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Search Results: 1 - 10 of 243128 matches for " O.B. Idonije "
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A Comparative Study of the Status of Oxidative Stress in Pregnant Nigerian Women
O.B. Idonije,O. Festus,O. Okhiai,U. Akpamu
Research Journal of Obstetrics and Gynecology , 2011,
Abstract: Normal pregnancy has been found to be associated with a high metabolic demand and elevated requirements for tissue oxygen which results in increased oxidative stress and antioxidant defenses. Hence this study evaluates in pregnancy the state of oxidative stress express by product of lipid peroxidation via the level of ThioBarbituric Acid-Reactive substances (TBARS). It involves 180 apparently healthy pregnant Nigerian women age between 20-40 years of different gestation period parity and socio status. In addition 20 apparently healthy tested non pregnant women formed the control group. The test groups were women attending ante-natal clinic at the University of Benin Teaching Hospital (UBTH) Benin City Edo state, Nigeria. Data from standard laboratory procedure were then subjected to statistical analysis using the paired sample t test of SPSS software version 17. Result shows increase in plasma TBARS as age advances and as the number of pregnancy increases. TBARS was lowest in women indulge in physical activity as in farm works (7.63.24 M) and highest among the physical inactivity as in full house-wife (16.286.69 M). A significant rise in TBARS in pregnant women (13.092.34 M) was observed compared to the non pregnant women (the control 4.410.50 M). There was a steady increase in TBARS as the gestation period advances and this was significantly different (p<0.05) from the control. Conclusively, normal pregnancy is associated with oxidative stress. We recommend therefore that there is a need for moderate physical activity during pregnancy and antioxidant supplementation which should increase as age, gestation and number of pregnancy (parity) advances.
Awareness of Health Risks of Female Genital Mutilation Among Women of Child Bearing Age in Two Rural Communities in Nigeria
O. Okhiai,O.B. Idonije,E.C. Asika
Asian Journal of Medical Sciences , 2011,
Abstract: Female genital mutilation has been found to be associated with myriad of physical, emotional and social health risks and the awareness of the consequences of these risks is paramount to the successful cubing/stoppage of the health danger pose by this harmful cultural practice. Hence this research was carried out to ascertain the awareness of health risks of female genital mutilation among women of child bearing age in two rural communities in South-Eastern Nigeria. Structured interview guide was the main instrument of data collection and was structured to meet the said goal of this research and Validity of the instrument was also ensured. Four stage simple random sampling procedure were used to draw the sample size of three hundred and eighty women of child bearing age in these communities. Descriptive statistics of frequency, percentages, grand mean and inferential statistics of Chi-square were used in data analysis. It was found that majority of the respondents (62.4%) were not aware of the physical, emotional and social health risks of female genital mutilation, but few are aware based on level of education, parity status and age. Recommendations made based on the findings were that the federal, state and local governments should enact and enforce laws that will prohibit female genital mutilation in Nigeria while women leaders organize interactive sessions during their meeting days to educate women on the risks associated with female genital mutilation.
Serum Lipid Profile in Nigerian Patients with Ischaemic Cerebrovascular Accident
O.O. Festus,O.B. Idonije,H.B. Osadolor
Current Research Journal of Biological Sciences , 2013,
Abstract: Ischaemic Cerebrovascular Accident (CVA) has been shown to be associated with abnormal lipid profile (dyslipidaemia) as a risk factor. There is paucity of data regarding this in this environment hence this study. In this study, a total number of 63 subjects were recruited comprised of 33 patients with cerebrovascular accident (stroke) and 30 apparently healthy volunteers as control. A complete lipid profile which included Total serum Cholesterol (TC), serum Triglyceride (TG), High Density Lipoprotein cholesterol (HDL-c) and Low Density Lipoprotein cholesterol (LDL-c) were assayed for both patients and controls. The lipid profile was determined using standard methods. The TC for both patients and control were 212±53 and 196±46 mg/dL respectively, TG for both patients and controls were 159±9 and 79±13 mg/dL respectively, HDL-c was 55±9 mg/dL for patients and 61±7 mg/dL for controls and LDL-c was 151±34 mg/dL for patients and 117±51 mg/dL for control subjects. TC, TG and LDL-c were higher in the ischaemic CVA patients than the controls; however only TG showed a significant increase while HDL-c although not significant was lower than control. The study therefore showed that ischaemic CVA is associated with hypercholesterolaemia, hypertriglyceridaemia and high LDL-cholesterol. We thus suggest preventive and management strategies that will reduce lipid levels (TC, TG and LDL) and enhance HDL-cholesterol in Nigeria patients that are prone to or diagnosed of ischaemic CVA.
A Comparative Study of the Effects of Clozapine and Risperidone Monotherapy on Lipid Profile in Nigerian Patients with Schizophrenia
O.B. Idonije,O.O. Festus,U. Akpamu,O. Okhiai
International Journal of Pharmacology , 2012,
Abstract: Although antipsychotic drugs are known to have an array of adverse effects, they also exhibit significant differences in causing these effects. The atherogenic effects of clozapine and risperidone have not been fully investigated among schizophrenics in Nigeria hence this research work. This study therefore investigated the extent to which monotherapy with clozapine and risperidone (atypical antipsychotic drugs) influence lipid profile in patients with schizophrenia. The study population comprised 29 Schizophrenic patients from Psychiatric Hospital, Uselu, Benin city, Nigeria. They were placed on typical antipsychotics for six weeks: 10 patients were on risperidone (1-4 mg day-1 in divided doses) and 19 patients were on clozapine (25-300 mg day-1 in divided doses). The control group comprised 30 apparently healthy volunteers. Blood samples were collected from all subjects on the first day before the commencement of treatment with antipsychotic drug and 24 h after the last administration of antipsychotics at the end of week 6 for analyses of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL) and very low density Lipoprotein cholesterol (VLDL) using standard methods. Comparing with the control, the basal serum TC, TG, LDL and VLDL of the clozapine treated group were not significantly different except for HDL which was significantly reduced and the atherogenic indices (TC/HDL and LDL/HDL) which were significantly increased. However the risperidone treatment group showed significantly higher TC, TG, LDL and VLDL levels while HDL was significantly reduced. At the end of week 6, there was significant increase in serum TC, TG, HDL and VLDL and a significant decrease in HDL in both treatment groups compared to the control except VLDL that was not significantly different in the clozapine group. Comparing the two treatment groups, risperidone caused a more significant increase on lipid profile and atherogenic indeces than clozapine. This effect was about two times or greater with risperidone than clozapine. Conclusively, additional prospective clinical trials are required to support a specific therapeutic approach for managing dyslipidaemia that are present in clozapine and risperidone treated schizophrenic patients in an attempt to avoid its consequent adverse effects.
Phytochemical, Chromatographic and Antimicrobial Studies of the Ethanolic Extract of the Stem Bark of Pentaclethra macrophylla (African Oil Bean Tree)
O.B. Idonije,E.C. Asika,O.O. Okhiai,I.N. Nweke
British Journal of Pharmacology and Toxicology , 2011,
Abstract: We investigated the ethanolic extract of the stem bark of Pentaclethra macroptyla for the presence of several metabolic and antimicrobial activities and also trial runs were carried out to detect a solvent system suitable for fractionation of the compounds present in the plant. Extraction was by the method of cold maceration land evaporation and by a vacuum evap orator to get the dried concentrate. The following compounds were present after the photochemical analysis: tannins alkaloids, glycosides, cyanogenicglycosides, phenols and saponins. The antimicrobial studies included sensitivity and Minimum Inhibitory Concentration (MIC). The organisms used include: Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhii, Staphylococcus aureus, Aspergillus nigger and Candida albicans. Chloramphenicol was used as the standard drug and compared with the extract. The sensitivity test showed that Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhii and Staphylococcus aureus were susceptible to the extract. Aspergillus nigger and Candida albicans were not susceptible. The MIC result of the extract showed the least MIC value of 0.4467 against Pseudomonas aeruginosa. The result for Bacillus subtilus, Escherichia coli, Salmonella typhi and Staphylococcus aureus were: 1.0471, 3.1189, 0.6309 and 3.1189, respectively. The Chromatographic studies carried out were to detect a suitable solvent system that can be used to carry out further studies on the plant extract. The solvent system determined for the plant extract in this study is ethylacetate: Ethanol solution in a ratio of 9:1. With this result fractionation process of the plant extract was made easier. The findings of the present study justify the use of Pentaclethra macrophylla in the treatment of various forms of infections. The ethanol extract may possess a degree of broad spectrum antibiotic activities. The Phytochemical constituents may be contributing to this effect. Further work is recommended to verify the therapeutic merits of the active constituents and to elucidate the exact mechanism of action responsible for the antimicrobial activity.
Effects of Vitamins A, C and E on Liver Function in Pregnancy
O.I. Iribhogbe,J.E. Emordi, A. Aigbiremolen, O.B. Idonije, E.O. Nwoke and U. Akpamu
Asian Journal of Medical Sciences , 2011,
Abstract: In a bid to investigate the effect of sub chronic administration of vitamin A, C and E on liver function in early pregnancy, eighty-five female Wister rats (255-300 g) were employed for the study. They were randomly assigned to three test groups (I, II and III) having 5 treatment subgroups with five rats each, and a control and vehicle group with five rats each. After allowing the female rats to mate with male rats for 6 days, pregnancy was confirmed. The control group was administered 1ml of distilled water, vehicle group 1ml of tween 80, while test groups I, II and III received varying doses of vitamin A, C and E respectively via the intragastric route for 11days. The results showed a significantly elevated albumin, total protein, AST and ALP levels (p<0.05), following vitamin C and vitamin A administration when compared with control. In the vitamin A treated group there was a dose dependent significant increase (p<0.05) in total protein, AST and ALP levels while vitamin E treated group presented a significantly reduced ALT (p<0.05) with no significant change in total protein levels when compared with control. Conclusively the therapeutic benefit of vitamin A, C and E supplementation in pregnancy is not without an impact on the functional and cellular integrity of the liver.
INTERNAL OPTICAL URETHROTOMY IN THE MANAGEMENT OF URETHRAL STRICTURES IN NIGERIANS: TECHNIQUE AND OUTCOME
O.B. SHITTU
African Journal of Urology , 2001,
Abstract: Objectives To evaluate the role of internal optical urethrotomy in the management of patients with urethral strictures seen at the University College Hospital, Ibadan, Nigeria. Patients and Methods The study was carried out over a five year period. The details of the technique used, including measures taken to ensure that the stricture tract is not lost during urethrotomy are described. A total of 40 patients with urethral strictures were treated by internal optical urethrotomy during the study period with an age range of 26-80 years (mean 42.2 years). The aetiology of the stricture was post-infective in 80% of the cases. Results Seventy-five percent of the patients have maintained a satisfactory flow rate of between 15 ml/sec and 28 ml/sec with a mean flow rate of 23 ml/sec after a single attempt at urethrotomy and over a period of follow-up of between 6 months and 5 years. Conclusion Internal optical urethrotomy can be effective in the management of patients with post-infective urethral strictures that do not involve the membranous urethra, and should be attempted in the first instance where the facility exists, particularly as a failed urethrotomy does not jeopardize the management of the stricture by other techniques. African Journal of Urology Vol. 7 No. 2 (May 2001): pp 62-65 Uréthrotomie Optique Interne dans le Traitement du Rétrécissement Uréthral chez les Nigerians: Techniques et Résultats Objectif Evaluer le r le de l'uréthrotomie optique interne dans le traitement des patients avec rétrécissment uréthral vus au Centre Hospitalier d'Ibadan au Nigéria. Patients et Méthodes L'étude a été menée pendant une période de 5 ans. Les détails des techniques utilisées, incluant les mesures prises pour s'assurer que la voie rétrécie n'est pas perdue pendant l'uréthrotomie sont décrites. Un total de 40 patients avec rétrécissement uréthral ont été traités par uréthrotomie optique interne pendant la période d'étude avec l'age qui variait de 26 à 80 ans (moyenne: 42,2 ans). L'étiologie du rétrécissement était post-infectieuse dans 80% des cas. Résultats Soixante-quinze pour cent des patients ont maintenu un débit urinaire satisfaisant entre 15 ml/sec et 28 ml/sec avec un débit moyen de 23 ml/sec après une seule séance d'uréthrotomie et sur une période de suivi allant de 6 mois à 5 ans. Conclusion L'uréthrotomie optique interne peut être efficace dans le traitement des patients avec rétrécissement uréthral post-infectieux n'affectant pas l'urètre membraneux, et devrait être pratiquée d'emblée où les facilités existent, car l'échec de l'uréthrotomie ne coupe pas les ponts pour le traitement du rétrécissement par d'autres techniques. African Journal of Urology Vol. 7 No. 2 (May 2001): pp 62-65
Access in Cities and Sustainable Urban Transport: A Challenge for Third World City Planning Practice
O.B. Akinbamijo
Pakistan Journal of Social Sciences , 2012,
Abstract: The way cities are organized constitutes a potential for increasing demand for motor based travels, road infrastructure needs and vehicles. This encourages energy profligacy, pollution, visible declining service levels in spite of increasing transport based investments and needless changes to our microclimate. All these threaten city sustainability. This study, relying on a current study from Akure Nigeria discusses the nature of travel patterns and characteristics from a Third World city. The methodology of study entailed the use of household based questionnaire survey exercise conducted on 360 household heads that were selected using the stratified systematic sampling technique. Descriptive and inferential statistics were used to analyse the intensity of travel characteristics and reported travel problems. The study affirms close relationship between intra urban travels and urban land use arrangements as well as travel characteristics which are dominantly work trips, commercial trips, ecclesiastical trips and recreational trips. Recommended policy thrusts include the need for reducing the number of vehicles in circulation hence an urgent viable mass transit scheme intervention is anticipated. Also, walkways and cycle ways need be provided and landscaped to attract patronage. This will ensure safety and guarantee clean city mobility . Beyond these, long term interventions of compact city development and regional balance around emerging cities of the Third World were proposed.
Effect of Storage of Millet Flour on the Quality and Acceptability of Millet Flour Porridge (Enyiokwolla)
O.B. Ocheme
Journal of Food Technology , 2013,
Abstract: The effect of storage of millet flour on the quality and acceptability of millet flour porridge was studied. Millet flours were produced from untreated millet grains, soaked millet grains, malted millet grains and an equal blend of malted millet grains and soaked millet grains. The flours were packaged in high density polyethylene and stored at ambient temperature and relative humidity (32 2 C and 65-70%RH, respectively) for 3 months. At monthly intervals, the flours were analysed for moisture content, pH, thiobabituric acid value and least gelation concentration while porridges made from the flours were subjected to sensory evaluation. The moisture content of the flours witnessed no significant (p>0.05) changes while the thiobabituric acid values increased significantly (p< 0.05)after 2 months of storage. The least gelation concentration of the samples were constant through the period of storage while pH of the flours decreased insignificantly (p>0.05). Porridges made from the flours were acceptable up to two months and three months of storage for flours from malted millet grains and flours untreated and soaked millet grains, respectively.
TRANSNATIONALIZATION AS AN ELEMENT OF MODERN PARADIGM OF GLOBAL MANAGEMENT ТРАНСНАЦИОНАЛИЗАЦИЯ КАК ЭЛЕМЕНТ ФОРМИРОВАНИЯ СОВРЕМЕННОЙ ПАРАДИГМЫ ГЛОБАЛЬНОГО МЕНЕДЖМЕНТА ТРАНСНАЦ ОНАЛ ЗАЦ Я ЯК ЕЛЕМЕНТ ФОРМУВАННЯ СУЧАСНО ПАРАДИГМИ ГЛОБАЛЬНОГО МЕНЕДЖМЕНТУ
O.B. Гончарова
Strategy of Ukraine : Economics, Sociology, Law , 2010,
Abstract: Transnationalization - the most important and also the main mechanism of general processes of globalization. It is the most essential element and one of the main contours of regulators to ensure the unity of the functioning of the world economy. Because TNCs and related transnational banks are financial and commodity flows that determine the development of the world economy. They are the leading factor of economic globalization, placing parts and stages of reproduction processes in different countries. These factors and determine the relevance of this study. Транснационализация - важнейшая составляющая и одновременно главный механизм общих процессов глобализации. Она представляется наиболее существенным элементом и одним из основных контуров-регуляторов, обеспечивающих единство функционирования мировой экономики. Через ТНК и связанные с ними транснациональные банки проходят финансовые и товарные потоки, которые определяют развитие мирового хозяйства. Они являются ведущим фактором глобализации экономики, размещая отдельные части и стадии воспроизводственных процессов по территориям разных стран. Именно эти факторы и обуславливают актуальность данного исследования. Транснац онал зац я - найважлив ша складова одночасно головний механ зм загальних процес в глобал зац . Вона представля ться найб льш стотним елементом одним з основних контур в-регулятор в, що забезпечують дн сть функц онування св тово економ ки. Через ТНК пов'язан з ними транснац ональн банки проходять ф нансов товарн потоки, як визначають розвиток св тового господарства. Вони пров дним чинником глобал зац економ ки, розм щаючи окрем частини й стад в дтворювальних процес в по територ ях р зних кра н. Саме ц чинники обумовлюють актуальн сть даного досл дження.
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