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Search Results: 1 - 10 of 4639 matches for " Oliver; "
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Renewing Oncological Hyperthermia—Oncothermia  [PDF]
Oliver Szasz
Open Journal of Biophysics (OJBIPHY) , 2013, DOI: 10.4236/ojbiphy.2013.34030

Hyperthermia was the very first oncotherapy in human medicine, but its applicability in modern oncology was dubious. The discovery of electromagnetism gave new hope a century ago, however, until up to now, it has been suffering from lack of wide acceptance. Oncological hyperthermia suffers from multiple unsolved medical and technical problems. The accurate selection of malignant tissue and its proper heating in depth are real challenges together with the control and repeatability of the treatments. However, the center of the problems is not technical: the living system tries to keep its homeostatic equilibrium and creates active feedback mechanisms to eliminate or at least correct the constrain heating in depth. The proper reaction on the “gage of battle” has to involve the physiology, handle it complexly together with bioelectromagnetism and update connected technology. The solution has to be the integration of the natural bio-effects into the technological constrains, acting in synergy with the physiological feedback mechanisms, and without forcing effects out of the homeostatic control. The solution lies in strict selection and adequate action in nanoscopic range, without exciting the robust transport-mechanisms to operate against the energy delivery to the tumor. Together with the local

Innovation Clusters and Public Policy—The Case of a Research-Driven Cluster in Germany  [PDF]
Oliver Mauroner
American Journal of Industrial and Business Management (AJIBM) , 2015, DOI: 10.4236/ajibm.2015.512072
Abstract: Regional innovation clusters are spatial concentrations of interconnected firms, suppliers, service providers, state institutions, and research organisation in a particular field of innovation. The stimulation and support of clusters are important agendas for governments and other public actors. Cluster development initiatives are actually an important direction in economic policy, building on earlier efforts in macroeconomic stabilization, privatisation, and market opening, and reducing the costs of doing business. The purpose of this paper is to look on a specific type of innovative clusters in Germany, which are supported by the Fraunhofer Society, one of the leading, partly public-funded organisations for application-oriented research in Europe. Based on an overview over current issues in cluster literature—beginning with Porter 1990 to the point of actual global-value-chain-approach and the concept of knowledge hubs—the particular cluster approach of the German Fraunhofer Society is classified with regard to the academic literature. Fraunhofer clusters are, in the first instance, project clusters compared to simple communication networks. The case study presented in this paper is a valid example for a long-term and well-established industry cluster, which actually opens out in a project-oriented cluster approach. Finally, it is possible to draw practical implications for policy makers and industry regarding the support of regional innovation clusters.
Bioelectromagnetic Paradigm of Cancer Treatment—Modulated Electro-Hyperthermia (mEHT)  [PDF]
Oliver Szasz
Open Journal of Biophysics (OJBIPHY) , 2019, DOI: 10.4236/ojbiphy.2019.92008

One of the most frequently applied bioelectromagnetic effects is the deep heating of the living species with EMF energy. Despite its long history, hyperthermia is a rarely applied oncotherapy. The reason is its controversial results and complicated control. One of the solutions is concentrating the electromagnetic energy nanoscopically on the parts of the malignant cells instead of heating up the complete tumor-mass. This approach is a kind of non-uniform energy absorption, providing energy liberation only in the selected regions. The energy-absorption of the malignant cells targets the membranes and creates a situation far from thermal equilibrium. The selection of the malignant cells is based on their decided differences from their healthy counterparts. The distinguishing parameters are the electromagnetic properties of the components of the malignant tissue which are the physiologic differences between the malignant cells and their healthy counterparts. The targets realize nano-range heating, using natural nanoclusters on the cell-membrane without artificially implementing them. This energy absorption generates consequent reactions, like programmed cell-death (apoptosis) continued by immunogenic cell-death involving extended immune reactions.?

The applied radiofrequency current is amplitude modulated by time-fractal modulation pattern. The accurately matched impedance realizes the self-selective mechanisms which are promoted by stochastic resonances. This complex method is a new kind of hyperthermia, named mEHT. Our objective is to analyze the problems of the selective, non-equilibrium energy absorption, and present a solution by the electromagnetic mechanisms for an effective and controllable hyperthermia in oncology.

Atheism and Humanism in a Globalized World: The Igbo Experience  [PDF]
Chizaram Onyekwere, Oliver Uche
Open Journal of Philosophy (OJPP) , 2013, DOI: 10.4236/ojpp.2013.31A015

Obnoxious labels are derogatory terms which speak extensively on the ignorant dispositions of scholars who either rush into faulty conclusions, or have prior decisions to promote class distinction through the uncomplimentary colours they paint of what others hold as divine, spiritual, and transcendental. For such derogatory terms to gain wide audience in a globalized age explain the frame of mind of discordant voices which have been based on arm-chair scholarship. The thrust of this article therefore, is to use Igbo experience to explore the problems of atheism and humanism in a globalized world. The exploratory research will help adopt cultural centred approach in analyzing the dichotomy between the various philosophical view points on God, spirits and man’s religious belief system in Igbo land in particular and Africa in general. It is hoped that the analyses of the challenges posed by atheism and humanism in a globalized world will balance ideas, views, attitudes and behaviour that will reposition Igbo religious beliefs, values and practices in line with the proposed theistic humanism associated with Igbo culture in particular and African culture in general. This will breach the persisted conflict between the sacred and the secular pointing to a dynamic and progressive Igbo culture.

Social Media in Science Marketing-Framework, Instruments, and Strategies. Cases from German Research Institutes  [PDF]
Oliver Mauroner, Dorit Fauck
Open Journal of Business and Management (OJBM) , 2014, DOI: 10.4236/ojbm.2014.23030
Abstract: Social media in science marketing at research institutions is still in its early stages. Based on studies on social media use at the German research institute Fraunhofer Society in 2010 and 2014, this article illustrates the progress made in the last four years. Even though the changes are significant, it is obvious that there is still a skeptical attitude towards social media and a lack of understanding of its value. The results of the studies show that many research institutes behave conservatively with regard to the variety of social media channels. Reservations can be seen in particular at the science and management levels. First and foremost, research institutions can benefit from social media usage by extending their channels of communication for marketing purposes and reaching their target audiences more effectively. Secondly, social media can also be used to receive information for market research, as social media is characterized by two-way communication. Therefore, it is important to implement a well thought-out social media strategy.
Thermochemical Parameters of Tetramethylthiourea Adducts of Certain Metal(II) Bromides  [PDF]
Pedro Oliver Dunstan
Open Journal of Physical Chemistry (OJPC) , 2015, DOI: 10.4236/ojpc.2015.51002
Abstract: Complexes of the general formula [MBr2(TMTU)n] (where M is Mn, Fe, Co, Ni, Cu, Zn or Cd; TMTU is Tetramethylthiourea; n is 0.75, 2 or 3) were obtained by the reaction of salts and ligand in solution. The bromides were selected among several other salts because they had thermochemical data in the literature. Properties as capillary melting points; C, H, N, Br and metal contents; TG/DTG and DSC curves; and IR and electronic spectra were determined. The values of several thermodynamic parameters for the complexes were found by solution calorimetry. From them, the standard enthalpies of the metal-sulphur coordinated bonds were calculated. The standard enthalpies of the formation of the gaseous phase adducts also were estimated.
M/G/1 Vacation Queueing Systems with Server Timeout  [PDF]
Oliver C. Ibe
American Journal of Operations Research (AJOR) , 2015, DOI: 10.4236/ajor.2015.52007
Abstract: We consider a single-server vacation queueing system that operates in the following manner. When the server returns from a vacation, it observes the following rule. If there is at least one customer in the system, the server commences service and serves exhaustively before taking another vacation. If the server finds the system empty, it waits a fixed time c. At the expiration of this time, the server commences another vacation if no customer has arrived; otherwise, it serves exhaustively before commencing another vacation. Analytical results are derived for the mean waiting time in the system. The timeout scheme is shown to be a generalized scheme of which both the single vacation and multiple vacations schemes are special cases, with c= and c=0, respectively. The model is extended to the N-policy vacation queueing system.
Cannabinoids Production by Hairy Root Cultures of Cannabis sativa L.  [PDF]
Sayed Farag, Oliver Kayser
American Journal of Plant Sciences (AJPS) , 2015, DOI: 10.4236/ajps.2015.611188
Abstract: Tetrahydrocannabinol (THC) derivatives are used clinically as analgesic, anti-inflammatory, appetite stimulant, anti-emetic and anti-tumor cannabinoids. THC and its related compounds are at present obtained by extraction from intact Cannabis plants or chemical synthesis, but plant cell cultures may be an alternative source of production. In the present study, hairy root cultures of C. sativa (Cannabaceae) were induced by incubation of aseptically grown callus culture with solid B5 medium supplemented with 4 mg/l naphthaleneacetic acid in darkness at 25°C. Hairy root growth profiles in shake flask, increased periodically during 35 days of growth cycle. The cannabinoid contents produced in minor levels and remained below 2.0 μg/g dry weight. The contents of can-nabinoid were analyzed by liquid chromatography and confirmed by mass spectrometry.
Heating, Efficacy and Dose of Local Hyperthermia  [PDF]
Oliver Szasz, Andras Szasz
Open Journal of Biophysics (OJBIPHY) , 2016, DOI: 10.4236/ojbiphy.2016.61002
Abstract: Hyperthermia in oncology needs a definite dose which fixes well the clinical protocols. The temperature is far not a dose, it is mass independent. The half of the mass has the same temperature in equilibrium, so the basic criteria of the dose mass-dependence are lost. The energy could be a great option for dosing, (like it is in radiation therapies by Gy) but it has numerous drawbacks. These are discussed in this paper, trying to unify the dosing of ionizing and non-ionizing radiations.
Increasing Profits by Strategic Patenting—A Change of Perspective from Bottom–Up to Top-Down  [PDF]
Oliver Baldus, Christian Heckmann
American Journal of Industrial and Business Management (AJIBM) , 2016, DOI: 10.4236/ajibm.2016.69093
Abstract: Classical patenting is driven by what one might consider an “internal” view of the firm, in which patents are primarily obtained for protecting self-made inventions based on one’s own research activities. This corresponds to a bottom-up approach where patents originate from the bottom of research and development activities. Sometimes and occasionally these patents can be used in upper business and management layers for actually generating profits. In contrast, strategic patenting is driven by an “external” view of the firm. This external view is not primarily focused on the protection of internal inventions simply for the sake of staking one’s claim vis-à-vis a de facto non-existent conflict party. Instead, it is directed at a particular external “target”, i.e. a firm or group of firms such as competitors, suppliers or demanders. This corresponds to an opposite top-down approach in which top business decisions primarily determine which patents matter. As a direct consequence these patents guide research and development activities at down layers. The basic concept behind strategic patenting is a coordinated improvement of a firm’s comparative IP right (Intellectual Property Right) situation vis-à-vis this target. The desired result of strategic patenting is a purposive “hit on target” as compared to the scattered, uncoordinated approach of classical patenting that hits targets rather randomly. Since all patenting activities of the firm are intentionally targeted against specific firms determined in a top management decision, strategic patenting is more efficient than classical patenting.
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