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Search Results: 1 - 10 of 226500 matches for " Nicole R. Villemarette-Pittman "
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Sporadic Creutzfeldt-Jakob disease with focal findings: caveats to current diagnostic criteria
Edward C. Mader,Rima El-Abassi,Nicole R. Villemarette-Pittman,Lenay Santana-Gould
Neurology International , 2013, DOI: 10.4081/ni.2013.e1
Abstract: The clinical diagnosis of Creutzfeldt-Jakob disease (CJD) is largely based on the 1998 World Health Organization diagnostic criteria. Unfortunately, rigid compliance with these criteria may result in failure to recognize sporadic CJD (sCJD), especially early in its course when focal findings predominate and traditional red flags are not yet present. A 61-year-old man presented with a 3-week history of epilepsia partialis continua (jerking of the left upper extremity) and a 2-week history of forgetfulness and left hemiparesis; left hemisensory neglect was also detected on admission. Repeated brain magnetic resonance imaging (MRI) showed areas of restricted diffusion in the cerebral cortex, initially on the right but later spreading to the left. Electroencephalography (EEG) on hospital days 7, 10, and 14 showed right-sided periodic lateralized epileptiform discharges. On day 20, the EEG showed periodic sharp wave complexes leading to a diagnosis of probable sCJD and subsequently to definite sCJD with brain biopsy. Neurological decline was relatively fast with generalized myoclonus and akinetic mutism developing within 7 weeks from the onset of illness. CJD was not immediately recognized because of the patient’s focal/lateralized manifestations. Focal/lateralized clinical, EEG, and MRI findings are not uncommon in sCJD and EEG/MRI results may not be diagnostic in the early stages of sCJD. Familiarity with these caveats and with the most current criteria for diagnosing probable sCJD (University of California San Francisco 2007, MRI-CJD Consortium 2009) will enhance the ability to recognize sCJD and implement early safety measures.
Typical Spike-and-Wave Activity in Hypoxic-Ischemic Brain Injury and its Implications for Classifying Nonconvulsive Status Epilepticus
Edward C. Mader Jr,Nicole R. Villemarette-Pittman,Sergei V. Kashirny,Lenay Santana-Gould
Clinical Medicine Insights: Case Reports , 2012,
Botulinum Toxin Injections for Simple Partial Motor Seizures Associated with Pain
Edward C. Mader Jr.,Bruce J. Fisch,Nicole R. Villemarette-Pittman,Piotr W. Olejniczak,Michael E. Carey
Case Reports in Medicine , 2012, DOI: 10.1155/2012/295251
Abstract: Intractable epilepsy with painful partial motor seizures is a relatively rare and difficult disorder to treat. We evaluated the usefulness of botulinum toxin to reduce ictal pain. Two patients received two or four botulinum toxin (BTX) injections at one-to-two-month intervals. Patient 1 had painful seizures of the right arm and hand. Patient 2 had painful seizures involving the left foot and leg. Injections were discontinued after improved seizure control following resective surgery. Both patients received significant pain relief from the injections with analgesia lasting at least two months. Seizure severity was reduced, but seizure frequency and duration were unaffected. For these patients, BTX was effective in temporarily relieving pain associated with muscle contraction in simple partial motor seizures. Our findings do not support the hypothesis that modulation of motor end-organ feedback affects focal seizure generation. BTX is a safe and reversible treatment that should be considered as part of adjunctive therapy after failure to achieve control of painful partial motor seizures.
Typical Spike-and-Wave Activity in Hypoxic-Ischemic Brain Injury and its Implications for Classifying Nonconvulsive Status Epilepticus
Edward C. Mader Jr, Nicole R. Villemarette-Pittman, Sergei V. Kashirny, Lenay Santana-Gould and Piotr W. Olejniczak
Clinical Medicine Insights: Case Reports , 2012, DOI: 10.4137/CCRep.S9861
Abstract: Introduction: Typical spike-and-wave activity (TSWA) in the electroencephalogram (EEG) indicates idiopathic generalized epilepsy (IGE). IGE-related nonconvulsive status epilepticus (NCSE) is typically an absence status epilepticus (ASE). ASE and TSWA respond dramatically to benzodiazepines. Patients with no history of seizure/epilepsy may develop ASE “de novo” in the context of an acute brain disorder. However, we are aware of only one previous case of de novo ASE with TSWA in hypoxic-ischemic brain injury. Case presentation: A 65-year-old man, with congestive heart failure and history of substance abuse, survived cardiorespiratory arrest after 18 minutes of cardiopulmonary resuscitation. Post-resuscitation, the patient was in coma with intact brainstem function. Toxicology was positive for cocaine and marijuana. Eyelid myoclonus suggested NCSE, which was initially treated with lorazepam and fosphenytoin. EEG monitoring showed sustained TSWA confirming NCSE and demonstrating de novo ASE (the patient and his family never had seizure/epilepsy). The TSWA was resistant to lorazepam, levetiracetam, and low-dose midazolam; it was eliminated only with midazolam at a dose that resulted in burst-suppression (≥1.2 mg/kg/hour). Conclusion: This is an unusual case of TSWA and hypoxic-ischemic brain injury in a patient with no history of seizure/epilepsy. The TSWA was relatively resistant to benzodiazepines suggesting that cerebral hypoxia-ischemia spared the thalamocortical apparatus generating TSWA but impaired the cortical/thalamic inhibitory circuits where benzodiazepines act to suppress TSWA. Albeit rare, ‘post-hypoxic’ TSWA offers us some valuable insights for classifying and managing nonconvulsive status epilepticus.
Advances in Development of Countermeasures for Potential Biothreat Agents
Phillip R. Pittman,Kelly T. McKee,Zygmunt F. Dembek
Advances in Preventive Medicine , 2012, DOI: 10.1155/2012/570246
Advances in Development of Countermeasures for Potential Biothreat Agents
Phillip R. Pittman,Kelly T. McKee Jr.,Zygmunt F. Dembek
Advances in Preventive Medicine , 2012, DOI: 10.1155/2012/570246
Monte Carlo Study of an Inhomogeneous Blume-Capel Model
S. M. Pittman,G. G. Batrouni,R. T. Scalettar
Physics , 2008, DOI: 10.1103/PhysRevB.78.214208
Abstract: Systems of particles in a confining potential exhibit a spatially dependent density which fundamentally alters the nature of phase transitions that occur. A specific instance of this situation, which is being extensively explored currently, concerns the properties of ultra-cold, optically trapped atoms. Of interest is how the superfluid-insulator transition is modified by the inhomogeneity, and, indeed, the extent to which a sharp transition survives at all. This paper explores a classical analog of these systems, the Blume-Capel model with a spatially varying single ion anisotropy and/or temperature gradient. We present results both for the nature of the critical properties and for the validity of the "local density approximation" which is often used to model the inhomogeneous case. We compare situations when the underlying uniform transition is first and second order.
Comentario bibliográfico: Juan Carlos Gómez Leyton (2011). "Política, Democracia y Ciudadanía en una Sociedad Neoliberal (Chile: 1990-2010)", Santiago de Chile: Editorial ARCIS/PROSPAL/CLACSO, 488 pp.
Nicole Ríos Kroyer
Divergencia , 2012,
The Relative Importance of Household Budget Categories: A Best-Worst Analysis  [PDF]
S. R. Dominick, Nicole Olynk Widmar, Lalatendu Acharya, Courtney Bir
Advances in Applied Sociology (AASoci) , 2018, DOI: 10.4236/aasoci.2018.85023
Abstract: Headlines regularly report on the changing or unmet needs of households and are often focused on costs of healthcare swamping household resources or childcare costs, forcing families to make tradeoffs that negatively influence children or society. Development of impactful educational programming and public policy necessitates an understanding of various households’ allocations of resources, specially the poor, food insecure households. In order to explore households’ relative prioritization of expenditures, a survey was conducted in this manuscript with a sample of Midwest residents (n = 1263), with the objective of evaluating the relationship between household demographics and budgeting prioritization of six expenditure categories. Individual respondent’s relative prioritization for budgeting categories was estimated using a best-worst experiment for six expenditure categories. Housing was the most important expenditure category identified for the sample. Housing also received the largest share of relative importance for two of four latent classes identified. For both low and the very low food secure households a significant and positive relationship was found between their food security status and the relative importance placed on childcare and transportation. Identification of segments of respondents with specific priorities (e.g., childcare expenditures) may aid in the development of impactful policies, particularly for at-risk populations (e.g., food insecure households).
Comparison of osteogenic potentials of human rat BMP4 and BMP6 gene therapy using [E1-] and [E1-,E2b-] adenoviral vectors
Hongwei Li, Jin Zhong Li, Debra D. Pittman, Andy Amalfitano, Gerald R. Hankins, Gregory A. Helm
International Journal of Medical Sciences , 2006,
Abstract: Osteogenic potentials of some recombinant human bone morphogenetic protein (BMP) first-generation adenoviral vectors (ADhBMPs) are significantly limited in immunocompetent animals. It is unclear what role expression of viral proteins and foreign proteins transduced by adenoviral vectors play in the host immune response and in ectopic bone formation. In this study two sets of experiments were designed and performed. First, rat BMP6 cDNA were amplified, sequenced, and recombined in first-generation adenoviral vector (ADrBMP6). A comparison of human and rat BMP6 adenoviral vectors demonstrated identical osteogenic activities in both immunodeficient and immunocompetent rats. Second, the activities of recombinant human BMP6 in E1- (ADhBMP6) and [E1-,E2b-] ( [E1-,E2b-]ADGFP&hBMP6, and [E1-,E2b-]ADhBMP6) adenoviral vectors were compared in both in vitro and in vivo models. Similar activities of these two generations of BMP adenoviral vectors were found in all models. These results indicate that the amount of viral gene expression and the source of the BMP cDNA are not major factors in the interruption of osteogenic potentials of recombinant BMP6 adenoviral vectors in immunocompetent animals.
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