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Search Results: 1 - 10 of 5283 matches for " Obidio Rubio Mercedes "
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Simultaneous controllability of wave sound propagations
Alexis Rodriguez Carranza,Luis J. Caucha,Obidio Rubio Mercedes
Mathematics , 2015,
Abstract: In this work we study one problem of mathematical interest for their applications in several topics in Applied Science. We study simultaneous controllability of a pair of systems which model the evolution of sound in a compressible ow considered as a transmission problem. We show the well posed of the problem. Furthermore provided appropriate conditions in the geometry of the domain are valid and suitable assumptions on the fluid, is possible to conduce the pair of systems to the equilibrium in a simultaneous way using only one control.
14-3-3 Proteins are Regulators of Autophagy
Mercedes Pozuelo-Rubio
Cells , 2012, DOI: 10.3390/cells1040754
Abstract: 14-3-3 proteins are implicated in the regulation of proteins involved in a variety of signaling pathways. 14-3-3-dependent protein regulation occurs through phosphorylation-dependent binding that results, in many cases, in the release of survival signals in cells. Autophagy is a cell digestion process that contributes to overcoming nutrient deprivation and is initiated under stress conditions. However, whether autophagy is a cell survival or cell death mechanism remains under discussion and may depend on context. Nevertheless, autophagy is a cellular process that determines cell fate and is tightly regulated by different signaling pathways, some of which, for example MAPK, PI3K and mTOR, are tightly regulated by 14-3-3 proteins. It is therefore important to understand the role of 14-3-3 protein in modulating the autophagic process. Within this context, direct binding of 14-3-3 to mTOR regulatory proteins, such as TSC2 and PRAS40, connects 14-3-3 with autophagy regulatory processes. In addition, 14-3-3 binding to human vacuolar protein sorting 34 (hVps34), a class III phosphatidylinositol-3-kinase (PI3KC3), indicates the involvement of 14-3-3 proteins in regulating autophagosome formation. hVps34 is involved in vesicle trafficking processes such as autophagy, and its activation is needed for initiation of autophagy. Chromatography and overlay techniques suggest that hVps34 directly interacts with 14-3-3 proteins under physiological conditions, thereby maintaining hVps34 in an inactive state. In contrast, nutrient starvation promotes dissociation of the 14-3-3–hVps34 complex, thereby enhancing hVps34 lipid kinase activity. Thus, 14-3-3 proteins are regulators of autophagy through regulating key components of the autophagic machinery. This review summarizes the role of 14-3-3 protein in the control of target proteins involved in regulating the master switches of autophagy.
Ramón Rubio M,Mercedes Ruiz F
Revista Chilena de Obstetricia y Ginecología , 2006,
MicroRNAs in metamorphic and non-metamorphic transitions in hemimetabolan insect metamorphosis
Rubio Mercedes,de Horna Anibal,Belles Xavier
BMC Genomics , 2012, DOI: 10.1186/1471-2164-13-386
Abstract: Background Previous work showed that miRNAs play key roles in the regulation of metamorphosis in the hemimetabolan species Blattella germanica. To gain insight about which miRNAs might be important, we have constructed two miRNA libraries, one of the penultimate, pre-metamorphic nymphal instar (N5) and the other of the last, metamorphic nymphal instar (N6). Results High throughput sequencing gave 61 canonical miRNAs present in the N5 and N6 libraries, although at different proportions in each. Comparison of both libraries led to the identification of three and 37 miRNAs significantly more expressed in N5 and N6 respectively. Twelve of these 40 miRNAs were then investigated further by qRT-PCR and results indicated that miR-252-3p was well expressed in N5 but not in N6, whereas let-7-5p, miR-100-5p and miR-125-5p showed the reverse pattern. 20-Hydroxyecdysone (20E) tended to stimulate miRNA expression, whereas juvenile hormone (JH) inhibited the 20E stimulatory effect. Expression of let-7, miR-100 and miR-125 was increased by 20E, which has also been observed in D. melanogaster. The only miRNA that was inhibited by 20E was miR-252-3p. The involvement of let-7, miR-100 and miR-125 in metamorphosis has been demonstrated in other insects. Depletion of miR-252-3p caused growth and developmental delays, which suggests that this miRNA is involved in regulating these processes prior to metamorphosis. Conclusions The comparative analysis of miRNA libraries from pre-metamorphic (N5) and metamorphic stages (N6) of B. germanica proved to be a useful tool to identify miRNAs with roles in hemimetabolan metamorphosis. Three miRNAs emerged as important factors in the metamorphic stage (N6): let-7-5p, miR-100-5p and miR-125-5p, whereas miR-252-3p appears to be important in the pre-metamorphic stage (N5).
El e-book y la industria editorial espa?ola
López Suárez,Mercedes; Larra?aga Rubio,Julio;
Revista Interamericana de Bibliotecología , 2010,
Abstract: this study reflects on the concept of the e-book. it reviews the available literature and uses a comparative approach to develop forecasts about publishing in spain. we take our figures from industry reports for the years 2008 and 2009 which contain information on the publishing market, reading habits, and e-book availability in spain. we present detailed descriptions of the typical readers of printed books and e-books, studied the current standing of the spanish publishing industry with respect to the electronic book, and conclude that in the short term, the e-book will have considerable growth but that it will not replace the printed book.
Cultura y cognición. La naturaleza heterogénea del pensamiento
Mercedes Cubero Pérez,David Rubio,Alejandro Barragán Felipe
Avances en Psicología Latinoamericana , 2005,
Abstract: El trabajo que presentamos a continuación constituye una aproximación cultural al estudiode determinadas cuestiones básicas sobre la naturaleza del pensamiento humano. En concreto,estamos interesados en demostrar la estrecha relación existente entre escenarios de actividad,modos de discurso y tipos de pensamiento. Para ello, tomamos como modelo interpretativo lahipótesis de la heterogeneidad del pensamiento verbal y dise amos una investigación eneducación de adultos para constatar las hipótesis básicas de dicho modelo. Nuestras hipótesisquedaron corroboradas. Se constató que la escolarización influye en la elección de destrezas yrecursos semióticos. Encontramos que las alumnas con mayor experiencia escolar usarondestrezas con una mayor planificación y recursos semióticos más descontextualizados. Por otrolado, obtuvimos evidencias para defender la heterogeneidad del pensamiento verbal. Losalumnas de pregraduados usaron recursos psicológicos asociados tanto al escenario cotidianocomo al científico en función de cómo percibían las demandas de la tarea. Y, por último, lasalumnas de pregraduado han transferido conceptos científicos hacia un escenario cotidiano.Esta transferencia es posible porque las alumnas de pregraduado han reconocido diferentesdemandas en la tarea y han considerado la utilidad del uso de los conceptos científicos en unescenario cotidiano con estas restricciones.
Una propuesta de evaluación de la calidad universitaria desde la perspectiva del grupo de discusión
Mercedes Sarmiento Cano,Jose Luis Martínez Rubio
Circunstancia , 2005,
Deep Sequencing of Organ- and Stage-Specific microRNAs in the Evolutionarily Basal Insect Blattella germanica (L.) (Dictyoptera, Blattellidae)
Alexandre S. Cristino,Erica D. Tanaka,Mercedes Rubio,Maria-Dolors Piulachs,Xavier Belles
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0019350
Abstract: microRNAs (miRNAs) have been reported as key regulators at post-transcriptional level in eukaryotic cells. In insects, most of the studies have focused in holometabolans while only recently two hemimetabolans (Locusta migratoria and Acyrthosiphon pisum) have had their miRNAs identified. Therefore, the study of the miRNAs of the evolutionarily basal hemimetabolan Blattella germanica may provide valuable insights on the structural and functional evolution of miRNAs.
Factores sociodemográficos y de salud asociados a la institucionalización de personas dependientes
Ayuso Gutiérrez,Mercedes; Pozo Rubio,Raúl del; Escribano Sotos,Francisco;
Revista Espa?ola de Salud Pública , 2010, DOI: 10.1590/S1135-57272010000600009
Abstract: background: the analysis of the effect that different variables have in the probability that dependent people are institutionalized is a topic scantily studied in spain. the aim of the work is to analyze as certain socio-demographic and health factors can influence probability of dependent person living in a residence. methods: a cross-section study has been conducted from a representative sample of the dependent population in cuenca (spain) in february, 2009. we have obtained information for people with level ii and iii of dependence. a binary logit regression model has been estimated to identify those factors related to the institutionalization of dependent people. results: people with ages between 65-74 years old are six times more likely to be institutionalized than younger people (<65 years old); this probability increases sixteen times for those individuals with ages equal or higher than 95 years. the probability of institutionalization of people who live in an urban area is three times the probability of people who live in a rural area. people who need pharmacological, psychotherapy or rehabilitation treatments have between two and four times more probability of being institutionalized that those who do not need those. conclusions: age, marital status, place of residence, cardiovascular and musculoskeletal diseases and four times of medical treatment are the principal variables associated with the institutionalization of dependent people.
Rara ubicación de un mixoma gigante
Valiente Mustelier,Juan; Román Rubio,Pedro; Paredes Cordero,ángel; Turro Fuentes,Mercedes; Amoedo Mon,Mireya;
Revista Cubana de Medicina , 2005,
Abstract: the case of a 25-year-old woman that on the 24th week of pregnancy was diagnosed a heart tumor of large size in the right ventricular cavity, denied to be operated on and gave birth being asymptomatic, was presented. four months later, she was admitted in this center due to heart failure and the echocardiogram showed an accelerated growth of the tumor. it was resected and the tricuspid valve was replaced with a bioprothesis. a mixoma of the right ventricle was diagnosed in the pathological anatomy study. she was asymptomatic at the time of discharge.
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