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Search Results: 1 - 10 of 1074 matches for " Natalie Swergold "
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Males at High Risk for Breast Cancer: Who Are They and How Should We Screen Them?  [PDF]
Natalie Swergold, Vijayashree Murthy, Ronald S. Chamberlain
Surgical Science (SS) , 2014, DOI: 10.4236/ss.2014.57054

Background: It is estimated that 2240 males in the United States will develop invasive breast cancer (BC) in 2013, resulting in 410 deaths. Overall, male breast cancers (MBCs) are diagnosed with larger tumor size, more frequent lymphatic invasion, and advanced tumor stage compared to their female counterparts. Several risk factors have been elucidated for the development of MBC, and this paper aims to critically review the existing literature on at-risk populations and provide screening recommendations. Methods: A comprehensive search for all published studies on populations at risk for MBC using PubMed, EBSCOhost, and Google Scholar was performed (1982- 2013). The search focused specifically on genetic and epidemiologic risk factors, and screening for MBC. Keywords searched included “male breast cancer risk factors”, “male breast cancer epidemiology”, and “male breast cancer genetics”. A total of 34 studies involving 4,865,819 patients were identified. Results: Five studies (N = 327,667) focused primarily on family history of breast cancer as a risk factor for MBC. 15% - 20% of men with BC have a family history of breast or ovarian cancer, and a family history of BC among first-degree relatives confers a 2-to 3-fold increase in MBC risk (odds ratio = 3.3). Seventeen studies (N = 5451) analyzed associations between several heritable genes and MBC. Lifetime MBC risk among BRCA1 mutation carriers is 1% - 5%, while MBC risk in BRCA2 mutation carriers is higher and varies between 4% - 40%. Less clear associations between MBC and PALB2, Androgen Receptor gene, CYP17, and CHEK2 mutations have also been documented. Five studies (N = 16,667) have addressed occupational risk factors for MBC. An 8-fold increase in MBC is reported in males working in the cosmetic cream manufacturing, and the motor vehicle industries. A meta-analysis of 18 trials also identified electromagnetic field exposure as a potential MBC risk, though causation remains undocumented. Eleven studies (N = 4,843,598) analyzed the role of abnormalities in the androgen-to-estrogen ratio as a risk factor for MBC. Conditions associated with increased MBC risk include Klinefelter’s syndrome (relative risk, RR = 29.64), obesity (RR = 1.98), orchitis/epididymitis (RR = 1.84), and gynecomastia (RR = 5.86). Conclusion: Routine screening for MBC should be considered in all high risk male populations, including those with a prior history of breast carcinoma, a strong family history of BC

Advances in the management of pectus deformities in children  [PDF]
Natalie Swergold, Prasanna Sridharan, Marios Loukas, Ronald S. Chamberlain
Open Journal of Pediatrics (OJPed) , 2013, DOI: 10.4236/ojped.2013.33038

Pectus excavatum (PE) and pectus carinatum (PC) are relatively common deformities involving the anterior chest wall, occurring in 1:1000 and 1:1500 live births, respectively. While the etiology remains an enigma, the association of pectus deformities with other skeletal abnormalities suggests that connective tissue disease may play a role in their pathogenesis. Clinical features of these deformities vary with severity, as determined by the Haller index and Backer ratio, but frequently include cardiac and respiratory abnormalities. Importantly, there exist profound psychosocial implications for children afflicted with these defofrmities, including but not limited to feelings of embarrassment and maladaptive social behaviors. These debilitating characteristics have prompted the development of novel medical and surgical corrective techniques. The correction of pectus deformities reduces the incidence of physiological complications secondary to chest wall malformation, while simultaneously improving body image and psychosocial development in the affected pediatric population. The Ravitch (open) and Nuss (minimally invasive) procedures remain the most frequently employed methods of pectus deformity repair, with no difference in overall complication rates, though individual complication rates vary with treatment. The Nuss procedure is associated with a higher rate of recurrence due to bar migration, hemothorax, and pneumothorax. Postoperative pain management is markedly more difficult in patients who have undergone Nuss repair. Patients undergoing the Ravitch procedure require less postoperative analgesia, but have longer operation times and a larger surgical scar. The cosmetic

results of the Nuss procedure and its minimally invasive nature make it preferable to the Ravitch repair. Newer treatment modalities, including the vacuum bell, magnetic mini-mover procedure (3MP), and dynamic compression bracing (DCB) appear promising, and may ultimately provide effective methods of noninvasive repair. However, these modalities suffer from a lack of extensive published evidence, and the limited number of studies currently published fail to adequately define their long-term effectiveness.

Multidimensional Wave Field Signal Theory: Transfer Function Relationships
Natalie Baddour
Mathematical Problems in Engineering , 2012, DOI: 10.1155/2012/478295
Abstract: The transmission of information by propagating or diffusive waves is common to many fields of engineering and physics. Such physical phenomena are governed by a Helmholtz (real wavenumber) or pseudo-Helmholtz (complex wavenumber) equation. Since these equations are linear, it would be useful to be able to use tools from signal theory in solving related problems. The aim of this paper is to derive multidimensional input/output transfer function relationships in the spatial domain for these equations in order to permit such a signal theoretic approach to problem solving. This paper presents such transfer function relationships for the spatial (not Fourier) domain within appropriate coordinate systems. It is shown that the relationships assume particularly simple and computationally useful forms once the appropriate curvilinear version of a multidimensional spatial Fourier transform is used. These results are shown for both real and complex wavenumbers. Fourier inversion of these formulas would have applications for tomographic problems in various modalities. In the case of real wavenumbers, these inversion formulas are presented in closed form, whereby an input can be calculated from a given or measured wavefield.
Authentic teaching and learning through synthetic biology
Natalie Kuldell
Journal of Biological Engineering , 2007, DOI: 10.1186/1754-1611-1-8
Abstract: "Plant a carrot get a carrot, not a Brussels sprout" sings a musical theater character in The Fantasticks [1], aptly contrasting the predictability of gardening over childrearing. Map this idea to education and it seems teaching more closely resembles horticulture than parenting. Traditional metrics and standards around education often restrict educators to fixed lesson plans and syllabi, many of which have not changed since teachers were students themselves. Such preset teaching agendas enable students to achieve predictable, measurable learning outcomes and provide a framework to till a uniform garden of carrots (or geneticists or physicists or computer programmers). This educational framework, however, leaves little to no room for students to wrestle with the flexible thinking and uncertainty that characterize true discovery. It minimally connects information at the boundaries of traditional disciplines. An alternative teaching model establishes collaboration between teacher and student, providing a more student-centered learning experience than traditional didactic or Socratic methods. Though the measurement tools for this kind of collaborative learning are blunt, it remains clear that an effective and lasting education must inspire student innovation, creativity, and confidence giving rise to a garden full of individuals who are independent, skillful and responsible thinkers.Synthetic biology is particularly well suited to collaborative and integrated learning but it should not be automatically lumped with all "interdisciplinary" approaches to problem solving. The catch-phrase "interdisciplinary" has grown popular in both education and research [2-7]. Reductionist approaches to understanding that tease systems apart are currently less fashionable than integrative efforts that draw from traditionally distinct specialties to more fully describe the whole. However, despite seeming inherently interdisciplinary, synthetic biology is, in fact, not. It does not simply
A ética relacional: uma prática de ressonancia interpessoal
Depraz, Natalie;
Revista do Departamento de Psicologia. UFF , 2005, DOI: 10.1590/S0104-80232005000200003
Abstract: we analyze relational ethics within the scope of phenomenological/existential studies related to the problem of donation. the distinction between "donation with return" and "donation without return" is discussed in connection with an incarnated and specified ethics, which grants the right to personal singularity and irreducibility to the other. we investigate this ethics of measurement in the context of the clinical experience of the team of rapid intervention in crisis. such ethics is based on: 1) the restoration of the dimension of the personal subject in the patient, as opposed to his reifying objectivation; 2) the practice of the dynamic epoché in immanent resonance with a personalized plurality of subjects; 3) the experience donation as the simple capacity to accept receiving the donation of the other, and bring out the authentic ethos of eros as the experience of availability to the every day life; 4) the activation of the antinomic functioning of the psyche in order to re-open the infinite potentialities of relating to the other.
Evaluación de la escala Borg de esfuerzo percibido aplicada a la rehabilitación cardiaca
Burkhalter, Natalie;
Revista Latino-Americana de Enfermagem , 1996, DOI: 10.1590/S0104-11691996000300006
Abstract: borg's perceived exertion scale measures the extent of perceived exertion which a person experiences during exercise. the perceived exertion scale is used to adjust exercise intensity (workload) for predictions and prescriptions of exercise intensities in sports and medical rehabilitation (borg, 1982). in addition, borg's scale can be used in the athletic arena, space, industry, military settings, or under everyday circumstances. the concept of perceived exertion is a subjective rating, indicating the subject's opinion about the intensity of the work being performed (morgan, 1973). the task of exercising subjects is to assign a number (from 1-20) to represent the subjective sensation of the amount of work being performed. this is a valuable tool in human performance setting, where an important consideration is not "what the individual is doing, but what he thinks and is doing" (morgan, 1973).
The conveniently forgotten human rights of the Rohingya
Natalie Brinham
Forced Migration Review , 2012,
Abstract: As stateless Rohingya in Burma face containment in IDP camps andwithin their homes and communities in what is effectively segregation,their human rights are on the whole being ignored by countries keeneither to support reform in Burma or to return refugees who have fledto their shores.
Raabes narrativ inszenierter Bilddiskurs als (gesellschafts-) kritischer Aufbruch Richtung Moderne?
Natalie Moser
Textpraxis : Digitales Journal für Philologie , 2010,
Abstract: Das Verh ltnis von Literatur und Gesellschaft l sst sich an Wilhelm Raabes sp tem Text Pfisters Mühle als textexterner Antrieb und als textinternes Strukturmoment aufzeigen. Die Frage nach der poetologischen Relevanz des Textes wird textintern aufgegriffen, indem die Kopplung von Frage und potentiellen Antworten durch einen narrativ inszenierten Bilddiskurs dargestellt wird. Dieser Bilddiskurs bildet die Folie für eine narrative Selbstreflexion, anhand derer sich die Zeitlosigkeit und Aktualisierbarkeit des Textes zeigt. Pfisters Mühle kann als eine Form von poetologischer Reflexion verstanden werden, da der Text erz hlend dem Erz hlen auf den Grund geht und zugleich Narration und Metanarration ist. Gleichzeitig wird auf die Unm glichkeit eines abschlie enden Metadiskurses verwiesen.
From the Frying Pan Into the Fire (and Back Again): Adventures in Subject-Based, Credit Instruction
Natalie Tagge
In the Library with the Lead Pipe , 2012,
Abstract: My best experience as a teacher-librarian was leading a credit, semester-long course while a librarian at the University of Illinois Springfield (UIS) during which my students came to care deeply about the topical content and used their developing research skills to further their engagement. For librarians, though, this is the exception rather than the [...]
Multidimensional wave field signal theory: Mathematical foundations
Natalie Baddour
AIP Advances , 2011, DOI: 10.1063/1.3596359
Abstract: Many important physical phenomena are described by wave or diffusion-wave type equations. Since these equations are linear, it would be useful to be able to use tools from the theory of linear signals and systems in solving related forward or inverse problems. In particular, the transform domain signal description from linear system theory has shown concrete promise for the solution of problems that are governed by a multidimensional wave field. The aim is to develop a unified framework for the description of wavefields via multidimensional signals. However, certain preliminary mathematical results are crucial for the development of this framework. This first paper on this topic thus introduces the mathematical foundations and proves some important mathematical results. The foundation of the framework starts with the inhomogeneous Helmholtz or pseudo-Helmholtz equation, which is the mathematical basis of a large class of wavefields. Application of the appropriate multi-dimensional Fourier transform leads to a transfer function description. To return to the physical spatial domain, certain mathematical results are necessary and these are presented and proved here as six fundamental theorems. These theorems are crucial for the evaluation of a certain class of improper integrals which arise in the evaluation of inverse multi-dimensional Fourier and Hankel transforms, upon which the framework is based. Subsequently, applications of these theorems are demonstrated, in particular for the derivation of Green's functions in different coordinate systems.
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