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Search Results: 1 - 10 of 80 matches for " Nosratollah Zarghami "
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Levels of oxidative stress biomarkers in seminal plasma and their relationship with seminal parameters
Ali Khosrowbeygi, Nosratollah Zarghami
BMC Clinical Pathology , 2007, DOI: 10.1186/1472-6890-7-6
Abstract: The patients consisted of 46 men with seminal parameters abnormalities. The patients were grouped into asthenozoospermic (n = 15), asthenoteratozoospermic (n = 16) and oligoasthenoteratozoospermic (n = 15). The control group consisted of 16 healthy males with normozoospermia. Catalase activity was measured by Aebi spectrophotometeric method. Levels of TAC and SOD were measured by commercially available colorimetric assays. Level of free 8-Isoprostane was assessed by commercially available enzyme immunoassay (EIA) method. Differences between groups were assessed using Mann-Whitney U test and Kruskal-Wallis test. Coefficients of correlation were calculated using Spearman's correlation analysis. All hypothesis tests were two-tailed with statistical significance assessed at the p value < 0.05 level with 95% confidence intervalsLevels of catalase and TAC were significantly lower in patients than the control group. No significant changes were seen in SOD activities. Levels of free 8-Isoprostane were significantly higher in patients than the control group. Furthermore, asthenozoospermic, asthenoteratozoospermic and oligoasthenoteratozoospermic groups had significantly lower values of catalase activity and TAC when compared to normozoospermic males. Levels of free 8-Isoprostane were significantly higher in all patients subgroups than the control group. Levels of catalase and TAC were positively correlated with sperm motility and morphology. Free 8-Isoprostane levels showed an inverse correlation with sperm motility and morphology.Decreasing seminal plasma antioxidants levels, especially catalase and TAC, could have significant role in etiology of impaired sperm function. Measurement of 8-Isoprostane may be used as a specific biomarker for assessing oxidative stress on sperm.In the etiology of male infertility, there is growing evidence that damage to spermatozoa by reactive oxygen species (ROS) play a key role [1,2]. Spermatozoa contain large quantities of polyunsaturated f
Studies of the Relationship between Structure and Antioxidant Activity in Interesting Systems, Including Tyrosol, Hydroxytyrosol Derivatives Indicated by Quantum Chemical Calculations  [PDF]
Rogaie Rezaei-Sadabady, Nosratollah Zarghami, Abolfazl Barzegar, Akram Eidi, Abolfazl Akbarzadeh, Mustafa Rezaei-Tavirani
Soft (Soft) , 2013, DOI: 10.4236/soft.2013.23004
Abstract:

In nature, tyrosol (TY) and hydroxytyrosol (HT) are found in olive leaves which are for medical aims, with immune stimulant and antibiotic properties as well as the ability to be used for the treatment of neurodegenerative diseases such as Alzheimer. This ability of phytochemical TY and HT compounds are mainly believed to be of higher radical scavenging potential with effective antioxidant properties. In order to establish the possible structure-antioxidant activity relationship of tyrosol, hydroxytyrosol, hydroxytyrosol acetate and two designed hydroxytyrosol derivatives were studied by the help of quantum chemical calculations. The molecular electronic properties such as heat formation of the neutral, radical and orbitals energies were calculated as descriptors to predict the H atom donating abilities of compounds. Considering the results from the calculated descriptors, the derivatives having OH group substitutions in position number four of the aromatic ring can be classified highly active and better antioxidant compound. Therefore, the designed hydroxytyrosol derivatives showed most active feasible H atom donation. This work can be useful to design novel antioxidants.

Comparison of Inhibitory Effect of Curcumin Nanoparticles and Free Curcumin in Human Telomerase Reverse Transcriptase Gene Expression in Breast Cancer
Fatemeh Kazemi-Lomedasht,Abbas Rami,Nosratollah Zarghami
Advanced Pharmaceutical Bulletin , 2013, DOI: 10.5681/apb.2013.021
Abstract: Purpose: Telomerase is expressed in most cancers, including breast cancer. Curcumin, a polyphenolic compound that obtained from the herb of Curcuma longa, has many anticancer effects. But, its effect is low due to poor water solubility. In order to improve its solubility and drug delivery, we have utilized a β-cyclodextrin-curcumin inclusion complex. Methods: To evaluate cytotoxic effects of cyclodextrin-curcumin and free curcumin, MTT assay was done. Cells were treated with equal concentration of cyclodextrin-curcumin and free curcumin. Telomerase gene expression level in two groups was compared by Real-time PCR. Results: MTT assay demonstrated that β-cyclodextrin-curcumin enhanced curcumin delivery in T47D breast cancer cells. The level of telomerase gene expression in cells treated with cyclodextrin-curcumin was lower than that of cells treated with free curcumin (P=0.001). Conclusion: Results are suggesting that cyclodextrin-curcumin complex can be more effective than free curcumin in inhibition of telomerase expression.
INFLUENCE OF CHRONIC EXERCISE ON RED CELL ANTIOXIDANT DEFENSE, PLASMA MALONDIALDEHYDE AND TOTAL ANTIOXIDANT CAPACITY IN HYPERCHOLESTEROLEMIC RABBITS
Mohsen Alipour,Mustafa Mohammadi,Nosratollah Zarghami,Nasser Ahmadiasl
Journal of Sports Science and Medicine , 2006,
Abstract: Despite the knowledge on the antiatherogenic effects of exercise, the mechanism by which exercise reduces atherogenic risk remains unknown. In this study, we investigated the hypothesis that chronic exercise-induced oxidative stress may increase plasma total antioxidant capacity and antioxidant defense in the red cells. For 8 weeks, 60 male Dutch rabbits were fed rabbit chow with or without the addition of 2% cholesterol. The animals were further divided into rest and exercise groups (n = 15 for each group). Animals in exercise groups ran on a rodent treadmill at 15 m/min for 10 to 60 minutes gradually for 5 days per week for a total of 8 weeks. At the end of experiments, blood samples were collected and glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) activities were determined in red blood cells. Total antioxidant capacity (TAC), malondialdehyde (MDA) and total thiol (T-SH) levels were measured in plasma. Thoracic aorta and carotid arteries were isolated for histological examination to evaluate atherosclerosis. Eight weeks of chronic exercise reduced atherogenic diet-induced atherosclerotic lesions in all the arteries studied, along with positive changes in cholesterol profile, especially increase of serum HDL-C level. Plasma MDA, TAC and T-SH concentrations were enhanced by exercise in both control and hypercholesterolemic diet groups. Erythrocyte catalase activity was significantly increased by chronic exercise (p < 0.05), whereas total SOD activity rose with exercise only in the control group. Surprisingly, GPX activity was significantly reduced (P < 0.05) in response to exercise in the control group and also in the high cholesterol diet group. Exercise is a useful tool for the prevention and regression of atherosclerosis which is evident by our findings of the enhancement of plasma TAC and positive change in serum cholesterol profile. However, the effect of exercise on red cell antioxidant activities is limited in the hypercholesterolemic animals compared to control animals, possibly in part because of alterations in the ability to adapt to exercise-induced oxidative stress in high cholesterol diet
Adiponectin Can Affect ER Signaling in Obese Breast Cancer Patients  [PDF]
Rana Jahanban Esfahlan, Nosratollah Zarghami, Samira Valiyari, Hamed Farshbaf Kamel, Maryam Daneshvar, Ali Jahanban Esfahlan, Majid Mobasseri, Kazem Nejati-Koshki
Journal of Cancer Therapy (JCT) , 2012, DOI: 10.4236/jct.2012.31015
Abstract: Background: While the various antitumororal activities of adiponectin as an adipocyte-derived hormone well studied, it is speculated that there is a crosstalk between adiponectin and esterogen receptor (ER) signaling. To test this hypothesis we evaluate the possible correlation between serum level of adiponectin with two estrogen receptors (ERα and ERβ) gene expression in breast cancer patients. Methods: In this case-control study, 70 women with breast cancer participated with different grades of obesity (36 none obese, BMI < 25 kg/m2 and 34 obese, BMI ≥ 25 kg/m2).The mean age of Participants was 44.53 yr ± 1.79 yr (21 yr - 70 yr) .Serum level of adiponectin determined by ELISA. Following quantitative expression of estrogen receptors mRNA in tumor tissues was evaluated by Real-time PCR. Results: We find a significant reverse correlation between serum level of Adiponectin and ERα mRNA (r = –0.229, n = 64, p = 0.035) but no correlation was between adiponectin and ERβ in samples (p = 0.228). The lower adiponectin multiplied the odds of having higher ERα mRNA level by a factor of OR = 4.33, 1.28 - 14.6, 95% confidence interval (CI) as compared with those that displayed a moderate or higher serum level of adiponectin (>7.02 ng/ml). The same odds for next estrogen receptor, ERβ, was not greater than unity (OR = 0.31, 0.06 - 1.56, 95% CI). Conclusion: According to the obtained results, it is speculated that as adiponectin can affect ERs gene expression, so affecting the steroid receptor signaling can be proposed as a new underling mechanism of action for this adipokine in breast cancer pathogenesis especially in obese ones.
Quantification of Steroid Receptors Gene Expression in Breast Cancer Patients: Possible Correlation with Serum Level of Adipocytokines  [PDF]
Rana Jahanban Esfahlan, Nosratollah Zarghami, Μohammad Rahmati-Yamchi, Amir Monfaredan, Samira Valiyari, Ali Jahanban Esfahlan, Raziallah Jafari Jozani, Morteza Gojazadeh, Fereidoun Mamaghani, Majid Mobasseri
Journal of Cancer Therapy (JCT) , 2011, DOI: 10.4236/jct.2011.25088
Abstract: Background: While the role of adipocyte-derived hormones in breast cancer pathogenesis well studied, it is speculated that there is a crosstalk between adipocytokines and Esterogen receptor(ER) signaling. To test this hypothesis we evaluate the possible correlation between serum levels of adipocytokins with steroid hormone receptors gene expression in breast cancer patients. Methods: In this case-control study, 70 women with breast cancer participated with different grades of obesity (36 none obese, BMI < 25 kg/m2 and 34 obese, BMI ≥ 25 kg/m2). Serum level of adiponectin, leptin, TNFα and IL6 determined by ELISA. Following quantitative expression of androgen receptor (AR), progesterone receptor (PR) and estrogen receptors (ERα and ERβ) mRNA in tumor tissues evaluated by Real-time PCR. Results: We find a significant reverse correlation between serum level of Adiponectin and ERα and PR mRNA (r = –0.229, n = 64, p = 0.035 and r = –0.220, n = 64, p = 0.041) but no correlation was between adiponectin and, ERβ and AR in samples (P > 0.05). In case of leptin, we observed a positive correlation between leptin and ERα and PR mRNA. (r = 0.553, n = 64, p < 0.001, r = 0.359, n = 64, p = 0.002 and a reverse significant correlation between leptin and ERβ (r= –0.506, n = 64 and p < 0.001). We also observed a significant correlation between TNFα and IL6 with steroid receptors gene expression in samples (P < 0.05). Conclusion: As the presence of steroid receptors are used as the most common prognostic markers in breast cancer patients, so targeting adipocytokines as potential regulators of steroid receptorsgene expression can be a new approach in treatment of obese breast cancer subjects.
Wool characteristics of crossbred Baghdadi wild ram and Iran native sheep  [PDF]
Nosratollah Taherpour, Farhad Mirzaei
Agricultural Sciences (AS) , 2012, DOI: 10.4236/as.2012.32021
Abstract: Twenty mid side wool samples of crossbred sheep were collected and their characteristics were determined. Data analyzed by SAS software and Duncan’s multiple range tests was used for comparison of mean wool characteristics. Average fleece weight, yield, wool diameter, Fine fiber and staple length were: 431.59 ± 38.95 gr, 65.14%, 14.24 ± 0.67 μm, 48.67 ± 5.59, and 43.65 ± 4.15 mm respectively. Mean fleece weight was significantly affected (p < 0.05) by sex (female 259 gr and male 506.55) and age (248.25, 458.38 and 637.75 gr for 1, 2 and 3 yr old respectively). Mean wool diameter was significantly affected by sex (male 12.78 ± 0.49, female 15.33 ± 0.85 μm) and there was a significant difference (p < 0.05) between F1 and F2 generation 11.84 ± 0.58, 16.27 ± 0.72 μm respectively. There were effective differences among ages (12.55 ± 0.74, 14.47 ± 0.58 and 13.11 ± 0.64 μm for 1, 2 and 3 yr old respectively). Wool diameter of younger animals, males and F1 was so fine (12.55, 12.87 and 11.84 μm respectively). Staple length of F2 crosses was significantly longer than F1 crosses (p < 0.05). However wool diameter of F1 was significantly finer than F2, but length and down fiber percentage was less than second generation. As wild sheep shed his fiber in winter, the first filial crosses also shed their fibers from the end of winter to early spring. Shedding was seldom observed in F2 generations. It seems likely that wool from crossbred sheep could be used for those applications for which cashmere is suitable. This study indicates that, such crossbred sheep have a superfine wool and could be used in pure or blend for textile industry.
Liposome: classification, preparation, and applications
Abolfazl Akbarzadeh, Rogaie Rezaei-Sadabady,, Soodabeh Davaran, Sang Woo Joo, Nosratollah Zarghami, Younes Hanifehpour, Mohammad Samiei, Mohammad Kouhi and Kazem Nejati-Koshki
Nanoscale Research Letters , 2013, DOI: 10.1186/1556-276X-8-102
Abstract: Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were first described in the mid-60s. Today, they are a very useful reproduction, reagent, and tool in various scientific disciplines, including mathematics and theoretical physics, biophysics, chemistry, colloid science, biochemistry, and biology. Since then, liposomes have made their way to the market. Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. Research on liposome technology has progressed from conventional vesicles to ‘second-generation liposomes’, in which long-circulating liposomes are obtained by modulating the lipid composition, size, and charge of the vesicle. Liposomes with modified surfaces have also been developed using several molecules, such as glycolipids or sialic acid. This paper summarizes exclusively scalable techniques and focuses on strengths, respectively, limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.
Evaluation certain environment factors on wool characteristics of Arabi sheep breeds  [PDF]
Nosratollah Taherpour, Mahnaz Salehi, Farhad Mirzaei
Open Journal of Animal Sciences (OJAS) , 2012, DOI: 10.4236/ojas.2012.21002
Abstract: Evaluation and grading of wool based on sex and age can help to improve economic value of wool. This study was conducted to investigate the wool production and fleece characteristics of Arabi sheep in Khuzestan province The right mid-side wool samples were taken from 90 Arabi sheep (1 - 4 years; 16 male and 74 female) by hand shearing. The staple length of shoulder, flank and rump were 13.18 ± 0.27, 13.31 ± 0.22 and 14.27 ± 0.25 cm, respectively. The greasy fleece weight, wool wax, vegetable matter, yield percentage, fiber diameter and its coefficient variation measures were 1.72 ± 0.06 Kg; 2.77% ± 0.12%; 0.54% ± 0.07%; 73.36% ± 0.68%; 30 ± 0.41 μm; 30.23% ± 0.3% respectively. Correspondingly, the medulated fibers, true wool fiber and Kemp fibers were 21.6% ± 1.9%, 76.1% ± 2.04% and 2.5% ± 0.57% respectively. Age and sex had a significant influence on staple lengths. Fleece weight (P < 0.01) and wool wax were (P < 0.05) affected by sex. There was no significant interaction between age and sex groups for fiber characteristics, but it was important for staple between body location (P < 0.05). There were a low considerable kemp and CV of wool diameter percentage on Arabi sheep in comparison with the other Iranian native sheep. The wide variation in fleece weight (0.8 - 3.9 kg); mean staple lengths (8.8 - 19.2 cm); medulated and kemp (0 - 84.04 and 0% - 30.22%); fiber diameter (24.9 - 37.43 μm) suggest potential for improvement of economical traits.
MOND, dark matter, and conservation of energy
Ahmad Shariati,Nosratollah Jafari
Physics , 2007,
Abstract: The MOND equation $m \vec a \mu(a) = \vec F$ could be transformed to the equivalent form $m \vec a = \vec{F'}$, where $\Vec{F'}$ is a transformed force. Using this transformation we argue that MOND could not avoid introducing dark matter, and introduces nonconservative terms to the equations of motion.
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