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OALib Journal期刊

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Formulation development of domperidone buccal bioadhesive hydrophilic matrix tablets
Madgulkar Ashwini,Bhalekar Mangesh,Ner Amruta,Wable Nitin
Asian Journal of Pharmaceutics , 2011,
Abstract: Buccoadhesives have long been employed to improve the bioavailability of drugs undergoing significant hepatic first pass metabolism. Domperidone is also reported to have low oral bioavailability due to an extensive hepatic first-pass effect. Buccoadhesive hydrophilic matrices containing Domperidone were prepared using a 32 factorial design. The amounts of Carbopol 934P (CP) and Methocel K100LV (HPMC) were taken as the formulation variables (factors) for optimizing bioadhesion and kinetics of dissolution. A mathematical model was generated for each response parameter. Bioadhesive strength tended to vary quite linearly in an increasing order with an increasing amount of each polymer. The drug release pattern for all the formulation combinations was found to be non Fickian, approaching zero-order kinetics. A suitable combination of two polymers provided adequate bioadhesive strength and fairly regulated the release profile up to 4 hr. The response surfaces and contour plots for each response parameter are presented for further interpretation of the results. The optimum formulations were chosen and their predicted results were found to be in close agreement with the experimental findings.
Light vector meson masses in strange hadronic matter -- a QCD sum rule approach
Amruta Mishra
Physics , 2014, DOI: 10.1103/PhysRevC.91.035201
Abstract: We study the properties of the light vector mesons ($\rho$, $\omega$ and $\phi$) in strange hadronic matter using the QCD sum rule approach. The in-medium masses of the vector mesons are calculated from the modifications of the light quark condensates and the gluon condensates in the hadronic medium. The light quark condensates in the hadronic matter are obtained from the values of the non strange and strange scalar fields of the explicit chiral symmetry breaking term in a chiral SU(3) model. The in-medium gluon condensate is calculated through the medium modification of a scalar dilaton field, which is introduced into the chiral SU(3) model to simulate the scale symmetry breaking of QCD. The mass of the $\omega$ meson is observed to have initially a drop with increase in density and then a rise due to the scattering with the baryons. The mass of the $\rho$ meson is seen to drop with density due to decrease of the light quark condensates in the medium. The effects of isospin asymmetry and strangeness of the medium on the masses of the vector mesons are also studied in the present work. The $\phi$ meson is observed to have marginal drop in its mass in the nuclear medium. However, the strangeness of the medium is seen to lead to an appreciable increase in its mass arising due to scattering with the hyperons.
Mechanisms of preventative and therapeutic role of probiotics in different allergic and autoimmune disorders  [PDF]
ner ?zdemir
Open Journal of Immunology (OJI) , 2013, DOI: 10.4236/oji.2013.33015
Abstract:

The prevalence of allergic and autoimmune diseases has been increasing from the last decades of 20th century. Intestinal microflora contributes to antigen exposure in early life and is one of the most abundant sources of early immune stimulation as well as adaptation. Because allergic and autoimmune responses manifest early in life, there has been obvious interest in the potential benefits of modifying the gastrointestinal flora by using probiotic supplementation. So far, there have been several studies to address the role of probiotics in primary prevention and therapy, with a reported suspicious reduction in the incidence of atopic and autoimmune diseases. Here, our aim is to evaluate the available knowledge of mechanisms of preventative and therapeutic role of probiotics in different allergic and autoimmune disorders. Promising mechanisms of probiotic effects may be categorized as local and systemic effects. Local influences of probiotics potentially include reduction of gut permeability and systemic penetration of antigens, increased local immunoglobulin A production, and alteration of local inflammation or tolerance induction. Some possible systemic effects consist of anti-inflammatory effects mediated by Th17 cells and Toll-like receptors, Th1 skewing of responses to allergens, activation of tolerogenic dendritic cells, in addition to T-regulatory cell production.

Prevalence of stigmatizing attitude among urban middle class in Maharashtra: Implications for HIV/AIDS education strategy
Kaulagekar Aarti,Godbole Amruta
Indian Journal of Community Medicine , 2007,
Abstract:
PERCEPTIONS OF PARENTS OF TYPICAL CHILDREN TOWARDS INCLUSIVE EDUCATION
Shruti Bhargava,Amruta Narumanchi
Disability, CBR & Inclusive Development , 2011, DOI: 10.5463/dcid.v22i1.10
Abstract: The purpose of the study was to explore the perceptions of parents of typical children towards inclusive education and children with special needs. The research design was exploratory and descriptive in nature. Fifty parents of typical children of an inclusive school and 5 experts heading an organisation for children with special needs formed the sample. In-depth interviews were conducted to gain information on the awareness and understanding about an inclusive setup, descriptions and explanations of children with special needs, and advantages and disadvantages of an inclusive setup for children. In addition, draw and dialogue technique was used with parents and experts to supplement the data from the interviews, to elicit descriptions and understanding of children with special needs. Results showed positive reactions towards children with special needs. Parents supported inclusion, but suggested separate classes for academics. Experts’ descriptions of children with special needs were more technical than those of the parents. DOI 10.5463/DCID.v22i1.10
Charmonium mass in hot asymmetric nuclear matter
Amruta Mishra,Arvind Kumar
Physics , 2010,
Abstract: We calculate the in-medium masses of J/$\psi$ and of the excited states of charmonium ($\psi$(3686) and $\psi$(3770)) in isospin asymmetric nuclear matter at finite temperatures. These mass modifications arise due to the interaction of the charmonium states with the gluon condensates of QCD, simulated by a scalar dilaton field introduced to incorporate the broken scale invariance of QCD within an effective chiral model. The change in the mass of J/$\psi$ in the nuclear matter with density is seen to be rather small, as has been shown in the literature by using various approaches, whereas, the masses of the excited states of charmonium ($\psi$(3686) and $\psi$(3770)) are seen to have considerable drop at high densities. The dependence of the masses of the charmonium states on the isospin asymmetry has also been investigated in the hot nuclear matter and is seen to be appreciable at moderate temperatures and high densities. These medium modifications of the charmonium states should modify the experimental observables arising from the compressed baryonic matter produced in asymmetric heavy ion collision experiments in the future facility of FAIR, GSI.
D mesons in asymmetric nuclear matter at finite temperatures
Arvind Kumar,Amruta Mishra
Physics , 2009,
Abstract: We study the in-medium properties of $D$ and $\bar{D}$ mesons in isospin-asymmetric nuclear matter at finite temperatures using an effective chiral SU(4) model. The interactions of $D$ and $\bar{D}$ mesons with nucleons, scalar isoscalar meson $\sigma$, and scalar iso-vector meson $\delta$ are taken into consideration. It is found that as compared to the $\bar{D}$ mesons, the properties of the $D$ mesons are observed to be quite sensitive to the isospin-asymmetry at high densities. At finite densities, the masses of $D$ and $\bar{D}$ mesons observed at finite temperatures are seen to be higher in comparison to the zero temperature case. The present study of the in-medium properties of $D$ and $\bar{D}$ mesons will be of relevance for the experiments in the future facility of the FAIR, GSI, where the compressed baryonic matter at high densities and moderate temperatures is expected to be produced. The mass modifications of $D$ and $\bar{D}$ mesons in hot nuclear medium can lead to decay of the charmonium states ($\Psi^{'}, \chi_{c}, J/\Psi$) to $D\bar{D}$ pairs in dense hadronic matter. The isospin-asymmetric effects on the properties of the open charm mesons for the doublets $D=(D^0,D^+)$ and $\bar D=(\bar D^0,D^-)$ should show in observables like their production and collective flow in asymmetric heavy-ion collisions. The small attractive potentials observed for the $\bar{D}$ mesons may also lead to formation of the $\bar{D}$ mesic nuclei.
LOFF and breached pairing with cold atoms
Amruta Mishra,Hiranmaya Mishra
Physics , 2006, DOI: 10.1140/epjd/e2009-00046-4
Abstract: We investigate here the Cooper pairing of fermionic atoms with mismatched fermi surfaces using a variational construct for the ground state. We determine the state for different values of the mismatch of chemical potential for weak as well as strong coupling regimes including the BCS BEC cross over region. We consider Cooper pairing with both zero and finite net momentum. Within the variational approximation for the ground state and comparing the thermodynamic potentials, we show that (i) the LOFF phase is stable in the weak coupling regime, (ii) the LOFF window is maximum on the BEC side near the Feshbach resonance and (iii) the existence of stable gapless states with a single fermi surface for negative average chemical potential on the BEC side of the Feshbach resonance.
Vacuum structure and effective potential at finite temperature: a variational approach
Amruta Mishra,Hiranmaya Mishra
Physics , 1996, DOI: 10.1088/0954-3899/23/2/002
Abstract: We compute the effective potential for $\phi^4$ theory with a squeezed coherent state type of construct for the ground state. The method essentially consists in optimising the basis at zero and finite temperatures. The gap equation becomes identical to resumming the infinite series of daisy and super daisy graphs while the effective potential includes multiloop effects and agrees with that obtained through composite operator formalism at finite temperature.
D mesons and charmonium states in asymmetric nuclear matter at finite temperatures
Arvind Kumar,Amruta Mishra
Physics , 2010, DOI: 10.1103/PhysRevC.81.065204
Abstract: We investigate the in-medium masses of $D$ and $\bar{D}$ mesons in the isospin-asymmetric nuclear matter at finite temperatures arising due to the interactions with the nucleons, the scalar isoscalar meson $\sigma$, and the scalar iso-vector meson $\delta$ within a SU(4) model. The in-medium masses of $J/\psi$ and the excited charmonium states ($\psi(3686)$ and $\psi(3770)$) are also calculated in the hot isospin asymmetric nuclear matter in the present investigation. These mass modifications arise due to the interaction of the charmonium states with the gluon condensates of QCD, simulated by a scalar dilaton field introduced to incorporate the broken scale invariance of QCD within the effective chiral model. The change in the mass of $J/\psi$ in the nuclear matter with the density is seen to be rather small, as has been shown in the literature by using various approaches, whereas, the masses of the excited states of charmonium ($\psi(3686)$ and $\psi(3770)$) are seen to have considerable drop at high densities. The present study of the in-medium masses of $D$ ($\bar{D}$) mesons as well as of the charmonium states will be of relevance for the observables from the compressed baryonic matter, like the production and collective flow of the $D$ ($\bar D$) mesons, resulting from the asymmetric heavy ion collision experiments planned at the future facility of the FAIR, GSI. The mass modifications of $D$ and $\bar{D}$ mesons as well as of the charmonium states in hot nuclear medium can modify the decay of the charmonium states ($\Psi^{'}, \chi_{c}, J/\Psi$) to $D\bar{D}$ pairs in the hot dense hadronic matter. The small attractive potentials observed for the $\bar{D}$ mesons may lead to formation of the $\bar{D}$ mesic nuclei.
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