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Search Results: 1 - 10 of 406 matches for " Noboru Hanaoka "
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Fulminant amoebic colitis during chemotherapy for advanced gastric cancer
Noboru Hanaoka, Katsuhiko Higuchi, Satoshi Tanabe, Tohru Sasaki, Kenji Ishido, Takako Ae, Wasaburo Koizumi, Katsunori Saigenji
World Journal of Gastroenterology , 2009,
Abstract: A 52-year-old man had bloody stools during chemotherapy for gastric cancer. A colonoscopy revealed necrotizing ulcer-like changes. A biopsy confirmed the presence of amoebic trophozoites. Subsequently, peritonitis with intestinal perforation developed, and emergency peritoneal lavage and colostomy were performed. After surgery, endotoxin adsorption therapy was performed and metronidazole was given. Symptoms of peritonitis and colonitis resolved. However, the patient’s general condition worsened with the progression of gastric cancer. The patient died 50 d after surgery. Fulminant amoebic colitis is very rarely associated with chemotherapy. Amoebic colitis should be considered in the differential diagnosis of patients who have bloody stools during chemotherapy.
An Electrosurgical Endoknife with a Water-Jet Function (Flushknife) Proves Its Merits in Colorectal Endoscopic Submucosal Dissection Especially for the Cases Which Should Be Removed En Bloc
Yoji Takeuchi,Toshio Shimokawa,Ryu Ishihara,Hiroyasu Iishi,Noboru Hanaoka,Koji Higashino,Noriya Uedo
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/530123
Abstract: Background. Previously, we reported that the Flushknife (electrosurgical endoknife with a water-jet function) could reduce the operation time of colorectal endoscopic submucosal dissection (ESD) however, suitable situation for the Flushknife was obscure. This subgroup analysis of a prospective randomized controlled trial was aimed to investigate the suitable situation for the Flushknife. Methods. A total of 48 superficial colorectal neoplasms that underwent ESD using either the Flexknife or the Flushknife in a referral center were enrolled. The differences of operation time between the Flexknife and the Flushknife groups in each subgroup (tumor size, location, and macroscopic type) were analyzed. Results. Median (95% CI) operation time calculated using survival curves was significantly shorter in the Flushknife group than in the Flexknife group (55.5?min [41, 78] versus 74.0 [57, 90]?min; , Hazard Ratio HR: 0.53; 95% CI (0.29–0.97)). In particular, the HR in patients with laterally spreading tumors-nongranular type (LST-NG) in the Flushknife group was significantly smaller than in the Flexknife group (HR: 0.165 0.17; 95% CI (0.04–0.66)). There was a trend of decreasing HRs according to larger lesion size. Conclusions. The Flushknife proved its merits in colorectal ESD especially for the lesions which should be removed en bloc (LST-NG and large lesion). 1. Introduction Endoscopic submucosal dissection (ESD) is one of the standard treatments for large upper gastrointestinal superficial neoplasms in Japan and South Korea [1–5] because of its high en bloc resection (entire tumor resection in one piece) rate. ESD is also considered as a promising procedure in Western countries [6]. Although there are some reports on ESD for colorectal superficial neoplasms [7–9], ESD has not been a standard therapy for large colorectal superficial neoplasms, even in Japan. The reason is that it is time consuming, technically difficult, and related to a higher incidence of complications (perforation and bleeding) than conventional endoscopic mucosal resection (EMR) [10]. Flushknife (DK2618JN15, Fujifilm Medical, Tokyo, Japan) is a short needle electrosurgical endo-knife combined with a water-jet function (Figure 1(a)) [11]. We have reported that the Flushknife could reduce the operation time of colorectal ESD for patients with large colorectal superficial neoplasms [12], compared with a standard electrosurgical endo-knife (Flexknife; KD-630L, Olympus Medical Systems, Tokyo, Japan, Figure 1(b)) [13, 14]. In the study, we enrolled lesions larger than 20?mm and smaller than
Bi-Directional Signal Transmission in EPR Correlation  [PDF]
Noboru Hokkyo
Journal of Modern Physics (JMP) , 2014, DOI: 10.4236/jmp.2014.514134
Abstract:

A solution of nonlocal EPR correlation between counter-propagating pair of polarization entangled photons emitted from a common source at S and detected at points P and Q is sought outside the EPR’s reality criterion of local causality but within the framework of time-symmetric quantum electrodynamics allowing the bi-directional signal transmission P \"\" S \"\" Q on the double-light cone where the future and the past cones share common light paths connecting the photon source S and the detection points P and Q.

Distinct functions of Dnmt3a and Dnmt3b de novo DNA methyltransferases in ES cell proliferation and differentiation  [PDF]
Yoshie Umehara, Kazunori Hanaoka, Daisuke Watanabe
Stem Cell Discovery (SCD) , 2013, DOI: 10.4236/scd.2013.32017
Abstract:

Two de novo DNA methyltransferases, Dnmt3a and Dnmt3b, have been identified in humans and mice to contribute to the methylation of unmodified DNA. We recently showed a transition of de novo DNA methyltransferase expression from Dnmt3b to Dnmt3a during mouse embryogenesis and in tissue-specific stem cells, suggesting distinct functions of Dnmt3a and Dnmt3b during these processes. In this study, to characterize the functions of Dnmt3a and Dnmt3b in pluripotent stem cells, we exogenously transfected ES cells with Dnmt3a and Dnmt3b cDNAs linked to an internal ribosome entry site-green fluorescent protein gene, and then analyzed the effects of expression of these de novo DNA methyltransferases on ES cell growth and differentiation. ES cells expressing Dnmt3b showed specific downregulation of pluripotency marker genes such as Nanog and Oct 3/4. In addition, Dnmt3a-transfected ES cells showed a specific increase in mitotic index, while Dnmt3b-transfected ES cells showed a decrease in mitotic index. These results suggest that Dnmt3b has important physiological roles in the initial process of stem cell differentiation and that Dnmt3a has a function in stem cell proliferation.

Prostate Carcinogenesis with Diabetes and Androgen-Deprivation-Therapy-Related Diabetes: An Update
Noboru Hara
Experimental Diabetes Research , 2012, DOI: 10.1155/2012/801610
Abstract: Prostate cancer and the androgen deprivation therapy (ADT) thereof are involved in diabetes in terms of diabetes-associated carcinogenesis and ADT-related metabolic disorder, respectively. The aim of this study is to systematically review relevant literature. About 218,000 men are estimated to be newly diagnosed with prostate cancer every year in the United States. Approximately 10% of them are still found with metastasis, and in addition to them, about 30% of patients with nonmetastatic prostate cancer recently experience ADT. Population-based studies have shown that dissimilar to other malignancies, type 2 diabetes is associated with a lower incidence of prostate cancer, whereas recent large cohort studies have reported the association of diabetes with advanced high-grade prostate cancer. Although the reason for the lower prevalence of prostate cancer among diabetic men remains unknown, the lower serum testosterone and PSA levels in them can account for the increased risk of advanced disease at diagnosis. Meanwhile, insulin resistance already appears in 25–60% of the patients 3 months after the introduction of ADT, and long-term ADT leads to a higher incidence of diabetes (reported hazard ratio of 1.28–1.44). Although the possible relevance of cytokines such as Il-6 and TNF-α to ADT-related diabetes has been suggested, its mechanism is poorly understood.
A New Look at the Most Successful Prodrugs for Active Vitamin D (D Hormone): Alfacalcidol and Doxercalciferol
Noboru Kubodera
Molecules , 2009, DOI: 10.3390/molecules14103869
Abstract: Alfacalcidol (1α-hydroxyvitamin D3) has been widely used since 1981 as a prodrug for calcitriol (1α,25-dihydroxyvitamin D3) in the treatment of hypocalcemia, chronic renal failure, hypoparathyroidism and osteoporosis. More recently, doxercalciferol (1α-hydroxyvitamin D2) has been used since 1999 as a prodrug for 1α,25-dihydroxyvitamin D2 for the treatment of secondary hyperparathyroidism. Currently, six forms of vitamin D are known. They range from vitamin D2 to vitamin D7 and are distinguished by their differing side chains. Only vitamin D2 and vitamin D3 have been found to be biologically active based on the elucidation of activation pathways. Alfacalcidol and osteoporosis/doxercalciferol and secondary hyperparathyroidism are discussed, with a new look at old compounds including their practical syntheses.
Considerations on HAM/TSP: rediscovering Tumaco
Yasuda, Noboru;
Arquivos de Neuro-Psiquiatria , 1993, DOI: 10.1590/S0004-282X1993000100023
Abstract: considerations are made on the role of htl.v-i in the etiopathogeny of ham/ tsp. neuroepidemiologic data reported in the literature are revisited for this purpose. among results of this evaluation it is pointed-out that the gkinawan community of brazil presents ethnographic and demographic characteristics which are ideal for designining new studies. for instance, analyses on htlv-i and on ham/tsp in face of the cohort of such community classified according to time and direction of the migration (japan-brazil and vice-versa), will ensure promising results for the understanding of etiopathogeny of ham/tsp. they can also be paths towards clarifying the simultaneous generating, of geographical foci of the disease distant one the other, as that of tumaco and that of south japan.
Prostate Carcinogenesis with Diabetes and Androgen-Deprivation-Therapy-Related Diabetes: An Update
Noboru Hara
Journal of Diabetes Research , 2012, DOI: 10.1155/2012/801610
Abstract: Prostate cancer and the androgen deprivation therapy (ADT) thereof are involved in diabetes in terms of diabetes-associated carcinogenesis and ADT-related metabolic disorder, respectively. The aim of this study is to systematically review relevant literature. About 218,000 men are estimated to be newly diagnosed with prostate cancer every year in the United States. Approximately 10% of them are still found with metastasis, and in addition to them, about 30% of patients with nonmetastatic prostate cancer recently experience ADT. Population-based studies have shown that dissimilar to other malignancies, type 2 diabetes is associated with a lower incidence of prostate cancer, whereas recent large cohort studies have reported the association of diabetes with advanced high-grade prostate cancer. Although the reason for the lower prevalence of prostate cancer among diabetic men remains unknown, the lower serum testosterone and PSA levels in them can account for the increased risk of advanced disease at diagnosis. Meanwhile, insulin resistance already appears in 25–60% of the patients 3 months after the introduction of ADT, and long-term ADT leads to a higher incidence of diabetes (reported hazard ratio of 1.28–1.44). Although the possible relevance of cytokines such as Il-6 and TNF-α to ADT-related diabetes has been suggested, its mechanism is poorly understood. 1. Introduction Prostate cancer and the hormonal therapy thereof (androgen deprivation therapy, ADT) have been associated with diabetes in terms of diabetes-associated carcinogenesis [1] and ADT-related metabolic disorder [2], respectively. The present paper systematically introduces prostate carcinogenesis with diabetes and ADT-related diabetes/insulin resistance both in epidemiological and etiological approaches. 2. Search Method PubMed and MEDLINE searches were performed for articles published between January 1991 and November 2011 based on the following key words for diabetes-associated prostate carcinogenesis: prostate cancer AND insulin resistance, hyperglycemia, cancer risk, and diabetes. Literature on ADT-related diabetes was searched using the following keywords: androgen deprivation therapy OR hormone therapy AND diabetes, insulin resistance, hyperglycemia, and metabolic syndrome. Relevant articles on growth hormone (GH)/insulin-like growth factor (IGF)-1 and androgen metabolism were searched with similar strategy. Except for studies concerning statistics, meta-analysis, or reanalysis, review articles were excluded. All full papers based on evidence level 1 and 2 and full papers on level 3
Holographic Origin of Missing Mass and Cosmological Constant Related to Mass Defect in Semiclosed Friedman Universe  [PDF]
Noboru Hokkyo
Open Access Library Journal (OALib Journal) , 2014, DOI: 10.4236/oalib.1101233
Abstract: A holographic origin of missing mass and extremely high value of Einstein’s cosmological constant Λ ~ 10122 in quantum cosmology, compared to observational data ≤ Λ ≤ 1, is sought and related to extremely large relativistic mass defect of gravitional semiclosure of Friedman universe joined to an asymptotically flat outer space.
Fractal Structure of Quantum Gravity in Two Dimensions
Noboru Kawamoto
Physics , 1993,
Abstract: Recent numerical results on the fractal structure of two-dimensional quantum gravity coupled to $c=-2$ matter are reviewed. Analytic derivation of the fractal dimensions based on the Liouville theory and diffusion equation is also discussed. Excellent agreements between the numerical and theoretical results are obtained. Some problems on the non-universal nature of the fractal structure in the continuum limit are pointed out. ============================================================================ This is a review paper on \lq\lq Fractal Structure of Quantum Gravity in Two Dimension. Talk given at Nishinomiya-Yukawa Simposium, Nov. 1992. Figures are available from the author directly as hard copies.
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