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Search Results: 1 - 10 of 288166 matches for " O.D. Ostroumova "
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Lercanidipine, calcium channel blocker of the third generation: new possibilities in the treatment of arterial hypertension
O.D. Ostroumova,M.L. Maksimov,I.I. Kopchenov
Rational Pharmacotherapy in Cardiology , 2013,
Abstract: Classification, modes of action and clinical effects of calcium channel blockers are presented. Advantages of the third generation of dihydropyridine calcium channel blockers are considered. Clinical pharmacology, studies on the efficacy, safety and prevention of hypertensive complications with lercanidipine are detailed.
New approaches of the hypertension treatment: from choosing the best drug to choose the optimum drugs combination
O.D. Ostroumova,E.A. Smolyarchuk,I.V. Khvorostyanaya
Rational Pharmacotherapy in Cardiology , 2010,
Abstract: The possible indications for the choice of two component antihypertensives combinations are presented. The advantages of ACE inhibitor+calcium channel blocker combination are shown in terms of antihypertensive efficacy, organoprotective properties, and positive metabolic effects. Clinical aspects of ACE inhibitor+thiazide diuretic combination usage, its possible side effects and ways to minimize them are considered.
Treatment of chronic heart failure: focus on metoprolol succinate
O.D. Ostroumova,G.N. Shchukina,V.M. Fomina
Rational Pharmacotherapy in Cardiology , 2012,
Abstract: Advantages of metoprolol succinate in patients with chronic heart failure (CHF) are covered. Results of MERIT-HF study are taken as the main evidences. Patterns of the metoprolol succinate use in the treatment of different categories of patients with CHF (women, the elderly, severe CHF forms, CHF with concomitant hypertension or diabetes) are considered.
Antihypertensive efficacy and vasoprotective properties of a new combination of beta-blocker, bisoprolol (2,5/5 mg) and diuretic, hydrochlorothiazide (6,25 mg)
O.D. Ostroumova,A.G. Sazonova,K.U. Reznikova,A.V. Srednjakov
Rational Pharmacotherapy in Cardiology , 2010,
Abstract: Aim. To study influence of the fixed bisoprolol (BIS) + hydrochlorothiazide (HCT) combination on blood pressure (BP) level and a blood flow in middle cerebral artery in patients with a arterial hypertension (HT), 1 degree.Material and methods. 18 patients with HT 1 degree (7 men, 11 women; age 50,1 }5,7 y.o.) were included in the non-comparative open study. All patients received a combination of selective beta1-adrenoblocker (BIS 2.5-5 mg) and diuretic (HCT 6,25 mg). Initially and in 12 weeks of the treatment all patients had a standard clinical examination, ambulatory BP monitoring, ultrasonography of mesencephalic arteries for evaluation of the cerebrovascular blood flow reactivity.Results. The target BP level (<140/90 mm Hg) in 12 weeks of the treatment (12 patients received BIS 5 mg/HCT 6,25 mg, 6 patients - BIS 2,5 mg/HCT 6,25 mg) was reached in 100% of patients. Besides, significant increase in cerebral blood flow reactivity was found in tests with hyper- and hypoventilation.Conclusion. The fixed BIS/HCT combination has high antihypertensive and vasoprotective efficacy.
Technological optimization of temperature efficiency of heat recoverers with intremediate heat carrier
O.D. Samarin
Magazine of Civil Engineering , 2011,
Abstract: In the paper the padding investment costs and decrease of the consumption on a thermal energy are reviewed at salvaging a heat of exhausting air under the scheme with intermediate heat carrier in systems of mechanical ventilation. The nature of relation of the data of costs from a factor of temperature efficiency of heat recoverer is parsed. The expression for optimum temperature efficiency is offered by minimization of cumulative discounted costs during given computational term. The analysis of the obtained outcomes is given and the nature of their change at different parameters of an outside climate, and also operational price level on the equipment and fares on power supplies also is justified. The comparison of conclusions of the investigation to the data of the previous author’s researches is conducted. The presentation is illustrated graphically and by an example of numerical calculation
John Lothrop Motley and the Netherlands
O.D. Edwards
BMGN : Low Countries Historical Review , 1982,
Coag-Flocculation Studies of Afzelia Bella Coagulant (ABC) in Coal Effluent Using Single and Simulated Multi Angle Nephelometry  [PDF]
M.C. Menkiti, O.D. Onukwuli
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.103019
Abstract: Following the need for the use of environmentally friendly, renewable resource in industrial processes, this work explores the potential of an effective application in pilot scale of Afzelia bella seed as a coag-flocculant. The study evaluates the coag-flocculation efficiency and functional kinetic parameter response to varying pH and dosage of coal washery effluent and ABC respectively. The maximum coag-flocculation performance is recorded at rate constant, K of 3.3333 x 10-3m3/kg.s, dosage of (0.3 and 0.2kg/m3); pH of 2 and coagulation period, τ1/2of 28.1216 s while the minimum is recorded at K of 1.6667 x 10-4m3/kg.s, dosage of 0.2kg/m3, pH of 10 and τ1/2 of 562.365 s. The least value of coag-flocculation efficiency, E (%)>89.00. Simulated and unsimulated values of rate constants Ks and K respectively are in close agreement, validating the concept of perikinetics. The potential of ABC as an effective organic coag-flocculant has been established. The results confirm that theory of rapid coagflocculation holds for the aggregation of coal washery effluent using ABC and at the conditions of the experiment.
Impact of pH Variation on Coag-flocculation Behaviour of Chitin Derived Coag-flocculant in Coal Washery Effluent Medium  [PDF]
M.C. Menkiti, O.D. Onukwuli
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.1015109
Abstract: This work investigates the influence of pH variation on coag-flocculation kinetics and performance of Chitin Derived Coag-flocculant (CDC) in removal of Suspended and Dissolved Particles (SDP) from Coal washery effluent (CWE) medium. Key parameters such as rate constant Km, half life t1/2,, and pH etc. were investigated. The best coag-flocculation performance is recorded at Km, of 0.007 l/mg.min, t1/2, of 0.0362min, pH of 8, dosage of 100mg/l and efficiency E(%) of 99.933. Minimum efficiency (%) > 94.00 was achieved at 30 minutes of coagflocculation, establishing CDC as an effective water treatment agent at the conditions of the experiment.
Coag-Flocculation Kinetics and Functional Parameters Response of Mucuna Seed Coagulant to pH Variation in Organic Rich Coal Effluent Medium  [PDF]
M.C. Menkiti, P.C. Nnaji, C.I. Nwoye, O.D. Onukwuli
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2010, DOI: 10.4236/jmmce.2010.92008
Abstract: The coag-flocculation performance of Mucuna Seed Coagulant as affected by pH variation in coal washery effluent has been investigated at room temperature using various dosages of unblended Mucuna Seed Coagulant. In addition, coag-flocculation parameters such as Coagflocculation reaction order α, αth order coag-flocculation constant K, Collision factor for Brownian Transport βBr, Smoluchowski constant KR,, Collision Efficiency εp, and Coagulation Period τ1/2 were determined. Turbidity measurement was employed using the nephelometric (turbidimetric) standard method while Mucuna Seed Coagulant preparation was adopted from the works of Adebowale and Adebowale (2007). The maximum Mucuna Seed Coagulant parameter performance is recorded at α of 2, K of 8.3334 x 10-3 m3/kg.s, dosages of (0.15 kg/m3; 0.2 kg/m3 ; 0.25 kg/m3); pH of 6 and τ1/2 of 1.7339 sec while the minimum parametric performance is recorded at α of 1; K of 6.3001 x 10-4 s-1; dosage of 0.2kg/m3; pH of 8 and τ1/2 of 1100.2161seconds. The minimum value of coag-flocculation efficiency E (%) recorded is greater than 88.00 %. Conclusively; Mucuna Seed Coagulant is an effective coagulant obeying the theory of fast coagulation at the conditions of the experiment.
Optimal Evaluation of Coag-Flocculation Factors for Alum-Brewery Effluent System by Response Surface Methodology  [PDF]
M.C. Menkiti, M.C. Aneke, E.B. Ogbuene, O.D. Onukwuli, E.O. Ekumankama
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2012, DOI: 10.4236/jmmce.2012.115039
Abstract: This work investigates coag-flocculation optimization treatment of alum-brewery effluent system via response surface methodology (RSM). To minimize suspended and dissolved particles (SDP), experiments were carried out using nephelometric jar test and 23-factorial design with three star-points, six-center-points and two replications. A central composite design, which is the standard design of RSM, was used to evaluate the effects and interactions of three major factors (coagulation pH, coagulant dosage, settling time) on the treatment efficiency. Multivariable quadratic model developed for the response studied indicates the optimum conditions to be 9, 500mg/l and 20minutes for coagulation pH, coagulant dosage and settling time, respectively. At optimum, the SDP was reduced from 10831.490mg/l to 801.451mg/l, representing 92.601% removal efficiency. RSM has demonstrated to be appropriate approach for the optimization of the coag-flocculation process by statistical evaluation.
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