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Search Results: 1 - 10 of 1196 matches for " Noriaki Sakamoto "
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A Method to Evaluate an Urban Area by Using the Model That Calculates a Number of Facilities from an Area and a Population  [PDF]
Noriaki Sakamoto
Current Urban Studies (CUS) , 2016, DOI: 10.4236/cus.2016.44028
Abstract: This paper presents 1) a new mathematical model improved from a conventional model that calculates a number of facility from an area and a population in a town and, 2) by using this model, a method to evaluate the enrichment (in other words, convenience or enough) of facilities in the town where many high-rise apartments have been built (the area is hereinafter referred to as the high-rise apartment town). The conventional model uses only a nighttime population, but this paper considers a daytime population in addition to the nighttime population. Also, there has not been the method to evaluate the enrichment of facilities in a town, but we can evaluate it using this model. We apply this method to 23 special wards in Tokyo and the highrise apartment towns, the results prove the effectiveness of the proposed method.
Fatal liver abscess caused by Clostridium perfringens complicated with transarterial chemoembolization  [PDF]
Noriaki Sakamoto, Masato Yamaguchi, Takuya Okada, Koji Idoguchi, Eisuke Ueshima, Akhmadu Muradi, Koji Sugimoto
Journal of Biomedical Science and Engineering (JBiSE) , 2012, DOI: 10.4236/jbise.2012.512A095

A 77-year-old man who received transarterial chemoembolization for large hepatocellular carcinomas complained of acute pain in the upper abdomen and suddenly developed severe jaundice, anemia, and massive hematuria. Abdominal computed tomography demonstrated gas gangrene at the tumor site. Clostridium perfringens was identified from blood samples and drainage cultures from the liver abscess. Despite intensive treatment, the patient died 55 hours after chemoembolization due to multiple organ failure. When treating patients with large tumors, such as in our case, this rare but fatal complication that causes sepsis and hemolysis with lightning-like rapidity should be considered.

Coil embolization of bronchial artery aneurysm with high flow bronchial artery-pulmonary artery fistula  [PDF]
Yoshiro Matsuo, Takuya Okada, Masato Yamaguchi, Akhamadu Muradi, Teruaki Okuno, Noriaki Sakamoto, Koji Idoguchi, Koji Sugimoto
World Journal of Cardiovascular Diseases (WJCD) , 2013, DOI: 10.4236/wjcd.2013.31004

We report a case of an asymptomatic 36-year-old man with a bronchial artery aneurysm in the right hilum. Selective angiography revealed a 25mmsaccular aneurysm and an efferent artery of the aneurysm forming a high flow bronchial artery-pulmonary artery fistula. Because of dilatation and tortuosity of the bronchial artery, the microcatheter could reach the efferent artery but not the fistula. Therefore, we embolized the fistula by sending microcoils through the bloodstream from the efferent artery to the fistula (the “flow-dependent” coil embolization technique), and further embolized the aneurysm by coil isolation and packing technique.

Feasibility of externalized peritoneovenous shunt (EPVS) for malignant ascites
Hiroyuki Tokue, Yoshito Takeuchi, Yasuaki Arai, Keitaro Sofue, Noriaki Sakamoto, Yoshito Tsushima, Keigo Endo
World Journal of Surgical Oncology , 2011, DOI: 10.1186/1477-7819-9-82
Abstract: We retrospectively reviewed 10 patients, who were not suited for conventional peritoneovenous shunts (PVS), with malignant ascites, which was refractory to medical therapies. Patient characteristics, technical success, efficacy, duration of EPVS placement, adverse events, and outcome were evaluated. Clinical efficacy of the EPVS was evaluated by the change in subjective symptoms.The primary reasons for applying EPVS were severe anasarca in 4 patients, potential PVS dysfunction in 3 patients, poor performance status in 2 patients, and a history of PVS occlusion in 1 patient. EPVS was successfully placed in all patients, and it provided clinical efficacy in 8 patients (80%). Early death occurred within 7 days after EPVS placement in 2 patients because of renal failure. The median duration of EPVS placement was 10.4 days (range, 2-28 days). In 6 patients (60%), the EPVS was exchanged to conventional PVS sequentially, since the initial EPVS placement resulted in an improvement of the subjective symptoms of the patients, without serious complications.EPVS placement may be an option for patients with malignant ascites who may not be appropriate for conventional PVS placement.A peritoneovenous shunt (PVS), which is also known as a Denver shunt, may be effective for palliating symptoms in patients with malignant ascites, which contribute to a deterioration of the patient's quality of life (QOL) and which are refractory to conservative nonsurgical therapies. Various shunts have been designed to use as peritoneovenous shunting [1,2], and radiological insertion of the Denver shunt may be the most widely used technique for nonsurgical PVS implantation in our country. However, the mortality rate of PVS implantation has been reported to be rather high, and indications are limited [3-6]. Possible contraindications for PVS implantation include ascites that is infected, hemorrhagic, chylous, or with loculated malignant effusion, advanced cardiac or renal failure, elevated serum bili
Transmedullary Decompression for Humeral Diaphysis Solitary Bone Cysts  [PDF]
Akio Sakamoto
Open Journal of Orthopedics (OJO) , 2013, DOI: 10.4236/ojo.2013.32015

Solitary bone cysts are benign, fluid-filled cavities that most often occur in childhood. Several minimally invasive decompression methods have been proposed; however, performing a surgical procedure through the thinned overlying cortex raises the risk of pathological fracture and neurovascular damage, especially in lesions located in the bone diaphysis. We describe a new technique that circumvents these problems: tunneling through the normal cortex and medullary space with a flexible reamer, placing a retrograde medullary nail for cyst decompression.

MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population
Aiko Miyaishi, Kayo Osawa, Yasunori Osawa, Natsuko Inoue, Kana Yoshida, Mayumi Kasahara, Akimitsu Tsutou, Yoshiki Tabuchi, Kazuo Sakamoto, Noriaki Tsubota, Juro Takahashi
Journal of Experimental & Clinical Cancer Research , 2009, DOI: 10.1186/1756-9966-28-10
Abstract: We analyzed associations among OGG1 Ser326Cys and MUTYH Gln324His gene polymorphisms in relation to lung cancer risk using PCR-RFLP. The study involved 108 lung cancer patients and 121 non-cancer controls divided into non-smokers, smokers according to pack-years smoked in Japanese.The results showed that the MUTYH His/His genotype compared with Gln/Gln genotype showed an increased risk for lung cancer (adjusted odds ratio [OR] 3.03, confidence interval [95%CI], 1.31–7.00, p = 0.010), whereas there was no significant increase for the Gln/His genotype (adjusted OR 1.35, 95%CI 0.70–2.61, p = 0.376). The MUTYH His/His genotype was at a borderline increased risk for both adenocarcinoma and squamous cell carcinoma (adjusted OR 2.50, 95%CI 0.95–6.62, p = 0.065 for adenocarcinoma; adjusted OR 3.20, 95%CI 0.89–11.49, p = 0.075 for squamous cell carcinoma, respectively). However, the OGG1 Ser/Cys or Cys/Cys genotypes compared with the Ser/Ser genotype did not have significantly increased risk for lung cancer, containing either adenocarcinoma or squamous cell carcinoma. The joint effect of tobacco exposure and the MUTYH His/His genotype compared with the Gln/Gln genotype showed a significant association with lung cancer risk in smokers, and there was not significantly increased in non-smokers (adjusted OR 3.82, 95%CI 1.22–12.00, p = 0.022 for smokers; adjusted OR 2.60, 95%CI 0.60–11.25, p = 0.200 for non-smokers, respectively). The effect of tobacco exposure and the OGG1 Ser326Cys showed also no significant risk for lung cancer.Our findings suggest that the MUTYH Gln324His polymorphism appear to play an important role in modifying the risk for lung cancer in the Japanese population.Lung cancer is a well-known cancer that is caused by carcinogens, such as those in tobacco smoke. Tobacco smoke contains many chemical carcinogens and reactive oxygen species, including polycyclic aromatic hydrocarbons. DNA damage induced by these carcinogens or by endogenous metabolic processes can
Attractors for nonautonomous multivalued evolution systems generated by time-dependent subdifferentials
Noriaki Yamazaki
Abstract and Applied Analysis , 2002, DOI: 10.1155/s1085337502204042
Abstract: In a real separable Hilbert space, we consider nonautonomousevolution equations including time-dependent subdifferentials andtheir nonmonotone multivalued perturbations. In this paper, wetreat the multivalued dynamical systems associated withtime-dependent subdifferentials, in which the solution is notunique for a given initial state. In particular, we discuss theasymptotic behaviour of our multivalued semiflows from theviewpoint of attractors. In fact, assuming that thetime-dependent subdifferential converges asymptotically to atime-independent one (in a sense) as time goes to infinity, weconstruct global attractors for nonautonomous multivalueddynamical systems and its limiting autonomous multivalueddynamical system. Moreover, we discuss the relationship betweenthem.
Radiative Electroweak Symmetry Breaking in TeV-Scale String Models
Kitazawa, Noriaki
High Energy Physics - Phenomenology , 2007,
Abstract: We examine the possibility of necessary and inevitable radiative electroweak symmetry breaking by one-loop radiative corrections in a class of string models which are the string realization of "brane world" scenario. As an example, we consider a simple quasi-realistic model based on a D3-brane at non-supersymmetric C^3/Z_6 orbifold singularity, in which the electroweak Higgs doublet fields are identified with the massless bosonic modes of the open string on that D3-brane. We calculate the one-loop correction to the Higgs potential, and find that its vacuum expectation value can be realized in this specific model.
Attractors of asymptotically periodic multivalued dynamical systems governed by time-dependent subdifferentials
Noriaki Yamazaki
Electronic Journal of Differential Equations , 2004,
Abstract: We study a nonlinear evolution equation associated with time-dependent subdifferential in a separable Hilbert space. In particular, we consider an asymptotically periodic system, which means that time-dependent terms converge to time-periodic terms as time approaches infinity. Then we consider the large-time behavior of solutions without uniqueness. In such a situation the corresponding dynamical systems are multivalued. In fact, we discuss the stability of multivalued semiflows from the view-point of attractors. Namely, the main object of this paper is to construct a global attractor for asymptotically periodic multivalued dynamical systems, and to discuss the relationship to one for the limiting periodic systems.
Crystal Structure of Apraclonidine Hydrochloride
Noriaki Hirayama
Journal of Crystallography , 2013, DOI: 10.1155/2013/249672
Abstract: Apraclonidine is used for the treatment of postsurgical elevated intraocular pressure. The crystal structure of its hydrochloride, C9H10Cl2N4·HCl, was determined by X-ray analysis. The crystal belongs to space group with the cell dimensions , , ??, and °. The final (all reflections) value is 0.053. Apraclonidine has a more twisted structure than its related drug of clonidine. The nitrogen atom bridging the two rings is protonated. 1. Introduction Apraclonidine (2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-1,4-benzenediamine) is a potent α-adrenergic agent similar to clonidine. The chemical structures of apraclonidine hydrochloride and clonidine are compared in Figure 1. Apraclonidine reduces aqueous humor formation. In clinical evaluation in the treatment of intraocular pressure, Robin et al. have showed that apraclonidine is effective in preventing the acute large postoperative intraocular pressure rise associated with argon laser iridotomy [1]. Apraclonidine is now used widely for the treatment of postsurgical elevated intraocular pressure. The additional amino group in apraclonidine makes it more polar than clonidine and reduces the penetration through the blood-brain barrier. Therefore, the pharmacological profile of apraclonidine is characterized by peripheral than central effects. Apraclonidine hydrochloride is clinically used now, but the crystal structure has not been determined yet. Therefore, the X-ray analysis of this drug was undertaken to disclose the inherent three-dimensional structure. Figure 1: Chemical diagrams of apraclonidine hydrochloride (a) and clonidine (b). 2. Method Apraclonidine hydrochloride was purchased from Sigma-Aldrich Co. The single crystals of the compound were grown from a methanol solution. A colorless platelet crystal with the size of 0.35 × 0.30 × 0.15?mm was mounted on a glass fiber and used for data collection. The structure was solved by direct methods, and non-H atoms were refined by a full-matrix least squares method with anisotropic temperature factors. Positions of H-atoms attached to carbon and nitrogen atoms were geometrically calculated and located from difference Fourier synthesis, respectively. All H-atoms were refined by the riding model. The crystal and experimental data are given in Table 1. Table 1: Crystal and experimental data. 3. Results and Discussion An ORTEP drawing [2] of apraclonidine hydrochloride is shown in Figure 2. Selected bond lengths, bond angles, torsion angles, and possible hydrogen bonds in the crystal structure are given in Table 2. Bond lengths and angles are within the
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