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Extracellular calcium-sensing receptor: structural and functional features and association with diseases
Hauache, O.M.;
Brazilian Journal of Medical and Biological Research , 2001, DOI: 10.1590/S0100-879X2001000500004
Abstract: the recently cloned extracellular calcium-sensing receptor (car) is a g protein-coupled receptor that plays an essential role in the regulation of extracellular calcium homeostasis. this receptor is expressed in all tissues related to this control (parathyroid glands, thyroid c-cells, kidneys, intestine and bones) and also in tissues with apparently no role in the maintenance of extracellular calcium levels, such as brain, skin and pancreas. the car amino acid sequence is compatible with three major domains: a long and hydrophilic aminoterminal extracellular domain, where most of the activating and inactivating mutations described to date are located and where the dimerization process occurs, and the agonist-binding site is located, a hydrophobic transmembrane domain involved in the signal transduction mechanism from the extracellular domain to its respective g protein, and a carboxyterminal intracellular tail, with a well-established role for cell surface car expression and for signal transduction. car cloning was immediately followed by the association of genetic human diseases with inactivating and activating car mutations: familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism are caused by car-inactivating mutations, whereas autosomal dominant hypoparathyroidism is secondary to car-activating mutations. finally, we will comment on the development of drugs that modulate car function by either activating (calcimimetic drugs) or antagonizing it (calcilytic drugs), and on their potential therapeutic implications, such as medical control of specific cases of primary and uremic hyperparathyroidism with calcimimetic drugs and a potential treatment for osteoporosis with a calcilytic drug.
Reflections on the Challenges of Anthropology in Contemporary Times and Future Prospects: The Douala Experience
O.M Savage
African Anthropologist , 2007,
Abstract: No
Infectious Dropsy of Hybrid Catfish Fingerlings from Nigeria
O.M. Edun
Journal of Animal and Veterinary Advances , 2012,
Abstract: Dropsy was observed in hybrid catfish (a cross between Clarias gariepnus and (Heteobranchus longifilis) fingerlings from African Regional Aquaculture Centre (ARAC), Aluu, Nigeria. It is characterized by swelling of the body of the fish in the ventral region with yellowish watery fluid. Aeromonas hydrophila was recovered from the diseased and dead fish. Pathogenicity of Aeromonas hydrophila isolate was also determined. Clinical manifestation of the disease was observed in the hybrid catfish fingerlings 48 h post inoculation followed by death after 6 days. A. hydrophila was also re-isolated from the experimental fish. Prevention of further spread of the disease was achieved by sanitary measures, disinfection of facilities and environmental control.
The Use of Wood By-Products for Making Concrete Blocks
O.M. Ogundipe
Journal of Engineering and Applied Sciences , 2012,
Abstract: In this research, sawdust concrete with nominal mixes 1:1:2, 1:1 :3 and 1:2:4 were subjected to the following tests; particle size distribution, compressive strength, water absorption and density. This was done to examine the suitability of wood by-products for concrete blocks production. The 28-day compressive strength of nominal mixes 1:1:2 and 1:1 :3 were 18.33 and 8.78N mm 2, respectively, while their 28-day absorption values were 5.69 and 8.97%, respectively and the densities were 2133 and 2914 kg m 3. These values indicated that wood by-products (sawdust) could be used for concrete blocks production. The successful utilization of wood by-products helps not only in reducing the amount of wastes requiring disposal but also in eliminating the pollution of the environment caused by burning the wastes.
Repair of Extensive Composite Alar Defects with Single Stage Nasolabial Turnover Flap and Auricular Composite Graft
O.M. Oluwatosin
Nigerian Journal of Surgical Research , 2001,
Abstract: Extensive and total (through and through) loss of ala or lobule of the nose as seen in severe traumas and neglected tumours should be replaced by the three anatomical layers of skin, cartilage and vestibular lining. A technique of nasolabial turnover flap transfer covered by a two layered auricular chondrocutaneous graft is described for reconstructing such total losses >1.5 cm. The method of survival of large volume chondrocutaneous grafts is described as well as the advantages of this technique over other alternatives. (Nig J Surg Res 2001; 3: 133 – 138) KEY WORDS: Alar defects, Repair
Features of choice of innovative strategies by industrial enterprises
O.M. Derykolenko
Marketing ì Mened?ment Innovacìj , 2012,
Abstract: In article features of the choice of innovative strategy by the industrial enterprises are investigated. It is offered to define innovative strategy depending on the extent of risk, and also from existence of available funds at the enterprise and the level of demand on these innovations.
Morphogenesis of the pancreas during the perinatal period of ontogenesis
Slobodian O.M.
Морфолог?я , 2008,
Abstract: The purpose of the research – to establish the chronological sequence of changes of the ratios between the parameters of the pancreas and the parietocalcaneal length in embryos and newborns. The morphometric researches of the anatomical parts of the pancreas has been carried out on 57 fetal and newborn corpses in situ. Two periods of an accelerated development (months 5 and 8-10) and a period of a relative deceleration (months 6 and 7) have been revealed. An essential degree of synergism and a harmony of development between the morphometric parameters of the anatomical parts of the pancreas and the parietocalcaneal fetal length has been determined during the first period of an accelerated development (the 5th month). It was validated by correlation analysis and reliable multifactor regression dependence.
Distribution of immunocompetent cells in the lungs of premature newborns on the background of some components of mother metabolic syndrome
Rudyak O.M.
Морфолог?я , 2011,
Abstract: In immunohistochemical researching of the local immune system of the lungs (90 premature newborns, 29-33 weeks gestation), divided into 3 groups with respect to the components of mothers metabolic syndrome , the features and patterns of distribution, quantitative indicators of immune cells in the bronchial and respiratory departments are detected. It was determined that children who belong to group №1 (mothers hypertension and dyslipidemia ) have the total depression of T-lymphocytes (CD3), reduction of helper function (CD4), mixed reaction of suppressors (CD8), decreasing the number of B-lymphocytes - subpopulations (CD20), inhibition of macrophagic function (CD68). In group№2 (mothers diabetes type 2 and dyslipidemia) we observed depression of helper-suppressor functions (CD4, CD8), increasing of macrophagic reaction (CD68). Reducing of the absolute number of suppressor and cytotoxic T-lymphocytes subpopulations, a decreasing of B-lymphocytes (CD20) and inhibition of macrophagic functions (CD68) is observed in group№3 of children at the background of mothers adiposity and dyslipidemia. Reducing of expression of CD3 lymphocytes and levels of CD4 cells shows intensive reaction of cellular immunity in premature newborns. Comparative analysis of the immune status of the lungs of children in three groups with different components of mothers metabolic syndrome shows an acute disbalance of immunoregulation index, and the negative impact of mothers disease on histogenetic processes of respiratory organization.
Histotopographic characteristics of the pancreatoduodenal organocomplex in fetuses and newborns
Slobodian O.M.
Морфолог?я , 2008,
Abstract: The object of the research was to establish a chronological order of the histotopography of the duodenum and pancreas during the perinatal period of ontogenesis. It has been established that the histostructure of the duodenal wall in early fetuses (4-5 months) is characterized by the availability of primary crypts, the muscular layer of the mucous tunic, variable thickness of the layers of the muscular coat and a feebly marked character of the serous tunic; in late fetuses (8-10 months) - by the forming of the villi of the mucous membrane, the presence of transparent goblet cells, Brunner’s glands in the submucous layer and an almost uniform thickness of the layers in the muscular tunic. The lobular structure of the pancreas becomes formed starting with the 5th-6th months of development. Goblet cells occur in the mucous tunic of the interlobular ducts and the main pancreatic duct in late fetuses and newborns. The islets of Langerhans in early fetuses make up 1.2-3.5% of the volume of the glandular component of the organ and distributed unevenly, 4.8-8.3% with a uniform distribution in late fetuses and newborns.
Morphogenesis of the gallbladder during the prenatal period of human ontogenesis.
Slobodian O.M.
Морфолог?я , 2007,
Abstract: The purpose of research: to establish chronological sequence morphometric changes between parameters of a bilious bubble and parietocalcaneal length at fruits and newborns. A morphometric study of the gallbladder on 40 isolated organocomplexes of fetal and newborns corpses in situ have been carried out. Two periods of accelerated development (during months 5 and 8-10) and a period of relative slowing down (during months 6 and 7) have been disclosed. During the 6th month the length and width of the gallbladder and the fetal parietocalcaneal length are linked between themselves by a reliable multifactor regression dependence.
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