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Search Results: 1 - 10 of 1337 matches for " Neal Simonsen "
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Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn's disease: a case-control study
Zapata-Velandia Adriana,Ng San-San,Brennan Rebecca F,Simonsen Neal R
Journal of Immune Based Therapies and Vaccines , 2004, DOI: 10.1186/1476-8518-2-6
Abstract: Background Polymorphisms in several genes (NOD2, MDR1, SLC22A4) have been associated with susceptibility to Crohn's disease. Identification of the remaining Crohn's susceptibility genes is essential for the development of disease-specific targets for immunotherapy. Using gene expression analysis, we identified a differentially expressed gene on 5q33, the colony stimulating factor 1 receptor (CSF1R) gene, and hypothesized that it is a Crohn's susceptibility gene. The CSF1R gene is involved in monocyte to macrophage differentiation and in innate immunity. Methods Patients provided informed consent prior to entry into the study as approved by the Institutional Review Board at LSU Health Sciences Center. We performed forward and reverse sequencing of genomic DNA from 111 unrelated patients with Crohn's disease and 108 controls. We also stained paraffin-embedded, ileal and colonic tissue sections from patients with Crohn's disease and controls with a polyclonal antibody raised against the human CSF1R protein. Results A single nucleotide polymorphism (A2033T) near a Runx1 binding site in the eleventh intron of the colony stimulating factor 1 receptor was identified. The T allele of this single nucleotide polymorphism occurred in 27% of patients with Crohn's disease but in only 13% of controls (X2 = 6.74, p < 0.01, odds ratio (O.R.) = 2.49, 1.23 < O.R. < 5.01). Using immunohistochemistry, positive staining with a polyclonal antibody to CSF1R was observed in the superficial epithelium of ileal and colonic tissue sections. Conclusions We conclude that the colony stimulating factor receptor 1 gene may be a susceptibility gene for Crohn's disease.
Environmental Exposure to Emissions from Petrochemical Sites and Lung Cancer: The Lower Mississippi Interagency Cancer Study
Neal Simonsen,Richard Scribner,L. Joseph Su,Donna Williams,Brian Luckett,Tong Yang,Elizabeth T. H. Fontham
Journal of Environmental and Public Health , 2010, DOI: 10.1155/2010/759645
Abstract: To investigate potential links between environmental exposure to petrochemical plant emissions and lung cancer, a population-based case-control study (LMRICS) was conducted in eleven Louisiana parishes bordering the Mississippi River. Cases and age, gender, and race-matched controls were interviewed regarding potential risk factors. Residential history was geocoded to provide indices of long-term proximity to industrial sites. Cases were more likely to have lived near a petrochemical site. Models adjusted for other risk factors, however, showed small or no association with lung cancer (odds ratio for residence within a half-mile of a site =1.10, 95% confidence interval 0.58–2.08). While associations were strongest for exposures exceeding 15 years, none approached statistical significance and there was no clear dose-response across exposure duration, distance categories, or when sites were grouped according to carcinogenicity rating of chemical releases. Residential proximity to petrochemical plants along the lower Mississippi thus showed no significant association with lung cancer.
Practice, Spatiality and Embodied Emotions: An Outline of a Geography of Practice
Kirsten Simonsen
Human Affairs , 2007, DOI: 10.2478/v10023-007-0015-8
Abstract: The paper outlines an approach to social analysis/human geography taking off from a social ontology of practice. This means a focus of attention to embodied or practical knowledges and their formation in people's everyday lives, to the world of experiences and emotions, and to the infinitude of encounters through which we make the world and are made by it in turn. The paper proceeds in three parts. First, considering the way in which subjectivity and identity are created in and through practices sets the ground. The two following sections are extensions from that discussing "embodiment and spatiality" and "affectivity and emotion" respectively. The purpose is threefold; to develop the sensuous character of practice, to consider the spatialities involved in that character, and to discuss possible developments including power and the social differentiation of bodies. The paper is concluded by a short discussion of the geographies following from the suggested account.
Into the open – or hidden away? – The construction of war children as a social category in post-war Norway and Germany
Eva Simonsen
Nordeuropaforum , 2006,
Abstract: After World War II two groups of children fathered by foreign soldiers were assigned special political functions in the building of a future peaceful Europe. In Norway, the children of German soldiers and Norwegian women and in West Germany, the children of African-American soldiers and German women were constructed as specific categories to be handled in certain ways by state authorities. The Norwegian government, after heated debates, decided that the children were allowed to stay and to be silently and discreetly assimilated into society. In West Germany however, the children begotten to African-Americans came to serve as objects in a national public campaign for international recognition as a democratic state. The two cases demonstrate how social politics for children may serve political purposes, rather than being in the interest of the child.
Numerical simulations of scattering of light from two-dimensional rough surfaces using the reduced Rayleigh equation
Ingve Simonsen
Frontiers in Physics , 2013, DOI: 10.3389/fphy.2013.00008
Abstract: A formalism is introduced for the non-perturbative, purely numerical, solution of the reduced Rayleigh equation (RRE) for the scattering of light from two-dimensional penetrable rough surfaces. Implementation and performance issues of the method, and various consistency checks of it, are presented and discussed. The proposed method is found, within the validity of the Rayleigh hypothesis, to give reliable results. For a non-absorbing metal surface the conservation of energy was explicitly checked, and found to be satisfied to within 0.03%, or better, for the parameters assumed. This testifies to the accuracy of the approach and a satisfactory discretization. As an illustration, we calculate the full angular distribution of the mean differential reflection coefficient for the scattering of p- or s-polarized light incident on two-dimensional dielectric or metallic randomly rough surfaces defined by (isotropic or anisotropic) Gaussian and cylindrical power spectra. Simulation results obtained by the proposed method agree well with experimentally measured scattering data taken from similar well-characterized, rough metal samples, or to results obtained by other numerical methods.
A Review of Minimal Supersymmetric Electro-Weak Theory
I. Simonsen
Physics , 1995,
Abstract: In this review article we study the Minimal Supersymmetric Electro-Weak theory (of leptons). The Lagrangian is constructed step by step in great detail, both in the superfield and component field formalism --- both on and off shell. Furthermore the Lagrangian is written in the more familiar four component formalism. Electro weak symmetry breaking is discussed, and the physical chargino- and neutralino states are introduced and discussed.
Diffusion and networks: A powerful combination!
Ingve Simonsen
Physics , 2005, DOI: 10.1016/j.physa.2005.06.032
Abstract: Over the last decade, an enormous interest and activity in complex networks have been witnessed within the physics community. On the other hand, diffusion and its theory, have equipped the toolbox of the physicist for decades. In this paper, we will demonstrate how to combine these two seemingly different topics in a fruitful manner. In particular, we will review and develop further, an auxiliary diffusive process on weighted networks that represents a powerful concept and tool for studying network (community) structures. The working principle of the method is the observation that the relaxation of the diffusive process towards the stationary state is {\em non-local} and fastest in the highly connected regions of the network. This can be used to acquire non-trivial information about the structure of clustered and non-clustered networks.
The Z CamPaign: Year Five
Mike Simonsen
Physics , 2014,
Abstract: Entering into the fifth year of the Z CamPaign, the author has developed a website summarizing our findings which will also act as a living catalog of bona fide Z Cam stars, suspected Z Cams and Z Cam impostors. In this paper we summarize the findings of the first four years of research, introduce the website and its contents to the public and discuss the way forward into year five and beyond.
A random walk through surface scattering phenomena: Theory and phenomenology
Ingve Simonsen
Physics , 2004,
Abstract: No surface is perfectly planar at all scales. The notion of flatness of a surface therefore depends on the size of the probe used to observe it. As a consequence rough interfaces are abundant in nature. Here the old, but still active field of rough surface scattering of electromagnetic waves is addressed. This topic has implications and practical applications in fields as diverse as observational astronomy and the electronics industry. This article reviews the theoretical and computational foundation and methods used in the study of rough surface scattering. Furthermore, it presents and explains the physical origin of a series of multiple scattering surface phenomena. In particular what is discussed are: the enhanced backscattering and satellite peak phenomena, coherent effects in angular intensity correlation functions and second harmonic generated light (a non-linear effect).
The Z CamPaign: Year 1
Mike Simonsen
Physics , 2011,
Abstract: The Cataclysmic Variable Section of the American Association of Variable Star Observers (AAVSO) has initiated an observing campaign to study a subset of dwarf novae (DNe), known as Z Cam type (UGZ). We call this program the Z CamPaign. Since there is no strong agreement between the various published catalogues as to which few dozen DNe are actually Z Cam type systems, our primary goal is to accumulate enough data to construct detailed light curves, covering the entire range of variability, to determine unequivocally the 30 Z CamPaign subjects' membership in the UGZ class of DNe. We discuss the organization, science goals, and some early results of the Z CamPaign in detail.
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