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Search Results: 1 - 10 of 145032 matches for " Noah F Shroyer "
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Insulin Concentration Modulates Hepatic Lipid Accumulation in Mice in Part via Transcriptional Regulation of Fatty Acid Transport Proteins
Samir Softic, Michelle Kirby, Nicholas G. Berger, Noah F. Shroyer, Stephen C. Woods, Rohit Kohli
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0038952
Abstract: Background Fatty liver disease (FLD) is commonly associated with insulin resistance and obesity, but interestingly it is also observed at low insulin states, such as prolonged fasting. Thus, we asked whether insulin is an independent modulator of hepatic lipid accumulation. Methods/Principal Findings In mice we induced, hypo- and hyperinsulinemia associated FLD by diet induced obesity and streptozotocin treatment, respectively. The mechanism of free fatty acid induced steatosis was studied in cell culture with mouse liver cells under different insulin concentrations, pharmacological phosphoinositol-3-kinase (PI3K) inhibition and siRNA targeted gene knock-down. We found with in vivo and in vitro models that lipid storage is increased, as expected, in both hypo- and hyperinsulinemic states, and that it is mediated by signaling through either insulin receptor substrate (IRS) 1 or 2. As previously reported, IRS-1 was up-regulated at high insulin concentrations, while IRS-2 was increased at low levels of insulin concentration. Relative increase in either of these insulin substrates, was associated with an increase in liver-specific fatty acid transport proteins (FATP) 2&5, and increased lipid storage. Furthermore, utilizing pharmacological PI3K inhibition we found that the IRS-PI3K pathway was necessary for lipogenesis, while FATP responses were mediated via IRS signaling. Data from additional siRNA experiments showed that knock-down of IRSs impacted FATP levels. Conclusions/Significance States of perturbed insulin signaling (low-insulin or high-insulin) both lead to increased hepatic lipid storage via FATP and IRS signaling. These novel findings offer a common mechanism of FLD pathogenesis in states of both inadequate (prolonged fasting) and ineffective (obesity) insulin signaling.
Atonal homolog 1 Is a Tumor Suppressor Gene
Wouter Bossuyt,Avedis Kazanjian,Natalie De Geest,Sofie Van Kelst,Gert De Hertogh,Karel Geboes,Greg P. Boivin,Judith Luciani,Francois Fuks,Marinee Chuah,Thierry VandenDriessche,Peter Marynen,Jan Cools,Noah F. Shroyer,Bassem A. Hassan
PLOS Biology , 2012, DOI: 10.1371/journal.pbio.1000039
Abstract: Colon cancer accounts for more than 10% of all cancer deaths annually. Our genetic evidence from Drosophila and previous in vitro studies of mammalian Atonal homolog 1 (Atoh1, also called Math1 or Hath1) suggest an anti-oncogenic function for the Atonal group of proneural basic helix-loop-helix transcription factors. We asked whether mouse Atoh1 and human ATOH1 act as tumor suppressor genes in vivo. Genetic knockouts in mouse and molecular analyses in the mouse and in human cancer cell lines support a tumor suppressor function for ATOH1. ATOH1 antagonizes tumor formation and growth by regulating proliferation and apoptosis, likely via activation of the Jun N-terminal kinase signaling pathway. Furthermore, colorectal cancer and Merkel cell carcinoma patients show genetic and epigenetic ATOH1 loss-of-function mutations. Our data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation.
Atonal homolog 1 Is a Tumor Suppressor Gene
Wouter Bossuyt equal contributor,Avedis Kazanjian equal contributor,Natalie De Geest,Sofie Van Kelst,Gert De Hertogh,Karel Geboes,Greg P Boivin,Judith Luciani,Francois Fuks,Marinee Chuah,Thierry VandenDriessche,Peter Marynen,Jan Cools,Noah F Shroyer ,Bassem A Hassan
PLOS Biology , 2009, DOI: 10.1371/journal.pbio.1000039
Abstract: Colon cancer accounts for more than 10% of all cancer deaths annually. Our genetic evidence from Drosophila and previous in vitro studies of mammalian Atonal homolog 1 (Atoh1, also called Math1 or Hath1) suggest an anti-oncogenic function for the Atonal group of proneural basic helix-loop-helix transcription factors. We asked whether mouse Atoh1 and human ATOH1 act as tumor suppressor genes in vivo. Genetic knockouts in mouse and molecular analyses in the mouse and in human cancer cell lines support a tumor suppressor function for ATOH1. ATOH1 antagonizes tumor formation and growth by regulating proliferation and apoptosis, likely via activation of the Jun N-terminal kinase signaling pathway. Furthermore, colorectal cancer and Merkel cell carcinoma patients show genetic and epigenetic ATOH1 loss-of-function mutations. Our data indicate that ATOH1 may be an early target for oncogenic mutations in tissues where it instructs cellular differentiation.
Does Pay Disparity Really Hamstring Team Performance? A Study of Professional Ice Hockey Players  [PDF]
Noah Stefanec
Sociology Mind (SM) , 2012, DOI: 10.4236/sm.2012.24058
Abstract: Here, I employ an unbalanced panel of data from the National Hockey League (NHL) to examine the impact of pay disparity on team-cohesiveness. I find evidence to suggest the existence of a negative relationship between higher degrees of within-position pay disparity and team performance; the evidence reported here shows a simple monotonic elasticity of team performance with respect to pay disparity to be roughly 19%.
Automatic Classifications of Malay Proverbs Using Naive Bayesian Algorithm
S.A. Noah,F. Ismail
Information Technology Journal , 2008,
Abstract: This research presented an experimental study on automatic classification of Malay proverbs using Na ve Bayesian algorithm. The automatic classification tasks were implemented using two Bayesian models, multinomial and multivariate Bernoulli model. Both models were calibrated using one thousand training and testing dataset which were classified into five categories: family, life, destiny, social and knowledge. Two types of testing have been conducted; testing on dataset with stop words and dataset with no stop words by using three cases of Malay proverbs, i.e., proverb alone, proverb with meaning and proverb with the meaning and example sentences. The intuition was that, since proverbs were commonly short statement, the inclusion of its meaning and associated used in sentences could improve the accuracy of classification. The results showed that a maximum of 72.2 and 68.2% of accuracy have been achieved respectively by the Multinomial model and the Multivariate Bernoulli for the dataset with no stop words using proverb with the meaning and example sentences. This experiment has indicated the capability of the Na ve Bayesian algorithm in performing proverbs classification particularly with the inclusion of meaning and example usage of such proverbs.
New Pore Pressure Evaluation Techniques for LAGIA-8 Well, Sinai, Egypt as a Case Study  [PDF]
Ahmed Zakaria Noah
International Journal of Geosciences (IJG) , 2016, DOI: 10.4236/ijg.2016.71004
Abstract: Drilling into a geopressured zone will generally cause a change in a number of basic formation/ drilling relationships. This change is usually seen as a reversal of a gradual depth related trend in a lithologically uniform formation. Of all the geophysical methods, the reflection seismic method is essentially the only technique used to predict pore pressures. The seismic method detects changes of interval velocity with depth from velocity analysis of the seismic data. These changes are in turn related to lithology, pore fluid type, rock fracturing and pressure changes within a stratigraphic column. When the factors affecting the velocity are understood for a given area, a successful pressure prediction can be made. For clastic environments such as the Tertiary section of the Gulf of Mexico or the Niger delta, the interval velocity of the rocks increases with depth because of compaction. In these areas, deviations from normal compaction trends are related to abnormally high pore pressures. The adapted methods provide a much easier way to handle normal compaction trend lines. In addition to well log methods, pressure detection can be obtained via drilling parameters by applying Eaton’s DXC methods. Seismic velocities have long been used to estimate pore pressure, indeed both these quantities are influenced by variations in rock properties such as porosity, density, effective stress and so on, and high pore pressure zones are often associated with low seismic velocities. Pressure prediction from seismic data is based on fundamentals of rock physics and seismic attribute analysis. This paper hence tries to assess the use of seismic waves as a viable means to calculate pore pressure, especially in areas where no prior drilling history can be found. Then we applied these methods on LAGIA-8 well, Sinai, Egypt as a case study. Pore pressure prediction from Seismic is a very essential tool to predict pore pressure before drilling operation. This could prevent the well problem as well blowout and to prevent formation damage, especially in areas where no prior drilling history can be found.
Religious Epistemology in John Hick’s Philosophy: A Nigerian Appreciation  [PDF]
Olusegun Noah Olawoyin
Open Journal of Philosophy (OJPP) , 2016, DOI: 10.4236/ojpp.2016.62019
Abstract: John Hick is well-known among philosophers and theologians for his philosophy of religious pluralism. Before proposing his theory of religious pluralism, however, he has made major contributions in religious epistemology and other religio-philosophical issues. His later philosophy of religious pluralism is based on his earlier proposal on religious epistemology. Hick affirmed that although religious statements are cognitive, the world is religiously ambiguous. This paper argues that Nigeria as a country riddled with religious conflicts can benefit from religious epistemology of John Hick. Using conceptual analytic method of philosophy to present Hick’s religious epistemology and applicatory technique to propose how the epistemology can be appropriated in Nigeria, the paper argues that such religious epistemology will result in tolerance and peace.
Energy Targeting for a Brewing Process Using Pinch Analysis  [PDF]
Noah Tibasiima, Aldo Okullo
Energy and Power Engineering (EPE) , 2017, DOI: 10.4236/epe.2017.91002
Abstract: The rising cost of energy and environmental concerns have led the brewing industry to search for techniques of reducing energy consumption in brewery operations. In this paper, pinch analysis was applied to a typical Ugandan based brewery process to target for the energy requirements of the process. Hint software was used for the analysis. At the chosen ΔTmin of 10, the minimum cooling and heating utility requirements of the brewery studied were determined as being 4862.21 kW and 8294.21 kW respectively, with a pinch temperature at 68. It was observed that using the technique, 1806.59 kW of energy could be recovered through process to process heat exchange which presented an energy saving potential of 21.5%. It is recommended that results from this study could be used in the design or retrofit of a heat exchanger network of a brewery for improved energy efficiency. Considerations can also be made for other values of ΔTmin.
The Local Migration of Plant-Based Medicines from Rural Communities to Gral. E. Aquino, Paraguay  [PDF]
Noah Goyke, Blair Orr
Natural Resources (NR) , 2018, DOI: 10.4236/nr.2018.912027
Abstract: Rural Paraguay presents interesting opportunities for investigating the subtle differences in the use of medicinal plants across seasons and the urban versus rural dichotomy in a local setting. This study investigates three aspects of plant-based medicinal use in rural Paraguay: 1) seasonal differences and 2) differences between urban and rural residents and 3) the source of medicinal plants used to treat thirteen common ailments. Interviews performed in January through March 2015 and repeated in June through August 2015 revealed small differences between seasons and between places of residence but a larger homogeneity in the two populations, a homogeneity that stems from the recent migration of urban residents from nearby rural communities. We also found that the important cultural and preventive medicinal use of plant-based additions to yerba mate contributes to the similarities between the urban and rural populations. The findings suggest the continued strength of medicinal plant use going into the near future.
Possible Topological Superconducting Phases of MoS$_{2}$
Noah F. Q. Yuan,Kin Fai Mak,K. T. Law
Physics , 2014, DOI: 10.1103/PhysRevLett.113.097001
Abstract: Molybdenum disulphide (MoS$_2$) has attracted much interest in recent years due to its potential applications in a new generation of electronic devices. Recently, it was shown that thin films of MoS$_2$ can become superconducting with a highest $T_{c}$ of 10K when the material is heavily gated to the conducting regime. In this work, using the group theoretical approach, we determine the possible pairing symmetries of heavily gated MoS$_2$. Depending on the electron-electron interactions, the material can support an exotic spin-singlet $p +ip $-wave-like, an exotic spin-triplet s-wave-like and an conventional spin-triplet $p$-wave pairing phases. Importantly, the exotic spin-singlet $p+ip$-wave phase is a topological superconducting phase which breaks time-reversal symmetry spontaneously and possesses chiral Majorana edge states.
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