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Search Results: 1 - 10 of 1467 matches for " Nehemiah Cox "
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NaCl Potentiates Human Fibrocyte Differentiation
Nehemiah Cox, Darrell Pilling, Richard H. Gomer
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0045674
Abstract: Excessive NaCl intake is associated with a variety of fibrosing diseases such as renal and cardiac fibrosis. This association has been attributed to increased blood pressure as the result of high NaCl intake. However, studies in patients with high NaCl intake and fibrosis reveal a connection between NaCl intake and fibrosis that is independent of blood pressure. We find that increasing the extracellular concentration of NaCl to levels that may occur in human blood after high-salt intake can potentiate, in serum-free culture conditions, the differentiation of freshly-isolated human monocytes into fibroblast-like cells called fibrocytes. NaCl affects the monocytes directly during their adhesion. Potassium chloride and sodium nitrate also potentiate fibrocyte differentiation. The plasma protein Serum Amyloid P (SAP) inhibits fibrocyte differentiation. High levels of extracellular NaCl change the SAP Hill coefficient from 1.7 to 0.8, and cause a four-fold increase in the concentration of SAP needed to inhibit fibrocyte differentiation by 95%. Together, our data suggest that NaCl potentiates fibrocyte differentiation. NaCl-increased fibrocyte differentiation may thus contribute to NaCl-increased renal and cardiac fibrosis.
Towards EHR interoperability in Tanzania hospitals: Issues, Challenges and Opportunities
Lawrence Nehemiah
Computer Science , 2014, DOI: 10.5121/ijcsea.2014.4404
Abstract: This study aimed at identifying the issue, challenges and opportunities from the health consumers in Tanzania towards interoperability of electronic health records. Recognizing that we conducted a study to identify the challenges, issues and opportunities towards health information exchange. The study was conducted in three major cities of Tanzania. This was in order to come up with a clear picture of how to implement some EHRs that will be trusted by health consumers. The participants (n=240) were surveyed on computer usage, EHRs knowledge, demographics, security and privacy issues. A total of 200 surveys were completed and returned (83.3% response rate). 67.5% were women, 62.6% had not heard of EHRs, 73% highly concerned about privacy and security of their information. 75% believed that introduction of various security mechanisms will make EHRs more secure. A number of chi-square tests (p<0.05) showed there was a strong relationship among the variable of age, computer use, EHRs knowledge and concerns for privacy and security. The study showed that there was a small difference of 8.5% between those who think EHRs are safer than paper records and those who think otherwise. The general observation of the study was that in order to make EHRs successful, then the issue of security, and health consumer involvement were two key towards the road of successful EHRs in our hospitals practices and that will make consumers more willing to allow their records to be shared.
Groundwater Potential on the Jos – Bukuru Plateau, North Central Nigeria. Using Lineaments from Gravity Measurements  [PDF]
Samaila Crah Alkali, Solomon Nehemiah Yusuf
Journal of Water Resource and Protection (JWARP) , 2011, DOI: 10.4236/jwarp.2011.38072
Abstract: The rocks of the Jos – Bukuru area in North Central Nigeria is characterized by negative and positive gravity residual anomalies ranging from –25 to +20 mGals. Lineaments were extracted from the gravity residual anomaly map for the purpose of assessing the groundwater resources in the area. The region is marked by more than one set of lineaments, each with its distinctive orientation and probably spacing. Lineaments shorter than 20 km in length are shallow structures suitable for this exercise because of their importance in groundwater recharge, transmission and discharge. In a bin size of 15oone major and one minimum striking directions between 000o and 030o were obtained. The major type lies between 000o and 015o, while the minimum one is oriented within the 015o and 030o direction. These directions correspond to the stress axis of the essentially north – south trending geological structures of Nigeria. Invasions of mineralizing fluids might had sealed some of the joints and other fractures, however where the open spaces are not sealed, weathering and erosion widen and deepened the joints paving routes for surface water flows and direct seepage into the underlying strata. On the lineament density and lineament intersection maps the closures suggest probable discontinuity of the aquifer units. On this basis of the lineament density and the lineament intersection results, the area was divided into three hydrogeological zones. Site 1 is considered most favourable for water well development, while site 3 may result in low yields or even in abortive water wells.
Application of Secondary Resistivity Parameters to Determine Potential Aquifer Horizon: Case Study of Basement Rocks of Hussara, Northeastern Nigeria  [PDF]
Solomon Nehemiah Yusuf, S. C. Alkali
Journal of Water Resource and Protection (JWARP) , 2012, DOI: 10.4236/jwarp.2012.41002
Abstract: Twenty five vertical electrical sounding using the Schlumberger configuration with current electrode spacing of AB/2 = 100 m were carried out in Hussara, north-eastern, Nigeria. The field data were smoothened and interpreted using IX1D inversion [1] computer software. Secondary resistivity and secondary resistivity derived parameters were used to determine the potential aquifer horizon. Longitudinal conductance map of the third geoelectric layer indicates a higher conducting zone along the eastern part which may indicate possible concentration of weathered materials. Intermediate conductance striking from the north to the southeast may constitute a horizon with increased aquifer materials, while the lower conductivity values may indicate areas of fractured bedrock where the degree of decomposition of the rock fragments is minimal. The transverse resistance map of the same horizon revealed the contour values increasing from the west towards the east perhaps due to the increasing presence of fresh bedrock close to the surface.
Issues in Software Development Practices A South African Software Practitioners’ Viewpoint
Nehemiah Mavetera,Jan Kroeze
Communications of the IBIMA , 2009,
Abstract: Software development is a process tasked with the development of artefacts that are used to implement organizational information systems. Depending on the social, economical and environmental setting, different software practices are used. These, however, have an effect on the resultant software product. In this paper, the authors investigate some of the software development practices that are used in South Africa. Through the use of interview techniques, the study highlighted a plethora of methods, techniques and tools that are used during the software development process. This paper advocates for a paradigm shift in the way information systems are developed. It motivates for developers to consider the social context of organizational information systems when developing software products. In a social context, capturing the organizational culture, context and human aspect contributes to the system’s responsiveness and its adaptiveness to the ever changing organizational environment.
Guiding Principles for Developing Adaptive Software Products
Nehemiah Mavetera,Jan Kroeze
Communications of the IBIMA , 2010,
Abstract: This paper presents an analysis of problems that are faced by software development practitioners. While communication, team management, coding and software documentation are some of the persistent problems, the first and major troubles for software practitioners is to select appropriate software development approach. This approach should allow developers to develop adaptive software products. The role of organizational culture, context, practice and concepts in developing adaptive software products is also discussed. This qualitative research study interviewed seven software development practitioners in South Africa, focusing on software developmental methods that allow the capturing of softer, human elements inherent in organizations and the accompanying problems that inhibit their inclusion in the resultant software products. The research used Grounded Theory Method, to construct a framework of requirements that must be considered when choosing a software development approach that allows the development of adaptive software products. This framework highlights the importance of employing a software development approach that is grounded in the relativistic paradigm, adopting a behavioral systems approach and adopting methods whose communication techniques and tools can capture the humanist elements that are inherent in organizational systems.
An Integration of Self Potential, Electromagnetic and Resistivity Profiling Methods in the Search for Sulfide Deposits in Gwoza, Borno State, Nigeria  [PDF]
Okwong Tom Nkereuwem, Solomon Nehemiah Yusuf, Manaja Uba Mijinyawa
International Journal of Geosciences (IJG) , 2012, DOI: 10.4236/ijg.2012.32040
Abstract: The combination of Self Potential (SP), Electromagnetic (EM) and Resistivity profiling methods in Gwoza has resulted in the delineation of conductive zones suspected to be sulfide mineralization in the area. Mineralization potentials of –201 mV on the profile AA’, –250.2 mV on the profile BB’ and –203 mV on the profile CC’ respectively have been observed. Correspondingly, both the vertical coil and the horizontal coil readings of the EM anomalies on the profiles AA’, BB’ and CC’ also show significant negative anomalies across the delineated conductive zones. Three resistivity profiles DD’, EE’ and KK’ have also shown very low resistivity values across the said conductive zones. These conductive zones have been established as sulfide mineralization within faults in this work. The recovery of chalcopyrite samples from a hand-dug well close to the delineated conductive zone of the profile BB’ tends to lend credence to the interpretation in this study.
An Intelligent System for Lung Cancer Diagnosis from Chest Radiographs
H. Khanna Nehemiah,A. Kannan
International Journal of Soft Computing , 2012,
Abstract: In this study we propose an Intelligent Lung Cancer Diagnosis System (ILCDS) that has been developed to detect all possible lung nodules from chest radiographs. Our system uses image processing techniques and feed forward neural networks for detection and validation of nodules. Nodules are relatively low-contrast white circular objects within the lung fields. As nodules are the most common sign of lung cancer, nodule detection in chest radiographs is a major diagnostic problem. Even experienced radiologists have trouble while distinguishing the normal pattern of blood vessels and nodules that indicate the Lung cancer. Our work is centered around two major sub systems namely Nodule Detection Subsystem (NDS) and Nodule Validation Subsystem (NVS). The Nodule Detection Subsystem is constructed using wavelet based image-processing techniques such as Besov ball projections, Laplacian of Gaussian filter and Gabor wavelet networks which are used to remove the noise from the image, find the edges of the image and detect the nodule, size and its location. The NDS detects all the possible nodules and gives the nodule-detected image. The processed image shows all nodules in the chest radiograph. Since all nodules are not cancerous, the nodules detected by the NDS are validated by the NVS. The NVS is constructed using Feed forward neural network classifiers, which classifies the nodules into non-cancerous and cancerous nodules.
Intelligent Fractured Image Retrieval From Medical Image Databases
H. Khanna Nehemiah,A. Kannan,D. Senthil Kumar
Asian Journal of Information Technology , 2012,
Abstract: The retrieval of stored medical images matching an input medical image is an imperative form of content-based retrieval. For efficient similarity image retrieval and integration, the medical images should be processed systematically to extract a representing feature space vector for each member image. This study explains a system, which takes a fractured image as a query image and retrieves the similar images from the image database using distance metrics and also provides the radiologists with details about the type of fracture and the treatment recommended. The key objective of present research is to retrieve similar X-ray images of fractured reports using K-Nearest Neighbor. Images are matched using color in gray level and texture attributes. Similarity between images is established based on the respective numeric values (Signature). Features are extracted from X-ray images. Indexing is also performed on extracted features using a k-d tree data structure for images and is stored in a backend database for effective retrieval.
Uptake of Cystatin by Melanoma Cells in Culture  [PDF]
Lauren Deady, James L. Cox
CellBio (CellBio) , 2013, DOI: 10.4236/cellbio.2013.22008

The cystatins are a super family of cysteine protease inhibitors which are ubiquitous in their biologic occurrence. Cystatin C, a type II cystatin, is primarily a secreted protein found in most biological fluids. Besides acting as inhibitors of cathepsin, the cystatins have been found to have some non-inhibitor related functions and multiple physiological roles. Much interest has been generated for the cystatins as metastasissuppressor-like proteins, as they have been shown to inhibit metastasis for multiple cancer types. The sites and actions of the cystatins related to tumor suppressor actions are still unclear, however. In this work, we have examined the uptake of cystatin by metastatic melanoma cells in culture. Our results indicate cystatin uptake is mediated by a non-canonical endocytotic pathway in B16 murine melanoma cells.

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