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Search Results: 1 - 10 of 4594 matches for " Nonata Trévia "
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Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals
Nonata Trévia,Izabela N. F. Almeida,Poliana S. Oliveira,Laura V. Warwick
Psychology & Neuroscience , 2011,
Abstract: The aim of the present study was to analyze the infuence of enriched environment on the distribution of perineuronal nets (PNNs) using a stereogically based unbiased protocol and visual acuity in adult Swiss albino mice that underwent monocular deprivation during the critical period of postnatal development. Eight female Swiss albino mice were monocular deprived on postnatal day 10 and divided into two groups at weaning: standard environment (SE group, n = 4) and enriched environment (EE group, n = 4). After 3 months, all of the mice were subjected to grating visual acuity tests, sacrifced, and perfused with aldehyde fxative. The brains were removed and cut at 70 μm thickness in a vibratome and processed for lectin histochemical staining with Wisteria foribunda agglutinin (WFA). Architectonic limits of area 17 were conspicuously defned by WFA histochemical staining, and the optical fractionator stereological method was applied to estimate the total number of PNNs in the supragranular, granular, and infragranular layers. All groups were compared using Student’s t-test at a 95% confdence level. Comparative analysis of the average PNN estimations revealed that the EE group had higher PNNs in the supragranular layer (2726.33 ± 405.416, mean ± standard deviation) compared with the SE group (1543.535 ± 260.686; Student’s t-test, p = .0495). No differences were found in the other layers. Visual acuity was signifcantly lower in the SE group (0.55 cycles/degree) than in the EE group (1.06 cycles/degree). Our results suggest that the integrity of the specialized extracellular matrix PNNs of the supragranular layer may be essential for normal visual acuity development.
Enriched environment contributes to recovery of visual acuity and increases perineuronal nets in monocular-deprived animals
Trévia, Nonata;Almeida, Izabela N. F.;Oliveira, Poliana S.;Warwick, Laura V.;Marques, Viviane;Santos, Denise C. dos;Paulo, Dario C.;Viegas, Maria L.;Pican?o-Diniz, Cristovam W.;
Psychology & Neuroscience , 2011, DOI: 10.3922/j.psns.2011.1.006
Abstract: the aim of the present study was to analyze the influence of enriched environment on the distribution of perineuronal nets (pnns) using a stereogically based unbiased protocol and visual acuity in adult swiss albino mice that underwent monocular deprivation during the critical period of postnatal development. eight female swiss albino mice were monocular deprived on postnatal day 10 and divided into two groups at weaning: standard environment (se group, n = 4) and enriched environment (ee group, n = 4). after 3 months, all of the mice were subjected to grating visual acuity tests, sacrificed, and perfused with aldehyde fixative. the brains were removed and cut at 70 μm thickness in a vibratome and processed for lectin histochemical staining with wisteria floribunda agglutinin (wfa). architectonic limits of area 17 were conspicuously defined by wfa histochemical staining, and the optical fractionator stereological method was applied to estimate the total number of pnns in the supragranular, granular, and infragranular layers. all groups were compared using student's t-test at a 95% confidence level. comparative analysis of the average pnn estimations revealed that the ee group had higher pnns in the supragranular layer (2726.33 ± 405.416, mean ± standard deviation) compared with the se group (1543.535 ± 260.686; student's t-test, p = .0495). no differences were found in the other layers. visual acuity was significantly lower in the se group (0.55 cycles/degree) than in the ee group (1.06 cycles/degree). our results suggest that the integrity of the specialized extracellular matrix pnns of the supragranular layer may be essential for normal visual acuity development.
Influence of Enriched Environment on Viral Encephalitis Outcomes: Behavioral and Neuropathological Changes in Albino Swiss Mice
Aline Andrade de Sousa,Renata Reis,Jo?o Bento-Torres,Nonata Trévia,Nara Alves de Almeida Lins,Aline Passos,Zaire Santos,José Antonio Pican?o Diniz,Pedro Fernando da Costa Vasconcelos,Colm Cunningham,Victor Hugh Perry,Cristovam Wanderley Pican?o Diniz
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015597
Abstract: An enriched environment has previously been described as enhancing natural killer cell activity of recognizing and killing virally infected cells. However, the effects of environmental enrichment on behavioral changes in relation to virus clearance and the neuropathology of encephalitis have not been studied in detail. We tested the hypothesis that environmental enrichment leads to less CNS neuroinvasion and/or more rapid viral clearance in association with T cells without neuronal damage. Stereology-based estimates of activated microglia perineuronal nets and neurons in CA3 were correlated with behavioral changes in the Piry rhabdovirus model of encephalitis in the albino Swiss mouse. Two-month-old female mice maintained in impoverished (IE) or enriched environments (EE) for 3 months were behaviorally tested. After the tests, an equal volume of Piry virus (IEPy, EEPy)-infected or normal brain homogenates were nasally instilled. Eight days post-instillation (dpi), when behavioral changes became apparent, brains were fixed and processed to detect viral antigens, activated microglia, perineuronal nets, and T lymphocytes by immuno- or histochemical reactions. At 20 or 40 dpi, the remaining animals were behaviorally tested and processed for the same markers. In IEPy mice, burrowing activity decreased and recovered earlier (8–10 dpi) than open field (20–40 dpi) but remained unaltered in the EEPy group. EEPy mice presented higher T-cell infiltration, less CNS cell infection by the virus and/or faster virus clearance, less microgliosis, and less damage to the extracellular matrix than IEPy. In both EEPy and IEPy animals, CA3 neuronal number remained unaltered. The results suggest that an enriched environment promotes a more effective immune response to clear CNS virus and not at the cost of CNS damage.
Avalia??o da contamina??o por organofosforados em águas superficiais no município de Rondinha - Rio Grande do Sul
Griza, Francieli Três;Ortiz, Karen Saldanha;Geremias, Douglas;Thiesen, Flávia Vallad?o;
Química Nova , 2008, DOI: 10.1590/S0100-40422008000700006
Abstract: water pollution is a serious environmental problem. in rondinha, rio grande do sul, on a small area planted with tobacco, it has been using organophosphates pesticides. the purpose of this study was to evaluate the organophosphates pesticides contamination of the superficial water in this municipality. the samples collected in fifteen places were evaluated by the method of organophosphates acethylcolinestherase inhibition. in five samples the organophosphates levels were above the limit established by conama, indicating the necessity of arrangements that allow reducing the risk of the population and the environment contamination.
Autoridade mesti a no Brasil: territórios de mando no sert o do S o Francisco, século XVIII
Célia Nonata da Silva
Fronteras de la Historia , 2010,
Abstract: This article is an analysis of some practices which are commonplace in the Minas captaincy concerning the normalization and enforcement of a private code of conduct in the backlands of the St. Francis River, stemming from the power of some local potentates. These rustic customs are interpreted as effective behaviors of a mestizo political culture, based on the maintenance of the so-called "Commanding Territories", which include a series of power arrangements based on systematic revenges, expropriations, protective policies granted by the local potentates, and on the exchange of favors between these and their slaves.
Controle glicêmico de pacientes diabéticos tipo 2 nos servi?os público e privado de Saúde
Panarotto, Daniel;Tr?sel, Henrique de Araújo Vianna;Oliveira, Michele Salibe de;Gravina,via Brancher;Teles, Alisson Roberto;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2009, DOI: 10.1590/S0004-27302009000600007
Abstract: objective: to compare the treatment of type 2 diabetic patients from a private clinic with those of a public health service. methods: it was designed a retrospective cohort study, including 80 patients attended at the central clinic of universidade de caxias do sul (amce), which is related to the single health system, and 277 patients attended at a private clinic, whom consult between may 2001 and october 2007. results: patients attended at amce showed a worse metabolic control, although only the values of a1c and total cholesterol have reached statistical significance. both groups had an improvement in almost all the metabolic parameters. the use of insulin at the end of follow-up (b = 4,66; ci95% = 2,18 - 9,89; p < 0,001) and initial a1c (b = 1,42; ci95% = 1,16 - 1,74; p = 0,001) were determinant of a worse glycemic control. the frequency of visits was determinant of a better control (b = 0,72; ci 95% = 0,55 - 0,93; p = 0,01). conclusions: the variables such as the initial a1c and the frequency of visits, which may be considered as indicators of patients' access to the heath system, have greater impact on the control of diabetes than the place where the patients are treated.
Tratamento da forma mucosa de leishmaniose sem resposta a glucantime, com anfotericina B liposomal
Sampaio, Raimunda Nonata Ribeiro;Marsden, Phillip Davis;
Revista da Sociedade Brasileira de Medicina Tropical , 1997, DOI: 10.1590/S0037-86821997000200007
Abstract: we treated six patients with mucosal leishmaniasis who failed to respond to glucantime (20mg/kg/day) with ambisome (2-5 grams total dose). the daily dose was 2-3mg/kg/day given for a minimum of 20 days. after 26-38 months of follow up, five patients were clinically cured. one relapsed after six months. no side effects of therapy were observed apart from headache after injection. ambisome is a therapeutic option for patients with mucosal leishmaniasis unresponsive to antimonials.
Tratamento da forma mucosa de leishmaniose sem resposta a glucantime, com anfotericina B liposomal
Sampaio Raimunda Nonata Ribeiro,Marsden Phillip Davis
Revista da Sociedade Brasileira de Medicina Tropical , 1997,
Abstract: Tratamos com ambisome (2 a 5g totais de dose) seis pacientes com leishmaniose mucosa sem resposta a tratamento com glucantime (20mg SbV/kg/dia). A dose diária usada foi 2 a 3mg/kg/dia, aplicada por um mínimo de 20 dias. Após 26 a 38 meses de acompanhamento, cinco pacientes est o clinicamente curados. Um recidivou aos 6 meses. N o foram observados efeitos colaterais além de cefaléia, após a inje o. O ambisome constitue uma op o terapêutica para os pacientes com leishmaniose mucosa sem resposta aos antimoniais.
Assessing Uncertainty and Risk in Public Sector Investment Projects  [PDF]
Katrin Bock, Stefan Trück
Technology and Investment (TI) , 2011, DOI: 10.4236/ti.2011.22011
Abstract: The feasibility and profitability of large investment projects are frequently subject to a partially or even fully undeterminable future, encompassing uncertainty and various types of risk. We investigate significant issues in the field of project appraisal techniques, including risks and uncertainties, appropriate risk analysis, project duration as well as the dependencies between (sub-) projects. The most common project appraisal techniques are examined addressing benefits and weaknesses of each technique. Furthermore, the practical use of the different techniques for the public sector is examined, exemplifying this with a small-scale analysis of the risk analysis procedures of the World Bank. Our finding suggest that in particular for the public sector, practical implementation of quantitative techniques like Monte Carlo simulation in the appraisal procedure of investment projects has not fully occurred to date. We strongly recommend further application of these approaches to the evaluation of processes and financial or economic risk factors in project appraisal of public sector institutions.
Emissions Mitigation Schemes in Australia—The Past, Present and Future  [PDF]
Deborah Cotton, Stefan Trück
Low Carbon Economy (LCE) , 2013, DOI: 10.4236/lce.2013.42009
Abstract:

Australia was one of the first countries in the world to adopt mandatory emissions trading schemes as part of its emissions mitigation program. To date there have been six states and one federal emissions mitigation schemes. Some state schemes operate in conjunction with other states or the federal scheme and some operate independently. This complex set of regulations and requirements for emitters has led to a deficiency in nationwide coverage with no firm target set for Australia. In July 2011 the Federal Labor Government released details of a carbon tax proposal which was passed by the two houses of Parliament by the end of 2011 and was introduced in July 2012. The Government states that an emissions trading scheme will be introduced in 2015 with a possible link to the European Emissions Trading Scheme (EU ETS). This paper provides a critical overview of Australian responses to climate change, with a particular emphasis on the numerous emissions mitigation schemes.

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