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Search Results: 1 - 10 of 112117 matches for " O. Konno "
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Coordination Always Occurs in a Two-Strategy Pure-Coordination Logit Game on Scale-Free Networks  [PDF]
Tomohiko Konno
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.54066
Abstract: We show that coordination always occurs in scale-free networks by social local interactions regardless of the values of parameters, while it occurs in regular networks if and only if the number of links times a payoff parameter exceeds the threshold. Scale-free networks are ubiquitous in the reality. We study a two-strategy pure coordination game on networks that indicate who plays with whom. A player chooses a strategy by Logit choice and the strategies are dynamically updated. Stable steady states are investigated.
Should a New Good Replace Existing Ones? A Network Approach  [PDF]
Tomohiko Konno
Theoretical Economics Letters (TEL) , 2015, DOI: 10.4236/tel.2015.54068
Abstract: We study goods (or service) with network effect. Social network services are examples. An existing service has an advantage over new one because of the network effect. We study the condition that new goods (or service) replace the existing one, and show that the condition depends on the underlying network structures. For this purpose, we study a coordination game with network structure. If more than half of the players change their strategies, then new strategy beats the existing one in regular networks. On the other hand, if very small number of players with large degree changes their strategies, then the new strategy beats the existing one in scale-free networks.
Potent Anticancer Effect of PET-Fraction (PET-F) in Comparison with Other Commercial Products on Canine Cancer Cells  [PDF]
Sensuke Konno, Muhammad Choudhury
Open Journal of Veterinary Medicine (OJVM) , 2015, DOI: 10.4236/ojvm.2015.55014
Abstract: A variety of nutritional supplements are commercially available for the potential therapeutic purpose for dogs and other domestic animals with cancers. However, the efficacy of these supplements on those cancer-bearing animals has not been verified and remains uncertain, due to the lack of the sufficient scientific studies/data. To address this important issue, we examined actual anticancer effects of five selected commercial products on the two types of canine cancer models in vitro. Among them, PET-Fraction (PET-F) obtained from maitake mushroom has been shown to have potent anticancer effect on canine cancer cells. In comparison with this PET-F, possible anticancer effects of the rest of four products were examined. Two of four products were found to have the significant anticancer effects on both cancer cells, while other two products had little effects. Nevertheless, PET-F exhibited the best anticancer effect. Cell cycle analysis indicated that the PET- F-induced growth reduction was attributed to a G1 cell cycle arrest, and Western blot analysis further revealed that such a growth reduction was coupled with apoptosis. Moreover, anticancer activity of PET-F was remarkably enhanced with vitamin C, but no such synergistic effect was seen with other four products. Therefore, although two other products besides PET-F yet have anticancer activities, PET-F appears to be the most potent and promising commercial product that can be useful in effectively and safely treating canine cancers.
Structural dissection of alkaline-denatured pepsin
Yuji O. Kamatari,Christopher M. Dobson,Takashi Konno
Spectroscopy: An International Journal , 2004, DOI: 10.1155/2004/769354
Abstract: Pepsin, a gastric aspartic proteinase, is a zymogen?derived protein that undergoes irreversible alkaline denaturation at pH 6–7. Detailed knowledge of the structure of the alkaline?denatured state is an important step in understanding the mechanism of the formation of the active enzyme. It has been established in a number of studies that the alkaline?denatured state of pepsin (the IP state) is composed of a compact C?terminal lobe and a largely unstructured N?terminal lobe. In the present study, we have investigated the residual structure in the IP state in more detail, using limited proteolysis to isolate and characterize a tightly folded core region from this partially denatured pepsin. The isolated core region corresponds to the 141 C?terminal residues of the pepsin molecule, which in the fully native state forms one of the two lobes of the structure. A comparative study using NMR and CD spectroscopy has revealed, however, that the N?terminal lobe contributes a substantial amount of additional residual structure to the IP state of pepsin. CD spectra indicate in addition that significant non?native α-helical structure is present in the C?terminal lobe of the structure when the N?terminal lobe of pepsin is either unfolded or removed by proteolysis. This study demonstrates that the structure of pepsin in the IP state is significantly more complex than that of a fully folded C?terminal lobe connected to an unstructured N?terminal lobe. The “misfolding” in this state could inhibit the proper refolding of the protein when returned to conditions that stabilize the native state.
On the Exact Solution of a Generalized Polya Process
Hidetoshi Konno
Advances in Mathematical Physics , 2010, DOI: 10.1155/2010/504267
Abstract: There are two types of master equations in describing nonequilibrium phenomena with memory effect: (i) the memory function type and (ii) the nonstationary type. A generalized Polya process is studied within the framework of a non-stationary type master equation approach. For a transition-rate with an arbitrary time-dependent relaxation function, the exact solution of a generalized Polya process is obtained. The characteristic features of temporal variation of the solution are displayed for some typical time-dependent relaxation functions reflecting memory in the systems. 1. Introduction The generalized master equation of memory function type [1] is a useful basis for analyzing non-equilibrium phenomena in open systems as where the kernel is conventionally assumed to have the product of a memory function with a transition rate as . The transition rate has the constraint with . This generalized master equation approach corresponds to the generalized Langevin equation of the memory function type [2, 3]. One can see many successful applications with long memory along the line of traditional formulation [1]. Looking around recent studies in complex open systems, there is an alternative approach based on a generalized non-stationary master equation [4] as The master equation in this form corresponds to the generalized Langevin equation of the convolutionless type, which is derived with the aid of projection operator method by Tokuyama and Mori [5]. The time-dependent coefficient may be written in the following form: . It is expected from the projection operator method [5] that the time-dependent function reflects the memory effect from varying environment in a different way associated with the memory function (cf. also H?nggi and Talkner [6]). The memory function (MF) formalism has been utilized in anomalous diffusion like Lévy type diffusion in atmospheric pollution, diffusion impurities in amorphous materials, and so on. The alternative convolution-less, non-stationary (NS) formalism gives only a small number of applications. The paper intends to exhibit a potential ability of the NS formalism by taking an arbitrary time-dependent function which is representing memory effect. The paper is organized as follows. Section 2 reviews the non-stationary Poisson process. Section 3 shows a generalized Polya process wherein it is involved a generalized non-stationary transition rate with an arbitrary function of time. The exact solution and the expression mean and variance are displayed as a function of . Some important remarks are given for a generalized
Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy
Sensuke Konno
International Journal of General Medicine , 2009, DOI: http://dx.doi.org/10.2147/IJGM.S5498
Abstract: ergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy Review (4735) Total Article Views Authors: Sensuke Konno Published Date May 2009 Volume 2009:2 Pages 91 - 108 DOI: http://dx.doi.org/10.2147/IJGM.S5498 Sensuke Konno Department of Urology, New York, Medical College, Valhalla, NY, USA Abstract: Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as β-glucan. PDF has been extensively studied and a number of its medicinal potentials/properties have been unveiled and demonstrated. Those include various physiological benefits ranging from immunomodulatory and antitumor activities to treatment for hypertension, diabetes, hypercholesterolemia, viral infections (hepatitis B and human immunodeficiency virus), and obesity. Particularly, two major biological activities of PDF, immunomodulatory and antitumor activities, have been the main target for scientific and clinical research. To demonstrate and confirm such biological activities, numerous studies have been performed in vitro and in vivo or in clinical settings. These studies showed that PDF was indeed capable of modulating immunologic and hematologic parameters, inhibiting or regressing the cancer cell growth, and even improving quality of life of cancer patients. Synergistic potentiation of PDF with vitamin C demonstrated in vitro is rather interesting and may have clinical implication, because such combination therapy appears to help improve the efficacy of currently ongoing cancer therapies. Recently, intravenous administration of vitamin C has been often used to increase its physiological concentration and this useful procedure may further make this combination therapy feasible. Therefore, PDF may have great potential, either being used solely or combined with other agents, for cancer therapy. Such relevant and detailed studies will be described and discussed herein with a special focus on the combination of PDF and vitamin C as a viable therapeutic option.
Dynamical R Matrices of Elliptic Quantum Groups and Connection Matrices for the q-KZ Equations
Hitoshi Konno
Symmetry, Integrability and Geometry : Methods and Applications , 2006,
Abstract: For any affine Lie algebra ${mathfrak g}$, we show that any finite dimensional representation of the universal dynamical $R$ matrix ${cal R}(lambda)$ of the elliptic quantum group ${cal B}_{q,lambda}({mathfrak g})$ coincides with a corresponding connection matrix for the solutions of the $q$-KZ equation associated with $U_q({mathfrak g})$. This provides a general connection between ${cal B}_{q,lambda}({mathfrak g})$ and the elliptic face (IRF or SOS) models. In particular, we construct vector representations of ${cal R}(lambda)$ for ${mathfrak g}=A_n^{(1)}$, $B_n^{(1)}$, $C_n^{(1)}$, $D_n^{(1)}$, and show that they coincide with the face weights derived by Jimbo, Miwa and Okado. We hence confirm the conjecture by Frenkel and Reshetikhin.
Methods for the Detection of D-Amino-Acid Oxidase
Konno Ryuichi
Biological Procedures Online , 1998, DOI: 10.1251/bpo7
Abstract: Four methods (an enzyme activity assay, western blotting, RT-PCR, and northern hybridization) to detect the enzyme D-amino-acid oxidase are described.
Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy
Sensuke Konno
International Journal of General Medicine , 2009,
Abstract: Sensuke KonnoDepartment of Urology, New York, Medical College, Valhalla, NY, USAAbstract: Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as β-glucan. PDF has been extensively studied and a number of its medicinal potentials/properties have been unveiled and demonstrated. Those include various physiological benefits ranging from immunomodulatory and antitumor activities to treatment for hypertension, diabetes, hypercholesterolemia, viral infections (hepatitis B and human immunodeficiency virus), and obesity. Particularly, two major biological activities of PDF, immunomodulatory and antitumor activities, have been the main target for scientific and clinical research. To demonstrate and confirm such biological activities, numerous studies have been performed in vitro and in vivo or in clinical settings. These studies showed that PDF was indeed capable of modulating immunologic and hematologic parameters, inhibiting or regressing the cancer cell growth, and even improving quality of life of cancer patients. Synergistic potentiation of PDF with vitamin C demonstrated in vitro is rather interesting and may have clinical implication, because such combination therapy appears to help improve the efficacy of currently ongoing cancer therapies. Recently, intravenous administration of vitamin C has been often used to increase its physiological concentration and this useful procedure may further make this combination therapy feasible. Therefore, PDF may have great potential, either being used solely or combined with other agents, for cancer therapy. Such relevant and detailed studies will be described and discussed herein with a special focus on the combination of PDF and vitamin C as a viable therapeutic option.Keywords: maitake D-fraction, PDF, vitamin C, synergism, cancer therapy
On the nature of fluctuations associated with fractional Poisson process
H. Konno
Advanced Studies in Theoretical Physics , 2012,
Abstract:
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