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Search Results: 1 - 10 of 82819 matches for " Nina Liu "
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Diarrhea and Hypokalemic Rhabdomyolysis Due to Apoptotic Colitis as the Initial Manifestation of Common-Variable Immunodeficiency in an Adolescent  [PDF]
David Green, Nina Dave, Hua Liu, Charu Subramony, Michael J. Nowicki
Open Journal of Pediatrics (OJPed) , 2014, DOI: 10.4236/ojped.2014.42018

We present the case of an adolescent who presented with rhabdomyolysis due to severe hypokalemia arising from chronic diarrhea. Initial evaluation for celiac disease, known to present in this manner, was negative. Further evaluation with colonoscopy showed a normal appearing colon but biopsies showed a significant number of apoptotic cells in the mucosal crypts supporting a diagnosis of apoptotic colitis. Investigation into the cause of apoptotic colitis resulted in a diagnosis of common variable immune deficiency due to a defect in the inducible T-cell costimulator (ICOS) gene. Physicians should be aware of this uncommon condition and the importance of mucosal biopsy despite the presence of normal appearing mucosa.

Comparison Study of Three Common Technologies for Freezing-Thawing Measurement
Xinbao Yu,Bin Zhang,Nina Liu,Xiong (Bill) Yu
Advances in Civil Engineering , 2010, DOI: 10.1155/2010/239651
Abstract: This paper describes a comparison study on three different technologies (i.e., thermocouple, electrical resistivity probe and Time Domain Reflectometry (TDR)) that are commonly used for frost measurement. Specially, the paper developed an analyses procedure to estimate the freezing-thawing status based on the dielectric properties of freezing soil. Experiments were conducted where the data of temperature, electrical resistivity, and dielectric constant were simultaneously monitored during the freezing/thawing process. The comparison uncovered the advantages and limitations of these technologies for frost measurement. The experimental results indicated that TDR measured soil dielectric constant clearly indicates the different stages of the freezing/thawing process. Analyses method was developed to determine not only the onset of freezing or thawing, but also the extent of their development. This is a major advantage of TDR over other technologies. 1. Introduction In cold regions, freeze-thaw cycles induce ground settlement and cause the loss of load bearing capacity of subgrades. Soils can be very strong when they are frozen during the winter but become substantially weak in the spring when they are thawing [1]. This leads to large deflection and accelerates crack initialization in pavement structure. In addition to the detrimental effects on soil mechanical properties, freeze-thaw cycles can also affect the subsurface drainage capability and produce additional soil pressure on the underground structures [2, 3]. While extensive research have been conducted on completely frozen soils, the current knowledge on soil behaviors during the freezing-thawing process is limited. For example, Spaans and Baker [4] evaluated the use of TDR in the context of freezing and thawing of soils based on a gas dilatomer calibration. Fen-Chong et al. [5] and Fabbri et al. [6] suggested an empirical method to estimate the degree of freezing in porous media based on permittivity. A few factors could have contributed to the lack of development in this area. This includes, for example, the requirements of sophisticate experimental control to ensure uniform freezing/thawing development; the technical challenge of accurately determining the extent of freezing/thawing in soils. Technologies commonly used for field frost measurement do not provide quantitative data on the extent of soil freezing-thawing. This paper describes a comparison study on frost measurement principles, including those based on the electrical resisitivity, the temperature and the dielectric properties. An
Preferences for mode of delivery in nulliparous Argentinean women: a qualitative study
Liu Nancy H,Mazzoni Agustina,Zamberlin Nina,Colomar Mercedes
Reproductive Health , 2013, DOI: 10.1186/1742-4755-10-2
Abstract: Background Over the last three decades, cesarean section (CS) rates have been rising around the world despite no associated improvement in maternal and perinatal mortality and morbidity. The role of women’s preferences for mode of delivery in contributing to the high CS rate remains controversial; however these preferences are difficult to assess, as they are influenced by culture, knowledge of risk and benefits, and personal and social factors. In this qualitative study, our objective was to understand women’s preferences and motivational factors for mode of delivery. This information will inform the development and design of an assessment aimed at understanding the role of the women’s preferences for mode of delivery. Methods We conducted 4 focus group discussions (FGDs) and 12 in-depth interviews with pregnant women in Buenos Aires, Argentina in 4 large non-public and public hospitals. Our sample included 29 nulliparous pregnant women aged 18–35 years old, with single pregnancies over 32 weeks of gestational age, without pregnancies resulting from assisted fertility, without known pre-existing medical illness or diseases diagnosed during pregnancy, without an indication of elective cesarean section, and who are not health professionals. FGDs and interviews followed a pre-designed guide based on the health belief model and social cognitive theory of health decisions and behaviors. Results Most of the women preferred vaginal delivery (VD) due to cultural, personal, and social factors. VD was viewed as normal, healthy, and a natural rite of passage from womanhood to motherhood. Pain associated with vaginal delivery was viewed positively. In contrast, women viewed CS as a medical decision and often deferred decisions to medical staff in the presence of medical indication. Conclusions These findings converge with quantitative and qualitative studies showing that women prefer towards VD for various cultural, personal and social reasons. Actual CS rates appear to diverge from women’s preferences and reasons are discussed.
Uncommon Presentation of a Benign Nasopharyngeal Mass in an Adolescent: Comprehensive Review of Pediatric Nasopharyngeal Masses
Victor M. Duarte,Yuan F. Liu,Nina L. Shapiro
Case Reports in Pediatrics , 2013, DOI: 10.1155/2013/816409
Abstract: Nasopharyngeal masses in the pediatric population are quite rare, and the majority of these are benign. In adolescent boys, there should be a high index of suspicion for juvenile nasopharyngeal angiofibromas. When malignant, the most common lesions encountered are rhabdomyosarcomas, carcinomas, and lymphomas. We report a single case from a tertiary care institution of an adolescent male with an unusual presentation of a benign nasopharyngeal mass and provide a comprehensive review of pediatric nasopharyngeal masses. Whenever possible, radiographic imaging should be obtained, in addition to biopsy, to assist in the diagnosis of pediatric nasopharyngeal masses. 1. Introduction Nasopharyngeal masses in the pediatric population are quite rare, and the majority of these are benign. Differential diagnoses of nasopharyngeal masses in the pediatric population include inflammatory lesions, malignant tumors, and congenital masses. The rarity of pediatric nasopharyngeal masses and the diversity of possible pathologies make a clinical diagnosis difficult. An understanding of the anatomy and histology of the nasopharynx is critical in deciphering the etiology of a lesion arising in this region. The nasopharynx is part of??the pharynx, which includes the oropharynx and hypopharynx, and is a part of the upper respiratory tract. Anteriorly it originates at the posterior aspect of the nasal turbinates and is perforated by the posterior nares, forming the choanae. Posteriorly and superiorly it is bordered by the skull base. Inferiorly it extends to the level of the soft palate, where the oropharynx begins. The lateral wall of the nasopharynx contains the ostium of the eustachian tube, which is surrounded by mucosa. The ostium of the eustachian tube is anterior to a pharyngeal recess known as the fossa of Rosenmuller. The nasopharynx is lined by stratified squamous epithelium at the anterior, posterior, and inferior walls and by respiratory epithelium at the roof and nasal choanae. The remaining areas have mixtures of squamous and respiratory or intermediate (transitional) epithelium. There is abundant lymphoid tissue present, particularly at the rim of eustachian tube opening, which is functionally equivalent to that of gastrointestinal tract or mucosal-associated lymphoid tissue [1]. We present a case of an adolescent male with a nasopharyngeal mass that presented with physical and radiographic findings concerning a malignancy. Although the pathology in this was benign, this prompted a comprehensive review of pediatric nasopharyngeal masses. Given the anatomical
Urban Growth and Its Impact on Cityscape: A Geospatial Analysis of Rohtak City, India  [PDF]
Nina Singh, Jitendra Kumar
Journal of Geographic Information System (JGIS) , 2012, DOI: 10.4236/jgis.2012.41002
Abstract: Rohtak is one of the eight priority towns (Regional Centres) of National Capital Region (NCR) Regional Plan 2001. It lies 70 kms north-west from Delhi, the National Capital of India. Located at 28?41'1'' North latitude and 76?12'42'' East longitude in the NCR region of Haryana state on National Highway No. 10, it spreads over 100.57 km2. Its population was projected to grow to 500,000 by 2001. Despite its nearness to the national capital it did not attract investment and the rate of urbanization remained low. Rohtak city grew slower than the state of Haryana in the three decades ending in 2001. On being declared as Municipal Corporation in 2010 urban growth of Rohtak took place in the form of extension in territorial jurisdiction and inclusion of urbanized eight villages. The new economic environment demands sustainable land management. Spatial information of land use/land cover types and their change detection in time series are important means for city planning and undertaking development activities. The present work is undertaken in that spirit. It has analyzed the relationship between urban growth and land use changes and their impact on Rohtak city. The period of focus is from 1983 to 2010. Both primary and secondary sources of data have been used for the present study. Secondary sources of data—guide map, topographical sheet and high resolution satellite imageries have been used to detect land use/land cover changes from the study area whereas primary source of data include ground truth and photographs from the field.
Recent Active Fires under El Niño Conditions in Kalimantan, Indonesia  [PDF]
Nina Yulianti, Hiroshi Hayasaka
American Journal of Plant Sciences (AJPS) , 2013, DOI: 10.4236/ajps.2013.43A087

Analysis of the most recent 10-year periods (2002 to 2011) of MODIS hotspots data (fires) and precipitation in Palangkaraya and Pontianak was carried out to identify seasonal and spatial fire occurrence in Kalimantan under El Nino conditions, and to asses future forest condition in Kalimantan. Most data was tallied every 10-day to analyze seasonal and spatial fire occurrence. Seasonal and spatial analysis results for severe fire years, namely 2006 and 2009, under El Nino conditions were as follows: the severest fire incidents for whole Kalimantan occurred in October in 2006 under the driest conditions in both Palangkaraya and Pontianak. The severest fires for the Mega Rice Project (MRP) area and its vicinity occurred in late September in 2009 under the driest conditions for Palangkaraya. Fire activities in the last 10-year in south Central Kalimantan were severe than other areas in Kalimantan. This may be explained by different dry conditions of peat. Namely, the peat in the southern part of Central Kalimantan could become dryer under the relatively longer dry season (about 3-month) compared with other areas (dry season in West Kalimantan is only 2/3-month). One of spatial analysis results clearly showed a so-called a fire belt shape arising from severe fires that occurred mainly on the southern coastal peatlands from West to Central Kalimantan in mid October in 2006.

RETRACTED: Biophysics and Cancer: The Electromagnetic Fields Produced by the Mitochondria and Its Effect on the Cell’s Metabolic Regulation  [PDF]
Nina Bardi de Alvarez
Journal of Electromagnetic Analysis and Applications (JEMAA) , 2014, DOI: 10.4236/jemaa.2014.610033

Short Retraction Notice

The paper does not meet the standards of \" Journal of Electromagnetic Analysis and Applications \".

This article has been retracted to straighten the academic record. In making this decision the Editorial Board follows COPE's Retraction Guidelines. The aim is to promote the circulation of scientific research by offering an ideal research publication platform with due consideration of internationally accepted standards on publication ethics. The Editorial Board would like to extend its sincere apologies for any inconvenience this retraction may have caused.

Please see the article page for more details. The full retraction notice in PDF is preceding the original paper which is marked \"RETRACTED\".

Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis
Sarah L. Kinnings ,Nina Liu ,Nancy Buchmeier ,Peter J. Tonge,Lei Xie ,Philip E. Bourne
PLOS Computational Biology , 2009, DOI: 10.1371/journal.pcbi.1000423
Abstract: The rise of multi-drug resistant (MDR) and extensively drug resistant (XDR) tuberculosis around the world, including in industrialized nations, poses a great threat to human health and defines a need to develop new, effective and inexpensive anti-tubercular agents. Previously we developed a chemical systems biology approach to identify off-targets of major pharmaceuticals on a proteome-wide scale. In this paper we further demonstrate the value of this approach through the discovery that existing commercially available drugs, prescribed for the treatment of Parkinson's disease, have the potential to treat MDR and XDR tuberculosis. These drugs, entacapone and tolcapone, are predicted to bind to the enzyme InhA and directly inhibit substrate binding. The prediction is validated by in vitro and InhA kinetic assays using tablets of Comtan, whose active component is entacapone. The minimal inhibition concentration (MIC99) of entacapone for Mycobacterium tuberculosis (M.tuberculosis) is approximately 260.0 μM, well below the toxicity concentration determined by an in vitro cytotoxicity model using a human neuroblastoma cell line. Moreover, kinetic assays indicate that Comtan inhibits InhA activity by 47.0% at an entacapone concentration of approximately 80 μM. Thus the active component in Comtan represents a promising lead compound for developing a new class of anti-tubercular therapeutics with excellent safety profiles. More generally, the protocol described in this paper can be included in a drug discovery pipeline in an effort to discover novel drug leads with desired safety profiles, and therefore accelerate the development of new drugs.
Novel GLP-1 Fusion Chimera as Potent Long Acting GLP-1 Receptor Agonist
Qinghua Wang,Kui Chen,Rui Liu,Fang Zhao,Sandeep Gupta,Nina Zhang,Gerald J. Prud'homme
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0012734
Abstract: GLP-1 has a variety of anti-diabetic effects. However, native GLP-1 is not suitable for therapy of diabetes due to its short half-life (t1/2<2 min). To circumvent this, we developed a long-lasting GLP-1 receptor agonist by the fusion of GLP-1 with human IgG2 Fc (GLP-1/hIgG2). ELISA-based receptor binding assay demonstrated that GLP-1/hIgG2 had high binding affinity to the GLP-1R in INS-1 cells (Kd = 13.90±1.52 nM). Upon binding, GLP-1/hIgG2 was rapidly internalized by INS-1 cells in a dynamin-dependent manner. Insulin RIA showed that GLP-1/IgG2 dose-dependently stimulated insulin secretion from INS-1 cells. Pharmacokinetic studies in CD1 mice showed that with intraperitoneal injection (i.p.), the GLP-1/hIgG2 peaked at 30 minutes in circulation and maintained a plateau for >168 h. Intraperitoneal glucose tolerance test (IPGTT) in mice showed that GLP-1/hIgG2 significantly decreased glucose excursion. Furthermore, IPGTT performed on mice one week after a single drug-injection also displayed significantly reduced glucose excursion, indicating that GLP-1/hIgG2 fusion protein has long-lasting effects on the modulation of glucose homeostasis. GLP-1/hIgG2 was found to be effective in reducing the incidence of diabetes in multiple-low-dose streptozotocin-induced type 1 diabetes in mice. Together, the long-lasting bioactive GLP-1/hIgG2 retains native GLP-1 activities and thus may serve as a potent GLP-1 receptor agonist.
Essential Role of the Small GTPase Ran in Postnatal Pancreatic Islet Development
Fang Xia, Takehiko Dohi, Nina M. Martin, Christopher M. Raskett, Qin Liu, Dario C. Altieri
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027879
Abstract: The small GTPase Ran orchestrates pleiotropic cellular responses of nucleo-cytoplasmic shuttling, mitosis and subcellular trafficking, but whether deregulation of these pathways contributes to disease pathogenesis has remained elusive. Here, we generated transgenic mice expressing wild type (WT) Ran, loss-of-function Ran T24N mutant or constitutively active Ran G19V mutant in pancreatic islet β cells under the control of the rat insulin promoter. Embryonic pancreas and islet development, including emergence of insulin+ β cells, was indistinguishable in control or transgenic mice. However, by one month after birth, transgenic mice expressing any of the three Ran variants exhibited overt diabetes, with hyperglycemia, reduced insulin production, and nearly complete loss of islet number and islet mass, in vivo. Deregulated Ran signaling in transgenic mice, adenoviral over-expression of WT or mutant Ran in isolated islets, or short hairpin RNA (shRNA) silencing of endogenous Ran in model insulinoma INS-1 cells, all resulted in decreased expression of the pancreatic and duodenal homeobox transcription factor, PDX-1, and reduced β cell proliferation, in vivo. These data demonstrate that a finely-tuned balance of Ran GTPase signaling is essential for postnatal pancreatic islet development and glucose homeostasis, in vivo.
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