Publish in OALib Journal
APC: Only $99
secretion of GHRH is a rare cause of acromegaly. However, its recognition is
clinically important because different therapeutic approaches are required. Case
Presentation: We present a challenging case of acromegaly secondary to
ectopic GHRH secretion from pancreatic neuroendocrine tumor in a 52-year-old
female. The patient is treated with different modalities which include
pegvisomant in an attempt to control the stimulated GH-axis considering the
limited data about its use in treatment of ectopic acromegaly. Conclusion: GHRH-secreting
tumor is a rare cause of acromegaly. Surgical resection of the tumor is the
therapy of choice whenever possible. However, further studies are warranted for
unresectable tumor or resistant cases.
Objectives: Endometrial sampling became the first choice in screening endometrial pathology. The technique is accurate and simple. The aim is to evaluate the use of endometrial sample in outpatients’ clinic as a routine by LEVEL of gynecological resident in training. Methods: A retrospective study of 463 patients seen by the residents at KAUH. A detailed history was obtained from medical records file. Reasons for endometrial sampling were divided into 6 categories, including screening, PMB, Menorrhagia or AUB, bulky uterus and cervical lesion. Endometrial sample was obtained using Pipelle. Results: Out of 463 patients, 128 had en-dometrial sampling as screening (27.6%), 84 had PMB (18.1%), 91 Menorrhagia (19.7%), 108 AUB (23.3%), 20 bulky uterus (4.3%) and 32 cervical lesion (6.9%). In 30% of cases the sample insufficient, diagnosis in 54.2% benign, endometrial hyperplasia (6.0%) 19 diagnosed (endometrial cancer) (4.1%) in (5.6%) had endometritis. 70% of patients saved had a D&C. Conclusion: Endometrial biopsy is found to be accurate, easy, and safe and can be done by LEVEL of gynecological residents, accuracy of 70% of cases, additional endometrial assessment undertaken if diagnosis is not made.