E), Port-Harcourt (4.51°N, 7.01°E) and Maiduguri (11.51°N, 13.05°E). Similarly, the trends of inter-decadal va-riability of minimum and maximum temperature show a non-uniformity increase over the analyzed period with a slight decrease before 1960. The long term behavior of minimum and maximum temperature shows a warming rate which ranges from 0.1°C/decade to 0.2°C/ decade across the six stations except for maximum temperature at Ilorin and minimum temperature at Sokoto which is at -0.2°C/decade and 0.3°C/decade respectively.

Type 2 Diabetes Mellitus: A Review of Current Trends
Abdulfatai B. Olokoba,Olusegun A. Obateru,Lateefat B. Olokoba
Oman Medical Journal , 2012,
Abstract: Type 2 diabetes mellitus (DM) is a chronic metabolic disorder in which prevalence has been increasing steadily all over the world. As a result of this trend, it is fast becoming an epidemic in some countries of the world with the number of people affected expected to double in the next decade due to increase in ageing population, thereby adding to the already existing burden for healthcare providers, especially in poorly developed countries. This review is based on a search of Medline, the Cochrane Database of Systemic Reviews, and citation lists of relevant publications. Subject heading and key words used include type 2 diabetes mellitus, prevalence, current diagnosis, and current treatment. Only articles in English were included. Screening and diagnosis is still based on World Health Organization (WHO) and American Diabetes Association (ADA) criteria which include both clinical and laboratory parameters. No cure has yet been found for the disease; however, treatment modalities include lifestyle modifications, treatment of obesity, oral hypoglycemic agents, and insulin sensitizers like metformin, a biguanide that reduces insulin resistance, is still the recommended first line medication especially for obese patients. Other effective medications include non-sulfonylurea secretagogues, thiazolidinediones, alpha glucosidase inhibitors, and insulin. Recent research into the pathophysiology of type 2 DM has led to the introduction of new medications like glucagon-like peptide 1 analogoues: dipeptidyl peptidase-IV inhibitors, inhibitors of the sodium-glucose cotransporter 2 and 11 -hydroxysteroid dehydrogenase 1, insulin-releasing glucokinase activators and pancreatic-G-protein-coupled fatty-acid-receptor agonists, glucagon-receptor antagonists, metabolic inhibitors of hepatic glucose output and quick-release bromocriptine. Inhaled insulin was licensed for use in 2006 but has been withdrawn from the market because of low patronage.
Religious Epistemology in John Hick’s Philosophy: A Nigerian Appreciation  [PDF]
Olusegun Noah Olawoyin
Open Journal of Philosophy (OJPP) , 2016, DOI: 10.4236/ojpp.2016.62019
Abstract: John Hick is well-known among philosophers and theologians for his philosophy of religious pluralism. Before proposing his theory of religious pluralism, however, he has made major contributions in religious epistemology and other religio-philosophical issues. His later philosophy of religious pluralism is based on his earlier proposal on religious epistemology. Hick affirmed that although religious statements are cognitive, the world is religiously ambiguous. This paper argues that Nigeria as a country riddled with religious conflicts can benefit from religious epistemology of John Hick. Using conceptual analytic method of philosophy to present Hick’s religious epistemology and applicatory technique to propose how the epistemology can be appropriated in Nigeria, the paper argues that such religious epistemology will result in tolerance and peace.
Evaluation of the antinociceptive activities of the aqueous root extract of Alchornea cordifolia (Schumach and Thonn) Müll. Arg. (Euphorbiaceace)
Ismaila O Ishola,Razaq B. Ashorobi,Olusegun Adeoluwa
International Journal of Applied Research in Natural Products , 2012,
Abstract: Summary. Alchornea cordifolia (Schumach and Thonn) Müll. Arg. (Euphorbiaceace) is used in traditional African medicine for the treatment of painful and inflammatory disorders. This study was carried out to investigate the antinociceptive effect of aqueous root extract of Alchornea cordifolia in mice. The antinociceptive activity of the oral doses of 100 – 400 mg/kg of Alchornea cordifolia was assessed using the acetic acid-induced mouse writhing reflex, formalin-induced paw licking, hot plate and tail clip models of pain.The extract (100–400 mg/kg) produced significant (P< 0.05) dose dependent inhibition of writhing reflex as well as significant dose-dependent inhibition of the neurogenic and inflammatory pains associated with the formalin test. The formalin test result showed that the extract (100-400 mg/kg, p.o) increased pain threshold in a dose dependent manner in both phases but the effect is more prominent against the inflammatory phase (second phase).This findings showed that A.cordifolia possesses both central and peripheral analgesic activity, as shown by its ability to significantly (p<0.05) inhibit nociceptive response associated with both phases. The ability of the oral doses of the extract (100-400 mg/kg) to prolonged the reaction time of the animals to noxious heat in hot plate and tail clip models of pain, in a dose dependent manner suggests a central analgesic effect. Acute toxicity studies of oral doses of aqueous root extract of Alchornea cordifolia in mice revealed that it has a wide margin of safety as it well tolerated by the animals.The results of the study suggest an analgesic property demonstrated by the aqueous root extract of Alchornea cordifolia possibly mediated by central and peripheral mechanisms and thus confirm the folkloric uses of the plant in painful disorders. Industrial relevance. In the recent past there has been a growing interest in Traditional medicine/Complementary and Alternative Medicine (TCAM) and their relevance to public health both in developed and developing countries. Diversity, flexibility, easy accessibility, broad continuing acceptance in developing countries and increasing popularity in developed countries, relative low cost, low levels of technological input, relative low side effects and growing economic importance are some of the positive features of traditional medicine. In this context, there is a critical need to mainstream traditional medicine into public health care to achieve the objective of improved access to healthcare facilities. Medicinal plants are largely used worldwide by the populat
Evaluation of Antistress Potential and Phytochemical Constituents of Aqueous Root Extract of Alchornea cordifolia
Ismaila O. Ishola,Razaq B. Ashorobi,Olusegun Adeoluwa
Asian Journal of Scientific Research , 2008,
Abstract: This study was conducted to evaluate phytochemical component and anti-stress potential of aqueous root extract of Alchornea cordifolia in mice. The phytochemical tests showed the presence of flavonoids, tannins, carbohydrates, glycosides, saponins and alkaloids. The antistress activity was evaluated using the forced swimming endurance and anoxic tolerance test. These activities were tested at oral doses of 100-400 mg kg-1 of the extract using Panax ginseng as experimental control. In the forced swimming test, A. cordifolia (100-400 mg kg-1, p.o) significantly prolonged the swimming time in a dose dependent manner. The swimming time (sec) was increased from 313.8±18.24 in the control group to 434.2±20.50 and 531.0±16.58 in groups pre-treated with 200 and 400 mg kg-1 of the extract respectively. In the same vein, the extract dose dependently prolonged the mean time (min) to onset of clonic convulsion, the onset of clonic convulsion was increased from 23.6±0.51 in control group to 39.4±1.84 and 52.0±1.30 in groups pretreated with 200 and 400 mg kg-1 of the extract, respectively. This ability of A. cordifolia to prolong both the swimming time and onset of clonic convulsion, therefore suggest an antistress property.
Use of long implants with distal anchorage in the skull base for treatment of extreme maxillary atrophy: The remote bone anchorage concept  [PDF]
Luc Vrielinck, Yi Sun, Serge Schepers, Constantinus Politis, Sarah Van Slycke, Jimoh Olubanwo Agbaje
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.27108
Abstract: The objectives of this study are to present a new concept of the bone anchorage using long implants in remote bone sites and to discuss four cases treated with this method. Our patients were treated with long implants with a distant anchorage in the skull bone. The planning procedure, the construction of the drill guide, and the surgical protocol are described. In the clinical cases described, all four patients were rehabilitated with the remote bone anchorage concept using long implants anchored in the skull base. Patients were followed for 5-12 years and the implants remained present and stable in these time periods. The skull base implant is a new concept of bone anchorage using long implants. It can be a solution for complicated clinical situations (often failed bone reconstructions and implant placements) or an alternative for bone grafting and maxillary augmentation procedures. There is effective implant retention in the skull base, an anatomical area that is often overlooked for implant placement.

A Statistical Rate Theory of Interface Concentration during Solution ZeoliteCrystal Growth  [PDF]
Hongwei Song, Olusegun J. Ilegbusi
Journal of Crystallization Process and Technology (JCPT) , 2011, DOI: 10.4236/jcpt.2011.13006
Abstract: A theoretical model is developed using statistical rate theory to determine the rate of molecular transport across the interface of a growing spherical zeolite crystal. The model is expressed in terms of the interface concentration. Two model constants appear in the expression for the equilibrium exchange rate. In order to validate the model, zeolite crystallization is investigated for a system for which experimental data exist. The model constants were first established using the measured growth rates at a specific temperature. Then the model was used to predict the growth rate at other temperatures.
Some Nigerian Primary School Pupils Knowledge, Attitude and Practices on Water Pollution
Olusegun Akinbote
The Social Sciences , 2013,
Abstract: Education is a powerful instrument for improving the health and the social well being of all citizens. Primary education as the largest sub sector of any educational system offers a unique opportunity for the transformation of societies through the education of the young ones. A good knowledge of personal hygiene and good environmental sanitation could reduce or eliminate the incidence of waterborne diseases which often keep many children away from school. This study therefore, investigated some Nigerian primary school pupils present knowledge, attitude and practices with regards to water pollution. It involved 476 primary 6 pupils form 20 randomly selected schools in Osun and Ondo States of Nigeria. A 4 part questionnaire designed and validated by the investigator was the only instrument used for data collection. The results showed that majority of the pupils had a good knowledge of the causes of water pollution and had positive attitude towards the prevention of water pollution. However, many of the pupils still contribute to water pollution through some of their current practices.
A Christian Critique of University Education in Nigeria
Olusegun Olawoyin
The Social Sciences , 2013, DOI: 10.3923/sscience.2010.25.29
Abstract: The standard of University education in Nigeria has drastically fallen. This is a fact, accepted by Christians and non-Christians alike. What these two groups disagree about include among other things, the causes of this fallen standard. This also leads to disagreement over the solutions. Various re-organisations have been suggested and carried out, especially since the commencement of Olusegun Obasanjo s administration in 1999. However, the desired effect had not been realised. This study gives a critique of the Universities from an evangelical Christian perspective and suggests that the Universities, like but more than other segments of the Nigerian society, require personality transformation and historical Christian ethos in relation to education. It is the conviction of this writer that evangelical Christianity has the resource to produce the personality changes, considering the phenomenal growth of this type of Christianity and its involvement in establishing private universities in Nigeria.
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