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Search Results: 1 - 10 of 2207 matches for " Neeraj Sinha "
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A Pre-Injection Analysis for Identifying Fault-Injection Tests for Protocol Validation
Neeraj Suri,Purnendu Sinha
Journal of Software , 2010, DOI: 10.4304/jsw.5.10.1144-1161
Abstract: Fault-injection (FI) based techniques for dependability assessment of distributed protocols face certain limitations in providing state-space coverage and also incur high operational cost. This is mainly due to lack of complete knowledge of fault-distribution at the protocol level which in turn limits the use of statistical approaches in deriving and estimating the number of test cases to inject. In practice, formal techniques have effectively being used in proving the correctness of dependable distributed protocols, and these techniques traditionally have not been directly associated with experimental validation techniques such as FI-based testing. There exists a gap between these two well-established approaches, viz. formal verification and FI-based validation techniques. If there exists an approach which utilizing a rich set of information pertaining to the protocol operation generated through formal verification process can provide guided-support to perform FI-based validation, then the overall effectiveness of such validation techniques can be greatly improved. With this viewpoint, in this paper, we propose a methodology which utilizes the theorem-proving technique as an underlying formal-engine, and is composed of two novel structured and graphical representation schemes (interactive user-interfaces) for (a) capturing/visualizing information generated over the formal verification process, (b) facilitating interactive analysis through the chosen formal-engine (any theorem-proving tool) and database, and (c) user-guided identification of influential parameters, those eventually used for generating test cases for FI-based testing. A case study of an on-line diagnosis protocol is used to illustrate and establish the viability of the proposed methodology.
Modular organization enhances the robustness of attractor network dynamics
Neeraj Pradhan,Subinay Dasgupta,Sitabhra Sinha
Quantitative Biology , 2011, DOI: 10.1209/0295-5075/94/38004
Abstract: Modular organization characterizes many complex networks occurring in nature, including the brain. In this paper we show that modular structure may be responsible for increasing the robustness of certain dynamical states of such systems. In a neural network model with threshold-activated binary elements, we observe that the basins of attractors, corresponding to patterns that have been embedded using a learning rule, occupy maximum volume in phase space at an optimal modularity. Simultaneously, the convergence time to these attractors decreases as a result of cooperative dynamics between the modules. The role of modularity in increasing global stability of certain desirable attractors of a system may provide a clue to its evolution and ubiquity in natural systems.
FT-IR spectra and vibrational spectroscopy of Andrographolide
P. K. Singh,Tanveer Hasan,Onkar Prasad,Leena Sinha,Kanwal Raj,Neeraj Misra
Spectroscopy: An International Journal , 2006, DOI: 10.1155/2006/463204
Abstract: A complete normal coordinate analysis was performed for andrographolide in terms of the calculation by using Wilson's G-F matrix method and Urey Bradley force field. Normal coordinate analysis has been carried out to understand the dynamical behaviour of the bioactive labdane diterpenoid of the medicinally useful terrestrial plant Andrographis paniculata. The structural elucidation of a novel, biologically active natural product followed by its total synthesis lays the groundwork for investigations into its biological mechanism of action including putative cellular receptor isolation.
Total Water, Phosphorus Relaxation and Inter-Atomic Organic to Inorganic Interface Are New Determinants of Trabecular Bone Integrity
Ratan Kumar Rai, Tarun Barbhuyan, Chandan Singh, Monika Mittal, Mohd. Parvez Khan, Neeraj Sinha, Naibedya Chattopadhyay
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0083478
Abstract: Bone is the living composite biomaterial having unique structural property. Presently, there is a considerable gap in our understanding of bone structure and composition in the native state, particularly with respect to the trabecular bone, which is metabolically more active than cortical bones, and is readily lost in post-menopausal osteoporosis. We used solid-state nuclear magnetic resonance (NMR) to compare trabecular bone structure and composition in the native state between normal, bone loss and bone restoration conditions in rat. Trabecular osteopenia was induced by lactation as well as prolonged estrogen deficiency (bilateral ovariectomy, Ovx). Ovx rats with established osteopenia were administered with PTH (parathyroid hormone, trabecular restoration group), and restoration was allowed to become comparable to sham Ovx (control) group using bone mineral density (BMD) and μCT determinants. We used a technique combining 1H NMR spectroscopy with 31P and 13C to measure various NMR parameters described below. Our results revealed that trabecular bones had diminished total water content, inorganic phosphorus NMR relaxation time (T1) and space between the collagen and inorganic phosphorus in the osteopenic groups compared to control, and these changes were significantly reversed in the bone restoration group. Remarkably, bound water was decreased in both osteopenic and bone restoration groups compared to control. Total water and T1 correlated strongly with trabecular bone density, volume, thickness, connectivity, spacing and resistance to compression. Bound water did not correlate with any of the microarchitectural and compression parameters. We conclude that total water, T1 and atomic space between the crystal and organic surface are altered in the trabecular bones of osteopenic rats, and PTH reverses these parameters. Furthermore, from these data, it appears that total water and T1 could serve as trabecular surrogates of micro-architecture and compression strength.
Vibrational analysis of deoxy-andrographolide using MM/QM methods
P. K. Singh,Tanveer Hasan,Onkar Prasad,Leena Sinha,Sudha Jain,Kanwal Raj,N. Sundaraganesan,Neeraj Misra
Spectroscopy: An International Journal , 2007, DOI: 10.1155/2007/486281
Abstract: Bioactive natural products have an enormous economic importance as speciality chemicals. Extracts of the shrub Andrographis paniculata are widely used as herbal medicines in many countries. Diterpenoid lactones isolated from these extracts have been the subject of extensive investigation, and one of its constituent diterpenoid is deoxy-andrographolide. A complete normal coordinate analysis was performed for deo-andrographolide in terms of the calculation by using Classical mechanics and Quantum mechanical methods.The study of vibrational spectra helps in understanding the dynamical behaviour and hence a lot of information can be derived about the conformation. The geometrical parameters and the vibrational spectra have been discussed in detail.
Quantum Information Processing by NMR using strongly coupled spins
T. S. Mahesh,Neeraj Sinha,Arindam Ghosh,Ranabir Das,N. Suryaprakash,Malcom H. Levitt,K. V. Ramanathan,Anil Kumar
Physics , 2002,
Abstract: The enormous theoretical potential of Quantum Information Processing (QIP) is driving the pursuit for its practical realization by various physical techniques. Currently Nuclear Magnetic Resonance (NMR) has been the forerunner by demonstrating a majority of quantum algorithms. In NMR, spin systems consisting of coupled nuclear spins are utilized as qubits. In order to carry out QIP, a spin system has to meet two major requirements: (i) qubit addressability and (ii) mutual coupling among the qubits. It has been demonstrated that the magnitude of the mutual coupling among qubits can be increased by orienting the spin-systems in a liquid crystal matrix and utilizing the residual dipolar couplings. While utilizing residual dipolar couplings may be useful to increase the number of qubits, nuclei of same species (homonuclei) might become strongly coupled. In strongly coupled spin-systems, spins loose their individual identity of being qubits. We propose that even such strongly coupled spin-systems can be used for QIP and the qubit-manipulation can be achieved by transition-selective pulses. We demonstrate experimental preparation of pseudopure states, creation of maximally entangled states, implementation logic gates and implementation of Deutsch-Jozsa (DJ) algorithm in strongly coupled 2,3 and 4 spin systems. The energy levels of the strongly coupled 3 and 4 spin systems were obtained by using a Z-COSY experiment.
Investigation of Crystallization Kinetics in Glassy Se and Binary Se98M2 (M=Ag, Cd, Zn) Alloys Using DSC Technique in Non-Isothermal Mode  [PDF]
Chandrabhan Dohare, Neeraj Mehta
Journal of Crystallization Process and Technology (JCPT) , 2012, DOI: 10.4236/jcpt.2012.24025
Abstract: The crystallization kinetics of glassy Se and binary Se98M2 (M=Ag, Cd, Zn) alloys have been studied at different heating rates (5, 10, 15, 20 Kmin-1) using Differential Scanning Calorimetric (DSC) technique. The crystallization temperature (Tc) is determined from exothermic peak obtained in DSC scans of present samples. The variation in peak crystallization temperature (Tc) with the heating rate (β) has been used to investigate the growth kinetics using Kissinger, Augis-Bennet and Matusita-Sakka models. The activation energy of crystallization (Ec) has been found to increase with Ag additive and to decrease with Zn and Cd additive. The value of various kinetic parameters such as rate constant (Kp), Avrami index (n), thermal stability (S) and Hruby number (Hr) have been calculated under non-isothermal mode. The maximum change in different kinetic parameters has been found after the incorporation of Ag additive.
Hypergammaglobulinemic purpura of waldenstorm associated with sjogren’s syndrome in a young female responding to rituximab treatment  [PDF]
Neeraj Jain, Lalit Duggal
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.22034

Hypergammaglobulinemic Purpura of Waldenstorm is one of the uncommon conditions with purpura and is often associated with collagen vascular disease. It is difficult to treat and sometimes needs anti CD 20 molecules for resistant cases.

Pathogenicity of Mycobacterium tuberculosis Is Expressed by Regulating Metabolic Thresholds of the Host Macrophage
Parul Mehrotra equal contributor,Shilpa V. Jamwal equal contributor,Najmuddin Saquib,Neeraj Sinha,Zaved Siddiqui,Venkatasamy Manivel,Samrat Chatterjee,Kanury V. S. Rao
PLOS Pathogens , 2014, DOI: doi/10.1371/journal.ppat.1004265
Abstract: The success of Mycobacterium tuberculosis as a pathogen derives from its facile adaptation to the intracellular milieu of human macrophages. To explore this process, we asked whether adaptation also required interference with the metabolic machinery of the host cell. Temporal profiling of the metabolic flux, in cells infected with differently virulent mycobacterial strains, confirmed that this was indeed the case. Subsequent analysis identified the core subset of host reactions that were targeted. It also elucidated that the goal of regulation was to integrate pathways facilitating macrophage survival, with those promoting mycobacterial sustenance. Intriguingly, this synthesis then provided an axis where both host- and pathogen-derived factors converged to define determinants of pathogenicity. Consequently, whereas the requirement for macrophage survival sensitized TB susceptibility to the glycemic status of the individual, mediation by pathogen ensured that the virulence properties of the infecting strain also contributed towards the resulting pathology.
Prevalence of Ringing Delusion among Mobile Phone Users  [PDF]
Neeraj Kumar, Raees A. Khan
E-Health Telecommunication Systems and Networks (ETSN) , 2012, DOI: 10.4236/etsn.2012.14006
Abstract: The exponential application of mobile technology has led to a concern about implications of electromagnetic radiation on human health. As we are aware that mobile phone radiates EMR when users communicate to others and that time subscribers of the device are regularly exposed nearby 40% - 50% of total mobile irradiation. We analyzed the risk of \"Ringing Delusion\" among normal users, moderate users and heavy users when compared to low users. Although the \"Ringing Delusion\" has not been added in medical terminology but we found frequently such kind of symptoms among mobile phone users. \"Ringing Delusion\" may be considered as an imagination of ringing voice from cellular phone. The risk was also compared between urban and rural, male and female and adult and children population. The information was gathered through well designed questionnaires for cellular user’s demographic and social characteristics, adopted safety measures and calling duration. Prevalence of “Ringing Delusion” among rural users was higher than the urban users. A trend for the risk was also observed in male users in comparison to female. Study may support innovators to re-examine health effects of mobile phones.
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