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Search Results: 1 - 10 of 3088 matches for " Nils ?berg "
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Entwicklung neuer Kommunikationswege - Einsatz und Nutzen von Foren in der Tiermedizin [Development of new structures - Message boarding: application and use in veterinary medicine]
Wilcken, Bj?rn,von Berg, Stephan,Baltersee, Nils,Carl, Thorsten
GMS Zeitschrift für Medizinische Ausbildung , 2008,
Abstract: [english] The availability of information and communication in german veterinary medicine is widespread and web-based media is a growing factor in this phenomenon. Parallel to this development, social and professional networks are becoming increasingly more important in the profession. The goal of the internet-based message board with the domain name Foren4Vet.de (founded 2002), is to establish a point of contact for professional members, students, and individuals interested in studying veterinary medicine. Today, in cooperation with the School of Veterinary Medicine in Hannover and with the veterinary panel of the Association of Medical Education, Foren4Vet provides an integrative platform for all members of the veterinary medicine profession. An online evaluation of the website showed a high demand for such a platform especially among the younger group of student users. Part of the website offers secure access for authorized members only, ensuring closed-group communication between professional groups and individuals associated with the university. At the same time, the message board supports the increasing demand for asynchronous and interdisciplinary communication. [german] Information und Kommunikation der veterin rmedizinischen Berufsgruppe findet heutzutage vielerorts statt, dabei gewinnen webbasierte Medien stetig an Bedeutung. Gleichzeitig nimmt die Bildung von fachlichen und sozialen Netzwerken innerhalb der Veterin rmedizin einen immer gr eren Stellenwert ein. Im Jahr 2002 wurde die Diskussionsplattform Foren4Vet gegründet mit dem Ziel, eine Anlaufstelle für Mitglieder dieser Berufsgruppe zu sein und einen Austausch zu erm glichen. Foren4Vet erfreut sich zunehmenden Interesses und bietet durch Kooperation mit der Tier rztlichen Hochschule Hannover und dem Ausschuss Tiermedizin der GMA, sowie anderen veterin rmedizinischen Projekten eine einheitliche und übergreifende Forenplattform. In einer Online-Befragung der Nutzer kristallisierte sich die Nachfrage nach solchen Medien in der gesamten Berufsgruppe, insbesondere in der Gruppe der jungen Studierenden. Die Einrichtung geschlossener Bereiche garantiert, dass berufsgruppen- sowie hochschulinterne Informationen nur an authentifizierte Teilnehmer gelangen. Gleichzeitig wird das Forum der steigenden Nachfrage an interdisziplin rer, asynchroner Kommunikation gerecht.
The Heterogeneity of Asthma Phenotypes in Children and Young Adults
Bill Hesselmar,Anna-Carin Enelund,Bo Eriksson,Leonid Padyukov,Lars ?. Hanson,Nilsberg
Journal of Allergy , 2012, DOI: 10.1155/2012/163089
Abstract: Objective. Genetic heterogeneity and risk factor distribution was analyzed in two previously proposed asthma phenotypes. Method. A sample of 412 subjects was investigated at 7-8, 12-13, and 21-22 years of age with questionnaires, skin prick tests, and genetic analysis of IL-4 receptor (IL4R) single-nucleotide polymorphisms. The sample was subdivided in one group with no asthma, and two groups with asthma separated by age of onset of symptoms, namely, early onset asthma (EOA) and late onset asthma (LOA). Risk factors and IL4R markers were analyzed in respect to asthma phenotypes. Results. EOA and LOA groups were both associated with atopy and a maternal history of asthma. Female gender was more common in LOA, whereas childhood eczema, frequent colds in infancy, and a paternal history of asthma were more common in EOA. The AA genotype of rs2057768 and the GG genotype of rs1805010 were more common in LOA, whereas the GG genotype of rs2107356 was less common in EOA. Conclusion. Our data suggest that early and late onset asthma may be of different endotypes and genotypes. 1. Introduction Asthma is a common disease, but it has been questioned if it is one single disease, or a group of asthmatic diseases. Such different “phenotypes” of asthma may vary in response to treatment [1], in prognosis [2], in inflammatory patterns [3], and in susceptibility to environmental exposure [4]. Identifying possible subphenotypes has therefore rendered increasing interest in recent years [5, 6]. But a reliable subgroup classification of asthma (or any other disease) can seldom include only clinical parameters, very often additional biomarkers have to be included [7] in order to find genetic or endotypic differences. In the 1990s, the Tucson group presented data on lung function of infants from a population-based birth-cohort study and they also retrospectively classified preschool wheeze into three subgroups or phenotypes, namely, transient wheeze, early persistent wheeze, and late onset asthma [8]. Interestingly, not only transient wheeze had a characteristic phenotype pattern, there were also differences between the two asthma subgroups, with eczema being more common among children with early persistent wheeze than among children with asthma onset after the age of 3 years. If the noticed difference in the prevalence of eczema in children with early versus late onset of respiratory symptoms is of any phenotypic significance is, however, not known. Our own data reveal that 12-13-year-old children with asthma and eczema differ regarding the interleukin-4 receptor genotype from
Serotonin Transporter Polymorphism Modulates N-Back Task Performance and fMRI BOLD Signal Intensity in Healthy Women
Rune Jonassen, Tor Endestad, Alexander Neumeister, Kari Bente Foss Haug, Jens Petter Berg, Nils Inge Landr?
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0030564
Abstract: Context Exploring intermediate phenotypes within the human brain's functional and structural circuitry is a promising approach to explain the relative contributions of genetics, complex behaviors and neural mechanisms in the development of major depressive disorder (MDD). The polymorphic region 5-HTTLPR in the serotonin transporter gene (SLC6A4) has been shown to modulate MDD risk, but the neural underpinnings are incompletely understood. Objective 37 right handed healthy women between 21 and 61 years of age were invited to participate in an fMRI modified n-back study. The functional polymorphism 5-HTTLPR located in the promoter region of the SLC6A4 gene was genotyped using polymerase chain reaction (PCR). Results Short 5-HTTLPR allele carriers showed more blood-oxygen-level-dependent (BOLD) bilateral prefrontal cortex activation in the right [F(2, 30) = 4.8, η2 = .25, p = .026] and left [F(2, 30) = 4.1, η2 = .22, p = .015] inferior frontal gyrus pars triangularis with increasing n-back task difficulty relative to long 5-HTTLPR allele carriers. Short 5-HTTLPR allele carriers had inferior task performance on the most difficult n-back condition [F(2, 30) = 4.9, η2 = .26, p = .014]. Conclusions This activation pattern found in healthy at risk individuals resembles an activation pattern that is typically found in patients suffering from acute MDD. Altered function in these areas may reflect intermediate phenotypes and may help explain the increased risk of depression in short 5-HTTLPR allele carriers.
The Vestibular Implant: Quo Vadis?
Raymond van de Berg,Nils Guinand,Robert J. Stokroos,Herman Kingma
Frontiers in Neurology , 2011, DOI: 10.3389/fneur.2011.00047
Abstract: Objective: To assess the progress of the development of the vestibular implant (VI) and its feasibility short-term. Data sources: A search was performed in Pubmed, Medline, and Embase. Key words used were “vestibular prosth*” and “VI.” The only search limit was language: English or Dutch. Additional sources were medical books, conference lectures and our personal experience with per-operative vestibular stimulation in patients selected for cochlear implantation. Study selection: All studies about the VI and related topics were included and evaluated by two reviewers. No study was excluded since every study investigated different aspects of the VI. Data extraction and synthesis: Data was extracted by the first author from selected reports, supplemented by additional information, medical books conference lectures. Since each study had its own point of interest with its own outcomes, it was not possible to compare data of different studies. Conclusion: To use a basic VI in humans seems feasible in the very near future. Investigations show that electric stimulation of the canal nerves induces a nystagmus which corresponds to the plane of the canal which is innervated by the stimulated nerve branch. The brain is able to adapt to a higher baseline stimulation, while still reacting on a dynamic component. The best response will be achieved by a combination of the optimal stimulus (stimulus profile, stimulus location, precompensation), complemented by central vestibular adaptation. The degree of response will probably vary between individuals, depending on pathology and their ability to adapt.
The Modified Ampullar Approach for Vestibular Implant Surgery: Feasibility and Its First Application in a Human with a Long-Term Vestibular Loss
Raymond van de Berg,Nils Guinand,Jean-Philippe Guyot,Herman Kingma,Robert J. Stokroos
Frontiers in Neurology , 2012, DOI: 10.3389/fneur.2012.00018
Abstract: Objective: To assess, for the first time in a human with a long-term vestibular loss, a modified approach to the ampullae and the feasibility of evoking a VOR by ampullar stimulation. Materials and methods: Peroperative stimulation of the ampullae, using the ampullar approach, was performed under full anesthesia during cochlear implantation in a 21-year-old female patient, who had experienced bilateral vestibular areflexia and sensorineural hearing loss for almost 20 years. Results: The modified ampullar approach was performed successfully with as minimally invasive surgery as possible. Ampullar stimulation evoked eye movements containing vectors congruent with the stimulated canal. As expected, the preliminary electrophysiological data were influenced by the general anesthesia, which resulted in current spread and reduced maximum amplitudes of eye movement. Nevertheless, they confirm the feasibility of ampullar stimulation. Conclusion: The modified ampullar approach provides safe access to the ampullae using as minimally invasive surgery as possible. For the first time in a human with long-term bilateral vestibular areflexia, it is shown that the VOR can be evoked by ampullar stimulation, even when there has been no vestibular function for almost 20 years. This approach should be considered in vestibular surgery, as it provides safe access to one of the most favorable stimulus locations for development of a vestibular implant.
Artificial Balance: Restoration of the Vestibulo-Ocular Reflex in Humans with a Prototype Vestibular Neuroprosthesis
Angelica Perez Fornos,Nils Guinand,Raymond Van De Berg,Robert Stokroos,Silvestro Micera,Marco Pelizzone,Jean Philippe Guyot
Frontiers in Neurology , 2014, DOI: 10.3389/fneur.2014.00066
Abstract: The vestibular system plays a crucial role in the multisensory control of balance. When vestibular function is lost, essential tasks such as postural control, gaze stabilization, and spatial orientation are limited and the quality of life of patients is significantly impaired. Currently there is no effective treatment for bilateral vestibular deficits. Research efforts both in animals and humans during the last decade set a solid background to the concept of using electrical stimulation to restore vestibular function. Still, the potential clinical benefit of a vestibular neuroprosthesis has to be demonstrated to pave the way for a translation into clinical trials. An important parameter for the assessment of vestibular function is the Vestibulo-Ocular Reflex (VOR), the primary mechanism responsible for maintaining the perception of a stable visual environment while moving. Here we show that the VOR can be artificially restored in humans using motion-controlled, amplitude modulated electrical stimulation of the ampullary branches of the vestibular nerve. Three patients received a vestibular neuroprosthesis prototype, consisting of a modified cochlear implant providing vestibular electrodes. Significantly higher VOR responses were observed when the prototype was turned ON. Furthermore, VOR responses increased significantly as the intensity of the stimulation increased, reaching on average 79% of those measured in healthy volunteers in the same experimental conditions. These results constitute a fundamental milestone and allow us to envision for the first time clinically useful rehabilitation of patients with bilateral vestibular loss.
A Study of Personality and Family- and School Environment and Possible Interactional Effects in 244 Swedish Children—A Multiple Regression Analysis  [PDF]
Nils Bertil Gerhard Persson
Psychology (PSYCH) , 2014, DOI: 10.4236/psych.2014.58100
Abstract:

The aim of the study was to examine relationships between psychosocial family- and school environment and personality as assessed by the Junior Eysenck Personality Questionnaire (EPQ-J) and possible personality interactional effects. The study was based on 244 Swedish girls and boys, 10 - 19 years old, who filled in the Family- and School Psychosocial Environment (FSPE) questionnaire and the EPQ-J. A multiple regression analysis showed that the FSPE-factor family conflicts and school discipline predicts psychoticism (antisocial personality), and that the FSPE-factor warmth, support and openness from parents, siblings and peers predict extraversion. Sex, psychoticism and the size of sibling group predicted neuroticism. Spanking was reported in various degrees by 8.1 percent of the children, and this factor was related to psychoticism. These results support socialization theories. The most unexpected finding was the impact of interactions between personality variables themselves, influencing the FSPE’s predictability of neuroticism. Discussion about the advantage of the use of statistic control in a multiple regression, possible causal links between psychosocial environment and personality, limitations and further research propositions concludes the article.

Asymmetric Special Theory of Relativity  [PDF]
Nils H. Abramson
Journal of Modern Physics (JMP) , 2018, DOI: 10.4236/jmp.2018.93033
Abstract: Einstein’s Special Theory of Relativity (SR) relates time dilation to the velocity between the observer and the observed object as if they are identical. Our new theory breaks this symmetry by relating the velocity of the object not directly to the observer, but instead to the center of gravity of object and observer. The reason why such a mass influence has not been reported might be that the mass of the observer in most experiments is much greater than that of the object, for example when earth is observing, satellites or detectors are studying nuclear masses.
A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs
Tommy J?nsson, Bo Ahrén, Giovanni Pacini, Frank Sundler, Nils Wierup, Stig Steen, Trygve Sj?berg, Martin Ugander, Johan Frosteg?rd, Leif G?ransson, Staffan Lindeberg
Nutrition & Metabolism , 2006, DOI: 10.1186/1743-7075-3-39
Abstract: Upon weaning twenty-four piglets were randomly allocated either to cereal based swine feed (Cereal group) or cereal free Paleolithic diet consisting of vegetables, fruit, meat and a small amount of tubers (Paleolithic group). At 17 months of age an intravenous glucose tolerance test was performed and pancreas specimens were collected for immunohistochemistry. Group comparisons of continuous variables were made by use of the t-test. P < 0.05 was chosen for statistical significance. Simple and multivariate correlations were evaluated by use of linear regression analysis.At the end of the study the Paleolithic group weighed 22% less and had 43% lower subcutaneous fat thickness at mid sternum. No significant difference was seen in fasting glucose between groups. Dynamic insulin sensitivity was significantly higher (p = 0.004) and the insulin response was significantly lower in the Paleolithic group (p = 0.001). The geometric mean of C-reactive protein was 82% lower (p = 0.0007) and intra-arterial diastolic blood pressure was 13% lower in the Paleolithic group (p = 0.007). In evaluations of multivariate correlations, diet emerged as the strongest explanatory variable for the variations in dynamic insulin sensitivity, insulin response, C-reactive protein and diastolic blood pressure when compared to other relevant variables such as weight and subcutaneous fat thickness at mid sternum. There was no obvious immunohistochemical difference in pancreatic islets between the groups, but leukocytes were clearly more frequent in sampled pancreas from the Cereal group.This study in domestic pigs suggests that a Paleolithic diet conferred higher insulin sensitivity, lower C-reactive protein and lower blood pressure when compared to a cereal based diet.Our pre-agricultural, hunter-gatherer human ancestors during the Paleolithic period (the old stone age; 2.5 million – 10,000 years BP) had a diet based on vegetables, fruit, nuts, roots, meat, organ meats and insects [1]. This Paleolit
Process Adaption and Modifications of a Nutrient Removing Wastewater Treatment Plant in Sri Lanka Operated at Low Loading Conditions  [PDF]
Johanna Berg, Stig Morling
Materials Sciences and Applications (MSA) , 2013, DOI: 10.4236/msa.2013.45038
Abstract:

The Sri Lankan national water authority, that is The National Water Supply and Drainage Board (NWS&DB) has taken a new wastewater treatment plant into operation at Ja Ela, North of Colombo. The plant has been in operation since September 2011. In April 2012, it was concluded how a test of the aeration efficiency and a performance test should be carried out. The tests have been based on the actual loading of the plant and the analysis results from the daily process control. The evaluation of the aeration efficiency is not reported in this paper. The paper presents the overall performance of the water treatment part of the plant during start-up conditions, from fall 2011 through the first five months of 2012. The results from the operation are found in Table 1. An important circumstance at the plant is the current very low loading in comparison with the design load. This fact has resulted in an introduction of an intermittent mode of the aeration (nitrification) reactor. Based on operation figures, during more than a month (May 2012), it has been possible to give a realistic assessment of the overall performance. The most striking results are summarized as follows: 1) The intermittent operation has enabled an energy efficient operation of the plant. By the introduction of the intermittent aeration, the energy consumption has been reduced by around 75%, compared with the continuous operation mode; 2) The plant performance during the intermittent operation has been improved with respect to virtually all important pollu

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