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Search Results: 1 - 10 of 331 matches for " Nicoletta Casartelli "
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Tetherin Restricts Productive HIV-1 Cell-to-Cell Transmission
Nicoletta Casartelli equal contributor,Marion Sourisseau equal contributor,Jerome Feldmann,Florence Guivel-Benhassine,Adeline Mallet,Anne-Geneviève Marcelin,John Guatelli,Olivier Schwartz
PLOS Pathogens , 2010, DOI: 10.1371/journal.ppat.1000955
Abstract: The IFN-inducible antiviral protein tetherin (or BST-2/CD317/HM1.24) impairs release of mature HIV-1 particles from infected cells. HIV-1 Vpu antagonizes the effect of tetherin. The fate of virions trapped at the cell surface remains poorly understood. Here, we asked whether tetherin impairs HIV cell-to-cell transmission, a major means of viral spread. Tetherin-positive or -negative cells, infected with wild-type or ΔVpu HIV, were used as donor cells and cocultivated with target lymphocytes. We show that tetherin inhibits productive cell-to-cell transmission of ΔVpu to targets and impairs that of WT HIV. Tetherin accumulates with Gag at the contact zone between infected and target cells, but does not prevent the formation of virological synapses. In the presence of tetherin, viruses are then mostly transferred to targets as abnormally large patches. These viral aggregates do not efficiently promote infection after transfer, because they accumulate at the surface of target cells and are impaired in their fusion capacities. Tetherin, by imprinting virions in donor cells, is the first example of a surface restriction factor limiting viral cell-to-cell spread.
DRAM Triggers Lysosomal Membrane Permeabilization and Cell Death in CD4+ T Cells Infected with HIV
Mireille Laforge,Sophie Limou,Francis Harper,Nicoletta Casartelli,Vasco Rodrigues,Ricardo Silvestre,Houda Haloui,Jean-Francois Zagury,Anna Senik,Jerome Estaquier
PLOS Pathogens , 2013, DOI: 10.1371/journal.ppat.1003328
Abstract: Productive HIV infection of CD4+ T cells leads to a caspase-independent cell death pathway associated with lysosomal membrane permeabilization (LMP) and cathepsin release, resulting in mitochondrial outer membrane permeabilization (MOMP). Herein, we demonstrate that HIV infection induces damage-regulated autophagy modulator (DRAM) expression in a p53-dependent manner. Knocking down the expression of DRAM and p53 genes with specific siRNAs inhibited autophagy and LMP. However, inhibition of Atg5 and Beclin genes that prevents autophagy had a minor effect on LMP and cell death. The knock down of DRAM gene inhibited cytochrome C release, MOMP and cell death. However, knocking down DRAM, we increased viral infection and production. Our study shows for the first time the involvement of DRAM in host-pathogen interactions, which may represent a mechanism of defense via the elimination of infected cells.
Which Future for Neuroscience in Forensic Psychiatry: Theoretical Hurdles and Empirical Chances
Luca Casartelli,Cristiano Chiamulera
Frontiers in Psychiatry , 2013, DOI: 10.3389/fpsyt.2013.00074
Le fonti slave dell’esperanto Le fonti slave dell’esperanto
Nicoletta Marcialis
Studi Slavistici , 2012,
Cooperative Hypertext: An Educational Example
Nicoletta SALA
The Turkish Online Journal of Distance Education , 2002,
La tutela del paesaggio: percorsi giuridici
Nicoletta Ferrucci
Aestimum , 2007,
Lucia Saetta e Cristina Vannini Parenti (a cura di), Blog & Nuvole. Un incontro tra la scrittura della rete e l’arte del fumetto.
Nicoletta Vallorani
Altre Modernità , 2009,
Abstract: Lucia Saetta e Cristina Vannini Parenti (a cura di), Blog & Nuvole. Un incontro tra la scrittura della rete e l’arte del fumetto.
Il Gesù di Stracci
Nicoletta Vallorani
Altre Modernità , 2010,
Abstract: Il Gesù di Stracci (Tomaso Subini, Pier Paolo Pasolini. La ricotta, Torino, Lindau, 2009, pp.221, ISBN 978-88-7180-814-7) di Nicoletta Vallorani
Path(o)s of Mourning. Memory, Death and the Invisible Body in Derek Jarman’s Blue
Nicoletta Vallorani
Altre Modernità , 2010,
Abstract: The essay addresses two quite complex issues. The first one is the virulence of the hostility toward gay men that the AIDS pandemic has released: this is the backdrop against which Jarman's extended elaboration and mourning for his own death is performed, after his diagnosis as body-positive in 1986. The second issue links to the open question of public mourning and its relation to AIDS in the early 90s, when the AIDS epidemic is not at its height, but it is certainly more visible than before, and many artists register the impact of the new sensibility this medical and social emergency actually moulds. Considering a specific time span (the 90s) and focusing mostly on cinema a strategic, privileged arena where gay cultures resist to social and cultural sanctions, this work elaborates on how AIDS as a deathly social and cultural destiny has suggested strategies of mournings that introduce new artistic practices. The analysis is specifically focused on Derek Jarman's last works, culminating in the film Blue (1993).
A. Pajalich, Il bianco, il nero, il colore. Cinema dell’Impero Britannico e delle sue ex colonie (1929-1972).
Nicoletta Vallorani
Altre Modernità , 2009,
Abstract: A. Pajalich, Il bianco, il nero, il colore. Cinema dell’Impero Britannico e delle sue ex colonie (1929-1972).
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