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MicroRNAs: um novo paradigma no tratamento e diagnóstico da insuficiência cardíaca?
Oliveira-Carvalho, Vagner;Carvalho, Vitor Oliveira;Silva, Miguel Morita;Guimar?es, Guilherme Veiga;Bocchi, Edimar Alcides;
Arquivos Brasileiros de Cardiologia , 2012, DOI: 10.1590/S0066-782X2012000400011
Abstract: micrornas (mirnas) are a group of newly discovered small rnas, non-coding, which represent one of the most exciting areas of modern medical science as they modulate a huge and complex regulatory network of gene expression. lines of evidence have recently suggested that mirnas play a key role in the pathogenesis of heart failure. some mirnas highly expressed in the heart, such as mir-1, mir-133 and mir-208, are strongly associated with the development of cardiac hypertrophy, while the exact role of mir-21 in the cardiovascular system remains controversial. serum levels of circulating mirnas such as mir-423-5p are being evaluated as potential biomarkers in the diagnosis and prognosis of heart failure. on the other hand, the manipulation of levels of mirnas using techniques such as mimicking the mirnas (mirmimics) and antagonistic mirnas (antagomirs) is making increasingly evident the enormous potential of mirnas as promising therapeutic strategies in heart failure.
Partial purification of tightly bound mitochondrial hexokinase from maize (Zea mays L.) root membranes
Rezende, G.L.;Logullo, C.;Meyer, L.;Machado, L.B.;Oliveira-Carvalho, A.L.;Zingali, R.B.;Cifuentes, D.;Galina, A.;
Brazilian Journal of Medical and Biological Research , 2006, DOI: 10.1590/S0100-879X2006000900003
Abstract: in mammals, hexokinase (hk) is strategically located at the outer membrane of mitochondria bound to the porin protein. the mitochondrial hk is a crucial modulator of apoptosis and reactive oxygen species generation. in plants, these properties related to hk are unknown. in order to better understand the physiological role of non-cytosolic hexokinase (nc-hk) in plants, we developed a purification strategy here described. crude extract of 400 g of maize roots (230 mg protein) contained a specific activity of 0.042 μmol g6p min-1 mg ptn-1. after solubilization with detergent two fractions were obtained by deae column chromatography, nc-hk 1 (specific activity = 3.6 μmol g6p min-1 mg ptn-1 and protein recovered = 0.7 mg) and nc-hk 2. a major purification (yield = 500-fold) was obtained after passage of nc-hk 1 through the hydrophobic phenyl-sepharose column. the total amount of protein and activity recovered were 0.04 and 18%, respectively. the nc-hk 1 binds to the hydrophobic phenyl-sepharose matrix, as observed for rat brain hk. mild chymotrypsin digestion did not affect adsorption of nc-hk 1 to the hydrophobic column as it does for rat hk i. in contrast to mammal mitochondrial hk, glucose-6-phosphate, clotrimazole or thiopental did not dissociate nc-hk from maize (zea mays) or rice (oryza sativa) mitochondrial membranes. these data show that the interaction between maize or rice nc-hk to mitochondria differs from that reported in mammals, where the mitochondrial enzyme can be displaced by modulators or pharmacological agents known to interfere with the enzyme binding properties with the mitochondrial porin protein.
Predispatch of Hydroelectric Power Systems with Modifications in Network Topologies  [PDF]
Silvia M. S. Carvalho, Aurelio Oliveira
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.515221
Abstract:

In this article, the primal-dual interior-point methods are used to minimize costs and losses in a predispatch model for the generation and transmission of direct current (DC) power flow in a hydroelectric system with pre-programmed manipulations; i.e., in cases of preventive maintenance, within a period of twenty-four hours. From the computational standpoint, the effort required to solve a problem with and without manipulations is similar, and the reasons why will be also discussed in this study. Computational results prove these findings.

Direito à memória das comunidades tradicionais: organiza??o de acervo nos terreiros de candomblé de Salvador, Bahia
Oliveira, Andréa Carvalho;
Ciência da Informa??o , 2010, DOI: 10.1590/S0100-19652010000200007
Abstract: this article recounts to the experience of the institution koinonia presen?a ecumênica e servi?o in carrying out workshops on right to the memory, with emphasis on the organization of collections with traditional communities of candomblé sites from different nations, situated in salvador, bahia.
Interven??o contra a pirataria nas costas da Somália: Naval peacekeeping?
Oliveira,Gilberto Carvalho de;
Rela??es Internacionais (R:I) , 2011,
Abstract: this article examines the implications of international intervention against piracy off the coast of somalia backed by several security council resolutions since 2008. based on a seminal academic debate generically known as naval peacekeeping, the article argues that the intervention against somali piracy is the empirical realization of an autonomous concept of peacekeeping at sea, disconnected from the concepts usually applied to the land-based un peace operations framework.
Hemangioendotelioma epitelióide da pleura: sobrevida de 29 meses
Oliveira,Anabela; Carvalho,Lina;
Revista Portuguesa de Pneumologia , 2006,
Abstract: epithelioid haemangioendothelioma of the pleura is a rare neoplasia with a very poor prognosis due to aggressive involvement of the pleura and incomplete surgical treatment. histological diagnosis and imagiology is also controversial, related to discrete development of the lesions that later reveal nodules. in 2005 there were 31 cases of vascular tumours described in the pleura. eleven were epithelioid haemangioendotheliomas. this is another case, a 52 year old woman who suffered a traumatism and died 29 months after the histological diagnosis because cat revealed discrete pleural involvement and a 2cm nodule was seen only one month before death.
OS FUNDAMENTOS HISTóRICOS E FILOSóFICOS DO MéTODO HERMENêUTICO DA ESCOLA DE TüBINGEN
Anselmo Carvalho de Oliveira
Synesis , 2011,
Abstract: Resumo: O método de interpreta o dos diálogos plat nicos, na segunda metade do século XX, passou por uma profunda revis o levada a termo pela Escola de Tübingen, que culminou em um novo paradigma histórico-hermenêutico para a leitura dos diálogos. Plat o, a partir do século XIX, foi interpretado à luz do método romantico proposto por Schleiermacher. Nesse método, considerava-se o texto como a express o acabada de um pensamento. De Plat o, excepcionalmente, possuímos todos os seus diálogos. Por consequência, podemos extrair de todos os seus diálogos, todo o seu pensamento. Para os autores de Tübingen, no entanto, esse método negligência os “autotestemunhos” presentes no Fedro e na Carta VII sobre o real valor da escrita na ótica plat nica e relega ao segundo plano as ideias ouvidas na Academia e transmitidas pelos seus discípulos (os “ensinamentos n o-escritos”). Baseados nesses ensinamentos, os autores de Tübingen formularam um novo paradigma. O presente trabalho busca apresentar de forma sucinta as bases desse novo paradigma que vem causando acirrada polêmica entre os estudiosos do assunto.Abstract: The interpretation method of the Platonic’s Dialogues, on the second half of the 20th Century, has suffered only a deep review carried by a done by Tübingen School that culminated in a new paradigm historical hermeneutic for the reading of Platonic’s Dialogues. Plato, since the 19th Century, was interpretaded at the light of the romantic method proposed for Schleiermacher. In this method was considerated the text as an accomplished expression by one thought. From Plato, excepnally, we have one of his dialogues. Thus we can extract of his dialogues, all this thought. For Tübingen’s authors, however, this method neglected the self testimonies present in Phaedrus and in the Seventh Letter about the real value from writting, in the foist of view and banish to the second plane ideas heard in the Academy and transmitted to his student’s (“unwritten teaching”). Based on these teachings, the Tübigen’s authors prescribed a new paradigm. The article search to show in a brief way the bases of this new paradigm that came causing a controversial polemic among the scholars of the subject.
O princípio de igual considera o de interesses semelhantes na ética prática de Peter Singeri
Anselmo Carvalho de Oliveira
Barbarói , 2011,
Abstract: Peter Singer estabelece um princípio ético para fundar a igualdade entre os seres sencientes humanos e n o humanos. Suas reflex es sobre o Princípio de Igual Considera o de Interesses Semelhantes e suas implica es práticas, no entanto, desafiam a compreens o da ética tradicional ao defender os animais como membros da comunidade moral, a moralidade do aborto, do infanticídio e da eutanásia. O presente artigo procura, através de uma revis o da bibliografia, reconstruir a argumenta o de Singer, especificamente no livro ética Prática, para apreciar o alcance desse princípio na ética. Abstract Peter Singer establishes an ethical principle to found the equality between sentient human and non-human beings. His reflections on the principle of equal consideration of similar interests and their practical implications, however, challenge the understanding of traditional ethics to defend the animals as members of the moral community, the morality of abortion, infanticide and euthanasia. This article seeks, through a revision of the bibliography, rebuild the argumentation of Singer, specifically in the book Pratical Ethics, to assess the scope of this principle in ethics.
Book Review - Empreendedorismo além do Plano de Negócio
Athos Oliveira Carvalho
Revista de Administra??o Contemporanea , 2009,
Abstract:
Interven o contra a pirataria nas costas da Somália: Naval peacekeeping? International intervention against piracy in Somalia’s coast: naval peacekeeping?
Gilberto Carvalho de Oliveira
Rela??es Internacionais (R:I) , 2011,
Abstract: Este artigo examina as implica es da interven o internacional contra a pirataria nas costas da Somália que, desde 2008, tem sido apoiada por diversas resolu es do Conselho de Seguran a. Com base num debate académico ainda embrionário, designado genericamente pelo termo naval peacekeeping, o artigo argumenta que a interven o contra a pirataria é a realiza o empírica de uma concep o autónoma de peacekeeping no mar, desvinculada dos conceitos geralmente aplicados ao modelo de opera es de paz, essencialmente, terrestre das Na es Unidas. This article examines the implications of international intervention against piracy off the coast of Somalia backed by several Security Council resolutions since 2008. Based on a seminal academic debate generically known as naval peacekeeping, the article argues that the intervention against Somali piracy is the empirical realization of an autonomous concept of peacekeeping at sea, disconnected from the concepts usually applied to the land-based un peace operations framework.
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