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Search Results: 1 - 10 of 230180 matches for " O.V. Lerman "
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A comparative study of the efficacy and tolerability of original and generic bisoprolol in monotherapy or in combination with S-amlodipine and indapamide in patients with arterial hypertension 1-2 degrees.
S.Yu. Martsevich,S.N. Tolpygina,V.P. Voronina,O.V. Lerman
Rational Pharmacotherapy in Cardiology , 2011,
Abstract: Aim. To study the clinical equivalence of original and generic drugs of bisoprolol in patients with arterial hypertension (HT) 1-2 degrees according to protocol recommended by the Society of Cardiology of the Russian Federation for comparative studies.Material and methods. 30 patients with HT 1-2 degrees were examined. Patients were randomized into group 1 (original bisoprolol 5 mg/day) or group 2 (generic bisoprolol 5 mg/day). In case of insufficient antihypertensive effect bisoprolol dose was increased or S-amlodipine and then indapamide were added. After the first treatment period (8 weeks) was completed 2-week wash-out period started and then the second period (8 weeks) of treatment (taking alternative medicine of bisoprolol) began. Blood pressure (BP), heart rate, ECG, adverse effects were recorded in patients.Results. After 8 weeks of therapy BP reduction was 27.2±12.2/12.0±6.1 mm Hg in group 1 and 29.9±10.5/12.5±7.2 mm Hg in group 2 (p<0.001 for both groups), intergroup differences were insignificant. Target BP levels were achieved in 79.3% of patients in both groups. Heart rate decrease was 11.1±12.9 in group 1 and 8.5±8.6 beats/min in group 2 (p<0.05 for both groups). Significant dynamics of PQ interval were not found in both groups. The groups were comparable in terms of treatment safety and tolerability.Conclusion. Therapeutic equivalence of original and generic bisoprolol is shown in patients with HT 1-2 degrees.
The comparative study of efficacy and tolerability of generic and original valsartan as a monotherapy or in combination with hydrochlorothiazide and bisoprolol in patients with arterial hypertension of 1-2 degree and metabolic syndrome
S.Yu. Martsevich,Yu.V. Lukina,N.A. Dmitrieva,O.V. Lerman
Rational Pharmacotherapy in Cardiology , 2012,
Abstract: Aim. To study the efficacy and safety of generic valsartan Valz (Actavis Group, Iceland) in comparison with the original valsartan Diovan (Novartis, Switzerland) in patients with arterial hypertension (HT) of 1-2 degrees and metabolic syndrome.Material and Methods. 30 hypertensive patients (12 men and 18 women) were enrolled in a randomized open-label crossover study. Each patient received generic and original valsartan (80 mg QD) sequentially during 8 weeks. When target blood pressure (BP) level (<130/80 mm Hg) was not reached, a fixed combination of valsartan with hydrochlorothiazide (80/12.5 mg, and then 160/12.5 mg), and bisoprolol 5 mg/daily, if necessary, were used. Treatment efficacy and safety was assessed at visit to doctor every 2 weeks throughout the study. The sequence of drug use was determined by randomization.Results. Systolic BP (SBP) decreased by 27.5 and 27.4 mm Hg from baseline due to generic and original valsartan 8 week treatment, respectively. Diastolic BP (DBP) decreased by 12.8 and 12.9 mm Hg , respectively (p>0.05). Target BP was achieved in 23 patients (77%) in both randomized groups. Serious adverse reaction were not observed during the treatment with both valsartan drugs.Conclusion. The therapeutic equivalence of generic and original valsartan drugs is shown. Therapy based on valsartan (in combination) was safe and effective in 77% of patients with HT of 1-2 degrees and metabolic syndrome.
Comparison of new generic and original ramipril in patients with arterial hypertension and high cardiovascular risk (Full english text)
S.Yu. Martsevich,Yu.V. Lukina,N.A. Dmitrieva,O.V. Lerman
Rational Pharmacotherapy in Cardiology , 2010,
Abstract: Aim. To compare efficacy of ramipril generic HartilR (Egis) to original drug TritaceR in patients with arterial hypertension (HT) of 1-2 degree and high cardiovascular risk, and to evaluate target blood pressure (BP) achievement when taking each drug separately and in combination with the calcium channel blocker amlodipine.Material and methods. A total of 27 patients (14 men, 13 women) with HT of 1-2 degree and high risk due to combination of HT with ischemic heart disease, diabetes or previous stroke were included in an open randomized crossover study. Each patient received generic and original ramipril during 6 weeks by turns. Antihypertensive efficacy (the target BP level <130/80) was evaluated every 2 weeks. In case of treatment inefficiency a dose was doubled and amlodipine (Cardilopin, Egis) was added. After 6 weeks of treatment with the first drug of ramipril the second one was administered.Results. After 6-week Hartil treatment the mean systolic BP (sBP) decreased by 20,0 mm Hg compared to the baseline level, while at Tritace treatment – by 22,2 mm Hg. The mean diastolic BP (dBP) decreased by 10,8 and 8,6 mm Hg respectively (differences between the drugs were insignificant). Twenty patients treated with Hartil and 16 patients treated with Tritace required Cardilopin prescription. The target BP<130/80 was achieved in 10 patients (38,5%) who took Hartil and in 13 patients (50%) treated with the original ramipril (differences between the drugs were insignificant).Conclusion. Therapeutic equivalence of the generic ramipril Hartil and the original drug Tritace was demonstrated. Monotherapy efficacy was low in high-risk patients with HT of 1-2 degree, and combined therapy with two antihypertensive drugs was effective in 40-50% of cases.
Permutation Generation Algorithm
O.V. Viktorov
Asian Journal of Information Technology , 2012,
Abstract: A new permutation generation algorithm is presented in this study. The algorithm has the fastest software implementation because it uses exchanges of two elements, but certain software overhead is present due to analysis of generating numbers and m-module forward-backward counters.
Significance of a Blood Flow Fractional Reserve Detection in Assessment of the Coronary artery Bifurcation Lesion Endovascular Treatment Effectiveness and Optimization
O.V. Britvina
Sovremennye Tehnologii v Medicine , 2010,
Abstract: Aim of investigation is a study of the blood flow fractional reserve measurement significance for optimization and assessment of the coronary artery lesion endovascular correction effectiveness.Materials and methods. An investigation of pressure in the coronary arteries was accomplished in a roentgenosurgical operating room with a use of the RADI Analyzer apparatus (Axle International). The results of endovascular interventions in 67 patients with the coronary artery bifurcation lesions are analyzed. An assessment of the coronary arteries in one group of patients was made on a basis of the selective coronarography data, and a measurement of a blood flow fractional reserve was made in the other group of patients beside a coronarography.Results. A circulation fractional reserve measurement is more significant for a bifurcation lateral branch state assessment because a negative correlation of its meanings and the selective coronarography results is established; the non-coincidences of the stenosis significance are mostly observed in the border stenosis group (II stage).
Energy-saving technical solutions for local and central microclimate systems using heat pumps as local aggregates united into one water circuit
O.V. Averyanova
Magazine of Civil Engineering , 2011,
Abstract: One of the priorities of energy savings is to implement energy saving measures in the work of heating systems, heating, ventilation and air conditioning systems based on heat pumps (HP). The dissertation considers using of a multizone central air-conditioning system with chilled beams for increase of power efficiency of a building was offered. In a transition period (the spring, autumn) in a building are observed both surplus of heat in one premises, and shortage of heat in others. At the expense of use low-temperature circuit and chilled beams of type "water-air" surpluses of heat are transferred in premises with shortages of heat and on the contrary. The given technology allows saving essentially thermal and electric energy in a transition period of year.
Economic efficiency of energy saving solutions (rus)
Averyanova O.V.
Magazine of Civil Engineering , 2011,
Abstract: One of the priorities in the development of Russian Federation is the policy of reducing energy consumption and implementation of energy efficient technologies. The article shows the example of the solution aimed at increasing the energy efficiency of systems which maintain optimal microclimate parameters in the office buildings. The solution is based on usage of WLHPS (Water Loop Heat Pump System). Consolidation into a united system makes it possible to utilize heat of the exhaust air heat and of other low-grade heat sources. The article shows the method of estimation the economic efficiency of these systems. The method is demonstrated on the example of office building. Comparison of various investment projects and selection the best solution was made by using economic indicators such as net present value (NPV) or the integrated effect and profitability index.
Ecological innovations are a way of market development ecologically clean commodities
O.V. Belyakova
Marketing ì Mened?ment Innovacìj , 2011,
Abstract: The key factors of competition success are considered at development of ecological marketing strategy; the value of introduction of ecological innovations is probed in activity of enterprises for providing of steady development; the list of ecological innovations and difficulties which arise up on the stage of their development is given.
The motivational mechanism of innovative development: components and the condition of its market structure
O.V. Prokopenko
Marketing ì Mened?ment Innovacìj , 2011,
Abstract: It is defined the condition of the modern motivational mechanism of innovative development of market type as a result of allocation of components of the motivational mechanism depending on elements to the market and estimations of effectiveness of each of the allocated components.
Methodical bases of market segmentation with ecological limitations
O.V. Sadchenko
Marketing ì Mened?ment Innovacìj , 2011,
Abstract: The article is devoted to the question of market segmentation taking into account the ecological factors, which foresee its division on certain spheres including ecological shortages and needs.
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