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Search Results: 1 - 10 of 25 matches for " Novaretti "
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Importancia dos carreadores de oxigênio livre de células
Novaretti, Marcia Cristina Z.;
Revista Brasileira de Hematologia e Hemoterapia , 2007, DOI: 10.1590/S1516-84842007000400014
Abstract: the procedures needed to reduce transfusion-associated adverse effects, especially those related to transfusion-transmitted diseases and leukocyte-mediated alloimmunization, have a great impact on the production cost of blood components. additionally, blood transfusion has increased worldwide making the need for a safe substitute for blood evident. these products have been named artificial blood or blood substitutes. based on the fact that their focus has been oxygen delivery to tissues, "free oxygen carrying cells" is more appropriate. two major groups of free oxygen carring cells have been tested: modified hemoglobin solutions (bovine or human) and perfluorocarbons (pfcs). even though not without adverse effects, extensive clinical trials are being conducted to test their safety and efficacy. the understanding of free oxygen carrying cell mechanisms has made testing of a new generation of these products for other applications possible thereby expanding transfusion medicine frontiers.
O relacionamento acadêmico com a indústria farmacêutica nas ciências da vida
Novaretti Jo?o,Marotti Marcelo
Revista da Associa??o Médica Brasileira , 2004,
Abstract:
Clinical applications of immunoglobulin: update
Novaretti, Marcia Cristina Zago;Dinardo, Carla Luana;
Revista Brasileira de Hematologia e Hemoterapia , 2011, DOI: 10.5581/1516-8484.20110058
Abstract: human immunoglobulin is the most used blood product in the clinical practice. immunoglobulin applications have increased quickly since the elucidation of its immunomodulatory and antiinflammatory properties which turned this blood product into a precious tool in the treatment of numerous diseases that present with humoral immune deficiency or that cause immune system dysfunction. currently, the approved indications for ig are: primary immunodeficiencies, secondary immunodeficiencies (multiple myeloma or chronic lymphoid leukemia), kawasaki syndrome, immune thrombocytopenic purpura, guillain barré syndrome, graft-versus-host disease following bone marrow transplantation and repeat infections in hiv children. on the other hand, there are numerous "off-label" indications of immunoglobulin, which represent 20-60% of all clinical applications of this drug. it is important to study all these indications and, above all, the scientific evidence for its use, in order to provide patients with a new therapeutic option without burdening the health system. this review results from a wide selection of papers identified in the pubmed and lilacs scientific electronic databases. a group of descriptors were used from human immunoglobulin to the names of each disease that immunoglobulin is clinically applied. our main objective is to list the numerous indications of immunoglobulin, both authorized and "off-label" and to analyze these indications in the light of the most recent scientific evidence.
Immunoglobulin: production, mechanisms of action and formulations
Novaretti, Marcia Cristina Zago;Dinardo, Carla Luana;
Revista Brasileira de Hematologia e Hemoterapia , 2011, DOI: 10.5581/1516-8484.20110102
Abstract: human immunoglobulin (ig) began to be applied in the clinical practice with the treatment of primary immunodeficiencies. quickly, applications of ig increased, as its anti-inflammatory and immunomodulatory functions were elucidated. currently, ig is the most commonly used blood product. ig is obtained by processing plasma; methods, in particular, techniques to reduce plasma viral loads have been evolving over the years and include: pasteurization, solvent/ detergent treatment, caprylic acid treatment and nanofiltration. these methods contribute to increased safety and quality of blood products. the mechanisms of action of ig not only involve the blockade of fc receptors of phagocytes, but also control complement pathways, idiotype-anti-idiotype dimer formation, blockage of superantigen binding to t cells, inhibition of dendritic cells and stimulation of regulatory t cells (tregs). there are several formulations of ig available, each one with its own peculiar characteristics. in brazil, there is stringent legislation regulating the quality of ig. only ig products that completely fulfill the quality control criteria are released for use. these standards involve different tests from visual inspection to determination of anti-complementary activity. this paper will further review the history and current status of ig, including its production and mechanisms of action. the formulations available in brazil and also the criteria of quality control currently applied will be presented.
Aspectos moleculares do Sistema Sangüíneo ABO
Batissoco, Ana Carla;Novaretti, Marcia Cristina Zago;
Revista Brasileira de Hematologia e Hemoterapia , 2003, DOI: 10.1590/S1516-84842003000100008
Abstract: the abo blood group is the most important blood group system in transfusion medicine. antigens of the abo system consist of a or b carbohydrate structure carried on the substrate h antigen the abo gene is responsible for encoding for glycosyltransferases a or b that defines which specific carbohydrate is added to the end of h substance oligosaccharide chains, galnaca1-3 and gala1-3, respectively. the dna structure of the three major alleles of the human blood group abo system, a1 and b, was first described in 1990. advances of molecular genetics have allowed understanding of the molecular basis of the abo blood group system and the knowledge of the common alleles polymorphisms of this locus. this review article has the purpose of describing the variants of these alleles and the underlying mutations, deletions or rearrangement of the genes responsible for the occurrence of abo subgroups and o transferases inactivation. finally, various methods available for abo genotyping are also evaluated, as well as its advantages and limitations.
Aspectos moleculares do Sistema Sangüíneo ABO
Batissoco Ana Carla,Novaretti Marcia Cristina Zago
Revista Brasileira de Hematologia e Hemoterapia , 2003,
Abstract: O sistema ABO é o mais importante grupo sangüíneo na medicina transfusional. O gene ABO codifica as glicosiltransferases responsáveis pela transferência dos resíduos específicos de a úcar, GalNaca1-3 e Gala 1-3, ao substrato H e os convertem ao antígeno A ou B respectivamente. A estrutura do DNA dos três principais alelos do sistema ABO, A1, B e O foi primeiramente descrita em 1990. Os avan os da genética molecular permitiram o entendimento da base molecular dos genes ABO e o conhecimento do polimorfismo dos alelos comuns a esse locus. Essa revis o tem como objetivo o estudo dos alelos variantes desse sistema, assim como a compreens o das muta es, dele es ou rearranjo de genes responsáveis pela ocorrência de alguns dos subgrupos do sistema ABO. As técnicas mais comumente utilizadas para a genotipagem ABO também s o avaliadas, bem como suas vantagens e limita es.
Sistema de grupo sangüíneo Duffy: biologia e prática transfusional
Jens, Eduardo;Pagliarini, Thiago;Novaretti, Marcia C. Z.;
Revista Brasileira de Hematologia e Hemoterapia , 2005, DOI: 10.1590/S1516-84842005000200011
Abstract: after the introduction of the indirect antiglobulin technique by coombs in the middle of the 1940's, several antibodies have been discovered. duffy blood group system came to light when cutbush and ikin detected the first antibodies related to this system in the beginning of the 1950's. the antibodies of this system are clinically significant in transfusional practice as they have been involved in hemolytic transfusion reactions and hemolytic disease of the newborn, showing them to be of worldwide occurrence. the fy gene is constituted of two exons and its locus was mapped on chromosome 1q22-q23. the fya and fyb antigens are encoded by fya and fyb alleles, and are responsible for the fy(a+b-), fy(a-b+) and fy(a+b+) phenotypes. they are carried by a 336 amino acid glycoprotein called darc (duffy antigen/receptor for chemokines) which has high affinity to chemokines, also being plasmodium vivax receptors. the polymorphisms related to its alleles have led to the development of a pcr genotyping technique, which is useful for the safety of blood transfusion, and determining fetus-maternal incompatibilities. in the last decade, much research has been done to determine the biological role of blood group antigens. in this paper we reviewed the duffy blood group system, especially in respect to transfusional practice and biological functions.
Fun??es biológicas dos antígenos eritrocitários
Bonifácio, Silvia L.;Novaretti, Marcia C. Z.;
Revista Brasileira de Hematologia e Hemoterapia , 2009, DOI: 10.1590/S1516-84842009005000015
Abstract: erythrocyte blood group antigens are macromolecules structures located on the extracellular surface of the red blood cell membrane. the development of molecular studies allowed the recognition of more than 250 antigens by the international society for blood transfusion (isbt). these studies have also shown that blood group antigens are carried on red blood cell membrane of wide structural diversity, including carbohydrate epitopes on glycoproteins and/or glycolipids and on proteins inserted within the membrane via single or multi-pass transmembrane domains, or via glycosylphosphatidylinositol linkages. in addition, to their structural diversity, many important functions associated with blood group antigens have been recently identified and can be didactically divided into: structural proteins, transporters, receptors and adhesion molecules, enzymes, complement control proteins and others. this review will focus on the potential functions of the molecules that express blood group antigens.
Estudo de grupos sangüíneos em doadores de sangue caucasóides e negróides na cidade de S?o Paulo
Novaretti, Marcia C. Z.;Dorlhiac-Llacer, Pedro E.;Chamone, Dalton A.F.;
Revista Brasileira de Hematologia e Hemoterapia , 2000, DOI: 10.1590/S1516-84842000000100004
Abstract: despite the fact mulattos (individuals resulting from admixture of caucasian and black individuals) represent one of the most common racial mixed individuals not only in brazil but in many other countries, there is little information regarding the distribution of blood groups among them. we studied 2,462 blood donors classified as caucasian, mulattos e blacks according to their anthropological characteristics as well as to their ancestry information. phenotype frequencies were studied in the abo, mns, p, rh, lutheran, kell, lewis, duffy e kidd blood group systems. we did not find significant statistically difference between blacks and mulattos for the majority of the blood groups systems here reported, excepting of p1 positive, dccee, le(a-b-), js(a+b+), js(a-b+), fy(a-b-), fy(a+b+) e fy(a-b+). on the other he there was a significant difference between caucasian and blacks for the following red blood cells phenotypes: a, b, m+n-s+s-, m+n-s-s+, p1 positivo, ddccee, dccee, dccee, dccee, dccee, k+k+, k-k+, kp(a-b+), kp(a+b+), js(a-b+), js(a+b-), le(a-b+), le(a-b-), fy(a-b+), fy(a+b+), fy(a-b-), jk(a+b-), jk(a+b+) e jk(a-b+). conclusion: as expected, the results for the mulattos group were intermediate between caucasian and blacks, with strong negroid influence.
Controle de qualidade interno de regentes em imunohematologia: aspectos práticos
Novaretti, Marcia C. Z.;Bueno, Valdecir J.;Dorlhiac-Llacer, Pedro E.;Chamone, Dalton A. F.;
Revista Brasileira de Hematologia e Hemoterapia , 2002, DOI: 10.1590/S1516-84842002000400005
Abstract: one of the main objectives of transfusion medicine is to promote safe transfusion. continuous improvement involves the standardization of techniques used for quality control of reagents, adequate equipment evaluation and its maintenance and staff training. quality control of reagents is critical for achieving reliable results in immunohematological testing. in brazil, as far as we know, there are no minimum requirements for immunohematological reagent guidelines. this paper has the purpose of describing practical aspects of quality control in imunohematology, as well as providing information on the most common immunohematological reagents available on the brazilian market.
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