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Search Results: 1 - 10 of 7408 matches for " Natural Gums "
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FORMULATION AND EVALUATION OF ONCE DAILY SUSTAINED RELEASE MATRIX TABLET OF ACECLOFENAC USING NATURAL GUMS
Prajapati SK,,Richhaiya R,Singh VK,Singh AK
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: In present study, an attempt has been made to evaluate the effect of natural gums on the release profile of drug from matrix system for once daily sustained release tablets formulations. Aceclofenac NSAIDs was used as a model drug to evaluate it release characteristics from different matrices. Matrix tablets of Aceclofenac were prepared by direct compression process using natural gums (xanthan gum and karaya gum) in different ratios drug: gum ratios of FX, FK and FXK (FX and FK in 1:1 ratios). The tablets were evaluated for physical characteristic like hardness, weight variation, friability, swelling index and drug content, in-vitro release of drug was performed in Phosphate buffer pH 7.4 for 24 hours. All the physical characteristic of fabricated tablet was within acceptable limits. The release of Aceclofenac from a gelatinous swollen mass, which controls the diffusion of drug molecules through the polymeric materials in to aqueous medium. The FXK matrices show prices controlled release than FX and FK matrices because of burst effect and fast release in case of FX and FK matrices respectively and there was no chemical interaction between drug and polymers in FXK formulation as confirmed by FTIR studies.The release mechanism was explained with zero order, first order, higuchi and korsmeyer equations via swelling and non fickian diffusion mechanism. The FXK matrices leads to more prices result than FX and FK alone by utilization of synergistic interaction between two biopolymers and uniformity in the hydration layer in dissolution media
Preparation and Evaluation of Pellets Using Acacia and Tragacanth by Extrusion-Spheronization
A. Akhgari,M R. Abbaspour,S. Pirmoradi
DARU : Journal of Pharmaceutical Sciences , 2011,
Abstract: Background and the purpose of the study: Extrusion-spheronization is an established technique for the production of pellets for pharmaceutical applications. In this study, the feasibility and influence of the incorporation of acacia, by itself and in combination with tragacanth, on the ability of formulations containing 2 model of drugs (ibuprofen and theophylline) to form spherical pellets by extrusion-spheronization was investigated.Material and Methods: Formulations containing different ratios of acacia and tragacanth (8:2, 9:1, and 10:0) and different drug concentrations (20%, 40%, and 60%) were prepared, on the basis of a 32 full factorial design. Pellet properties, such as aspect ratio, sphericity (image analysis), crushing strength and elastic modulus (mechanical tests), mean dissolution time, and dissolution profiles were evaluated. The effect of particular factors on responses was determined by linear regression analysis.Results: The sphericity, drug release rate, and the mechanical properties of the pellets were affected by the amounts and types of the drugs, and the ratio of the gums. Acacia, relative to tragacanth, produced pellets with higher mechanical strength and a faster drug release rate. Addition of small amounts of tragacanth to ibuprofen formulations resulted in matrix pellets with slow drug release.Conclusion: The results showed that acacia and tragacanth can be used successfully as 2 natural binders in the pellet formulations.
ROLE OF NATURAL POLYMERS IN SUSTAINED RELEASE DRUG DELIVERY SYSTEM: APPLICATIONS AND RECENT APPROACHES
Prakash Pawan,Porwal Mayur,Saxena Ashwin
International Research Journal of Pharmacy , 2011,
Abstract: In recent years there have been important developments in different dosage forms for existing and newly designed drugs and natural products, and semi-synthetic as well as synthetic excipients often need to be used for a variety of purposes. Gums and mucilages are widely used natural materials for conventional and novel dosage forms. These natural materials have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, biodegradable and widely available. They can also be modified in different ways to obtain tailor-made materials for drug delivery systems and thus can compete with the available synthetic excipients. Various polymers have been investigated as drug retarding agents, each presenting a different approach to the matrix system. Based on the features of the retarding polymer, hydrophilic polymers are the most suitable for retarding drug release and there is growing interest in using these polymers in sustained drug delivery. This review discusses some of the most important plant-derived polymeric compounds that are used or investigated as release retardant in sustained or controlled release drug delivery systems.
DESIGN AND EVALUATION OF LOSARTAN POTASSIUM MATRIX TABLETS WITH NATURAL AND SYNTHETIC POLYMERS
R. L. C. Sasidhar et al.
International Journal of Pharmaceutical Sciences and Research , 2012,
Abstract: The objective of the study was to formulate controlled release matrix tablets of losartan Potassium by using a combination of hydrophilic synthetic polymer like poly (ethylene oxides) and natural gums like xanthan gum, karaya gum and guar gum. A combination of synthetic hydrophobic polymers like methacrylates with synthetic hydrophilic polymer like poly (ethylene oxide) was also used in the preparation of matrix tablets and evaluated for their influence on controlled drug release. The matrix tablets were prepared by direct compression process and evaluated for hardness, weight variation, friability, swelling index and for in-vitro release of the drug. Preliminary evaluations showed that matrix tablets containing xanthan gum, guar gum and sodium alginate alone or in combination could not efficiently retard the drug release for prolonged period of time. The tablets containing combination of natural polymers and poly(ethylene oxides) and also methacrylates and poly(ethylene oxides) exhibited controlled release for a prolonged period of time. All the physical characteristics evaluated for the tablets were found to be within the acceptable limits.
COLON TARGETED DRUG DELIVERY USING NATURAL POLYMERS
A. D. Kajale
International Journal of Pharmaceutical Research and Development , 2010,
Abstract: Targeting of drugs to the colon by the oral route could be achieved by different approaches including matrix and coated systems, for which the drug release is controlled by the gastrointestinal pH, transit times or intestinal flora. The method by which the drug release will be triggered by the colonic flora appears to be more interesting with regard to the selectivity . A number of synthetic azo polymers and natural or modified polysaccharides (chondroitin sulphate, guar gum, xanthan gum, locust gum, inulin, dextrans, starch, amylose,pectins) degraded by the human colonic flora, have thus been investigated as colonic drug delivery carriers. Metronidazole benzoate is only used antibiotics which can be used in colonic diseases. Guargum in the ratio 1:0.72, 1:0.6, 1:0.5, and 1:0.32 gives 70%, 75.5%, 81.5% and 99.5% in 24 hours. Xanthangum in ratio 1:0.72, 1:0.6 and 1:0.32 gives 61%, 66% and 97.5% in 24 hours. And these polymer in combination in 1:1 ratio gives 86% drug release in 24 hours. All these batches in first two hours i.e. pH 1.2 hydrochloric buffer shows very neglible release, then it showed slight increase in 7.0 Phosphate Buffer drug release up to 12 hours but it showed high and fast increase in drug release from 12 th hour as it enters in colonic region as the retention time of drug in colonic media is 15 to 48 hours. So natural polymers are most cheap and suitable for colonic drug delivery.
Water Soluble Polymers for Pharmaceutical Applications
Veeran Gowda Kadajji,Guru V. Betageri
Polymers , 2011, DOI: 10.3390/polym3041972
Abstract: Advances in polymer science have led to the development of novel drug delivery systems. Some polymers are obtained from natural resources and then chemically modified for various applications, while others are chemically synthesized and used. A large number of natural and synthetic polymers are available. In the present paper, only water soluble polymers are described. They have been explained in two categories (1) synthetic and (2) natural. Drug polymer conjugates, block copolymers, hydrogels and other water soluble drug polymer complexes have also been explained. The general properties and applications of different water soluble polymers in the formulation of different dosage forms, novel delivery systems and biomedical applications will be discussed.
Nanocompósitos eletroativos de poli-o-metoxianilina e polissacarídeos naturais
Eiras, Carla;Passos, Ionara Nayana Gomes;Brito, Ana Cristina Facundo de;Santos Júnior, José Ribeiro dos;Zucolotto, Valtencir;Oliveira Jr, Osvaldo N.;Kitagawa, Igor L.;Constantino, Carlos J. L.;Cunha, Helder Nunes da;
Química Nova , 2007, DOI: 10.1590/S0100-40422007000500020
Abstract: in this work we take advantage of the polyelectrolyte character of some brazilian native gums to fabricate electrically conductive, nanostructured films. the gums sterculia urens, (caraia), sterculia striata (chicha) or anadenanthera macrocarpa benth were assembled in conjunction with poly(o-methoxyaniline) (poma) in the form of layered nanostructured films using the layer-by-layer (lbl) technique. all the lbl films displayed a well-defined electroactivity, as confirmed via cyclic voltammetry. in comparison to poma lbl films fabricated with conventional polyelectrolytes (viz. poly(vinyl sulfonic acid)-pvs), the presence of the gums in the lbl films increased remarkably the electrochemical stability of the films.
Preparation and Characterization of Mucoadhesive Microcapsules of Gliclazide with Natural Gums
Santhosh Kumar Mankala,Nishanth Kumar Nagamalli,Ramakrishna Raprla,Rajyalaxmi Kommula
Stamford Journal of Pharmaceutical Sciences , 2011,
Abstract: Gliclazide is an oral hypoglycemic agent used in management of non-insulin dependent diabetes mellitus. Among people who are suffering from long term disorders, the major were categorized under diabetes so, a dosage form is needed to provide continuous therapy with high margin of safety & such dosage form can be achieved by microencapsulation. Gliclazide microspheres with sodium alginate (coat material, gum kondagogu, gum guar and xanthan gum (mucoadhesive agents) were prepared by orifice-ionic gelation and emulsification ionic gelation techniques varying concentrations (1:0.25, 1:0.5, 1:0.75 and 1:1). Formulations were then evaluated for surface morphology, particle shape, Carr’s index, microencapsulation efficiency, drug release, mucoadhesion studies. Compatibility studies were performed by FTIR, DSC, and XRD techniques and no interactions were found between drug and excepients used. The microspheres were found spherical and free flowing with emulsion ionic gelation technique with a size range 400-600μm. % drug content and encapsulation efficiency found in the range of 55%-68% and, 86.23%-94.46% respectively. All microspheres showed good mucoadhesive property in in-vitro wash of test. In vitro drug release studies showed that the guar gum has more potentiality to retard the drug release compared to other gums and concentrations. Drug release from the microspheres was found slow following zero order release kinetics with non-fickian release mechanism stating release depended on the coat: core ratio and the method employed. The concentration of 1:1 of SA: GG (EMG 4) found suitable for preparing the controlled release formulation of gliclazide stating emulsification gelation technique is the best among followed.
Application and Characterization of Gum from Bombax buonopozense Calyxes as an Excipient in Tablet Formulation
Ndidi C. Ngwuluka,Jehu Kyari,John Taplong,Onyinye J. Uwaezuoke
Pharmaceutics , 2012, DOI: 10.3390/pharmaceutics4030354
Abstract: This study was undertaken to explore gum from Bombax buonopozense calyxes as a binding agent in formulation of immediate release dosage forms using wet granulation method. The granules were characterized to assess the flow and compression properties and when compressed, non-compendial and compendial tests were undertaken to assess the tablet properties for tablets prepared with bombax gum in comparison with those prepared with tragacanth and acacia gums. Granules prepared with bombax exhibited good flow and compressible properties with angle of repose 28.60°, Carr’s compressibility of 21.30% and Hausner’s quotient of 1.27. The tablets were hard, but did not disintegrate after one hour. Furthermore, only 52.5% of paracetamol was released after one hour. The drug release profile followed zero order kinetics. Tablets prepared with bombax gum have the potential to deliver drugs in a controlled manner over a prolonged period at a constant rate.
Fractional Order for Food Gums: Modeling and Simulation  [PDF]
Sergio A. David, Aline H. Katayama
Applied Mathematics (AM) , 2013, DOI: 10.4236/am.2013.42046
Abstract:

Fractional order calculus can represent systems with high-order dynamics and complex nonlinear phenomena using few coefficients, since the arbitrary order of the derivatives provides an additional degree of freedom to fit a specific behavior. Numerous mathematicians have contributed to the history of fractional calculus by attempting to solve a fundamental problem to the best of their understanding. Each researcher sought a definition and therefore different approaches, which has led to various definitions of differentiation and anti-differentiation of non-integer orders that are proven equivalent. Although all these definitions may be equivalent, from one specific standpoint, i.e., for a specific application, some definitions seem more attractive. Furthermore, it is well known that food gums are complex carbohydrates that can suit for a wide variety of functions in the context of food engineering. The viscoelastic behavior of food gums is crucial for these applications and formulations of new or improved food products. Small progress has been made to understand the viscoelastic behavior of food gums and there are few studies in the literature about these models. In this paper, we applied the Riemann-Liouville approach and the Fourier transform in order to obtain numerical simulations results of a fractional derivative model based on previous literature that to make a quantitative description of the viscoelastic properties behavior for a food gum. The results reveal that the fractional model shows good simulation capability and can be an attractive means for predicting and to elucidate the dynamic viscoelastic behavior of food gums.

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