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Search Results: 1 - 10 of 22 matches for " Narimatsu "
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Immune Reactions following Cord Blood Transplantations in Adults
Hiroto Narimatsu
Stem Cells International , 2011, DOI: 10.4061/2011/607569
Abstract: Cord blood transplantation (CBT) is an attractive alternative therapy in adult patients with advanced hematological malignancies in whom matched donors are unavailable. However, the risk of complications, especially infections, post-CBT increases the mortality rates in these patients. Although the incidence of acute and chronic graft versus host disease (GVHD) post-CBT is lower than that following bone marrow transplantation and peripheral blood stem cell transplantation (SCT), the additional immunosuppressive therapy required to treat it could increase the mortality in these patients. Further, chronic GVHD following CBT is milder and responds better to treatment than that occurring after bone marrow transplants. Unlike bone marrow transplantation, the onset of GVHD is a positive prognostic indicator of overall survival in patients receiving CBT, due to the graft versus malignancy (GVM) effect. This paper focuses on the immune reactions following CBT and aims to elucidate a management strategy for acute and chronic GVHD. 1. Introduction Cord blood transplantation (CBT) represents an attractive alternative for patients with advanced hematological malignancy who lack matched related or unrelated donors. Adult patients receiving myeloablative or reduced-intensity CBT display a 90% chance of engraftment, but also experience a 50% rate of transplant-related mortality, mostly attributable to infection [1–6]. Unique manifestations of immune reactions that differ from those seen in conventional allogeneic stem cell transplantation (allo-SCT) may occur after CBT. Fortunately, the incidence and severity of acute graft-versus-host disease (GVHD) after unrelated CBT are low compared with those after allo-SCT from a matched unrelated or mismatched family donor, despite infusion of human leukocyte antigen (HLA)-mismatched graft [7, 8]. The clinical characteristics of patients with chronic GVHD after CBT have not been well described. Studies dealing with CBT have mainly focused on short-term events, such as engraftment, acute GVHD, infections, and regimen-related toxicities. Several groups have reported chronic GVHD rates ranging from 17% to 89% [5, 6, 9–20]. However, studies dealing with details of the clinical characteristics of chronic GVHD, including the target organs, grading and treatment response, are limited [5, 6, 9–20]. In this paper, I focus on the characteristics of immune reactions following CBT, review the research performed to date in Japan, Europe, and the United States, and attempt to elucidate a management strategy that takes those clinical
Duration and Interval Hidden Markov Model for Sequential Data Analysis
Hiromi Narimatsu,Hiroyuki Kasai
Computer Science , 2015,
Abstract: Analysis of sequential event data has been recognized as one of the essential tools in data modeling and analysis field. In this paper, after the examination of its technical requirements and issues to model complex but practical situation, we propose a new sequential data model, dubbed Duration and Interval Hidden Markov Model (DI-HMM), that efficiently represents "state duration" and "state interval" of data events. This has significant implications to play an important role in representing practical time-series sequential data. This eventually provides an efficient and flexible sequential data retrieval. Numerical experiments on synthetic and real data demonstrate the efficiency and accuracy of the proposed DI-HMM.
Bilateral Blunt Internal Carotid Artery Occlusions Associated with Multiple Trauma: A Case Report  [PDF]
Ayumu Yamaoka, Kei Miyata, Naofumi Bunya, Eichi Narimatsu
Open Journal of Modern Neurosurgery (OJMN) , 2017, DOI: 10.4236/ojmn.2017.73006
Abstract:

In multiple trauma, blunt carotid artery injuries (BCAIs) have occasionally been reported. However, bilateral blunt carotid artery occlusions (Grade 4 BCAIs) associated with multiple trauma are rare, and delays in diagnosis and treatment result in a lethal outcome. Here, we report our experience with bilateral carotid artery occlusions. A 76-year-old female suffered multiple traumas in a motor vehicle accident. On arrival at our hospital, she presented in a coma, with left mydriasis and unreactive pupils. Computed tomography (CT) showed bifrontal intracranial epidural hematoma and fractures of the facial bone and anterior skull base, and osteoplastic craniotomy was urgently undertaken for the epidural hematoma. However, the comatose state and unreactive pupils persisted during the post-operative course. Serial head CT findings showed progressive bilateral ischemic changes, and radiological examinations revealed bilateral internal carotid artery occlusions. We speculated that bilateral Grade 4 BCAIs had induced progressive cerebral infarctions. The patient partially responded to anticoagulation therapy with heparin infusion, but died of multiple organ failure on day 15. When bilateral progressive ischemic changes are observed in a patient with severe traumatic brain injury, bilateral Grade 4 BCAIs should be considered in the differential diagnosis. CT angiography as part of whole-body CT at admission may be effective for preventing delays in diagnosis and treatment of bilateral Grade 4 BCAIs.

Coverage of genomic medicine: information gap between lay public and scientists
Sugawara Y, Narimatsu H, Fukao A
Risk Management and Healthcare Policy , 2012, DOI: http://dx.doi.org/10.2147/RMHP.S33661
Abstract: verage of genomic medicine: information gap between lay public and scientists Original Research (1713) Total Article Views Authors: Sugawara Y, Narimatsu H, Fukao A Published Date August 2012 Volume 2012:5 Pages 83 - 90 DOI: http://dx.doi.org/10.2147/RMHP.S33661 Received: 06 May 2012 Accepted: 13 June 2012 Published: 02 August 2012 Yuya Sugawara,1 Hiroto Narimatsu,2,3 Akira Fukao2,3 1Department of Medical Informatics, Graduate School of Medical Science, Yamagata University, Yamagata, 2Advanced Molecular Epidemiology Research Institute, Faculty of Medicine, Yamagata University, Yamagata, 3Department of Public Health, Yamagata University Graduate School of Medicine, Yamagata, Japan Abstract: The sharing of information between the lay public and medical professionals is crucial to the conduct of personalized medicine using genomic information in the near future. Mass media, such as newspapers, can play an important role in disseminating scientific information. However, studies on the role of newspaper coverage of genome-related articles are highly limited. We investigated the coverage of genomic medicine in five major Japanese newspapers (Asahi, Mainichi, Yomiuri, Sankei, and Nikkei) using Nikkei Telecom and articles in scientific journals in PubMed from 1995 to 2009. The number of genome-related articles in all five newspapers temporarily increased in 2000, and began continuously decreasing thereafter from 2001 to 2009. Conversely, there was a continuous increasing trend in the number of genome-related articles in PubMed during this period. The numbers of genome-related articles among the five major newspapers from 1995 to 2009 were significantly different (P = 0.002). Commentaries, research articles, and articles about companies were the most frequent in 2001 and 2003, when the number of genome-related articles transiently increased in the five newspapers. This study highlights the significant gap between newspaper coverage and scientific articles in scientific journals.
Coverage of genomic medicine: information gap between lay public and scientists
Sugawara Y,Narimatsu H,Fukao A
Risk Management and Healthcare Policy , 2012,
Abstract: Yuya Sugawara,1 Hiroto Narimatsu,2,3 Akira Fukao2,31Department of Medical Informatics, Graduate School of Medical Science, Yamagata University, Yamagata, 2Advanced Molecular Epidemiology Research Institute, Faculty of Medicine, Yamagata University, Yamagata, 3Department of Public Health, Yamagata University Graduate School of Medicine, Yamagata, JapanAbstract: The sharing of information between the lay public and medical professionals is crucial to the conduct of personalized medicine using genomic information in the near future. Mass media, such as newspapers, can play an important role in disseminating scientific information. However, studies on the role of newspaper coverage of genome-related articles are highly limited. We investigated the coverage of genomic medicine in five major Japanese newspapers (Asahi, Mainichi, Yomiuri, Sankei, and Nikkei) using Nikkei Telecom and articles in scientific journals in PubMed from 1995 to 2009. The number of genome-related articles in all five newspapers temporarily increased in 2000, and began continuously decreasing thereafter from 2001 to 2009. Conversely, there was a continuous increasing trend in the number of genome-related articles in PubMed during this period. The numbers of genome-related articles among the five major newspapers from 1995 to 2009 were significantly different (P = 0.002). Commentaries, research articles, and articles about companies were the most frequent in 2001 and 2003, when the number of genome-related articles transiently increased in the five newspapers. This study highlights the significant gap between newspaper coverage and scientific articles in scientific journals.Keywords: coverage, personalized medicine, mass media, newspaper
Skull Base Penetration Due to Cervical Impalement Injury: A Case Report and Review of the Literature  [PDF]
Kei Miyata, Takeshi Mikami, Yukinori Akiyama, Toshiya Sugino, Reiko Kiyan, Eichi Narimatsu, Nobuhiro Mikuni
Open Journal of Modern Neurosurgery (OJMN) , 2014, DOI: 10.4236/ojmn.2014.41003
Abstract: Impalement injury is a rare type of trauma, and the management should be performed carefully. In cases with impalement injuries, the area of injury and crush might be extensive because the penetrating object itself is generally large and long. Herein, we report our experience with a rare case of cervical impalement injury caused by an iron reinforcing bar penetrating the optic canal and thereby causing brain contusion. A 32-year-old man fell while working at a construction site and sustained an injury due to an iron reinforcing bar that penetrated his right neck. On arrival at the hospital, consciousness was clear and the bar was removed by himself. The patient had lost the sight in his right eye, and cerebrospinal fluid (CSF) rhinorrhea was present. Based on the results of computed tomography (CT) of the head and neck, the bar was thought to have passed through the right mandible and the right optic canal and penetrated the frontal lobe. Surgical repair of frontal base was performed using femoral fascia, completely stopping the CSF leak. The patient was discharged on the 31st hospital day walking independently. In our present case, the top of a foreign body was reached an intracranial site. Impalement injuries require detailed assessment of the injury sites because outcomes depend on the severity of injuries at surrounding anatomical structures. Multiple planar reconstruction using recent multidetector row CT scanning was considered to be useful for the assessment of penetrating routes and injury severity.
IgA Nephropathy Caused by Unusual Polymerization of IgA1 with Aberrant N-Glycosylation in a Patient with Monoclonal Immunoglobulin Deposition Disease
Yoshiki Narimatsu, Atsushi Kuno, Hiromi Ito, Hiroyuki Kaji, Syuzo Kaneko, Joichi Usui, Kunihiro Yamagata, Hisashi Narimatsu
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0091079
Abstract: Immunoglobulin A nephropathy (IgAN) is a form of chronic glomerulonephritis characterized by the deposition of IgA immune complexes in the glomerular region. The cause of IgAN is unknown, but multiple mechanisms have been suggested. We previously reported a rare case of mesangioproliferative glomerulonephritis in a patient with monoclonal immunoglobulin deposition disease associated with monoclonal IgA1. In this study, we performed the detailed analyses of serum IgA1 from this patient in comparison with those from patients with mIgA plasma cell disorder without renal involvement and healthy volunteers. We found unusual polymerization of IgA1 with additional N-glycosylation distinctive in this patient, which was different from known etiologies. Glycan profiling of IgA1 by the lectin microarray revealed an intense signal for Wisteria floribunda agglutinin (WFA). This signal was reduced by disrupting the native conformation of IgA1, suggesting that the distinct glycan profile was reflecting the conformational alteration of IgA1, including the glycan conformation detected as additional N-glycans on both the heavy and light chains. This unusually polymerized state of IgA1 would cause an increase of the binding avidity for lectins. WFA specifically recognized highly polymerized and glycosylated IgA1. Our results of analysis in the rare case of a patient with monoclonal immunoglobulin deposition disease suggest that the formation of unusually polymerized IgA1 is caused by divergent mechanisms including multiple structural alterations of glycans, which contributes to IgA1 deposition and mesangium proliferation.
Vertical pneumatic conveying in dilute and dense-phase flows: experimental study of the influence of particle density and diameter on fluid dynamic behavior
Narimatsu, C.P.;Ferreira, M.C.;
Brazilian Journal of Chemical Engineering , 2001, DOI: 10.1590/S0104-66322001000300002
Abstract: in this work, the effects of particle size and density on the fluid dynamic behavior of vertical gas-solid transport of group d particles in a 53.4 mm diameter transport tube were studied. for the conditions tested, the experimental curves of pressure gradient versus air velocity presented a minimum pressure gradient point, which is associated with a change in the flow regime from dense to dilute phase. the increases in particle size from 1.00 to 3.68 mm and in density from 935 to 2500 kg/m3 caused an increase in pressure gradient for the dense-phase transport region, but were not relevant in dilute transport. the transition velocity between dense and dilute flow (umin) also increased with increasing particle density and diameter. an empirical equation was fitted for predicting transition air velocity for the transport of glass spheres. additional experiments, covering a wider range of conditions and particles properties, are still needed to allow the fitting of a generalized equation for prediction of umin.
Vertical pneumatic conveying in dilute and dense-phase flows: experimental study of the influence of particle density and diameter on fluid dynamic behavior
Narimatsu C.P.,Ferreira M.C.
Brazilian Journal of Chemical Engineering , 2001,
Abstract: In this work, the effects of particle size and density on the fluid dynamic behavior of vertical gas-solid transport of Group D particles in a 53.4 mm diameter transport tube were studied. For the conditions tested, the experimental curves of pressure gradient versus air velocity presented a minimum pressure gradient point, which is associated with a change in the flow regime from dense to dilute phase. The increases in particle size from 1.00 to 3.68 mm and in density from 935 to 2500 kg/m3 caused an increase in pressure gradient for the dense-phase transport region, but were not relevant in dilute transport. The transition velocity between dense and dilute flow (Umin) also increased with increasing particle density and diameter. An empirical equation was fitted for predicting transition air velocity for the transport of glass spheres. Additional experiments, covering a wider range of conditions and particles properties, are still needed to allow the fitting of a generalized equation for prediction of Umin.
Cancer patients on Twitter: a novel patient community on social media
Yuya Sugawara, Hiroto Narimatsu, Atsushi Hozawa, Li Shao, Katsumi Otani, Akira Fukao
BMC Research Notes , 2012, DOI: 10.1186/1756-0500-5-699
Abstract: Fifty-one highly influential "power accounts" belonging to cancer patients were extracted from a dataset of 731 Twitter accounts with cancer terminology in their profiles. In accordance with previously established methodology, "power accounts" were defined as those Twitter accounts with 500 or more followers. We extracted data on the cancer patient (female) with the most followers to study the specific relationships that existed between the user and her followers, and found that the majority of the examined tweets focused on greetings, treatment discussions, and other instances of psychological support. These findings went against our hypothesis that cancer patients' tweets would be centered on the dissemination of medical information and similar "newsy" details.At present, there exists a rapidly evolving network of cancer patients engaged in information exchange via Twitter. This network is valuable in the sharing of psychological support among the cancer community.
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