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Search Results: 1 - 10 of 767 matches for " OV Gaisenok "
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Cardiac arrhythmias in medical practice: clinical case of amiodarone-induced thyrotoxicosis type 2 as a cause of recurrent atrial fibrillation
OV Gaisenok
Rational Pharmacotherapy in Cardiology , 2010,
Abstract: Atrial fibrillation is a common cardiac arrhythmia. Amiodarone is an effective drug used for atrial fibrillation treatment. Various side effects of this drug including amiodarone-induced thyrotoxicosis are discussed. A clinical case is presented to provide data for the differential diagnosis between types 1 and 2 of amiodarone-induced thyrotoxicosis and to define approaches to the treatment.
The role of modern antiplatelet therapy in prevention of atherothrombosis: the importance of clopidogrel and its generic drugs
O.V. Gaisenok
Rational Pharmacotherapy in Cardiology , 2011,
Abstract: Current issues of atherothrombosis prevention and treatment optimization with antiplatelet therapy in patients with cardioascular diseases are discussed. Role of clopidogrel in contemporary antiplatelet therapy is focused on, especially in the aspect of the problem of aspirin resistance. Chronology of the clopidogrel generics appearance and prospects of their use is presented.
The use of amiodarone in clinical practice: the problem of side effects
O.V. Gaisenok
Rational Pharmacotherapy in Cardiology , 2010,
Abstract: Characteristics of amiodarone in clinical practice are focused on. Amiodarone pharmacological mode of action and its pro-arrhythmic effect is presented. As well as various side effects that can happen in clinical practice. Special attention is paid to the problem of amiodarone-induced thyrotoxicosis, its classification, diagnosis and treatment. Prospects of new anti-arrhythmic drugs class III, in particular dronedaron are also discussed.
Sudden cardiac death: etiologicy in patients of different ages, risk factors and prevention
O.V. Gaisenok
Rational Pharmacotherapy in Cardiology , 2011,
Abstract: Sudden cardiac death etiologicy in different diseases is analyzed as well as its prevalence in different ages, risk factors and prevention.
Fatigue Strength of Laser Welded Joints of PP and PC Components  [PDF]
Vlastimil Votrubec, Pavel Hisem, Lenka Vin?ová, Gabriela Bene?ová
World Journal of Mechanics (WJM) , 2018, DOI: 10.4236/wjm.2018.86017
Abstract: The paper describes research of fatigue properties of laser welded joints of PP and PC reinforced composites. Welded specimens were tested on dynamic testing machine to obtain data for fatigue strength and fatigue life evaluation. Materials used for testing were PP and PC plastics filled with various amounts of glass fibers. Nine combinations of PP specimens and 6 combinations of PC specimens were welded and loaded on testing machine by fluctuating stress with constant stress ratio. Presented results include fatigue strength of welded joints and also the S-N curves based on experimental data and theory are derived.
Applications of nanoparticles in biology and medicine
OV Salata
Journal of Nanobiotechnology , 2004, DOI: 10.1186/1477-3155-2-3
Abstract: Nanotechnology [1] is enabling technology that deals with nano-meter sized objects. It is expected that nanotechnology will be developed at several levels: materials, devices and systems. The nanomaterials level is the most advanced at present, both in scientific knowledge and in commercial applications. A decade ago, nanoparticles were studied because of their size-dependent physical and chemical properties [2]. Now they have entered a commercial exploration period [3,4].Living organisms are built of cells that are typically 10 μm across. However, the cell parts are much smaller and are in the sub-micron size domain. Even smaller are the proteins with a typical size of just 5 nm, which is comparable with the dimensions of smallest manmade nanoparticles. This simple size comparison gives an idea of using nanoparticles as very small probes that would allow us to spy at the cellular machinery without introducing too much interference [5]. Understanding of biological processes on the nanoscale level is a strong driving force behind development of nanotechnology [6].Out of plethora of size-dependant physical properties available to someone who is interested in the practical side of nanomaterials, optical [7] and magnetic [8] effects are the most used for biological applications.The aim of this review is firstly to give reader a historic prospective of nanomaterial application to biology and medicine, secondly to try to overview the most recent developments in this field, and finally to discuss the hard road to commercialisation. Hybrid bionanomaterials can also be applied to build novel electronic, optoelectronics and memory devices (see for example [9,10]). Nevertheless, this will not be discussed here and will be a subject of a separate article.A list of some of the applications of nanomaterials to biology or medicine is given below:- Fluorescent biological labels [11-13]- Drug and gene delivery [14,15]- Bio detection of pathogens [16]- Detection of proteins [17]- Pro
Nanotechnology in Therapeutics: hydrogels and beyond
OV Salata
Journal of Nanobiotechnology , 2007, DOI: 10.1186/1477-3155-5-5
Abstract: The very first chapter of this section overviews the "concepts of medical chronobiology, chronopharmacology and chronotherapeutics" as the basis for applications of drug delivery technology" and is dealing with the drug delivery matching to the biological rhythms. Can a doctor who takes decisions on the drug dosage by monitoring patient's progress be replaced by an automated system (see Chapter 2, dedicated to the "Feedback Control in Drug delivery")? Four diseases are analysed in this context and only in the simplest single input case of glucose control in diabetes a feedback control seems to be feasible at present. One of the major non-technical hurdles in this field is the acceptance of the technology by both clinicians and patients.The advances in drug delivery for nanoparticles are discussed in the third chapter of this thrilling volume. The main reason for creating nanoparticles is to improve solubility and bioavailability of drugs. It is a well known phenomenon that nanoparticles can be taken much faster across the cell membranes. There are also opportunities here to create a targeted drug delivery. Routes of nanoparticle preparation are described, followed by the discussion of the requirements to their physical and chemical properties for effective delivery.Molecular recognition is one of the central concepts in biology and is of great importance for the creation of active synthetic nanomaterials. In the Chapter 4 ("Synthetic Ligand-Receptor Interactions in Delivery Systems") the authors are describing what is involved in the design of a synthetic receptor (as opposed to designing a ligand, which is a more common pharmaceutical problem). The next chapter is entitled "Nanoscale Analysis of Mucus-Carrier Interactions for Improved Drug Absorption". It describes the structure of the mucous layer on the molecular level and discusses the interaction of this layer with synthetic polymers.The final sixth chapter of the "intelligent therapeutics" part is dedicated to
Fake and Counterfeit Drug: A review
OV Buowari
Afrimedic Journal , 2012,
Abstract: BACKGROUND: Drugs are used to cure or treat disease, relieve symptoms, ease pain, prevent disease or symptoms,eliminate or reduce symptoms and to slow the disease process. The problem of fake drugs is wide spread affecting both developing and developed nations, assumes added significance in view of rapid globalisation and is assuming a dangerous dimension in most countries. METHODOLOGY: A review of literature on counterfeit drug and it impact was done. The articles were accessed from public libraries, as well as online through internet search engines and relevant information extracted. RESULTS: The burden of counterfeit is a enormous and can result in treatment failure, end organs damage and toxicity, death, economic loss as well as of loss of confidence in the healthcare system Conclusion: Trade in counterfeit drugs appears to be wide spread and affects both developing and developed countries. The fight against counterfeit and fake drugs is multisectional and requires a prolonged approach. It requires all stake holders to contribute actively in order to achieve success.
The Subtle Plague: Materialistic Visage of Neocolonialism and Its Consequences in Armah’s Fragments
OV Ogbeide
African Research Review , 2011,
Abstract: This paper examines the materialistic visage of neocolonialism in Ayi Kwei Armah’s Fragments. While neocolonialism is often seen in African leaders’ role as stooges of the erstwhile colonial powers in order to perpetuate themselves in office, this paper argues that the masses’ unbridled penchant for foreign goods and life styles is itself another form of neocolonialism, albeit subtle. This paper not only sees this development as part of the “new realism” which came in the wake of political independence but also posits that the way forward in the continent may lie in nonconformity, its repercussions notwithstanding and a return to the way of production, human relationship and reciprocity as symbolized by the visionary Naana.
Petrenko OV
Annals of Mechnikov's Institute , 2012,
Abstract: Bacterial DNA floatings, which relate to separate genes recombination as well as genomic blocks gaining resulted from horizontal transgenesis, underlie phenotypic and genotypic properties transformations of vibriosis causative agents. The environmental spread of the vibrios with different pathogenic potential assists to form vibriosis new causative agents with various combination of the genes of pathogenicity.
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