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Search Results: 1 - 10 of 3562 matches for " Natalia Santucci "
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A Multifaceted Analysis of Immune-Endocrine-Metabolic Alterations in Patients with Pulmonary Tuberculosis
Natalia Santucci, Luciano D'Attilio, Leandro Kovalevski, Verónica Bozza, Hugo Besedovsky, Adriana del Rey, María Luisa Bay, Oscar Bottasso
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026363
Abstract: Our study investigated the circulating levels of factors involved in immune-inflammatory-endocrine-metabolic responses in patients with tuberculosis with the aim of uncovering a relation between certain immune and hormonal patterns, their clinical status and in vitro immune response. The concentration of leptin, adiponectin, IL-6, IL-1β, ghrelin, C-reactive protein (CRP), cortisol and dehydroepiandrosterone (DHEA), and the in vitro immune response (lymphoproliferation and IFN-γ production) was evaluated in 53 patients with active untreated tuberculosis, 27 household contacts and 25 healthy controls, without significant age- or sex-related differences. Patients had a lower body mass index (BMI), reduced levels of leptin and DHEA, and increased concentrations of CRP, IL-6, cortisol, IL-1β and nearly significant adiponectin values than household contacts and controls. Within tuberculosis patients the BMI and leptin levels were positively correlated and decreased with increasing disease severity, whereas higher concentrations of IL-6, CRP, IL-1β, cortisol, and ghrelin were seen in cases with moderate to severe tuberculosis. Household contacts had lower DHEA and higher IL-6 levels than controls. Group classification by means of discriminant analysis and the k-nearest neighbor method showed that tuberculosis patients were clearly different from the other groups, having higher levels of CRP and lower DHEA concentration and BMI. Furthermore, plasma leptin levels were positively associated with the basal in vitro IFN-γ production and the ConA-driven proliferation of cells from tuberculosis patients. Present alterations in the communication between the neuro-endocrine and immune systems in tuberculosis may contribute to disease worsening.
Dynamics of Adrenal Steroids Are Related to Variations in Th1 and Treg Populations during Mycobacterium tuberculosis Infection in HIV Positive Persons
Maria Florencia Quiroga, Matias Tomas Angerami, Natalia Santucci, Diego Ameri, Jose Luis Francos, Jorge Wallach, Omar Sued, Pedro Cahn, Horacio Salomón, Oscar Bottasso
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0033061
Abstract: Tuberculosis (TB) remains the most frequent cause of illness and death from an infectious agent, and its interaction with HIV has devastating effects. We determined plasma levels of dehydroepiandrosterone (DHEA), its circulating form DHEA-suphate (DHEA-s) and cortisol in different stages of M. tuberculosis infection, and explored their role on the Th1 and Treg populations during different scenarios of HIV-TB coinfection, including the immune reconstitution inflammatory syndrome (IRIS), a condition related to antiretroviral treatment. DHEA levels were diminished in HIV-TB and HIV-TB IRIS patients compared to healthy donors (HD), HIV+ individuals and HIV+ individuals with latent TB (HIV-LTB), whereas dehydroepiandrosterone sulfate (DHEA-s) levels were markedly diminished in HIV-TB IRIS individuals. HIV-TB and IRIS patients presented a cortisol/DHEA ratio significantly higher than HIV+, HIV-LTB and HD individuals. A positive correlation was observed between DHEA-s and CD4 count among HIV-TB individuals. Conversely, cortisol plasma level inversely correlated with CD4 count within HIV-TB individuals. M. tuberculosis-specific Th1 lymphocyte count was increased after culturing PBMC from HIV-TB individuals in presence of DHEA. We observed an inverse correlation between DHEA-s plasma level and Treg frequency in co-infected individuals, and CD4+FoxP3+ Treg frequency was increased in HIV-TB and IRIS patients compared to other groups. Strikingly, we observed a prominent CD4+CD25-FoxP3+ population across HIV-TB and HIV-TB IRIS patients, which frequency correlated with DHEA plasma level. Finally, DHEA treatment negatively regulated FoxP3 expression without altering Treg frequency in co-infected patients. These data suggest an enhancing role for DHEA in the immune response against M. tuberculosis during HIV-TB coinfection and IRIS.
Urogenital trauma
Santucci Richard A.
International braz j urol , 2004,
Abstract:
Urogenital trauma
Santucci Richard A.
International braz j urol , 2003,
Abstract:
Urogenital trauma
Santucci Richard A.
International braz j urol , 2004,
Abstract:
Urogenital trauma
Santucci Richard A
International braz j urol , 2003,
Abstract:
Urogenital trauma
Santucci Richard A.
International braz j urol , 2003,
Abstract:
Le multipartisme marocain entre les contraintes d’un pluralisme contr lé et les dilemmes d’un pluripartisme autoritaire The multi-party system in Morocco: between the limitations of a "controlled pluralism" and an "authoritarian multi-party" dilemna
Jean-Claude Santucci
Revue des Mondes Musulmans et de la Méditerranée , 2011, DOI: 10.4000/remmm.2864
Abstract: Ancrés dans l’histoire politique du Mouvement national, et largement associés dans la lutte anti-coloniale aux c tés du Sultan, les partis marocains avaient vocation à s’attribuer sinon la plénitude du moins une part prépondérante de l’exercice du pouvoir dans le Maroc indépendant. En réalité, et malgré la reconnaissance constitutionnelle de leur fonction d’or-ganisation et de représentation des citoyens, la monarchie marocaine a déployé une stratégie de dépérissement et de marginalisation des formations issues du mouvement national, tout en perpétuant un pluripartisme qui serve à maintenir et conforter son leadership. Les multiples élections qui ont scandé l’histoire politique du Maroc, ont fourni un cadre d’expression et de renouvellement du champ partisan, soigneusement contr lé par la Monarchie et dénué de toute dimension réellement compétitive quant aux enjeux d’appropriation du pouvoir. En dépit de la libéralisation du régime amorcée depuis une décennie, et qui a laissé entrevoir un certain renouveau partisan, le multipartisme marocain relève du pluralisme autoritaire , avec les contraintes et les dilemmes imposés par les modes de régulation politique des régimes autoritaires : pour les formations, accepter de continuer à jouer le jeu de l’intégration ou de la cooptation au risque d’affaiblir leurs assises sociales et d’augmenter leur discrédit populaire ; pour la monarchie, s’assurer du concours des structures partisanes à travers une certaine légiti-mité électorale, pour garantir sinon son hégémonie du moins sa stabilité et sa survie. Anchored in the political history of the national Movement, and largely associated with the anti-colonial fight alongside the Sultan, the Moroccan parties were typically granted, if not full power, at least the lion’s share in the exercise of power in an independent Morocco. Actually, and in spite of their constitutionally recognized function as organizations and citizens’ repre-sentatives, parties formed out of the national movement were undermined and marginalized by the monarchy which promoted a multi-party system to help maintain and consolidate its own leadership. The succession of elections that mark the political history of Morocco, pro-vided a context in which parties could express and renew themselves under the close watch of the Monarchy and without any real competitive dimension as to the appropriation of power. Despite liberalization of the regime that began a decade ago with a vision of a revived party system, the Moroccan multi-party system is better defined as an "authoritarian pluralism", with th
Ricci Loredana, Maghreb e mondializzazione : sfide aperte su percorsi incrociati, Napoli, Istituto italiano per gli Studi filosofici, 2008.
Jean-Claude Santucci
Revue des Mondes Musulmans et de la Méditerranée , 2009,
Abstract: L’ouvrage de Loredana Ricci relève de cette catégorie de livres qui font regretter que la connaissance de l’italien ne soit pas davantage répandue dans les milieux scientifiques. En effet, l’auteure appartient à ce groupe de chercheurs italiens dont la qualité des travaux justifierait, à défaut d’une traduction en d’autres langues européennes, une plus grande diffusion éditoriale. Elle fait également partie de ce groupe de chercheurs qui ont spécialement orienté leur champ disciplinaire dans ...
Effect of Stacking Fault Energy on the Mechanism of Texture Formation during Alternating Bending of FCC Metals and Alloys  [PDF]
Natalia Shkatulyak
International Journal of Nonferrous Metallurgy (IJNM) , 2013, DOI: 10.4236/ijnm.2013.22005
Abstract:

Alternating bending shear stresses lead to the formation of twin orientations in the texture of FCC materials with middle and low stacking fault energy (SFE). Only in the stainless steel with a low SFE during alternating bending with different number of cycles components of shear texture {111}; {hkl}<110>; {001}<110> were formed. Copper (middle SFE), along with orientations of twinning and cubic texture formed orientation of deformation {135}<211>. During alternating bending of aluminum (high SFE), a dynamic recovery occurred. The share of initial cubic texture increases with the increase of number of cycles of alternating bending and reaches its maximum after three cycles. Share of component of texture Goss increased slightly. The most significant change of the microstructure and texture occurred during the first 3 - 5 cycles

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