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Search Results: 1 - 10 of 11106 matches for " Neves-Pinto Cleverson "
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Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study
De Moura Kelly C. G.,Emery Flávio S.,Neves-Pinto Cleverson,Pinto Maria do Carmo F. R.
Journal of the Brazilian Chemical Society , 2001,
Abstract: Naphthoquinones isolated from the wood of trees of the families Bignoniaceae and Verbenaceae have been subjected to an interdisciplinary study since the seventies, when Dr. Benjamin Gilbert, at the Federal University of Rio de Janeiro, launched a program on the chemistry of natural products active against endemic diseases. In this paper we describe the synthesis of five naphthoimidazoles, derived from this program and their activity towards T. cruzi, the etiologic agent of Chagas disease. We also review the influence of chemical structure on trypanocidal action of naphthoquinones and of derived heterocycles with imidazole, oxazole, phenoxazine, indole, dipyrane and cyclopentene rings. The overall analysis corroborates the tendency of trypanocidal activity in compounds with an imidazole or oxazole ring linked to a naphthopyrane structure. Two naphthoimidazoles presented higher activities (14.5x and 34.8x) than the standard crystal violet. Emphasis is given to the biodiversity of the Brazilian flora as a starting point for the development of an autonomous and creative medicinal chemistry.
Trypanocidal activity of isolated naphthoquinones from Tabebuia and some heterocyclic derivatives: a review from an interdisciplinary study
De Moura, Kelly C. G.;Emery, Flávio S.;Neves-Pinto, Cleverson;Pinto, Maria do Carmo F. R.;Dantas, Andrea P.;Salom?o, Kelly;Castro, Solange L. de;Pinto, Ant?nio V.;
Journal of the Brazilian Chemical Society , 2001, DOI: 10.1590/S0103-50532001000300003
Abstract: naphthoquinones isolated from the wood of trees of the families bignoniaceae and verbenaceae have been subjected to an interdisciplinary study since the seventies, when dr. benjamin gilbert, at the federal university of rio de janeiro, launched a program on the chemistry of natural products active against endemic diseases. in this paper we describe the synthesis of five naphthoimidazoles, derived from this program and their activity towards t. cruzi, the etiologic agent of chagas disease. we also review the influence of chemical structure on trypanocidal action of naphthoquinones and of derived heterocycles with imidazole, oxazole, phenoxazine, indole, dipyrane and cyclopentene rings. the overall analysis corroborates the tendency of trypanocidal activity in compounds with an imidazole or oxazole ring linked to a naphthopyrane structure. two naphthoimidazoles presented higher activities (14.5x and 34.8x) than the standard crystal violet. emphasis is given to the biodiversity of the brazilian flora as a starting point for the development of an autonomous and creative medicinal chemistry.
Fístula oroantral e retalho mucoso geniano: revis?o de 25 casos
Meirelles, Roberto Campos;Neves-Pinto, Roberto Machado;
Revista Brasileira de Otorrinolaringologia , 2008, DOI: 10.1590/S0034-72992008000100014
Abstract: the oroantral fistula is a pathological connection between the maxillary sinus and with the oral cavity. the condition mostly follows dental extraction. aim: to present the experience of 25 cases. material and methods: retrospective cases between 1996-2000. the orl examination included nasal or sinusal endoscopy, a ct scan and histopathological analysis. results: twenty-five cases were found: ten 2nd molar cases, eight 1st molar cases, six 2nd premolar cases, and one canine case. all patients underwent a caldwell-luc operation plus excision of the epithelium lining the fistula, that was then completely covered by a flap of mucosa rotated from the genian region. discussion: in cases of major fistulae a bone autograft taken from the anterior sinus wall was used. bacterial cultures (n=19) revealed streptococus pneumoniae (13), haemophillus influenza (6), moraxella catharralis (2) and staphylococus aureus (2). aspergillus niger was found in one case presenting as a "fungic ball". conclusions: the only case of surgical failure, after 30 days postoperatively, was reoperated, using a bone graft. after a 6-month follow up all of the patients progressed satisfactorily, including the reoperated patient.
Vanishing ideals over complete multipartite graphs
Jorge Neves,Maria Vaz Pinto
Mathematics , 2013,
Abstract: We study the vanishing ideal of the parametrized algebraic toric associated to the complete multipartite graph $\G=\mathcal{K}_{\alpha_1,...,\alpha_r}$ over a finite field of order $q$. We give an explicit family of binomial generators for this lattice ideal, consisting of the generators of the ideal of the torus, (referred to as type I generators), a set of quadratic binomials corresponding to the cycles of length 4 in $\G$ and which generate the \emph{toric algebra of $\G$} (type II generators) and a set of binomials of degree $q-1$ obtained combinatorially from $\G$ (type III generators). Using this explicit family of generators of the ideal, we show that its Castelnuovo--Mumford regularity is equal to $\max\set{\alpha_1(q-2),...,\alpha_r(q-2), \lceil (n-1)(q-2)/2\rceil}$, where $n=\alpha_1+... + \alpha_r$.
Efeitos da adi o de montmorilonita sódica na dieta sobre o perfil bioquímico de frangos de corte intoxicados com aflatoxina
Batina Patricia Neves,Lopes Sonia Terezinha dos Anjos,Santurio Janio Moraes,Souza Cleverson de
Ciência Rural , 2005,
Abstract: Este estudo teve como objetivo avaliar os valores bioquímicos e atividade enzimática hepática e renal em frangos de corte submetidos à intoxica o experimental com aflatoxina B1 com e sem a adi o de montmorilonita sódica na dieta. Foram utilizados 528 frangos de corte, da linhagem Cobb, subtimetidos a seis tratamentos entre 1degrees ao 42degrees dia de vida: (T1) Controle: dieta normal; (T2) dieta com 5 ppm de aflatoxina; (T3) dieta com 0,25% montmorilonita sódica; (T4) dieta com 5ppm de aflatoxina + 0,25% montmorilonita sódica; (T5) dieta com 0,5% montmorilonita sódica; (T6) dieta com 5ppm de aflatoxina + 0,5% montmorilonita sódica. O tratamento (T2) com aflatoxina demonstrou significante (P<0,01) diminui o dos níveis de ácido úrico, albumina, colesterol, creatinina, triglicerídeos, globulinas e proteína total. Houve aumento significativo da alamino amino transferase (ALT) enquanto que a enzima aspartato amino transferase (AST) n o foi significantemente diferente entre os tratamentos. Nos tratamentos T3 e T5, n o houve altera o nas dosagens bioquímicas em rela o ao tratamento controle (T1). A adi o 0,5% de montmorilonita sódica na dieta (T6) apresentou melhores resultados na redu o da adsor o da aflatoxina em rela o à adi o de 0,25% de montmorilonita sódica (T4). Os resultados obtidos, nas condi es em que foi realizado este experimento, sugerem que altos níveis de aflatoxina (5ppm) na dieta causam altera es bioquímicas significativas na atividade enzimática de frangos de corte e que o tratamento preventivo com a montmorilonita sódica pode ser usado para se evitar o risco causado pela contamina o alimentar com aflatoxinas.
Spatial distribution of palynomorphs in the surface sediments of the Lagoa do Campelo lake, North region of Rio de Janeiro State, Brazil
Luz, Cynthia Fernandes Pinto da;Barth, Ortrud Monika;Silva, Cleverson Guisan;
Acta Botanica Brasilica , 2005, DOI: 10.1590/S0102-33062005000400009
Abstract: four samples of the surface sediments of the lagoa do campelo lake bottom were collected in a transect of 500 m by 500 m from edge to edge, in a northeast/southwest direction, the dominant wind direction in the region. the analysis of pollen grains, fern spores and algae were used to evaluate their spatial deposition and level of deterioration. in total, 58 types of pollen grains were identified, mainly from herbs as cyperaceae, poaceae and typhaceae. pollen grains occurred in all the analyzed sediments. the area of highest concentration was the northeast side of the lake. the southwest side showed the highest pollen grain and fern spore degradation and mechanical damage, probably as they were carried across the lake by wind-driven currents, confirming the depositional tendency of damaged palynomorphs in the same direction as the dominant wind. among the pollen of trees and shrubs, alchornea, arecaceae, cecropia, celtis, clethra and myrtaceae were dominant at more than 1,000 pollen grains per gram of sediment. the quantity of fern spores was practically constant in all samples (± 10% of the total of palynomorphs). the algae pediastrum tetras (ehrenberg) ralfs and mougeotia occurred in all samples, but spirogyra only in three of them. the results obtained gave new information about the richness, concentration and distribution of palynomorphs in the lake, representing the local and regional vegetation.
Viabilidade da realiza??o de espirometria em pré-escolares
Veras, Tiago Neves;Pinto, Leonardo Araujo;
Jornal Brasileiro de Pneumologia , 2011, DOI: 10.1590/S1806-37132011000100011
Abstract: objective: to determine the rate at which satisfactory spirometry results are obtained (spirometry success rate) in preschool children. methods: we analyzed the spirometry results of children < 6 years of age. all tests were conducted between june of 2009 and february of 2010 in the pulmonary function laboratory of the hospital infantil jeser amarante faria, located in the city of joinville, brazil. the spirometry program employed features an animated incentive (soap bubbles). the procedures were performed by a pediatric pulmonologist, in accordance with the reproducibility and acceptability criteria recommended by the american thoracic society. we attempted to achieve an expiratory time of at least 1 s. the following parameters were measured: fvc, fev0.5, fev1, and the fev1/fvc ratio. results: our sample comprised 74 children. the spirometry success rate was 82%. although the performance improved with age, the difference between younger and older children was not significant (p > 0.05). an average of 6.6 attempts/test were needed in order to achieve acceptable, reproducible curves. all 61 successful tests produced satisfactory fev0.5 and fev1 values. by calculating z scores, we found that 21.6% of the children presented with an obstructive pattern. conclusions: in our sample, the spirometry success rate was high, showing that spirometry is a valid method for assessing pulmonary function in preschool children. the high success rate in our sample might be attributable to the use of an incentive and to the fact that the tests were performed by professionals specializing in pediatrics.
Efeitos da adi??o de montmorilonita sódica na dieta sobre o perfil bioquímico de frangos de corte intoxicados com aflatoxina
Batina, Patricia Neves;Lopes, Sonia Terezinha dos Anjos;Santurio, Janio Moraes;Souza, Cleverson de;Martins, Danieli Brolo;
Ciência Rural , 2005, DOI: 10.1590/S0103-84782005000400012
Abstract: the aim of this research was to evaluate the hepatic biochemical profile and the renal enzymatic activity of broiler chicken experimentally intoxicated with aflatoxin and supplemented with sodic montmorilonite on the diet. 528 cobb?s broiler chickens were used divided in 6 treatments (from 1st to the 42th day of life) as described: (t1) control: normal diet; (t2) diet with 5ppm of aflatoxin; (t3) diet with 0.25% sodic montmorilonite; (t4) diet with 5 ppm of aflatoxin + 0.25% sodic montmorilonite; (t5) diet with 0.5% sodic montmorilonite; (t6) diet with 5 ppm of aflatoxin + 0.5% sodic montmorilonite. the treatment t2 showed significantly decreased levels of uric acid, albumin, cholesterol, creatinine, triglycerides, globulins and total serum proteins and an increase of serum alanine aminotransferase (alt) activity. aspartate aminotransferase (ast) did not showed important differences among treatments. in treatments t3 and t5, there were no variations on the biochemical values, when compared to treatment t1. addition of 0.5% of montmorilonite in the diet (t6), presented better results on the increase of the adsorption of aflatoxin when compared to 0.25% sodic montmorilonite (t4). clearly, the results showed that high levels of aflatoxin in the diet (5ppm) causes important changes in the serum enzymatic activity of broiler chickens. also, it was demonstrated that using sodic montmorilonite may be used to avoid risks caused by food contaminated by aflatoxins.
Bankruptcy and Fierce Competition in the Market: Evidence from the US Airline Market
Cleverson Bringhenti
Revista de Literatura dos Transportes , 2009,
Abstract: This paper is a review of Ciliberto and Schenone (2008), where it is empirically tested the hypothesis that airlines enter the US Chapter 11 regime for bankrupts as a result of fierce competition in capacity. The authors present empirical evidence that a bankruptcy state may emerge from a war of attrition using capacity as the strategic variable, with losers ultimately increasing their debts considerably. Authors also discuss the impacts on operational costs, and argue that neither during nor after the Chapter 11 period the cost of bankrupt airlines are affected.[Paper in Portuguese]
Bankruptcy and fierce competition in the market: evidence from the US airline market [paper in Portuguese]
Cleverson Bringhenti
Journal of Transport Literature , 2009,
Abstract: This paper is a review of Ciliberto and Schenone (2008), where it is empirically tested the hypothesis that airlines enter the US Chapter 11 regime for bankrupts as a result of fierce competition in capacity. The authors present empirical evidence that a bankruptcy state may emerge from a war of attrition using capacity as the strategic variable, with losers ultimately increasing their debts considerably. Authors also discuss the impacts on operational costs, and argue that neither during nor after the Chapter 11 period the cost of bankrupt airlines are affected.
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