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Hyperthermia was the very first oncotherapy in human medicine, but
its applicability in modern oncology was dubious. The discovery of electromagnetism
gave new hope a century ago, however, until up to now, it has been suffering from lack
of wide acceptance. Oncological hyperthermia suffers from multiple
unsolved medical and technical problems. The accurate selection of malignant
tissue and its proper heating in depth are real challenges together with the control and repeatability of the treatments. However, the
center of the problems is not technical: the living system tries to keep its
homeostatic equilibrium and creates active feedback mechanisms to eliminate or
at least correct the constrain heating in depth. The proper reaction on the
“gage of battle” has to involve the physiology, handle it complexly together
with bioelectromagnetism and update connected technology. The solution has to
be the integration of the natural bio-effects into the technological
constrains, acting in synergy with the physiological feedback mechanisms, and without
forcing effects out of the homeostatic control. The solution lies in strict
selection and adequate action in nanoscopic range, without exciting the robust
transport-mechanisms to operate against the energy delivery to the tumor.
Together with the local
One of the most frequently applied bioelectromagnetic effects is the deep heating of the living species with EMF energy. Despite its long history, hyperthermia is a rarely applied oncotherapy. The reason is its controversial results and complicated control. One of the solutions is concentrating the electromagnetic energy nanoscopically on the parts of the malignant cells instead of heating up the complete tumor-mass. This approach is a kind of non-uniform energy absorption, providing energy liberation only in the selected regions. The energy-absorption of the malignant cells targets the membranes and creates a situation far from thermal equilibrium. The selection of the malignant cells is based on their decided differences from their healthy counterparts. The distinguishing parameters are the electromagnetic properties of the components of the malignant tissue which are the physiologic differences between the malignant cells and their healthy counterparts. The targets realize nano-range heating, using natural nanoclusters on the cell-membrane without artificially implementing them. This energy absorption generates consequent reactions, like programmed cell-death (apoptosis) continued by immunogenic cell-death involving extended immune reactions.？
The applied radiofrequency current is amplitude modulated by time-fractal modulation pattern. The accurately matched impedance realizes the self-selective mechanisms which are promoted by stochastic resonances. This complex method is a new kind of hyperthermia, named mEHT. Our objective is to analyze the problems of the selective, non-equilibrium energy absorption, and present a solution by the electromagnetic mechanisms for an effective and controllable hyperthermia in oncology.
Obnoxious labels are derogatory terms which speak extensively on the ignorant dispositions of scholars who either rush into faulty conclusions, or have prior decisions to promote class distinction through the uncomplimentary colours they paint of what others hold as divine, spiritual, and transcendental. For such derogatory terms to gain wide audience in a globalized age explain the frame of mind of discordant voices which have been based on arm-chair scholarship. The thrust of this article therefore, is to use Igbo experience to explore the problems of atheism and humanism in a globalized world. The exploratory research will help adopt cultural centred approach in analyzing the dichotomy between the various philosophical view points on God, spirits and man’s religious belief system in Igbo land in particular and Africa in general. It is hoped that the analyses of the challenges posed by atheism and humanism in a globalized world will balance ideas, views, attitudes and behaviour that will reposition Igbo religious beliefs, values and practices in line with the proposed theistic humanism associated with Igbo culture in particular and African culture in general. This will breach the persisted conflict between the sacred and the secular pointing to a dynamic and progressive Igbo culture.