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Search Results: 1 - 10 of 4044 matches for " Nuno; Carneiro "
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Extensive intragenic recombination and patterns of linkage disequilibrium at the CSN3 locus in European rabbit
Carneiro Miguel,Ferrand Nuno
Genetics Selection Evolution , 2007, DOI: 10.1186/1297-9686-39-3-341
Abstract: Kappa-casein (CSN3) plays an important role in stabilising the Ca-sensitive caseins in the micelle. The European rabbit (Oryctolagus cuniculus) CSN3 has previously been shown to possess two alleles (A and B), which differ deeply in their intronic regions (indels of 100 and 1550 nucleotides in introns 1 and 4, respectively). Furthermore, a correlation between several reproductive performance traits and the different alleles was described. However, all these data were exclusively collected in rabbit domestic breeds, preventing a deeper understanding of the extensive polymorphism observed in the CSN3 gene. Additionally, the techniques available for the typing of both indel polymorphisms were until now not suitable for large-scale studies. In this report, we describe a simple, PCR-based typing method to distinguish rabbit CSN3 alleles. We analyse both ancient wild rabbit populations from the Iberian Peninsula and France, and the more recently derived English wild rabbits and domestic stocks. A new allele (C) showing another major indel (250 bp) in intron 1 was found, but exclusively detected in Iberian wild rabbits. In addition, our survey revealed the occurrence of new haplotypes in wild populations, suggesting that intragenic recombination is important in creating genetic diversity at this locus. This easy and low cost single-step PCR-based method results in an improvement over previous described techniques, can be easily set up in a routine molecular laboratory and would probably be a valuable tool in the management of rabbit domestic breeds.
“Do anel à alian a”: Sentido dos iguais e emancipa o pessoal na psicologia das sexualidades “From Ring to Wedding Band”: The sense of equals and personal emancipation in the psychology of sexualities “De l’anneau à l’alliance” : Le sens des égaux et l’émancipation personnelle dans la psychologie des sexualités
Nuno Santos Carneiro,Isabel Menezes
Revista Crítica de Ciências Sociais , 2012, DOI: 10.4000/rccs.864
Abstract: Sistematizando alguns processos subjacentes ao desenvolvimento psicológico da identidade (sexual), este artigo prop e uma Análise Psicossocial Crítica das sexualidades contemporaneas. A partilha vivencial da opress o nos contextos dos “iguais” é sublinhada pelos autores como dimens o nuclear do desenvolvimento identitário. Mais se prop e esta partilha como potenciadora de uma concilia o conceptual entre a abordagem psicológica das identidades sexuais e as propostas Queer a respeito das sexualidades. Em conclus o, s o apresentadas as implica es dessa concilia o para o desenvolvimento do sujeito nos múltiplos contextos de negocia o relacional das sexualidades “minoritárias”, enfatizando a complexidade psicológica necessária à emancipa o pessoal no seio destes contextos. Systematizing some of the processes that underlie the psychological development of (sexual) identity, this paper proposes a Critical Psychosocial Analysis of contemporary sexualities. The authors underline the experiential sharing of oppression in contexts of “equals” as the nuclear dimension of the development of identity. They further argue that this sharing potentiates a conceptual conciliation between the psychological approach to sexual identities and queer proposals regarding sexualities. In conclusion, the authors discuss the implications of this conciliation for the development of the subject in the multiple contexts of relational negotiation of “minority” sexualities, emphasizing the psychological complexity that is needed for personal emancipation within these contexts. Systématisant certains processus sous-jacents au développement psychologique de l’identité (sexuelle), cet article propose une analyse psychologique critique des sexualités contemporaines. Le partage vécu de l’oppression dans les contextes des “égaux” est souligné par les auteurs comme dimension nucléaire du développement identitaire. Cependant, ce partage est proposé comme potentiellement créateur d’une conciliation conceptuelle entre l’approche psychologique des identités sexuelles et les propositions queer au sujet des sexualités. Dans la conclusion seront présentées les implications de cette conciliation pour le développement du sujet dans les multiples contextes de négociation relationnelle des sexualités “minoritaires”, en mettant en relief la complexité psychologique nécessaire à l’émancipation personnelle au sein de ces contextes.
Escala multidimensional de atitudes face a lésbicas e a gays: constru o e valida o preliminar Escala multidimensional de actitudes hacia lesbianas y gays: construcción y validación preliminar Multidimensional scale of attitudes toward lesbians and gay men: construction and preliminary validation
Jorge Gato,Anne Marie Fontaine,Nuno Santos Carneiro
Paidéia (Ribeir?o Preto) , 2012, DOI: 10.1590/s0103-863x2012000100003
Abstract: O preconceito contra as pessoas n o heterossexuais persiste e atualmente assume diversas formas. Este estudo teve por objetivo apresentar o processo de constru o e valida o de um instrumento multidimensional de avalia o de atitudes face a lésbicas e a gays. Partindo de uma revis o teórica sobre diversos aspectos do preconceito anti-homossexual, foram definidos três tipos de atitudes negativas. Selecionou-se, em seguida, um conjunto de escalas pré-existentes, tendo os seus itens sido categorizados de acordo com as atitudes previstas. Análises fatoriais exploratórias revelaram uma escala composta por três dimens es atitudinais negativas, duas de caráter mais tradicional (Rejei o da proximidade e Homopatologiza o) e uma de caráter mais atual (Heterossexismo moderno), assim como por uma atitude positiva (Suporte). Todas as dimens es apresentaram uma b oa consistência interna. Provas adicionais da validade de constructo do instrumento foram obtidas através de um estudo diferencial, em fun o do sexo dos participantes e do seu contato interpessoal com lésbicas e gays. El prejuicio contra las personas no heterosexuales persiste, asumiendo diversas formas hoy día. Se presenta en este trabajo el proceso de construcción y validación de un instrumento multidimensional de evaluación de las actitudes hacia las lesbianas y los gays. Partiendo de una revisión teórica sobre diversos aspectos del prejuicio, fueron definidos tres tipos de actitudes negativas. Posteriormente fueron seleccionadas escalas de evaluación pre-existentes, siendo sus ítems categorizados de acuerdo con las actitudes propuestas. Análisis factoriales exploratorias revelaron una escala compuesta por tres dimensiones negativas, dos de carácter más tradicional (Rechazo de aproximación y Homopatologización) y una de carácter más actual (Heterosexismo moderno), así como por una actitud positiva (Soporte). Todas las dimensiones presentaron consistencia interna adecuada. Pruebas adicionales de validez de constructo fueron obtenidas a través de un estudio diferencial, en función del sexo de los participantes y de su contacto interpersonal con lesbianas y gays. Prejudice against non-heterosexual individuals persists and currently assumes various forms. This study describes the process of developing and validating a multidimensional instrument to assess attitudes toward lesbians and gay men. Three types of negative attitudes were defined based on a literature review of the various aspects of antigay prejudice. Existing scales were selected and their items were categorized according to expected attitudes
Quisto de Duplica??o Gástrica com Epitélio Pancreático Ectópico: Apresenta??o na Idade Adulta
Ribeiro,Sofia; Rego,Ana Catarina; Nunes,Nuno; Pereira,José Renato; Paz,Nuno; Carneiro,Vítor; Duarte,Maria Antónia;
Jornal Português de Gastrenterologia , 2012,
Abstract: gastrointestinal duplications cysts are a rare congenital disease and may arise anywhere in the gastrointestinal tract. the ileum and the jejunum are the most common sites and gastric localization is rare, comprising about 4 % of all alimentary tract duplications. most of them are diagnosed early in life. the authors report a case of gastric duplication cyst with ectopic pancreatic epithelium diagnosed in an adult submitted to surgery
Relationships of Selected Soil Parameters and Natural Pastures Yield in the Montado Ecosystem of the Mediterranean Area Using Multivariate Analysis
Ferreira,Eugénio Mendes; Sim?es,Nuno; Castro,Isabel Videira e; Carneiro,Luís;
Silva Lusitana , 2010,
Abstract: chemical, physical and biological soil parameters (om, total n, ph, p2o5, k2o, mg, b, whc, free-living nitrogen fixing and rhizobial microflora properties) and pastures yield were characterized and used to determine relationships in 40 locations covering different growth conditions of the "montado" ecosystem. soil samples were collected in spring. reasonable soil fertility was found. the soils presented, in general, intermediate values for om, k2o, mg, and bo and low values for ph and p2o5. populations of free-living nitrogen fixing bacteria were high, with an average of 4.2 x 107 cfu g-1 of soil, being nitrogenase activity highly variable, with an average of 34 nmoles of c2h4 g-1 of soil h-1. rhizobial population associated to trifolium subterraneum was high, with an average of 106 bacteria g-1 of soil, having adequate nitrogen fixing potential for the majority of the soils. rhizobial population associated to medicago polymorpha was low, with an average of 6.5 x 104 bacteria g-1 of soil, an insufficient value for a good nodulation, having low nitrogen fixing potential for the majority of the soils. annual yield of natural pastures varied highly among locals, with an average of 3245 kg ha-1, a usual value for this ecosystem. in general, soil properties were independent of the soil samples. the chemical parameters om, p2o5, k2o and total n were important factors to pasture yield. a great variability, even in soil samples collected within a short distance, was observed. a relationship between geological origin and productivity was found, being the granitic soils more productive in non-legume plants.
Multimodal Imaging of Acquired Vitelliform Lesion Diagnosed at Pseudohypopyon Stage
Nuno Moreira Gon?alves,?ngela M. Carneiro,Elisete Brand?o,Fernando M. Falc?o-Reis
Case Reports in Ophthalmological Medicine , 2013, DOI: 10.1155/2013/461758
Abstract: Purpose. To present a case study of a monocular acquired vitelliform lesion, studied with multimodal fundus imaging (spectral-domain-optical coherence tomography, fundus autofluorescence, and fluorescein angiography) with a followup of three years. Case Report. An asymptomatic macular lesion was detected on a 64-year-old man. Fundus exam revealed a macular lesion with an apparent horizontal level associated with multiple round small whitish lesions, suggestive of cuticular drusen. He was studied with autofluorescence of the fundus (FAF), fluorescein angiography (FA), spectral domain-optical coherence tomography (SD-OCT), and electrooculogram. The findings were compatible with the diagnosis of acquired vitelliform lesion, associated with cuticular drusen. After one year, the visual acuity decreased to 20/50, without identifiable alterations of the FAF, FA, or SD-OCT. Three years later, fundoscopy and imaging showed an evolution to a state similar to vitelli disruptive phase of Best disease with an improvement of visual acuity to 20/25. We report the results of FAF, FA, and SD-OCT at this stage. Conclusion. Acquired vitelliform lesions associated with cuticular drusen can present as a pseudohypopyon lesion, and the evolution to the atrophic phase can be associated with an improvement of visual acuity. 1. Introduction The term vitelliform lesions refers to accumulation of yellowish subretinal material. In younger patients, they usually occur in the setting of Best vitelliform macular dystrophy, an autosomal dominant disorder, associated with mutations in bestrophin 1 gene [1]. In adults, vitelliform lesions can occur associated with various disorders: age-related macular degeneration, cuticular drusen, or tractional maculopathies [1]. The classical staging of Best vitelliform macular dystrophy divides the progression of the disease into five stages: subclinical, vitelliform, pseudohypopyon, vitelliruptive, and atrophic [2]. These stages are also observed in acquired lesions; however, the pseudohypopyon stage is rarely identified. The case report we present shows a multimodal image study of an acquired vitelliform lesion, associated with cuticular drusen, diagnosed in the stage of pseudohypopyon. 2. Case Presentation In April 2009, a 64-year-old man was referred to the Retina Department to study a macular lesion OS. There was the suspicion of a choroidal neovascular lesion. The patient had a history of trauma to OD during childhood, with resulting traumatic cataract, exotropia, and amblyopia of OD. He had undergone phacoemulsification with insertion of an
Midair collisions enhance saltation
Marcus V. Carneiro,Nuno A. M. Araújo,Thomas P?htz,Hans J. Herrmann
Physics , 2012, DOI: 10.1103/PhysRevLett.111.058001
Abstract: Here we address the old question in Aeolian particle transport about the role of midair collisions. We find that, surprisingly, these collisions do enhance the overall flux substantially. The effect depends strongly on restitution coefficient and wind speed. We can explain this observation as a consequence of a soft-bed of grains which floats above the ground and reflects the highest flying particles. We make the unexpected observation that the flux is maximized at an intermediate restitution coefficient of about 0.7, which is comparable to values experimentally measured for collisions between sand grains.
Quantification of reachable attractors in asynchronous discrete dynamics
Nuno D. Mendes,Pedro T. Monteiro,Jorge Carneiro,Elisabeth Remy,Claudine Chaouiya
Computer Science , 2014,
Abstract: Motivation: Models of discrete concurrent systems often lead to huge and complex state transition graphs that represent their dynamics. This makes difficult to analyse dynamical properties. In particular, for logical models of biological regulatory networks, it is of real interest to study attractors and their reachability from specific initial conditions, i.e. to assess the potential asymptotical behaviours of the system. Beyond the identification of the reachable attractors, we propose to quantify this reachability. Results: Relying on the structure of the state transition graph, we estimate the probability of each attractor reachable from a given initial condition or from a portion of the state space. First, we present a quasi-exact solution with an original algorithm called Firefront, based on the exhaustive exploration of the reachable state space. Then, we introduce an adapted version of Monte Carlo simulation algorithm, termed Avatar, better suited to larger models. Firefront and Avatar methods are validated and compared to other related approaches, using as test cases logical models of synthetic and biological networks. Availability: Both algorithms are implemented as Perl scripts that can be freely downloaded from http://compbio.igc.gulbenkian.pt/nmd/node/59 along with Supplementary Material.
Discrete Element Method simulations of the saturation of aeolian sand transport
Thomas P?htz,Amir Omerad?i?,Marcus V. Carneiro,Nuno A. M. Araújo,Hans J. Herrmann
Physics , 2015, DOI: 10.1002/2014GL062945
Abstract: The saturation length of aeolian sand transport ($L_s$), characterizing the distance needed by wind-blown sand to adapt to changes in the wind shear, is essential for accurate modeling of the morphodynamics of Earth's sandy landscapes and for explaining the formation and shape of sand dunes. In the last decade, it has become a widely-accepted hypothesis that $L_s$ is proportional to the characteristic distance needed by transported particles to reach the wind speed (the ``drag length''). Here we challenge this hypothesis. From extensive numerical Discrete Element Method simulations, we find that, for medium and strong winds, $L_s\propto V_s^2/g$, where $V_s$ is the saturated value of the average speed of sand particles traveling above the surface and $g$ the gravitational constant. We show that this proportionality is consistent with a recent analytical model, in which the drag length is just one of four similarly important length scales relevant for sand transport saturation.
Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
André Albergaria, Joana Paredes, Bárbara Sousa, Fernanda Milanezi, Vítor Carneiro, Joana Bastos, Sandra Costa, Daniella Vieira, Nair Lopes, Eric W Lam, Nuno Lunet, Fernando Schmitt
Breast Cancer Research , 2009, DOI: 10.1186/bcr2327
Abstract: We evaluate FOXA1 and GATA-3 expression in 249 breast carcinomas by immunohistochemistry, associating it with breast cancer molecular markers, clinicopathological features and patient's survival. The clinicopathological features and immunohistochemical markers of the tumours were compared using the chi-square test and ANOVA. Disease-free survival was analysed through Kaplan–Meier survival curves and Cox regression.FOXA1 expression was demonstrated in 42% of invasive carcinomas, while GATA-3 was detected in 48% of the cases. FOXA1 expression was inversely associated with tumour size, Nottingham Prognostic Index, histological grade, lymph vascular invasion, lymph node stage and human epidermal growth factor receptor-2 (HER-2) overexpression, while GATA-3 expression showed inverse association with histological grade and HER-2. Both FOXA1 and GATA-3 were directly associated with ERα and progesterone receptor. Among FOXA1-positive tumours, 83.1% are comprised in the luminal A subtype, similar to GATA-3 where 87.7% of positive tumours were classified within this molecular subtype. In the subset of ERα-negative patients, those who were FOXA1-negative had a 3.61-fold increased risk of breast cancer recurrence when compared with the FOXA1-positive.FOXA1 was a significant predictor of good outcome in breast cancer, whereas GATA-3 was an important luminal marker. The expression of FOXA1 may be used for risk stratification among ERα-negative patients.The expression of oestrogen receptor (ER) is an important prognostic and predictive factor in breast cancer and has relevant implications for the biology of this type of carcinomas. Patients with tumours that express ER have a longer disease-free interval and overall survival than patients with tumours lacking ER expression [1].According to international treatment guidelines for early breast cancer, patients with ERα and/or progesterone receptor (PR) expression should receive an adjuvant endocrine therapy, since their expression is
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