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A vida sexual dos anúncios pessoais: Uma revis?o da literatura
Análise Psicológica , 2007,
Abstract: the current review covers the scientific literature that uses personal advertisements published in the press, on the internet and in other media as a source of data. the reviewed studies can be separated into three non-discreet categories: (1) the analysis of courtship patters in men and women, (2) the analysis of gender and sexuality patterns in their relation with sexual orientation, and (3) the analysis of hiv sexual risk and protective behaviours, in particular among gay men. advantages and limitations of the use of personal ads within the context of scientific research are discussed, as well as the impact of increased popularity of the internet upon this phenomenon.
A depress?o nas perturba??es da alimenta??o
Análise Psicológica , 1999,
Abstract: the relationship between eating disorders, like anorexia and bulimia, and depression are known, although not much discussed in the literature. this article presents a review of the literature concerning the relationship between those two eating disorders and depressive symptoms. the available information and the different explanative hypotheses concerning this subject are discussed. particular attention is given to the addictive hypothesis, according to which anorexia and bulimia are considered the reflection of a dependency problem that is also the cause of depression.
As representa??es dos técnicos de saúde de uma Maternidade face à substitui??o gestacional e às hospedeiras gestacionais ("Barrigas de Aluguer")
Leonardo,Joana; Nodin,Nuno;
Análise Psicológica , 2005,
Abstract: the goal of this study was to characterize and describe the evaluative dimensions that may be found in the social representations of health professionals (physicians, nurses, psychologists, social workers, dieticians, physiotherapists) working in a maternity hospital, in what concerns surrogacy, surrogate motherhood and surrogate mothers. an instrument was developed composed of five open questions and twenty three closed questions in a likert scale. the surveys were filled by a sample of eighty health professionals of a maternity hospital in lisbon. in general, the results show that personal inferences of the health professionals about the subject under investigation were related with pre-existent representations and preconceptions and not with scientific knowledge.
Representa??es paternas na anorexia nervosa
Nodin,Nuno; Leal,Isabel Pereira;
Análise Psicológica , 2005,
Abstract: the purpose of this study was to get more information about the father figure and its function in individuals suffering from anorexia nervosa, considering that this subject is very unusual in the specific literature available. according to the results, the anorectics are very ambivalent regarding their father figure, which is, at a conscious level, very affectionately invested and, at an unconscious level, felt as unwanted and negative.
A importancia do exercício físico nos anos maduros da sexualidade
Vaz,Raquel Almeida; Nodin,Nuno;
Análise Psicológica , 2005,
Abstract: the aim of this work is to study the influence that physical exercise may have upon the sexuality of elderly people. the sample is composed of 54 married subjects, with an age range of 65-75 years. it was divided into two groups, one of which consists of 27 subjects who regularly exercise, the other consisting of 27 subjects who do not exercise. a questionnaire about sexuality after the age of 65 was used as our instrument, after some adjustments. the non-exercising subjects were interviewed individually in a room at their respective day care centers, with the questionnaires being filled by the interviewer. the remaining subjects filled their own enquiries, which were handed at their gymnasiums along with filling instructions. the investigation was designed as an observational-descriptive study of inter-group comparison, and the results were analyzed using the mann-whitney (ordinal level answer options) and qui-square (nominal level answer options) tests. the results showed statistically relevant differences between the two samples on some of the studied dimensions, namely the sexual initiative, the mean frequency of sexual intercourse, the interest in sex life, the perceived changes of the couple?s mutual activities/ /amusements, the sensations obtained through sexual intercourse and the factors the subjects consider influence sex life. on this sample, on a general level, it was observed that exercising subjects are sexually more active than non-exercising subjects and a relation was established between the practice of physical exercise and some dimensions of elderly sexuality.
Modifying effect of gender on the prognostic value of clinicopathological factors and Ki67 expression in melanoma: a population-based cohort study
Marie Fridberg, Liv Jonsson, Julia Bergman, Bjorn Nodin, Karin Jirstrom
Biology of Sex Differences , 2012, DOI: 10.1186/2042-6410-3-16
Abstract: The study included 255 incident cases of melanoma, 132 females and 123 males, in the Malm? Diet and Cancer Study. Tumours from 226 (88.6%) cases had been assembled in tissue microarrays. Clinicopathological factors and immunohistochemical Ki67 expression were assessed and correlated with disease-free survival (DFS) and overall survival (OS) using Kaplan-Meier analysis, log rank test and univariable and multivariable Cox regression analyses, stratified for gender. Effect of gender on melanoma-specific survival (MSS) after first recurrence was also analysed.Women were significantly younger at diagnosis than men (p?=?0.012). The most common tumour sites were the legs in women (37.5%) and the dorsal trunk in men (37.8%). Kaplan-Meier analysis revealed that tumour location had no prognostic impact in women, but in men, location to the frontal trunk was significantly associated with a reduced DFS compared with all other locations combined and location to the dorsal trunk was significantly associated with a prolonged OS. High Ki67 expression was significantly associated with a reduced DFS and OS in men but not in women, also when adjusted for other factors. In men, but not in women, ulceration was an independent prognostic factor for both DFS and OS. MSS after first local, regional or distant recurrence was significantly shorter for men than for women.The results from this study demonstrate that the prognostic value of tumour location, Ki67 expression and ulceration in melanoma differs according to gender. These findings need to be validated in future studies, as they may help improve prognostication in patients with melanoma. Moreover, our findings demonstrate that sex-stratified analyses add valuable information to biomarker studies.
Gender, anthropometric factors and risk of colorectal cancer with particular reference to tumour location and TNM stage: a cohort study
Br?ndstedt Jenny,Wangefjord Sakarias,Nodin Bj?rn,Gaber Alexander
Biology of Sex Differences , 2012, DOI: 10.1186/2042-6410-3-23
Abstract: Background It remains unclear whether the increased risk of colorectal cancer (CRC) associated with obesity differs by gender, distribution of fat, tumour location and clinical (TNM) stage. The primary aim of this study was to examine these associations in 584 incident colorectal cancer cases from a Swedish prospective population-based cohort including 28098 men and women. Methods Seven anthropometric factors; height, weight, bodyfat percentage, hip circumference, waist circumference, BMI and waist-hip ratio (WHR) were categorized into quartiles of baseline anthropometric measurements. Relative risks of CRC, total risk as well as risk of different TNM stages, and risk of tumours located to the colon or rectum, were calculated for all cases, women and men, respectively, using multivariate Cox regression models. Results Obesity, as defined by all anthropometric variables, was significantly associated with an overall increased risk of CRC in both women and men. While none of the anthropometric measures was significantly associated with risk of tumour (T)-stage 1 and 2 tumours, all anthropometric variables were significantly associated with an increased risk of T-stage 3 and 4, in particular in men. In men, increasing quartiles of weight, hip, waist, BMI and WHR were significantly associated with an increased risk of lymph node positive (N1 and N2) disease, and risk of both non-metastatic (M0) and metastatic (M1) disease. In women, there were no or weak associations between obesity and risk of node-positive disease, but statistically significant associations between increased weight, bodyfat percentage, hip, BMI and M0 disease. Interestingly, there was an increased risk of colon but not rectal cancer in men, and rectal but not colon cancer in women, by increased measures of weight, hip-, waist circumference and bodyfat percentage. Conclusions This study is the first to show a relationship between obesity, measured as several different anthropometric factors, and an increased risk of colorectal cancer of more advanced clinical stage, in particular in men. These findings suggest that risk of CRC differs according to the method of characterising obesity, and also according to gender, location, and tumour stage.
ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data
Nodin Weddington, Alexander Stuy, Ichiro Hiratani, Tyrone Ryba, Tomoki Yokochi, David M Gilbert
BMC Bioinformatics , 2008, DOI: 10.1186/1471-2105-9-530
Abstract: We have developed ReplicationDomain http://www.replicationdomain.org webcite as a web-based database for analysis of genome-wide replication timing maps (replication profiles) from various cell lines and species. This database also provides comparative information of transcriptional expression and is configured to display any genome-wide property (for instance, ChIP-Chip or ChIP-Seq data) via an interactive web interface. Our published microarray data sets are publicly available. Users may graphically display these data sets for a selected genomic region and download the data displayed as text files, or alternatively, download complete genome-wide data sets. Furthermore, we have implemented a user registration system that allows registered users to upload their own data sets. Upon uploading, registered users may choose to: (1) view their data sets privately without sharing; (2) share with other registered users; or (3) make their published or "in press" data sets publicly available, which can fulfill journal and funding agencies' requirements for data sharing.ReplicationDomain is a novel and powerful tool to facilitate the comparative visualization of replication timing in various cell types as well as other genome-wide chromatin features and is considerably faster and more convenient than existing browsers when viewing multi-megabase segments of chromosomes. Furthermore, the data upload function with the option of private viewing or sharing of data sets between registered users should be a valuable resource for the scientific community.In eukaryotic cells, segments of chromosomes replicate via the synchronous firing of clusters of replication origins [1]. These segments or "replication domains" replicate in a defined temporal order during S-phase. This replication-timing program is cell type specific [2], and developmentally regulated changes in this program are associated with changes in chromatin structure and gene expression [2-5]. In particular, a global re-org
High MCM3 expression is an independent biomarker of poor prognosis and correlates with reduced RBM3 expression in a prospective cohort of malignant melanoma
Bj?rn Nodin, Marie Fridberg, Liv Jonsson, Julia Bergman, Mathias Uhlén, Karin Jirstr?m
Diagnostic Pathology , 2012, DOI: 10.1186/1746-1596-7-82
Abstract: Immunohistochemical MCM3 expression was examined in 224 incident cases of primary melanoma from the Malm? Diet and Cancer Study, previously analysed for RBM3 expression. Spearman′s Rho and Chi-Square tests were used to explore correlations between MCM3 expression, clinicopathological factors, and expression of RBM3 and Ki67. Kaplan Meier analysis, the log rank test, and univariable and multivariable Cox proportional hazards modelling were used to assess the impact of MCM3 expression on disease-free survival (DFS) and melanoma-specific survival (MSS).High MCM3 expression was significantly associated with unfavourable clinicopathological features and high Ki67 expression. A significant inverse correlation was seen between expression of MCM3 and RBM3 (p?=?0.025). High MCM3 expression was associated with a reduced DFS (HR?=?5.62) and MSS (HR?=?6.03), and these associations remained significant in multivariable analysis, adjusted for all other factors (HR?=?5.01 for DFS and HR?=?4.96 for MSS). RBM3 expression remained an independent prognostic factor for MSS but not DFS in the multivariable model.These findings provide validation of the utility of MCM3 expression as an independent biomarker for prognostication of patients with primary melanoma. Moreover, the inverse association and prognostic impact of MCM3 and RBM3 expression indicate a possible interaction of these proteins in melanoma progression, the functional basis for which merits further study.The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1814908129755401 webciteMalignant melanoma is an aggressive form of cancer with an increasing incidence and mortality worldwide [1]. Once a patient has moved into the stage of generalized disease, survival is very poor [2,3], but the clinical course of melanoma is highly variable even in patients with thin melanomas and localized disease [4-6]. Despite increasing insights into melanoma biology and advances in various “omic
Associations of beta-catenin alterations and MSIscreening status with expression of key cell cycleregulating proteins and survival from colorectalcancer
Sakarias Wangefjord, Jenny Br?ndstedt, Kajsa Ericson Lindquist, Bj?rn Nodin, Karin Jirstr?m, Jakob Eberhard
Diagnostic Pathology , 2013, DOI: 10.1186/1746-1596-8-10
Abstract: Immunohistochemical MSI-screening status and expression of p21, p27 and p53 was assessed in tissue microarrays with tumours from 557 cases of incident CRC in the Malmo Diet and Cancer Study. Chi Square and Spearman's correlation tests were used to explore the associations between beta-catenin expression, MSI status, clinicopathological characteristics and investigative parameters. Kaplan-Meier analysis and Cox proportional hazards modelling were used to assess the relationship between beta-catenin overexpression, MSI status and cancer specific survival (CSS).Positive MSI screening status was significantly associated with older age, female sex, proximal tumour location, non-metastatic disease, and poor differentiation, and inversely associated with beta-catenin overexpression. Beta-catenin overexpression was significantly associated with distal tumour location, low T-stage and well-differentiated tumours. Patients with MSI tumours had a significantly prolonged CSS in the whole cohort, and in stage III-IV disease, also in multivariable analysis, but not in stage I-II disease. Beta-catenin overexpression was associated with a favourable prognosis in the full cohort and in patients with stage III-IV disease. Neither MSI nor beta-catenin status were predictive for response to adjuvant chemotherapy in curatively treated stage III patients. P53 and p27 expression was positively associated with beta-catenin overexpression and inversely associated with MSI. Cyclin D1 expression was positively associated with MSI and beta-catenin overexpression, and p21 expression was positively associated with MSI but not beta-catenin overexpression.Findings from this large, prospective cohort study demonstrate that MSI screening status in colorectal cancer is an independent prognostic factor, but not in localized disease, and does not predict response to adjuvant chemotherapy. Beta-catenin overexpression was also associated with favourable outcome but not a treatment predictive factor Assoc
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