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Search Results: 1 - 10 of 9357 matches for " Nicolas Anton "
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Low energy nanoemulsification to design veterinary controlled drug delivery devices
Thierry F Vandamme, Nicolas Anton
International Journal of Nanomedicine , 2010, DOI: http://dx.doi.org/10.2147/IJN.S13273
Abstract: w energy nanoemulsification to design veterinary controlled drug delivery devices Original Research (6342) Total Article Views Authors: Thierry F Vandamme, Nicolas Anton Published Date October 2010 Volume 2010:5 Pages 867 - 873 DOI: http://dx.doi.org/10.2147/IJN.S13273 Thierry F Vandamme, Nicolas Anton, University of Strasbourg, Faculty of Pharmacy, Illkirch Cedex, France; UMR CNRS 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, Illkirch Cedex, France, This work is selected as Controlled Release Society Outstanding Veterinary Paper Award 2010 Abstract: The unique properties of nanomaterials related to structural stability and quantum-scale reactive properties open up a world of possibilities that could be exploited to design and to target drug delivery or create truly microscale biological sensors for veterinary applications. We developed cost-saving and solvent-free nanoemulsions. Formulated with a low-energy method, these nanoemulsions can find application in the delivery of controlled amounts of drugs into the beverage of breeding animals (such as poultry, cattle, pigs) or be used for the controlled release of injectable poorly water-soluble drugs.
Low energy nanoemulsification to design veterinary controlled drug delivery devices
Thierry F Vandamme,Nicolas Anton
International Journal of Nanomedicine , 2010,
Abstract: Thierry F Vandamme, Nicolas Anton, University of Strasbourg, Faculty of Pharmacy, Illkirch Cedex, France; UMR CNRS 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, Illkirch Cedex, France, This work is selected as Controlled Release Society Outstanding Veterinary Paper Award 2010Abstract: The unique properties of nanomaterials related to structural stability and quantum-scale reactive properties open up a world of possibilities that could be exploited to design and to target drug delivery or create truly microscale biological sensors for veterinary applications. We developed cost-saving and solvent-free nanoemulsions. Formulated with a low-energy method, these nanoemulsions can find application in the delivery of controlled amounts of drugs into the beverage of breeding animals (such as poultry, cattle, pigs) or be used for the controlled release of injectable poorly water-soluble drugs.Keywords: nanoemulsion, nanomedicine, low-energy emulsification, veterinary, ketoprofen, sulfamethazine
Trojan Microparticles for Drug Delivery
Nicolas Anton,Anshuman Jakhmola,Thierry F. Vandamme
Pharmaceutics , 2012, DOI: 10.3390/pharmaceutics4010001
Abstract: During the last decade, the US Food and Drug Administration (FDA) have regulated a wide range of products, (foods, cosmetics, drugs, devices, veterinary, and tobacco) which may utilize micro and nanotechnology or contain nanomaterials. Nanotechnology allows scientists to create, explore, and manipulate materials in nano-regime. Such materials have chemical, physical, and biological properties that are quite different from their bulk counterparts. For pharmaceutical applications and in order to improve their administration (oral, pulmonary and dermal), the nanocarriers can be spread into microparticles. These supramolecular associations can also modulate the kinetic releases of drugs entrapped in the nanoparticles. Different strategies to produce these hybrid particles and to optimize the release kinetics of encapsulated drugs are discussed in this review.
Update on quantum cohomology of IG(2,2n)
Anton Mellit,Nicolas Perrin,Maxim Smirnov
Mathematics , 2015,
Abstract: We give another proof of the generic semisimplicity of the big quantum cohomology of the symplectic isotropic Grassmannians IG(2,2n).
From stochastic, individual-based models to the canonical equation of adaptive dynamics - In one step
Martina Baar,Anton Bovier,Nicolas Champagnat
Quantitative Biology , 2015,
Abstract: We consider a model for Darwinian evolution in an asexual population with a large but non-constant populations size characterized by a natural birth rate, a logistic death rate modelling competition and a probability of mutation at each birth event. In the present paper, we study the long-term behavior of the system in the limit of large population $(K\to \infty)$ size, rare mutations $(u\to 0)$, and small mutational effects $(\sigma\to 0)$, proving convergence to the canonical equation of adaptive dynamics (CEAD). In contrast to earlier works, e.g. by Champagnat and M\'el\'eard, we take the three limits simultaneously, i.e. $u=u_K$ and $\sigma=\sigma_K$, tend to zero with $K$, subject to conditions that ensure that the time-scale of birth and death events remains separated from that of successful mutational events. This slows down the dynamics of the microscopic system and leads to serious technical difficulties that requires the use of completely different methods. In particular, we cannot use the law of large numbers on the diverging time needed for fixation to approximate the stochastic system with the corresponding deterministic one. To solve this problem we develop a "stochastic Euler scheme" based on coupling arguments that allows to control the time evolution of the stochastic system over time-scales that diverge with $K$.
A New Application of Lipid Nanoemulsions as Coating Agent, Providing Zero-Order Hydrophilic Drug Release from Tablets
Nicolas Anton,Astrid de Crevoisier,Sabrina Schmitt,Thierry Vandamme
Journal of Drug Delivery , 2012, DOI: 10.1155/2012/271319
Abstract: The objective of the present investigation was to evaluate potential of nanoemulsions as a coating material for the tablets. The nanoemulsion of size less than 100 nm was prepared using a simple and low-energy spontaneous emulsification method. Conventional tablets containing theophylline as a model hydrophilic drug were prepared. The theophylline tablets were coated with the nanoemulsion using a fluid bed coater. The effect of different levels of the nanoemulsion coating on the theophylline release was evaluated. The theophylline tablets containing different levels of the nanoemulsion coating could be successfully prepared. Interestingly, the coating of tablet with the nanoemulsion resulted in zero-order release of theophylline from the tablets. The noncoated theophylline tablets release the entire drug in less than 2 minutes, whereas nanoemulsion coating delayed the release of theophylline from tablets. This investigation establishes the proof of concept for the potential of nanoemulsions as a coating material for tablets.
Seamless Gene Tagging by Endonuclease-Driven Homologous Recombination
Anton Khmelinskii, Matthias Meurer, Nurlanbek Duishoev, Nicolas Delhomme, Michael Knop
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0023794
Abstract: Gene tagging facilitates systematic genomic and proteomic analyses but chromosomal tagging typically disrupts gene regulatory sequences. Here we describe a seamless gene tagging approach that preserves endogenous gene regulation and is potentially applicable in any species with efficient DNA double-strand break repair by homologous recombination. We implement seamless tagging in Saccharomyces cerevisiae and demonstrate its application for protein tagging while preserving simultaneously upstream and downstream gene regulatory elements. Seamless tagging is compatible with high-throughput strain construction using synthetic genetic arrays (SGA), enables functional analysis of transcription antisense to open reading frames and should facilitate systematic and minimally-invasive analysis of gene functions.
Impact of Ionic Liquid 1-Ethyl-3-Methylimidazolium Acetate Mediated Extraction on Lignin Features  [PDF]
Idi Guga Audu, Isabelle Ziegler-Devin, Heiko Winter, Martina Bremer, Anton Hoffmann, Steffen Fischer, Marie-Pierre Laborie, Nicolas Brosse
Green and Sustainable Chemistry (GSC) , 2017, DOI: 10.4236/gsc.2017.72010
Abstract: This study aims at investigating the impact of ionic liquid extraction on lignin structure by studying the mechanism of lignin depolymerization in 1-ethyl-3-methylimidazolium acetate EMIM[OAc]) and comparing it with that of organosolv and milled wood methods. Ionic liquid mediated lignin (ILL) using EMIM[OAc]), ethanol organosolv lignin (EOL) and milled wood lignin (MWL) were isolated from Typha capensis (TC) and subjected to several analytical characterizations. Experimental data shows that ILL exhibited a relatively lower degree of condensation, lower aromatic C-C structures and a higher aliphatic OH with values of 0.42/Ar, 1.94/Ar and 1.33/Ar moieties compared with EOL values of 0.92/Ar, 2.22/Ar and 0.51/Ar moieties respectively. The ILL was depolymerized under mild conditions giving relatively higher β-aryl ether linkages content, higher molecular mass, and exhibited closer structures and reactivity to native lignin than EOL. These insights on TC lignin depolymerization in EMIM[OAc]) acetate may contribute to better value-addition of lignocellulosic biomass.
Merging Effluent Discharge Plumes from Multiport Diffusers on a Sloping Beach  [PDF]
Anton Purnama
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.31004
Abstract: Multiport diffusers are the effective engineering devices installed at the marine outfall systems for the steady discharge of effluent streams from the modern coastal plants, such as municipal sewage treatment, power generation and seawater desalination. A far field mathematical model using a two-dimensional advection-diffusion equation is presented for continuous discharges of effluent streams from multiple outfalls on a uniformly sloping beach with a current parallel to the shoreline. The analytical solutions are illustrated graphically to replicate and capture the merging process of effluent plumes in shallow coastal waters, and then asymptotic approximation will be made to the maximum shoreline’s concentration to formulate effluent discharge plume dilution from a multiport diffuser.
Effluent Discharges from Two Outfalls on a Sloping Beach  [PDF]
Anton Purnama
Applied Mathematics (AM) , 2014, DOI: 10.4236/am.2014.519295
Abstract: A marine outfall is a long pipeline that continuously discharges large amounts of effluent streams into the sea. As the number of marine outfalls along the coastal areas is growing, a far field mathematical model with two point sources on a sloping beach is used to assess the coastal water quality following discharges from two outfalls. Asymptotic approximation will be made to the concentration at the beach to measure how well the effluent plumes are mixed and diluted in the coastal waters. The result found agrees with the engineering practice of installing a two-port diffuser at the end of a single outfall to minimize its potential environment impacts.
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