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Search Results: 1 - 10 of 26761 matches for " Novak Martin "
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Risk of infection after placement of an extraventricular drainage catheter
Novak Vesna,Stefanovi? Ivan,Kosti? Aleksandar,Novak Martin
Srpski Arhiv za Celokupno Lekarstvo , 2012, DOI: 10.2298/sarh1204138n
Abstract: Introduction. The occurrence of infection after the placement of an extraventricular drainage (EVD) catheter can be a very serious problem in neurosurgery. Objective. The aim of this study was to confirm that the use of special catheters with impregnated antibiotics decreased the percentage of infection. Methods. The prospective study conducted at the Clinic of Neurosurgery in Ni in the period 2006-2009 is presented. Group 1 comprised of 43 patients in whom a commonly used system for EVD was applied. Group 2 comprised of 39 patients in whom the Rifampycin and Clindamycin impregnated EVD catheters were applied (Bactiseal catheters). Results. In Group 1 infection occurred in nine patients, mainly caused by bacteria of Staphylococcus genus. In Group 2 only two patients developed infections caused by Acinetobacter. Conclusion. The use of Bactiseal EVD catheters considerably decreased the percentage of infection occurrence with prolonged EVD catheter drainage period.
Vesna Novak,Velimir Kostic,Goran Ignjatovic,Martin Novak
Acta Medica Medianae , 2001,
Abstract: Intrahospital infections represent a serious problem in medicine. Withneurochirurgical patients infections can seriously damage the quality of treatmentwhile in some cases they can threaten patients' lives. Meningitis, brain abscess,osteomyelitis or secondary wound healing are complications caused by infection. Inthe period between October, 28, to December, 24, 1999, at the Neurochirurgicalclinic in Ni there was an intrahospital infection caused by the bacteria Serattia. Thesource of the infection was not discovered. Comprehensive measures wereundertaken for disinfecting the operation block and the intensive treatment unit aswell as a sanitary examination of the staff. In 2000 there was no record of any new a e of the infection caused by the bacteria.
Factors Impacting Corn (Zea mays L.) Establishment and the Role of Uniform Establishment on Yield  [PDF]
Lindsey Novak, Joel Ransom
Agricultural Sciences (AS) , 2018, DOI: 10.4236/as.2018.910092
Abstract: Information from actual farm fields can help corn producers understand the value and importance of establishing uniform crop emergence and within-row plant spacing. Thirty-eight fields planted with corn (Zea mays L.) by North Dakota producers were evaluated to determine the effects of uneven plant emergence timing and within-row plant space variability, as well as identifying contributing factors. Rows within a planter’s width with the most variability yielded 6% less than the least variable rows. Individual ear weights decreased as the number of days after normal emergence (date when 50% of plant stand emerged) increased. Ears next to within-row gaps (>30.5 cm) weighed 11% more than the normally spaced plants. Combined ears from both plants situated <5.1 cm apart weighed 36% more than from a single ear from normally spaced plants. Surface residue and planting speed impacted stand establishment variability more often than other factors measured. Producers should assess each field environment individually in order to identify best practices to achieve uniform stand establishment.
Effect of step-synchronized vibration stimulation of soles on gait in Parkinson's disease: a pilot study
Peter Novak, Vera Novak
Journal of NeuroEngineering and Rehabilitation , 2006, DOI: 10.1186/1743-0003-3-9
Abstract: This pilot study assessed the effects of enhanced proprioceptive feedback using step-synchronized vibration stimulation of the soles (S-VS) on gait in PD. S-VS was used in 8 PD subjects (3 women and 5 men, age range 44–79 years, on medication) and 8 age-matched healthy subjects (5 women and 3 men). PD subjects had mild or moderate gait impairment associated with abnormal balance, but they did not have gait freezing. Three vibratory devices (VDs) were embedded in elastic insoles (one below the heel and two below the forefoot areas) inserted into the shoes. Each VD operates independently and has a pressure switch that activates the underlying vibratory actuator. The VD delivered the 70-Hz suprathreshold vibration pulse upon touch by the heel or forefoot, and the vibration pulse was deactivated upon respective push-offs. Six-minute hallway walking was studied with and without S-VS. Gait characteristics were measured using the force-sensitive foot switches. The primary outcome was the stride variability expressed as a coefficient of variation (CV), a measure of gait steadiness. Secondary outcome measures were walking distance and speed, stride length and duration, cadence, stance, swing and double support duration, and respective CVs (if applicable).The walking speed (p < 0.04) and the CV of the stride interval (p < 0.02) differed between the groups and S-VS conditions. In the PD group, S-VS decreased stride variability (p < 0.002), increased walking speed (p < 0.0001), stride duration (p < 0.01), stride length (p < 0.0002), and cadence (p < 0.03). In the control group, S-VS decreased stride variability (p < 0.006) and increased gait speed (p < 0.03), but other locomotion parameters were not significantly altered.Augmented sensory feedback improves parkinsonian gait steadiness in the short-term setting. Because the suprathreshold stimulation prevented blinding of subjects, the learning effect and increased attention can be a confounding factor underlying results. Long-t
N-Terminal Domain of Nuclear IL-1α Shows Structural Similarity to the C-Terminal Domain of Snf1 and Binds to the HAT/Core Module of the SAGA Complex
Blanka Zamostna, Josef Novak, Vaclav Vopalensky, Tomas Masek, Ladislav Burysek, Martin Pospisek
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041801
Abstract: Interleukin-1α (IL-1α) is a proinflammatory cytokine and a key player in host immune responses in higher eukaryotes. IL-1α has pleiotropic effects on a wide range of cell types, and it has been extensively studied for its ability to contribute to various autoimmune and inflammation-linked disorders, including rheumatoid arthritis, Alzheimer’s disease, systemic sclerosis and cardiovascular disorders. Interestingly, a significant proportion of IL-1α is translocated to the cell nucleus, in which it interacts with histone acetyltransferase complexes. Despite the importance of IL-1α, little is known regarding its binding targets and functions in the nucleus. We took advantage of the histone acetyltransferase (HAT) complexes being evolutionarily conserved from yeast to humans and the yeast SAGA complex serving as an epitome of the eukaryotic HAT complexes. Using gene knock-out technique and co-immunoprecipitation of the IL-1α precursor with TAP-tagged subunits of the yeast HAT complexes, we mapped the IL-1α-binding site to the HAT/Core module of the SAGA complex. We also predicted the 3-D structure of the IL-1α N-terminal domain, and by employing structure similarity searches, we found a similar structure in the C-terminal regulatory region of the catalytic subunit of the AMP-activated/Snf1 protein kinases, which interact with HAT complexes both in mammals and yeast, respectively. This finding is further supported with the ability of the IL-1α precursor to partially rescue growth defects of snf1Δ yeast strains on media containing 3-Amino-1,2,4-triazole (3-AT), a competitive inhibitor of His3. Finally, the careful evaluation of our data together with other published data in the field allows us to hypothesize a new function for the ADA complex in SAGA complex assembly.
Searching for mechanisms that matter in early septic acute kidney injury: an experimental study
Jan Benes, Jiri Chvojka, Roman Sykora, Jaroslav Radej, Ales Krouzecky, Ivan Novak, Martin Matejovic
Critical Care , 2011, DOI: 10.1186/cc10517
Abstract: Thirty-six pigs were anesthetized, mechanically ventilated, and instrumented. After a recovery period, progressive sepsis was induced either by peritonitis (n = 13) or by continuous intravenous infusion of live Pseudomonas aeruginosa (n = 15). Eight sham operated-on animals served as time-matched controls. All animals received standard intensive care unit (ICU) care, including goal-directed hemodynamic management. Before, and at 12, 18, and 22 hours of sepsis, systemic and renal (ultrasound flow probe) hemodynamics, renal cortex microcirculation (laser Doppler), inflammation (interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), oxidative stress (thiobarbituric acid reactive species (TBARS), nitrite/nitrate concentrations (NOx), and renal oxygen kinetics and energy metabolism were measured.In 14 (50%) pigs, AKI developed (62% in peritonitis, 40% in bacteria infusion model). Fecal peritonitis resulted in hyperdynamic circulation, whereas continuous bacteria infusion was associated with normodynamic hemodynamics. Despite insults of equal magnitude, comparable systemic hemodynamic response, and uniform supportive treatment, only those pigs with AKI exhibited a progressive increase in renal vascular resistance. This intrarenal vasoconstriction occurred predominantly in the live-bacteria infusion model. In contrast to AKI-free animals, the development of septic AKI was preceded by early and remarkable inflammatory response (TNF-α, IL-6) and oxidative stress (TBARS).The observed variability in susceptibility to septic AKI in our models replicates that of human disease. Early abnormal host response accompanied by subsequent uncoupling between systemic and renal vascular resistance appear to be major determinants in the early phase of porcine septic AKI. Nonuniform and model-related renal hemodynamic responses that are unpredictable from systemic changes should be taken into consideration when evaluating hemodynamic therapeutic interventions in septic AKI.The major imp
Modelling the steady state and dynamic conditions of a biotrickling filter treating styrene and acetone in air
Gerrard, Andrew Mark;Havranek, Josef;Novak, Vratislav;Halecky, Martin;Jones, Kim;Soccol, Carlos Ricardo;Paca, Jan;
Brazilian Archives of Biology and Technology , 2010, DOI: 10.1590/S1516-89132010000500028
Abstract: the aim of this work was the study a trickling biofilter, where water was circulated throughout the bed. in the first steady state experiment, the packing materials used were 25mm pall rings. the airflow rate was increased gradually and the concentration of styrene in the air stream was held constant. in the second experiment, 15mm pall rings were used. in this case, the feed contained both styrene and a small amount of acetone. the concentration of acetone and the air flow rate were kept constant, but the styrene inlet concentration was increased. the concentrations were measured at the input, and also at an intermediate and the outlet position in the biotrickling filter to determine the concentration profile along the reactor. using the values of coefficient of determination (r2) and the coefficient of variation of the fitted constant as criteria, a zero order model with diffusional limitation was chosen as the best representation of the data. then a further, third, set of experiments were done at unsteady state, using step changes of the inlet concentration levels of both styrene and acetone at a steady air flow-rate . inlet and outlet concentrations were measured as a function of time and the results were adequately described using a simple first order model.
Professional terminology - a component of interoperability of cultural and with them associated contents
Miroslav Novak
Knji?nica : Revija za Podro?je Bibliotekarstva in Informacijske Znanosti , 2011,
Abstract: The author defines the term "interoperability" as the ability of information systems to interexchange data, information and knowledge. These processes can take place within a field or among different professional areas. One of the preliminary conditions for successful implementation of these processes is the establishment of successful communication based on consistent professional terminology. The author exposes some basic archival professional terms defined in the current Slovenian archival legislation and professional standards. He stresses some semantic problems of implementation of these terms in different fields. In his opinion terminological deficiencies must be coordinated if we want to achieve long-term sustainability and usability of the cultural contents in the electronic environment. Otherwise these problems can represent a serious threat of the expected interoperability realization.
On archiving of web sites and the problems of their keeping, preserving and using
Miroslav Novak
Knji?nica : Revija za Podro?je Bibliotekarstva in Informacijske Znanosti , 2002,
Abstract: Web sites are defined as part of the cultural heritage. They are systematised in frame of electronic documents and appear in different contexts. From the evaluation point of view, we can realise that not only are contents important, but also the esthetical, communicational and other elements, which have direct influence on the level of the formation of inter-human communication in modern society, are significant as well. This is also the main reason why certain web sites must be kept and preserved through longer periods, others however should be archived with wholeness of contexts, in which they had been established or had operated.
The Highway Razdrto-Diva a-Se ana and its In uence upon the Groundwater on Kras (Karst)
Du?an Novak
Geologija , 1992,
Abstract: The future highway Razdrto-Diva a-Se ana will cross the area of intense karstification and the narrow district of the underground course of the Notranjska Reka.The karstic groundwater flows from various directions towards the Timava near Nabre ina and towards the pumping station of the Kras Water Supply System at Brestovica.The influences from the highway area can reach the Timava springs within 11days. The adequate protection has to be forseen in order to prevent the pollution of the karst underground waters.
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