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Search Results: 1 - 10 of 1465 matches for " Natalie Hicks "
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Regeneration of Hyaline Cartilage Using a Mechanically-Tuned Chondrocyte-Seeded Biomimetic Tissue-Engineered 3D Scaffold: A Theoretical Approach  [PDF]
Addie Hicks
Advances in Bioscience and Biotechnology (ABB) , 2014, DOI: 10.4236/abb.2014.57074
Abstract:

The limited ability of cartilage tissue to repair itself poses a functionally impairing health problem. While many treatment methods are available, full restoration of the tissue to its original state is rare. Often, complete joint replacement surgery is required to obtain long-term relief. Tissue engineering approaches, however, provide new opportunities for cartilage replacement. They seek to provide mechanisms to repair or replace lost tissue or function. A theoretical method is presented here for regenerating hyaline cartilage in vitro using a chondrocyte-seeded three-dimensional biomimetic engineered scaffold with mechanical properties similar to those occurring naturally. The scaffold composition, type II collagen, aggrecan, hyaluronan, hyaluronan binding protein (for link protein), and BMP-7, were chosen to encourage synthesis of hyaline cartilage by providing a more native environment and signaling cue for the seeded chondrocytes. The scaffold components mimic the macrofibrillar collagen network found in articular cartilage. Type II collagen provides tensile strength, and aggrecan, the predominant proteoglycan, provides compressive strength.

Impact of biodiversity-climate futures on primary production and metabolism in a model benthic estuarine system
Natalie Hicks, Mark T Bulling, Martin Solan, Dave Raffaelli, Piran CL White, David M Paterson
BMC Ecology , 2011, DOI: 10.1186/1472-6785-11-7
Abstract: The effects of elevated CO2 concentration, temperature and invertebrate diversity were not additive, rather they interacted to determine MPB biomass, and overall this effect was negative. Diversity effects were underpinned by strong species composition effects, illustrating the importance of individual species identity.Overall, our findings suggest that in natural systems, the complex interactions between changing environmental conditions and any associated changes in invertebrate assemblage structure are likely to reduce MPB biomass. Furthermore, these effects would be sufficient to affect the net metabolic balance of the coastal ecosystem, with important implications for system ecology and sustainable exploitation.Rising global temperatures and increasing atmospheric CO2 concentrations are causing changes to a wide range of ecosystems [1]. The influence of these changing conditions on ocean chemistry and the distribution of species in marine systems [2-4] is of particular concern. Atmospheric concentrations of CO2 have risen from pre-industrial levels (275 ppmv) to 370 ppmv and continue to increase by ~1.5 ppmv yr-1 [5]. Up to 50% of the global increase in carbon dioxide has been absorbed by the oceans [6] and the pH of the sea is predicted to fall by up to 0.5 pH units by the end of the century [2]. Concerns over the likely consequences are now widespread [7,8]. Studies of elevated carbon dioxide concentrations have demonstrated potential impacts on nutrient availability, primary productivity and decomposition [1,9,10]. This directly influences the functionality of ecosystems [9] across multiple trophic levels [11] and effects are difficult to anticipate.Empirical research to date has concentrated on the responses of a variety of ecosystems to individual anthropogenic drivers of change (terrestrial [12]; marine [13]; terrestrial soil [14]; freshwater [9]), and few studies have considered the combined effects of multiple drivers [15]. This is of particular importa
Physician-assisted suicide: a review of the literature concerning practical and clinical implications for UK doctors
Madelyn Hicks
BMC Family Practice , 2006, DOI: 10.1186/1471-2296-7-39
Abstract: Most deaths by physician-assisted suicide are likely to occur for the illness of cancer and in the elderly. GPs will deal with most requests for assisted suicide. The UK is likely to have proportionately more PAS deaths than Oregon due to the bill's wider application to individuals with more severe physical disabilities. Evidence from other countries has shown that coercion and unconscious motivations on the part of patients and doctors in the form of transference and countertransference contribute to the misapplication of physician-assisted suicide. Depression influences requests for hastened death in terminally ill patients, but is often under-recognized or dismissed by doctors, some of whom proceed with assisted death anyway. Psychiatric evaluations, though helpful, do not solve these problems. Safeguards that are incorporated into physician-assisted suicide criteria probably decrease but do not prevent its misapplication.The UK is likely to face significant clinical problems arising from physician-assisted suicide if it is legalized. Terminally ill patients with mental illness, especially depression, are particularly vulnerable to the misapplication of physician-assisted suicide despite guidelines and safeguards.A bill to legalize physician-assisted suicide in the UK recently progressed further than ever before in the British House of Lords. In 2005 Lord Joffe revised his Assisted Dying for the Terminally Ill Bill, originally written to legalize euthanasia and physician-assisted suicide (EAS), to narrow the focus to physician-assisted suicide (PAS) in England and Wales. The bill subsequently progressed to its second reading in the House of Lords in May 2006. Though peers voted to block the bill, Lord Joffe has declared his intention to continue reintroducing his bill to legalize PAS until it has proceeded through all parliamentary stages. Over the course of this legislative process, there has been little discussion of the clinical implications of physician-assis
Firming up the Foundations: Reflections on Verifying the 248 Quotations in a Historical Dict ionary, with Reference to "A Dictionary of South African English on Historical Principles"
S Hicks
Lexikos , 2010,
Abstract: A Dictionary of South African English on Historical Principles (DSAEHist) is rooted in quotation evidence. It contains just over 8 000 South African English entries, with about 45 000 citations to support those words included as headwords in the dictionary. Using the legacy electronic format in which DSAEHist was typeset, the Dictionary Unit for South African English embarked on a digitising process of DSAEHist, during which it became clear that the quotations would benefit from a full review involving the verification of all quotations against their original sources. This article examines the evolution of the quotation verification project from its beginnings as an entirely manual exercise to its current use of software developed for the purpose. Some of the project’s achievements, such as antedatings and primary source identification, are highlighted, and challenges, such as unverifiable quotations and sometimes highly convoluted research paths, are described. In addition to this, the article looks at the necessarily systematic nature of quotation handling and the main types of considerations determining methodology (for example, lexicographic, bibliographic and typographic requirements).
Pentaquark Searches
Hicks, Ken
High Energy Physics - Phenomenology , 2007,
Abstract: Current evidence does not favor the existence of the \thplus pentaquark, which was reported by several groups in the years after 2002. The question naturally arises: how could many groups could have seen fluctuations in their data at the level of 3-5 $\sigma$ statistical significance? An example of a statistical fluctuation is given and the number of $\sigma$'s necessary for claims of discovery are examined. Using this guideline, a possible answer to the above question is presented.
Sexuality and the ‘Relations of Ruling’: Using Institutional Ethnography to Research Lesbian and Gay Foster Care and Adoption.
Hicks, Stephen
Social Work and Society , 2009,
Abstract: This article makes use of institutional ethnography to research foster care and adoption by lesbians and gay men, drawing on the work of the feminist sociologist Dorothy E. Smith in order to demonstrate the investigation of social work institutional categories and the ‘relations of ruling’. Through an analysis of the ways in which ‘gender’ and the idea of the ‘gender role model’ is used within the assessment of gay and lesbian foster carers and adopters, the author shows how these categories are produced and used to police relationship forms and to identify ‘deviant instances’.
The Naueti relationship terminology: A new instance of asymmetric prescription from East Timor
David Hicks
Bijdragen tot de Taal-, Land- en Volkenkunde , 2008,
Abstract: Relationship terminologies of an asymmetric prescriptive character are widespread throughout mainland and insular Southeast Asia. Their western limit is marked by the Kachin of northern Burma (Leach 1961:28-53) while their eastern limit is marked by the Mambai people of central East Timor (Figures 1 and 2). Between these limits are such other instances as occur, for example, among the Lamet of Cambodia (Needham 1960), the various Batak groups of Sumatra (Rodgers 1984), and the Rindi of eastern Sumba (Forth 1981). The principal intention of the present paper is to establish the existence of a new asymmetric prescriptive terminology in East Timor, and by doing so provide empirical justification for adjusting the easternmost limits of nomenclatures of this kind. A subsidiary intent is to offer a contribution to current speculations regarding the transformation of relationship terminologies in eastern Indonesia (Guermonprez 1998; Smedal 2002).
Indexing social space: A marketplace in Timor-Leste
David Hicks
Bijdragen tot de Taal-, Land- en Volkenkunde , 2012,
Abstract: This article shows how space and time indexed social identity in the market place of one of the larger ‘towns’ of Timor-Leste (or ‘East Timor’), Viqueque during the years 1966-1967 and examine their relevance for today’s Viqueque town. The space occupied by the weekly emporium offered a forum in which ethnicity, social hierarchy, gender, a pastime (cockfighting), and religious affiliation visually played themselves out and presented a physical replication of social distinctions that defined the character of the town and the sub-district it served.Focusing on gender, ethnicity, social class, and social identity, and their economic implications, also enables us to gain insight into the process whereby post-colonial nations transform themselves after gaining independence. By comparing the use made of social space at two periods of time separated by four decades during which momentous developments took place in Timor-Leste we can see in sharper relief the kind of changes urban spaces experience when they are subject to colonial authority, pressures resulting from independence, and – ultimately – the tortuous process of nation-building.
New calculations show as many as 7.3 million Americans know someone killed or injured in Iraq and Afghanistan [A comment on: Fighting a Hydra: A Note on the Network Embeddedness of the War on Terror
Sally Hicks
Structure and Dynamics : e-Journal of Anthropological and Related Sciences , 2006,
Abstract: This is a simply a press release at Duke University on James Moody’s assessment (Structure and Dynamics 1#2) of impact of the U.S. wars’ casualty tolls.
Firming Up the Foundations: Reflections on Verifying the Quotations in a Historical Dictionary, with Reference to A Dictionary of South African English on Historical Principles
Sheila Hicks
Lexikos , 2011, DOI: 10.5788/20-0-142
Abstract: ABSTRACT: A Dictionary of South African English on Historical Principles (DSAEHist) is rooted in quotation evidence. It contains just over 8 000 South African English entries, with about 45 000 citations to support those words included as headwords in the dictionary. Using the legacy electronic format in which DSAEHist was typeset, the Dictionary Unit for South African English embarked on a digitising process of DSAEHist, during which it became clear that the quotations would benefit from a full review involving the verification of all quotations against their original sources. This article examines the evolution of the quotation verification project from its beginnings as an entirely manual exercise to its current use of software developed for the purpose. Some of the project’s achievements, such as antedatings and primary source identification, are highlighted, and challenges, such as unverifiable quotations and sometimes highly convoluted research paths, are described. In addition to this, the article looks at the necessarily systematic nature of quotation handling and the main types of considerations determining methodology (for example, lexicographic, bibliographic and typographic requirements). OPSOMMING: Verstewiging van die fondamente: Gedagtes oor die kontrolering van aanhalings in 'n historiese woordeboek, met verwysing na A Dictionary of South African English on Historical Principles. A Dictionary of South African English on Historical Principles (DSAEHist) het ontstaan uit aanhalingsbewysmateriaal. Dit bevat net oor 8 000 inskrywings van Suid-Afrikaanse Engels, met ongeveer 45 000 sitate om daardie woorde te staaf wat as trefwoorde in die woordeboek ingesluit is. Deur die arga ese elektroniese formaat te gebruik waarin die DSAEHist geset is, het die Woordeboekeenheid van Suid-Afrikaanse Engels 'n digitaliseringsproses van die DSAEHist onderneem waartydens die duidelik geword het dat die aanhalings sal baat by 'n volledige hersiening wat die kontrolering van alle aanhalings in hulle oorspronklike bronne behels. Die artikel ondersoek die vordering van die aanhalingskontroleringsprojek vanaf sy begin as 'n algehele handtaak tot sy huidige gebruik van programmatuur wat vir die doel ontwikkel is. 'n Aantal van die projek se suksesse soos vroe re daterings en primêrebronidentifikasie word uitgelig, en uitdagings soos onkontroleerbare aanhalings en somtyds hoogs verstrengelde navorsingsroetes word beskryf. Hierbenewens kyk die artikel na die noodsaaklik sistematiese aard van aanhalingshantering en die hoofsoorte oorwegings wat metodologie (byvoorbe
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