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Search Results: 1 - 10 of 51516 matches for " Oliveira-Souza "
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Motor hemiplegia and the cerebral organization of movement in man: II. The myth of the human extrapyramidal system
Oliveira-Souza, R.;
Arquivos de Neuro-Psiquiatria , 1989, DOI: 10.1590/S0004-282X1989000100003
Abstract: following a brief review of the concept of extrapyramidal system, clinical and anatomic evidence is presented against its relative prominence in man. it is proposed that the greatest part of those structures traditionally labeled as extrapyramidal effects its respective functional activities by way of the pyramidal tracts themselves. such structures, centered around the basal nuclei, the cerebellum and possibly, the limbic areas of the prosencephalon are, according to the present suggestion, indeed, pre pyramidal. this model is based upon the clinical analysis of patients and agrees with more than one century of anatomic verifications in human brains, favoring the notion of the singularity of the human brain.
Relevancia diagnóstica da massagem do seio carotídeo durante teste de inclina??o
Benchimol, Marcos;Oliveira-Souza, Ricardo;
Arquivos Brasileiros de Cardiologia , 2008, DOI: 10.1590/S0066-782X2008000400009
Abstract: background: syncope due to carotid sinus hypersensitivity (csh) may be underdiagnosed due to a low level of diagnostic suspicion and fear of complications caused by massage of the carotid sinus. objective: to investigate the relevance of carotid sinus massage in the diagnosis of non-convulsive faints and unexplained falls. methods: two-hundred and fifty-nine patients with a mean age of 50±24 years referred for the investigation of non-convulsive faints or unexplained falls were evaluated with a head up tilt table test (hutt) without ("passive") and with pharmacological stimulation. clinical and laboratory work-up did not reveal an obvious cause for the complaints. fifty-five volunteers with a mean age of 57±21 years with no history of seizures, faints or falls were used as controls. all participants underwent a hutt preceded by digital stimulation of each carotid sinus both at zero and 60o. results: carotid sinus massage was positive in 4 controls. the relevance of csh in the evaluation of syncope was supported by a positive response to carotid sinus massage at 60o in 28 patients, most of whom were elderly men. carotid sinus massage was positive at 0o in only three of such patients. the results of the hutt did not show statistical difference between patients with and without csh. conclusion: carotid sinus massage at 60o under controlled conditions should be included in the assessment of patients with non-convulsive faints or unexplained falls. routine cardiovascular exams, including the hutt, are not useful for the diagnosis in such cases. further studies in normal individuals are needed to establish the significance of a positive response to carotid sinus massage in the absence of a history of fainting or falling.
Síncope no idoso: utilidade diagnóstica da massagem do seio carotídeo na posi??o ortostática durante o "tilt test"
Benchimol, Marcos;Oliveira-Souza, Ricardo de;
Arquivos de Neuro-Psiquiatria , 2003, DOI: 10.1590/S0004-282X2003000100016
Abstract: a 71-year-old man presented with a 6-month history of fainting. consciousness was quickly regained without clouding or confusion. ancillary investigations were inconclusive and he was treated with carbamazepine. the fainting spells did not cease and he was referred for a tilt-table test exam. in the head-up position (table tilted at 60°), massage of the carotid sinus was immediately followed by asystole, unconsciousness, and a sharp drop in arterial pressure for 5 seconds. the same procedure in the lying position did not elicit clinical symptoms or h?modynamic imbalance. a diagnosis of carotid sinus hypersensitivity with a cardio-inhibitory response pattern was made. carbamazepine was withdrawn and a double-chamber pacemaker was implanted in his right ventricle. he remained symptom-free for the ensuing 18 months. this case supports the diagnostic utility of carotid sinus massage during the head-up tilt test in patients with unexplained non-convulsive loss of consciousness.
Coma e síndrome de hernia??o transtentorial consequentes a les?o hemisférica n?o expansiva aguda
Oliveira-Souza, Ricardo De;Benchimol, Marcos;
Arquivos de Neuro-Psiquiatria , 1995, DOI: 10.1590/S0004-282X1995000500019
Abstract: an 81 -year-old woman developed left hemiplegia and coma due to a right hemisphere infarct and died 6 days later. when first seen in coma she had the classical signs of descending central herniation in the diencephalic stage. the ct scan of the third day showed a large hypodense area occupying the superficial and deep territories of the middle and anterior cerebral arteries on the left as well as a frontal cortico-subcortical hypodense area indicative of an older infarct on the opposite hemisphere. no mass effects were apparent. she followed a downhill course with signs of brainstem deterioration. a second ct scan a few hours before death revealed the expected pattern of brain shift and herniations. this case adds to the available evidence showing that the clinical signs of encroachment of supratentorial structures upon the basal forebrain can be reproduced by an acute mono-hemispheral lesion without visible mass effects. it indicates, further, that the role of intracranial displacements in the genesis and short-term prognosis of coma remains an unsettled matter. in at least a few number of cases, diaschisis might play a major role.
Síncope no idoso: utilidade diagnóstica da massagem do seio carotídeo na posi o ortostática durante o "tilt test"
Benchimol Marcos,Oliveira-Souza Ricardo de
Arquivos de Neuro-Psiquiatria , 2003,
Abstract: Um senhor aposentado veio à consulta com história de desmaios há vários meses e uma série de exames cardiológicos e de neuroimagem inconclusivos. Medicado com carbamazepina, os desmaios persistiram, ocasionando ferimentos na face e nos bra os. Durante o "tilt test" n o sensibilizado farmacologicamente, a massagem do seio carotídeo na posi o ortostática (mesa inclinada a 60degrees) produziu assistolia, perda da consciência e queda drástica da press o arterial por 5 segundos. A mesma manobra na posi o supina n o provocou sintomas ou altera es hemodinamicas. Implantado marca-passo de dupla camara e suspensa a carbamazepina, os desmaios n o se repetiram ao longo dos 18 meses de acompanhamento, confirmando o diagnóstico de hipersensibilidade do seio carotídeo com resposta cárdio-inibitória. Este caso ilustra e reafirma a utilidade do "tilt test" e da inclus o da massagem dos seios carotídeos na posi o ortostática no protocolo de investiga o de todo paciente com síncope de causa inaparente.
ANP impairs the dose-dependent stimulatory effect of ANG II or AVP on H+-ATPase subcellular vesicle trafficking  [PDF]
M. Oliveira-Souza, P. Morethson, G. Malnic, M. Mello-Aires
Open Journal of Molecular and Integrative Physiology (OJMIP) , 2013, DOI: 10.4236/ojmip.2013.33015

The effect of angiotensin II (ANG II) or arginine vasopressin (AVP) alone or plus atrial natriuretic peptide (ANP) on H+-ATPase subcellular vesicle trafficking was investigated in MDCK cells following intracellular pH (pHi) acidification by exposure to20 mMNH4Cl for 2 min in a Na+-free solution containing Schering 28080, conditions under which H+-AT-Pase is the only cell mechanism for pHi recovery. Using the acridine orange fluorescent probe (5mM) and confocal microscopy, the vesicle movement was quantified by determining, for each experimental group, the mean slope of the line indicating the changes in apical/basolateral fluorescence density ratio over time during the first 5.30 min of the pHi recovery period. Under the control conditions, the mean slope was 0.079 ± 0.0033 min-1 (14) and it increased significantly with ANG II [10-12 and 10-7 M, respectively to 0.322 ± 0.038 min-1 (13) and 0.578 ± 0.061 min-1 (12)] or AVP [10-12 and 10-6 M, respectively to 0.301 ± 0.018 min-1 (12) and 0.687 ± 0.049 min-1 (11)]. However, in presence of ANP (10-6 M, decreases cytosolic free calcium), dimethyl-BAPTA/AM (5 × 10-5 M, chelates intracellular calcium) or colchicine (10-5 M, 2-h preincubation; inhibits microtubule-dependent vesicular trafficking) alone or plus ANG II or AVP the mean slopes were similar to the control values, indicating that such agents blocked the stimulatory effect of ANG II or AVP on

Determination of Essential (Ca, Fe, I, K, Mo) and Toxic Elements (Hg, Pb) in Brazilian Rice Grains and Estimation of Reference Daily Intake  [PDF]
Bruno Lemos Batista, Letícia Ramos Nacano, Rodolfo de Freitas, Vanessa Cristina de Oliveira-Souza, Fernando Barbosa
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.31019
Abstract: The levels of Hg and Pb (toxic elements) and Ca, Fe, I, K, Mo (essential elements) were measured in 44 Brazilian rice samples divided among white polished (W), parboiled white (PW) and parboiled brown (PB). Rice grains were ana- lyzed by inductively coupled plasma mass spectrometry (ICP-MS). Concentrations of toxic elements varied from 0.3 to 13.4 and 0.4 to 14.5 ng?g–1 for Hg and Pb, respectively. The values for essential elements were in the same range of those for rice produced in other countries. In general parboiled samples presented higher levels of all elements in study compared to white samples. The Estimated Daily Intake through rice consumption was 0.44 μg for Pb, 0.22 μg for Hg, 0.65 μg for I, 39.5 μg for Mo, 0.43 mg for Fe, 4.1 mg for Ca and 88.9 mg for K. Our findings demonstrated that rice can contribute significantly to the RDIs of molybdenum and potassium, but it can not be considered an important source of I, Fe and Ca. Moreover, the estimated dail
The pyramidal syndrome and the pyramidal tract: a brief historical note
Rezende-Cunha, Fernando;Oliveira-Souza, Ricardo de;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000600021
Abstract: the discovery of the pyramidal syndrome and tract is briefly reviewed with emphasis on a few key historical aspects. the pursuit of the relationship between the lateralized deficits resulting from contralateral head trauma begins in the fourth century bc with the hippocratic school and continues until the present day.
Frontopolar and anterior temporal cortex activation in a moral judgment task: preliminary functional MRI results in normal subjects
Moll, Jorge;Eslinger, Paul J.;Oliveira-Souza, Ricardo de;
Arquivos de Neuro-Psiquiatria , 2001, DOI: 10.1590/S0004-282X2001000500001
Abstract: objective: to study the brain areas which are activated when normal subjects make moral judgments. method: ten normal adults underwent bold functional magnetic resonance imaging (fmri) during the auditory presentation of sentences that they were instructed to silently judge as either "right" or "wrong". half of the sentences had an explicit moral content ("we break the law when necessary"), the other half comprised factual statements devoid of moral connotation ("stones are made of water"). after scanning, each subject rated the moral content, emotional valence, and judgment difficulty of each sentence on likert-like scales. to exclude the effect of emotion on the activation results, individual responses were hemodynamically modeled for event-related fmri analysis. the general linear model was used to evaluate the brain areas activated by moral judgment. results: regions activated during moral judgment included the frontopolar cortex (fpc), medial frontal gyrus, right anterior temporal cortex, lenticular nucleus, and cerebellum. activation of fpc and medial frontal gyrus (ba 10/46 and 9) were largely independent of emotional experience and represented the largest areas of activation. conclusions: these results concur with clinical observations assigning a critical role for the frontal poles and right anterior temporal cortex in the mediation of complex judgment processes according to moral constraints. the fpc may work in concert with the orbitofrontal and dorsolateral cortex in the regulation of human social conduct.
O reflexo cutaneo-plantar em extens?o (Babinski, 1896/1898)
Oliveira-souza, R.;De Figueiredo, W. Martignoni;
Arquivos de Neuro-Psiquiatria , 1995, DOI: 10.1590/S0004-282X1995000200026
Abstract: the extensor plantar reflex was described by babinski in 1896. given the obvious relevance of the sign for internal medicine as well as the paucity of translations of the original sources into portuguese, we thought it timely to recall the ingenious arguments babinski used to demonstrate his views on the "toe phenomenon", as he would call it. a careful analysis of babinski's writings suggests, further, that he was driven by keen intuition as well as by medico-legal interests.
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