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Search Results: 1 - 10 of 39063 matches for " Norma Fernández Delgado "
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Clasificación de la organización mundial de la salud (OMS) de los síndromes mielodisplásicos: Un breve comentario Classification of myelodysplastic syndromes: A brief comment
Norma Fernández Delgado
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2002,
Abstract:
Anemia de los procesos crónicos: Aspectos clínicos y de laboratorio
Forrellat Barrios,Mariela; Fernández Delgado,Norma;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2002,
Abstract: anemia is one of the most common signs found in patients with infectious, inflammatory and neoplastic diseases and may be a marker of the level of activity of the disease. the term anemia of chronic diseases refers to a syndrome involving a substantial part of these diseases. metabolic and iron homeostasis disorders occurring in anemia cause hyposideremia and hyperferritinemia in all the cases. this review sets forth the clinical and lab characteristics related to this disease as well as some therapeutical considerations
Anemia de los procesos crónicos: Aspectos clínicos y de laboratorio Anemia of chronic diseases: Clinical and lab aspects
Mariela Forrellat Barrios,Norma Fernández Delgado
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2002,
Abstract: La anemia es uno de los signos más comunes encontrado en pacientes con enfermedades infecciosas, inflamatorias y neoplásicas; esta suele ser un indicador del grado de actividad de la enfermedad. El término anemia de los procesos crónicos se refiere a un síndrome que involucra gran parte de estos procesos. Los trastornos del metabolismo y homeostasis del hierro que ocurren en la misma provocan hiposideremia con hiperferritinemia en la generalidad de los casos. En esta revisión se exponen las características clínicas y de laboratorio afines con esta entidad, así como algunas consideraciones terapéuticas Anemia is one of the most common signs found in patients with infectious, inflammatory and neoplastic diseases and may be a marker of the level of activity of the disease. The term anemia of chronic diseases refers to a syndrome involving a substantial part of these diseases. Metabolic and iron homeostasis disorders occurring in anemia cause hyposideremia and hyperferritinemia in all the cases. This review sets forth the clinical and lab characteristics related to this disease as well as some therapeutical considerations
Hepcidina: nueva molécula, nuevos horizontes Hepcidine: a new molecule opening up new horizons
Mariela Forrellat Barrios,Norma Fernández Delgado
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2004,
Abstract: En los últimos a os se han descubierto al menos 7 nuevas moléculas relacionadas con la homeostasia del hierro, lo que cambia la visión clásica acerca del metabolismo de este mineral. Probablemente sea la hepcidina la más interesante de todas, por considerarse un regulador negativo de la absorción del hierro en el intestino delgado y de su liberación por los macrófagos. Esta proteína es un péptido antimicrobiano rico en cisteínas, producido en el hígado, que se estima como considerado como un elemento clave en la regulación de la absorción y cinética del hierro en el organismo. Su expresión es regulada por el hierro y el estímulo inflamatorio, por lo que es considerada una reactante de fase aguda. La hepcidina se presenta como un candidato atractivo para mediador en la anemia de los procesos crónicos y en otros trastornos del metabolismo férrico, lo que le confiere a esta molécula un futuro prometedor en el diagnóstico y tratamiento de estos estados patológicos In the last few years, at least 7 new molecules related to iron homeostasis have been discovered, which changes the vision on iron metabolism. Hepcidin is likely to be the most interesting molecule because it is considered as a negative regulator of iron uptake in the small intestine and of iron release by the macrophages. This liver-synthetized cysteine-rich antimicrobial peptide appears to be a key element in the regulation of iron absorption and kinetics in the body. Both iron and inflammatory stimulus control hepcidin expression, therefore it is considered an acute-phase reactant. Hepcidin constitutes an attractive candidate for mediator in anemia of chronic processes and in other iron metabolism disorders, which turns this molecule into a promising element for the diagnosis and treatment of these pathological states
Síndrome mielodisplásico: I. Biología y clínica
Fernández Delgado,Norma; Hernández Ramírez,Porfirio;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2000,
Abstract: myelodysplastic syndromes (mds) include a group of clonic disorders characterized by progressive cytopenias and dishematopoiesis. etiology of primary mds is unknow, and secondary ones may be due to use of antineoplastic agents, chemicals and in children, are related to constitutional diseases. their general biological features include cytogenetic, molecular, and immunologic alterations accompaning hematopoiesis alterations. for diagnosis it is necessary 10% of cellular involvement in each serie, where dishematopoiesis be the cause. in 80% of bone marrow biopsies, we found signs of dismegacaryopoiesis and disarrangement in normal hematopoietic structure. recently, it was proposed existence of mds variants, including hyperfibrotic type, the early one, and mds with features of myeloproliferative syndrome. diagnosis of mds is by exclusion and in differential diagnosis, it is necessary rule out some processes presenting myelodisplastic alterations, including anemias by vitamin b12, folic acid, or piridoxin deficiency, chronic liver disease, chronic diseases anemia, chemotherapy, aids virus infection, and medullary aplasia, etc
Síndrome mielodisplásico: I. Biología y clínica Myelodysplastic syndrome: I. Biology and Clinic
Norma Fernández Delgado,Porfirio Hernández Ramírez
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2000,
Abstract: Los síndromes mielodisplásicos (SMD) constituyen un grupo de trastornos clonales caracterizados por citopenias progresivas y dishematopoyesis. La etiología de los SMD primarios es desconocida y los secundarios pueden deberse al uso de agentes antineoplásicos, productos químicos y en los ni os, se asocian con enfermedades constitucionales. Sus características biológicas generales incluyen las alteraciones de la hematopoyesis, que pueden ir acompa adas por alteraciones citogenéticas, moleculares e inmunológicas. Para el diagnóstico es necesario que la dishematopoyesis afecte, al menos, el 10 % de las células en cada una de las series. En el 80 % de las biopsias de médula ósea se observan signos de dismegacariopoyesis y desorganización en la arquitectura hematopoyética habitual. Recientemente se ha planteado la existencia de variantes de SMD, entre ellos el hiperfibrótico, el temprano y el SMD con características de síndrome mieloproliferativo. El diagnóstico de SMD es por exclusión, por lo que es necesario en el diagnóstico diferencial destacar algunos procesos que pueden presentar alteraciones mielodisplásicas, entre ellos las anemias por deficiencia de vitamina B12, ácido fólico o piridoxina, las hepatopatías crónicas, la anemia de las enfermedades crónicas, el tratamiento con quimioterápicos, la infección por el virus del SIDA y la aplasia medular, entre otros Myelodysplastic syndromes (MDS) include a group of clonic disorders characterized by progressive cytopenias and dishematopoiesis. Etiology of primary MDS is unknow, and secondary ones may be due to use of antineoplastic agents, chemicals and in children, are related to constitutional diseases. Their general biological features include cytogenetic, molecular, and immunologic alterations accompaning hematopoiesis alterations. For diagnosis it is necessary 10% of cellular involvement in each serie, where dishematopoiesis be the cause. In 80% of bone marrow biopsies, we found signs of dismegacaryopoiesis and disarrangement in normal hematopoietic structure. Recently, it was proposed existence of MDS variants, including hyperfibrotic type, the early one, and MDS with features of myeloproliferative syndrome. Diagnosis of MDS is by exclusion and in differential diagnosis, it is necessary rule out some processes presenting myelodisplastic alterations, including anemias by vitamin B12, folic acid, or piridoxin deficiency, chronic liver disease, chronic diseases anemia, chemotherapy, AIDS virus infection, and medullary aplasia, etc
Matriptasa 2:: nuevo eslabón en el metabolismo del hierro
Forrellat Barrios,Mariela; Fernández Delgado,Norma; Hernández Ramírez,Porfirio;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2009,
Abstract: the maintenance of iron homeostasis is essential for the normal physiological functioning of the living beings. recently, it was discovered the matriptase 2, a type ii trans-membrane serine protease, also known by english acronyms tmprss6, having an essential function in homeostasis of this mineral. this finding initially derived from the observation that mice deficient of this protein had anemia as consequence of rise of hepcidine levels and the interruption of iron intestinal absorption. the in vitro later analyses showed that 2 matriptase suppress the stimulation way of hepcidine transcription involving to hemojuvelin as a co-receptor. in agreement with the anemia pattern of mutant mice, we founded that pattern from subjects presenting with iron-deficiency anemia and iron-resistant (irida) was created by tmprsst gen mutations involving the elimination of enzymatic proteolytic activity. in present paper are showed the features related to identification and characterization of the 2 matriptase, as well as, its involvement in iron metabolism.
Nuevos conocimientos sobre el metabolismo del hierro
Forrellat Barrios,Mariela; Fernández Delgado,Norma; Hernández Ramírez,Porfirio;
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2005,
Abstract: iron is a very important mineral for the organism and its regulation requires a complex molecular network. only 3 proteins that took part in iron metabolism were known a few years ago, but in the last decade, new proteins that participate in iron homeostasis and that are involved in its transportation, absorption, recycling and balance in the organism have been discovered in a sequential way, starting from the study of some genetical diseases, such as hereditary hemochromatosis. the identification and isolation of these proteins lead inevitably to the modification of the classical models of regulation of the homeostasis of this powerful mineral. a review of the esential elements known up to now of each of these new proteins and the interaction among them was made in this paper
Matriptasa 2:: nuevo eslabón en el metabolismo del hierro Matriptase 2:: a new link in iron metabolism
Mariela Forrellat Barrios,Norma Fernández Delgado,Porfirio Hernández Ramírez
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2009,
Abstract: El mantenimiento de la homeostasia del hierro es esencial para el funcionamiento fisiológico normal de los seres vivos. Recientemente se descubrió que la matriptasa 2, una serin proteasa transmembrana tipo II, también conocida por las siglas en inglés TMPRSS6, tiene una función esencial en la homeostasis de este mineral. Este hallazgo derivó inicialmente de la observación de que ratones con deficiencia de esta proteína presentaban anemia como consecuencia de la elevación de los niveles de hepcidina y la interrupción de la absorción intestinal de hierro. Los análisis posteriores in vitro demostraron que la matriptasa 2 suprime la vía de estimulación de la transcripción de la hepcidina que implica a la hemojuvelina como co-receptor. En concordancia con el patrón de anemia de los ratones mutantes, se encontró que el patrón de individuos con anemia por deficiencia de hierro resistente al hierro (en inglés IRIDA), era ocasionado por mutaciones del gen Tmprss6 que implican anulación de la actividad proteolítica de la enzima. En este trabajo se presentan aspectos relacionados con la identificación y caracterización de la matriptasa 2, así como su participación en el metabolismo del hierro. The maintenance of iron homeostasis is essential for the normal physiological functioning of the living beings. Recently, it was discovered the Matriptase 2, a type II trans-membrane serine protease, also known by English acronyms TMPRSS6, having an essential function in homeostasis of this mineral. This finding initially derived from the observation that mice deficient of this protein had anemia as consequence of rise of hepcidine levels and the interruption of iron intestinal absorption. The in vitro later analyses showed that 2 Matriptase suppress the stimulation way of hepcidine transcription involving to hemojuvelin as a co-receptor. In agreement with the anemia pattern of mutant mice, we founded that pattern from subjects presenting with iron-deficiency anemia and iron-resistant (IRIDA) was created by Tmprsst gen mutations involving the elimination of enzymatic proteolytic activity. In present paper are showed the features related to identification and characterization of the 2 Matriptase, as well as, its involvement in iron metabolism.
Regulación de la hepcidina y homeostasis del hierro: avances y perspectivas Regulation of hepcidin and iron homeostasis: progress and prospects
Mariela Forrellat-Barrios,Norma Fernández-Delgado,Porfirio Hernández-Ramírez
Revista Cubana de Hematolog?-a, Inmunolog?-a y Hemoterapia , 2012,
Abstract: El estudio de los desórdenes genéticos del metabolismo del hierro, la identificación de sus transportadores y el descubrimiento de la hepcidina, hormona reguladora de la homeostasia del hierro, han contribuido grandemente a aumentar los conocimientos sobre este metabolismo y han cambiado sustancialmente la visión sobre las enfermedades relacionadas con alteraciones del metabolismo férrico. En la última década, no solo se han esclarecido elementos de la patogénesis de estas enfermedades, sino que ya se vislumbran aplicaciones terapéuticas de estos avances. Así, ya se habla de una nueva era basada en el tratamiento de los desórdenes de la homeostasia del hierro a través de la modulación de la hepcidina. The study of genetic disorders of iron metabolism, identification of transporters and the discovery of hepcidin- a hormone regulating iron homeostasis- have contributed greatly to increase awareness of this metabolism. Substantially, the vision on diseases related to disorders of iron metabolism has been changed. In the last decade, elements of the pathogenesis of these diseases have not only been clarified, but therapeutic applications of these advances are looming. Thus, there are expectations of a new era based on the treatment of iron homeostasis disorders through hepcidin modulation.
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