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Search Results: 1 - 10 of 5401 matches for " Olivier Lipp "
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Progesterone and Cerebral Function during Emotion Processing in Men and Women with Schizophrenia
Julie Champagne,Nadia Lakis,Josiane Bourque,Emmanuel Stip,Olivier Lipp,Adrianna Mendrek
Schizophrenia Research and Treatment , 2012, DOI: 10.1155/2012/917901
Abstract: Schizophrenia has been associated with disturbed levels of sex-steroid hormones, including estrogen and testosterone. In the present study we have examined the implication of a less studied hormone progesterone. Forty-three patients with schizophrenia (21 women) and 43 control participants (21 women) underwent functional MRI while viewing emotionally positive, negative, and neutral images. Blood samples were taken prior to the scanning session to evaluate progesterone levels. Simple regression analyses between levels of progesterone and brain activations associated with emotion processing were performed using SPM5. A positive correlation was found between progesterone levels and brain activations during processing of emotionally charged images in both healthy and schizophrenia men, but no significant relationship was revealed in women. These preliminary results indicate that progesterone is significantly associated with brain activations during processing of positive and negative affect in healthy and schizophrenia men, but not in women. Further investigation is warranted.
Progesterone and Cerebral Function during Emotion Processing in Men and Women with Schizophrenia
Julie Champagne,Nadia Lakis,Josiane Bourque,Emmanuel Stip,Olivier Lipp,Adrianna Mendrek
Schizophrenia Research and Treatment , 2012, DOI: 10.1155/2012/917901
Abstract: Schizophrenia has been associated with disturbed levels of sex-steroid hormones, including estrogen and testosterone. In the present study we have examined the implication of a less studied hormone progesterone. Forty-three patients with schizophrenia (21 women) and 43 control participants (21 women) underwent functional MRI while viewing emotionally positive, negative, and neutral images. Blood samples were taken prior to the scanning session to evaluate progesterone levels. Simple regression analyses between levels of progesterone and brain activations associated with emotion processing were performed using SPM5. A positive correlation was found between progesterone levels and brain activations during processing of emotionally charged images in both healthy and schizophrenia men, but no significant relationship was revealed in women. These preliminary results indicate that progesterone is significantly associated with brain activations during processing of positive and negative affect in healthy and schizophrenia men, but not in women. Further investigation is warranted. 1. Introduction There is some evidence of a relationship between sex-steroid hormones (i.e., estrogen, testosterone, and less commonly progesterone) and emotion processing in the general population [1–3]. Fluctuations in estrogen and progesterone have been linked with increased vulnerability to mood disorders in women, while elevated levels of testosterone have been primarily associated with antisocial behaviours, behaviours of dominance, and aggressiveness in both men and women [4]. In schizophrenia, some studies have found abnormal levels of estrogens and testosterone in patients, but the results have been equivocal and sometimes attributed to the antipsychotic-induced hyperprolactinemia, which may alter levels of gonadal hormones [5]. Despite numerous studies and clinical observations of lower relapse of clinical symptoms during pregnancy, high relapse postpartum, and the fluctuation of symptoms across the menstrual cycle (attributed typically to the changing levels of estrogens), a link between progesterone and affect in schizophrenia has yet to be examined [6]. The little emphasis that has been placed on the relationship between progesterone and emotional functioning has been explored primarily in healthy women because this hormone is a female reproductive hormone. Nonetheless, it is produced in both men and women, and recent evidence suggests that it is implicated in brain function of both sexes. Thus, progesterone has been shown to play an important role in mood regulation [7],
Deciphering Novel Host–Herpesvirus Interactions by Virion Proteomics
Roger Lippé
Frontiers in Microbiology , 2012, DOI: 10.3389/fmicb.2012.00181
Abstract: Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than anticipated. One particularly interesting and novel aspect is the analysis of cellular proteins incorporated into mature virions. Though sometimes considered purification contaminants in the past, their repeated detection by different laboratories suggests that a number of these proteins are bona fide viral components, some of which likely contribute to the viral life cycles. The present mini review focuses on cellular proteins detected in herpesviruses. It highlights the common cellular functions of these proteins, their potential implications for host–pathogen interactions, discusses technical limitations, the need for complementing methods and probes potential future research avenues.
The Neural Correlates of Mental Rotation Abilities in Cannabis-Abusing Patients with Schizophrenia: An fMRI Study
Stéphane Potvin,Josiane Bourque,Myriam Durand,Olivier Lipp,Pierre Lalonde,Emmanuel Stip,Sylvain Grignon,Adrianna Mendrek
Schizophrenia Research and Treatment , 2013, DOI: 10.1155/2013/543842
Abstract: Growing evidence suggests that cannabis abuse/dependence is paradoxically associated with better cognition in schizophrenia. Accordingly, we performed a functional magnetic resonance imaging (fMRI) study of visuospatial abilities in 14 schizophrenia patients with cannabis abuse (DD), 14 nonabusing schizophrenia patients (SCZ), and 21 healthy controls (HCs). Participants performed a mental rotation task while being scanned. There were no significant differences in the number of mistakes between schizophrenia groups, and both made more mistakes on the mental rotation task than HC. Relative to HC, SCZ had increased activations in the left thalamus, while DD patients had increased activations in the right supramarginal gyrus. In both cases, hyper-activations are likely to reflect compensatory efforts. In addition, SCZ patients had decreased activations in the left superior parietal gyrus compared to both HC and DD patients. This latter result tentatively suggests that the neurophysiologic processes underlying visuospatial abilities are partially preserved in DD, relative to SCZ patients, consistently with the findings showing that cannabis abuse in schizophrenia is associated with better cognitive functioning. Further fMRI studies are required to examine the neural correlates of other cognitive dysfunctions in schizophrenia patients with and without comorbid cannabis use disorder. 1. Introduction Neuropsychological studies have shown that 70% to 75% of patients with schizophrenia have significant cognitive deficits [1]. These deficits encompass attention, reasoning and problem solving, speed of processing, verbal memory, visual memory, and working memory [2]. Cognitive performance of patients with schizophrenia is 1 to 1.5 standard deviations below the performance of the general population [3]. Importantly, cognitive deficits are better predictors of social and occupational functioning than positive and negative symptoms [4]. The cognitive deficits of schizophrenia may be further amplified by the chronic use of psychoactive substances. In schizophrenia, the lifetime prevalence of substance use disorders approaches 50%; this estimate represents a 3- to 5-fold increased risk relative to the general population [5, 6]. Noteworthy, in younger schizophrenia populations, cannabis is one of the most frequently used psychoactive substances with lifetime prevalence rates of cannabis abuse/dependence up to 45% [7]. In addition to producing acute psychotic-like experiences [8], cannabis smoking has been shown to increase the risk for psychotic outcomes in nonpsychosis
Cognitive Outcome of Status Epilepticus in Children
Emilie Sheppard,Sarah Lippé
Epilepsy Research and Treatment , 2012, DOI: 10.1155/2012/984124
Abstract: Epileptic encephalopathy encompasses conditions in which cognitive, motor, or sensory deficits result as a consequence of epileptic activity defining certain syndromes. It therefore represents a more severe subset of epilepsy, which can be generally characterized as frequent or severe seizures leading to cerebral dysfunction. This disturbance in cerebral functioning can in turn hinder, somewhat dramatically, cognitive development and further impact the future lives of patients. In this paper, we describe the cognitive consequences of status epilepticus in children and in adults in the context of plasticity theories. Recent studies maintain that consequences of SE may be severe cognitive sequelae, especially in early life. Since the residual consequences of SE in adulthood seem less detrimental and long-lasting, we argue that early life insults, such as those created by SE, during a rapid period of development and functional specialization, result in specific cognitive deficits dependent on the sensitive period at which SE occurred. 1. Introduction Epileptic encephalopathy encompasses conditions in which cognitive, motor, or sensory deficits result as a consequence of epileptic activity defining certain syndromes [1]. It therefore represents a more severe subset of epilepsy, which can be generally characterized as frequent or severe seizures leading to cerebral dysfunction. This disturbance in cerebral functioning can in turn hinder, somewhat dramatically, cognitive development and further impact the future lives of patients. In this paper, we consider status epilepticus as an epileptic encephalopathy owing to its impact on cognitive development in early life. 2. Status Epilepticus (SE) Status Epilepticus (SE) is a medical epileptic emergency characterized by either rapidly repeating seizures without recovery or regain of consciousness between episodes, or prolonged continuous epileptic activity, both creating a fixed or lasting condition [2, 3]. It is an event rather than a syndrome. It is accepted that the duration of an episode of SE is 30 minutes or more, period after which cerebral functioning is highly probable of being affected and immediate medical attention is needed [4]. Recently, the notions of impending SE and established SE have been introduced [5] in order to provide the best possible care for patients presenting with SE. In adults, patients presenting a seizure lasting more than five minutes can be designated as impending SE. In children, impending seizures are considered when seizures last between 5 and 10 minutes [5]. The prevalence of
Symposium 9: Ecology, Brain and Behaviour
H. P. Lipp
Neural Plasticity , 1999, DOI: 10.1155/np.1999.34
Abstract:
Novel oral anticancer drugs: perspectives and limitations
Hans-Peter Lipp
European Journal of Oncology Pharmacy , 2011,
Abstract: Within the last decade, the development of novel, orally available anticancer drugs has made great progress, but this oral treatment requires the same amount of patient instruction as IV treatments.
A graphite-prism definition for Avogadro's "integer"
P. Fraundorf,Melanie Lipp
Physics , 2012,
Abstract: The new International System of Units may let us select an integer value for Avogadro's number. Some might prefer an integer that's divisible by 12, so that an integer number of $^{12}C$ atoms may be associated (to first order) with a gram's mass. For educational and practical reasons it may also help to choose a {\em physically-meaningful} definition within measurement error of the current numeric value. Cubes of diamond face-centered-cubic Si and (much rarer) face-centered-cubic C have been proposed, but these structures do not have naturally-occurring facets (or numbers of atoms generally divisible by 12). We show here that graphite prisms formed by stacking $m$ hexagonal graphene sheets, with $m \equiv 51,150,060$ carbon-12 atoms on each side, are a natural solution that may facilitate generation of precise molar standards as well.
Contra los métodos en el Derecho Internacional: una crítica a partir de su contribución para la realización de la función social de la dogmática jurídica
André Lipp Pinto Basto Lupi
ACDI : Anuario Colombiano de Derecho Internacional , 2010,
Abstract: This article aims to analyze how methods contribute to accomplishdoctrine’s social function. In this context, methods are presented as tools to elaborate more precise answers for legal practice. The article wants to demonstrate the ontological impossibility of that task. Methods cannot give certainty to doctrinal arguments.To demonstrate this assumption through bibliographical research, thearticle presents the recent debate in international legal academy, and then starts with an example that serves as starting point to analyze the issue: the indeterminacy of the international customary law.Based on the best known methods, the article projects their answers tothe practical issue concerning custom. The outcome is negative, reaffirming the initial hypothesis: we have to abandon the dream of a theoretical method laid on deductive models to give certainty for legal “science”.
A COMPOSI O DO MOSAICO: ORIENTA ES DOUTRINáRIAS SOBRE A IDENTIFICA O DA NORMA CONSUETUDINáRIA NO DIREITO INTERNACIONAL
André Lipp Pinto Basto Lupi
Prolegómenos. Derechos y Valores , 2009,
Abstract: Este trabajo presenta las múltiples orientaciones ofrecidas por la doctrina especializada en Derecho Internacional para la identificación de la costumbre internacional, con la finalidad de demostrar la transformación del proceso de definición de la costumbre en una actividad practica y técnicamente dirigida. Con eso, se quiere contribuir para incrementar el uso de normas consuetudinarias por académicos, abogados y jueces.
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