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Search Results: 1 - 10 of 468 matches for " Neeraj Mehla "
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Vineet Kumar Vashishtha,,Rahul Makade,,Neeraj Mehla
International Journal of Engineering Science and Technology , 2011,
Abstract: Rapid prototyping technology have emerged a new innovation to reduced the time cost of moulds fabrication by creating 3D product directly from computer aided design thus the designer is able to perform design validation and accuracy analysis easily in a virtual environment as if using a physical model. The primary aim of this paper is to give the reader an overview of the current state of the art in rapid prototyping technology .The paper also deal with feature’s of rapid prototyping in Aerospace industry and some of the existing problem’s of rapid rototyping.
Neeraj Mehla,,Rahul Makade,,N.S.Thakur
International Journal of Engineering Science and Technology , 2011,
Abstract: A solar updraft tower consists of an air collector 1.4 m in diameter and 80 cm tall chimney was set upin NIT Hamirpur, Himachal-Pradesh, India. The objective of the study was to investigate the variation of velocity with essential geometricparameter of the system. The solar updraft tower system consists of three essential elements- collector, chimney height and wind turbine. The output power of a system is depended on the input velocity to the wind turbine. Turbine inlet velocity (V) is the function of five parameter of the solar updraft tower systems such as collector diameter (Dc), roof glass angle (β), entrance height (h), tower's height (Ht), tower's diameter (D), out of which variable roof angle and the chimney height is analysis. It was found that the solar chimney diameter of 8 cm is having the maximum velocity for the constructed setup, and the ratio of chimney diameter to chimney heightwas found to be 0.1.
The comparative cost analysis of EAP Re-authentication Protocol and EAP TLS Protocol
Seema Mehla,Bhawna Gupta
International Journal on Computer Science and Engineering , 2010,
Abstract: the Extensible Authentication Protocol (EAP) is a generic framework supporting multiple types of authentication methods. In systems where EAP is used for authentication, it is desirable to not repeat the entire EAP exchange with another authenticator. The EAP reauthentication Protocol provides a consistent, methodindependentand low-latency re-authentication. It is extension to current EAP mechanism to support intradomain handoff authentication. This paper analyzed the performance of the EAP re-authentication protocol, andcompared it with that of the EAP-TLS protocol. The result shows that the authentication delay of EAP reauthentication protocol is only twentieth of that in the EAPTLS protocol.
A Flavonoid, Luteolin, Cripples HIV-1 by Abrogation of Tat Function
Rajeev Mehla, Shalmali Bivalkar-Mehla, Ashok Chauhan
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027915
Abstract: Despite the effectiveness of combination antiretroviral treatment (cART) against HIV-1, evidence indicates that residual infection persists in different cell types. Intensification of cART does not decrease the residual viral load or immune activation. cART restricts the synthesis of infectious virus but does not curtail HIV-1 transcription and translation from either the integrated or unintegrated viral genomes in infected cells. All treated patients with full viral suppression actually have low-level viremia. More than 60% of treated individuals also develop minor HIV-1 –associated neurocognitive deficits (HAND) due to residual virus and immune activation. Thus, new therapeutic agents are needed to curtail HIV-1 transcription and residual virus. In this study, luteolin, a dietary supplement, profoundly reduced HIV-1 infection in reporter cells and primary lymphocytes. HIV-1inhibition by luteolin was independent of viral entry, as shown by the fact that wild-type and VSV–pseudotyped HIV-1 infections were similarly inhibited. Luteolin was unable to inhibit viral reverse transcription. Luteolin had antiviral activity in a latent HIV-1 reactivation model and effectively ablated both clade-B- and -C -Tat-driven LTR transactivation in reporter assays but had no effect on Tat expression and its sub-cellular localization. We conclude that luteolin confers anti–HIV-1 activity at the Tat functional level. Given its biosafety profile and ability to cross the blood-brain barrier, luteolin may serve as a base flavonoid to develop potent anti–HIV-1 derivatives to complement cART.
Programming of neurotoxic cofactor CXCL-10 in HIV-1-associated dementia: abrogation of CXCL-10-induced neuro-glial toxicity in vitro by PKC activator
Mehla Rajeev,Bivalkar-Mehla Shalmali,Nagarkatti Mitzi,Chauhan Ashok
Journal of Neuroinflammation , 2012, DOI: 10.1186/1742-2094-9-239
Abstract: Background More than 50% of patients undergoing lifelong suppressive antiviral treatment for HIV-1 infection develop minor HIV-1-associated neurocognitive disorders. Neurological complications during HIV-1 infection are the result of direct neuronal damage by proinflammatory products released from HIV-1-infected or -uninfected activated lymphocytes, monocytes, macrophages, microglia and astrocytes. The specific pro-inflammatory products and their roles in neurotoxicity are far from clear. We investigated proinflammatory cytokines and chemokines in the cerebrospinal fluid (CSF) of HIV-demented (HIV-D) and HIV-nondemented (HIV-ND) patients and studied their affect on neuroglial toxicity. Methods and results Bioplex array showed elevated levels of signatory chemokines or cytokines (IL-6, IFN-γ, CXCL10, MCP-1 and PDGF) in the CSF of HIV-D patients (n = 7) but not in that of HIV-ND patients (n = 7). Among the signatory cytokines and chemokines, CXCL10 was distinctly upregulated in-vitro in HIV-1 (NLENG1)-activated human fetal astrocytes, HIV-1 (Ba-L)-infected macrophages, and HIV-1 (NLENG1)-infected lymphocytes. Virus-infected macrophages also had increased levels of TNF-α. Consistently, human fetal astrocytes treated with HIV-1 and TNF-α induced the signatory molecules. CXCL10 in combination with HIV-1 synergistically enhanced neuronal toxicity and showed chemotactic activity (~ 40 fold) for activated peripheral blood mononuclear cells (PBMC), suggesting the intersection of signaling events imparted by HIV-1 and CXCL10 after binding to their respective surface receptors, CXCR4 and CXCR3, on neurons. Blocking CXCR3 and its downstream MAP kinase (MAPK) signaling pathway suppressed combined CXCL10 and HIV-1-induced neurotoxicity. Bryostatin, a PKC modulator and suppressor of CXCR4, conferred neuroprotection against combined insult with HIV-1 and CXCL10. Bryostatin also suppressed HIV-1 and CXCL10-induced PBMC chemotaxis. Although, therapeutic targeting of chemokines in brain may have adverse consequences on the host, current findings and earlier evidence suggest that CXCL10 could strongly impede neuroinflammation. Conclusion We have demonstrated induction of CXCL10 and other chemokines/cytokines during HIV-1 infection in the brain, as well as synergism of CXCL10 with HIV-1 in neuronal toxicity, which was dampened by bryostatin.
Investigation of Crystallization Kinetics in Glassy Se and Binary Se98M2 (M=Ag, Cd, Zn) Alloys Using DSC Technique in Non-Isothermal Mode  [PDF]
Chandrabhan Dohare, Neeraj Mehta
Journal of Crystallization Process and Technology (JCPT) , 2012, DOI: 10.4236/jcpt.2012.24025
Abstract: The crystallization kinetics of glassy Se and binary Se98M2 (M=Ag, Cd, Zn) alloys have been studied at different heating rates (5, 10, 15, 20 Kmin-1) using Differential Scanning Calorimetric (DSC) technique. The crystallization temperature (Tc) is determined from exothermic peak obtained in DSC scans of present samples. The variation in peak crystallization temperature (Tc) with the heating rate (β) has been used to investigate the growth kinetics using Kissinger, Augis-Bennet and Matusita-Sakka models. The activation energy of crystallization (Ec) has been found to increase with Ag additive and to decrease with Zn and Cd additive. The value of various kinetic parameters such as rate constant (Kp), Avrami index (n), thermal stability (S) and Hruby number (Hr) have been calculated under non-isothermal mode. The maximum change in different kinetic parameters has been found after the incorporation of Ag additive.
Hypergammaglobulinemic purpura of waldenstorm associated with sjogren’s syndrome in a young female responding to rituximab treatment  [PDF]
Neeraj Jain, Lalit Duggal
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.22034

Hypergammaglobulinemic Purpura of Waldenstorm is one of the uncommon conditions with purpura and is often associated with collagen vascular disease. It is difficult to treat and sometimes needs anti CD 20 molecules for resistant cases.

Anti-Amnesic Activity of Vitex Negundo in Scopolamine Induced Amnesia in Rats  [PDF]
Abhinav Kanwal, Jogender Mehla, Madhusudana Kuncha, Vegi Ganga Modi Naidu, Yogendra Kumar Gupta, Ramakrishna Sistla
Pharmacology & Pharmacy (PP) , 2010, DOI: 10.4236/pp.2010.11001
Abstract: In the present study we investigated the anti-amnesic activity of Vitex negundo in scopolamine induced amnesia in rats. Wistar rats (180-200 g) were trained on active avoidance task. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. Scopolamine (3 mg/kg, i.p) was administered at different time periods on the basis of stages of memory i.e acquisition, consolidation and retention in different groups (n = 6). Effect of Vitex negundo extract was evaluated and compared to a standard drug, Donepezil. Significant (p < 0.05) increase in the avoidance response on the 5th session has been observed as compared to 1st session in control group. Scopolamine treatment significantly (p < 0.05) reduced the avoidance response compared to control. Extract treated groups shown significant (p < 0.05) increase in number of avoidance responses as compared to scopolamine treated groups. Increased oxidative stress in brain after scopolamine treatment, as observed by increase in MDA & decrease in GSH & SOD, was lowered in the groups treated with extracts. AChE activity was also improved after V. negundo treatment. Results of the study have shown that V. negundo treated groups decrease the phenomenon of amnesia by increasing learning of memory through antioxidant effect and decreasing AChE activity.
Perturbation of Host Nuclear Membrane Component RanBP2 Impairs the Nuclear Import of Human Immunodeficiency Virus -1 Preintegration Complex (DNA)
Ruonan Zhang,Rajeev Mehla,Ashok Chauhan
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0015620
Abstract: HIV-1 is a RNA virus that requires an intermediate DNA phase via reverse transcription (RT) step in order to establish productive infection in the host cell. The nascent viral DNA synthesized via RT step and the preformed viral proteins are assembled into pre-integration complex (PIC) in the cell cytoplasm. To integrate the viral DNA into the host genome, the PIC must cross cell nuclear membrane through the nuclear pore complex (NPC). RanBP2, also known as Nup358, is a major component of the cytoplasmic filaments that emanates from the nuclear pore complex and has been implicated in various nucleo-cytoplasmic transport pathways including those for HIV Rev-protein. We sought to investigate the role of RanBP2 in HIV-1 replication. In our investigations, we found that RanBP2 depletion via RNAi resulted in profound inhibition of HIV-1 infection and played a pivotal role in the nuclear entry of HIV DNA. More precisely, there was a profound decline in 2-LTR DNA copies (marker for nuclear entry of HIV DNA) and an unchanged level of viral reverse transcription in RanBP2-ablated HIV-infected cells compared to RanBP3-depleted or non-specific siRNA controls. We further demonstrated that the function of Rev was unaffected in RanBP2-depleted latently HIV infected cells (reactivated). We also serendipitously found that RanBP2 depletion inhibited the global ectopic gene expression. In conclusion, RanBP2 is a host factor that is involved in the nuclear import of HIV-1 PIC (DNA), but is not critical to the nuclear export of the viral mRNAs or nucleo-cytoplasmic shuttling of Rev. RanBP2 could be a potential target for efficient inhibition of HIV.
Analyzing security of Authenticated Routing Protocol (ARAN)
Seema Mehla,Bhawna Gupta,Preeti Nagrath
International Journal on Computer Science and Engineering , 2010,
Abstract: Ad hoc network allow nodes to communicate beyond their direct wireless transmission range by introducing cooperation in mobile computer (nodes). Many proposed routing protocol for ad hoc network operate in an ad hoc fashion, as on demand routing protocol often have low overhead and faster reaction time than other type of routingbased on periodic protocol. However variety of attacks targeting routing protocol have been identified. By attacking the routing protocol attacker can absorb network traffic, inject them in the path between source and destination and can thus control network traffic. So many secure routing protocols have been developed that deals with these attacks. This paper analyzes the security aspects of one commonly used secure routing protocol ARAN.
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